DK1981519T3 - protease inhibition - Google Patents
protease inhibition Download PDFInfo
- Publication number
- DK1981519T3 DK1981519T3 DK06848187.8T DK06848187T DK1981519T3 DK 1981519 T3 DK1981519 T3 DK 1981519T3 DK 06848187 T DK06848187 T DK 06848187T DK 1981519 T3 DK1981519 T3 DK 1981519T3
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- DK
- Denmark
- Prior art keywords
- protein
- human
- kunitz
- protease
- tfpi
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US75490305P | 2005-12-29 | 2005-12-29 | |
| PCT/US2006/049322 WO2007079096A2 (en) | 2005-12-29 | 2006-12-27 | Protease inhibition |
Publications (1)
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| DK1981519T3 true DK1981519T3 (en) | 2018-02-19 |
Family
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Family Applications (1)
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|---|---|---|---|
| DK06848187.8T DK1981519T3 (en) | 2005-12-29 | 2006-12-27 | protease inhibition |
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| EP (1) | EP1981519B1 (enExample) |
| JP (2) | JP5632126B2 (enExample) |
| AU (1) | AU2006332774A1 (enExample) |
| CA (1) | CA2635589C (enExample) |
| CY (1) | CY1119967T1 (enExample) |
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| ES (1) | ES2663497T3 (enExample) |
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| LT (1) | LT1981519T (enExample) |
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| PT (1) | PT1981519T (enExample) |
| SI (1) | SI1981519T1 (enExample) |
| WO (1) | WO2007079096A2 (enExample) |
Families Citing this family (33)
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| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| PT1941867E (pt) | 2002-06-07 | 2012-02-16 | Dyax Corp | Polipeptídeo contendo um domínio kunitz modificado |
| DK2386310T3 (en) | 2002-08-28 | 2019-02-25 | Dyax Corp | Methods of preserving organs and tissues |
| PT1663281E (pt) * | 2003-08-29 | 2014-03-17 | Dyax Corp | Inibidores de proteases poli-peguilados |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| WO2006108826A1 (en) | 2005-04-15 | 2006-10-19 | Novo Nordisk A/S | Basic protein purification tags from thermophilic bacteria |
| WO2008043847A1 (en) | 2006-10-13 | 2008-04-17 | Novo Nordisk Health Care Ag | Processing enzymes fused to basic protein tags |
| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| JP2010536883A (ja) * | 2007-08-23 | 2010-12-02 | ジェンザイム・コーポレーション | カリクレイン阻害剤を用いた治療 |
| WO2010048432A1 (en) * | 2008-10-22 | 2010-04-29 | Dyax Corp. | Combination treatments comprising protease binding proteins for inflammatory disorders |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| WO2010103475A2 (en) * | 2009-03-10 | 2010-09-16 | Med Discovery Sa | Use of serine protease inhibitors in the treatment of neutropenia |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| HRP20181419T1 (hr) | 2010-01-06 | 2018-11-16 | Dyax Corp. | Plazma kalikrein vezni proteini |
| US9597379B1 (en) * | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| WO2013059439A2 (en) | 2011-10-21 | 2013-04-25 | Dyax Corp. | Combination therapy comprising an mmp-14 binding protein |
| WO2014107171A1 (en) | 2013-01-07 | 2014-07-10 | Omniox, Inc. | Polymeric forms of h-nox proteins |
| JP6444315B2 (ja) * | 2013-01-20 | 2018-12-26 | ダイアックス コーポレーション | ブラジキニン媒介障害の評価および治療 |
| KR20250066486A (ko) | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| KR102665705B1 (ko) * | 2013-10-21 | 2024-05-14 | 다케다 파머수티컬 컴패니 리미티드 | 자가면역 질환의 진단 및 치료 |
| ES2700149T3 (es) | 2014-02-24 | 2019-02-14 | Takeda Gmbh | Proteínas de fusión de UTI |
| KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| AU2016232866B2 (en) | 2015-03-17 | 2021-10-21 | Omniox, Inc. | Modulation of tumor immunity by protein-mediated 02 delivery |
| EP3365685B1 (en) | 2015-10-19 | 2020-11-25 | Dyax Corp. | Immunoassay to detect cleaved high molecular weight kininogen |
| WO2017100679A1 (en) | 2015-12-11 | 2017-06-15 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| JP6467073B2 (ja) * | 2018-01-04 | 2019-02-06 | オムニオクス， インコーポレイテッド | Ｈ−ｎｏｘタンパク質の重合体形態 |
| CA3093802A1 (en) | 2018-03-13 | 2019-09-19 | Shire Human Genetic Therapies, Inc. | Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof |
| MX2022001812A (es) * | 2019-08-12 | 2022-03-11 | Regeneron Pharma | Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos. |
| CN114667289B (zh) | 2019-09-18 | 2025-08-26 | 武田药品工业有限公司 | 杂芳基血浆激肽释放酶抑制剂 |
| ES2987744T3 (es) | 2019-09-18 | 2024-11-18 | Takeda Pharmaceuticals Co | Inhibidores de calicreína plasmática y usos de los mismos |
