SI1981519T1 - INHIBITION PROTEAZE - Google Patents
INHIBITION PROTEAZE Download PDFInfo
- Publication number
- SI1981519T1 SI1981519T1 SI200632240T SI200632240T SI1981519T1 SI 1981519 T1 SI1981519 T1 SI 1981519T1 SI 200632240 T SI200632240 T SI 200632240T SI 200632240 T SI200632240 T SI 200632240T SI 1981519 T1 SI1981519 T1 SI 1981519T1
- Authority
- SI
- Slovenia
- Prior art keywords
- isolated protein
- kunitz
- domains
- protein according
- engineering
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title claims abstract 4
- 239000004365 Protease Substances 0.000 title claims abstract 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title claims 2
- 230000005764 inhibitory process Effects 0.000 title claims 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 18
- 108090000623 proteins and genes Proteins 0.000 claims abstract 18
- 102000035195 Peptidases Human genes 0.000 claims abstract 2
- 230000013595 glycosylation Effects 0.000 claims 3
- 238000006206 glycosylation reaction Methods 0.000 claims 3
- 108010039627 Aprotinin Proteins 0.000 claims 2
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000000541 Defensins Human genes 0.000 claims 1
- 108010002069 Defensins Proteins 0.000 claims 1
- 108700035531 EC 3.4.24.6 Proteins 0.000 claims 1
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 1
- 101710187853 Macrophage metalloelastase Proteins 0.000 claims 1
- 102100024131 Matrix metalloproteinase-25 Human