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| EP0332640A1 (en) | 1986-11-17 | 1989-09-20 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
| IL87172A (en) | 1987-07-23 | 1994-12-29 | Univ Washington | Method of isolating highly purified tissue factor inhibitor |
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| US4966852A (en) | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
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| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
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| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| US5378614A (en) | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| IL104314A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| IL104327A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| US5212091A (en) | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
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| DE69533544T2 (de) | 1994-01-11 | 2006-02-23 | Dyax Corp., Cambridge | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
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| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| HU221311B1 (en) * | 1994-06-02 | 2002-09-28 | Merrell Pharma Inc | Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use |
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| ATE226249T1 (de) | 1994-08-05 | 2002-11-15 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
| US5648331A (en) | 1994-08-26 | 1997-07-15 | G.D. Searle & Co. | Method of inhibiting tissue ischemia and reperfusion injury |
| US5914316A (en) | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
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| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
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| US6180607B1 (en) | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
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| US20020102703A1 (en) | 1999-12-29 | 2002-08-01 | Sheppard Paul O. | Kunitz domain polypeptide zkun10 |
| WO2001068707A1 (en) | 2000-03-13 | 2001-09-20 | Eli Lilly And Company | Human hepatocyte growth factor activator inhibitor homologue |
| US20040152633A1 (en) | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
| US20030129659A1 (en) | 2001-12-03 | 2003-07-10 | Whelihan E. Fayelle | Library screening |
| CN1646154B (zh) * | 2002-02-07 | 2010-12-01 | 诺维信生物制药英国有限公司 | 与白蛋白融合的抗-血管生成肽 |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| AU2004266246A1 (en) | 2003-08-14 | 2005-03-03 | Dyax Corp. | Endotheliase-2 ligands |
| WO2005021556A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
| PT1663281E (pt) | 2003-08-29 | 2014-03-17 | Dyax Corp | Inibidores de proteases poli-peguilados |
| US20050164945A1 (en) | 2003-10-21 | 2005-07-28 | Andrew Nixon | Endotheliase-1 ligands |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20060111296A1 (en) * | 2004-11-22 | 2006-05-25 | Dyax Corp. | Plasmin-inhibitory therapies |
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2006
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- 2006-12-27 PL PL06848187T patent/PL1981519T3/pl unknown
- 2006-12-27 DK DK06848187.8T patent/DK1981519T3/en active
- 2006-12-27 WO PCT/US2006/049322 patent/WO2007079096A2/en not_active Ceased
- 2006-12-27 ES ES06848187.8T patent/ES2663497T3/es active Active
- 2006-12-27 PT PT68481878T patent/PT1981519T/pt unknown
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- 2006-12-27 JP JP2008548690A patent/JP5632126B2/ja active Active
- 2006-12-27 SI SI200632240T patent/SI1981519T1/en unknown
- 2006-12-27 CA CA2635589A patent/CA2635589C/en active Active
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2018
- 2018-02-09 CY CY20181100165T patent/CY1119967T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006332774A1 (en) | 2007-07-12 |
| US8828703B2 (en) | 2014-09-09 |
| SI1981519T1 (en) | 2018-05-31 |
| JP2009521926A (ja) | 2009-06-11 |
| PL1981519T3 (pl) | 2018-07-31 |
| WO2007079096A2 (en) | 2007-07-12 |
| CA2635589A1 (en) | 2007-07-12 |
| JP2012235793A (ja) | 2012-12-06 |
| EP1981519B1 (en) | 2017-12-27 |
| LT1981519T (lt) | 2018-04-25 |
| CA2635589C (en) | 2017-01-17 |
| CY1119967T1 (el) | 2018-12-12 |
| PT1981519T (pt) | 2018-02-23 |
| ES2663497T3 (es) | 2018-04-13 |
| HUE038243T2 (hu) | 2018-10-29 |
| WO2007079096A3 (en) | 2008-02-14 |
| JP5632126B2 (ja) | 2014-11-26 |
| EP1981519A4 (en) | 2010-01-06 |
| US20080255025A1 (en) | 2008-10-16 |
| EP1981519A2 (en) | 2008-10-22 |
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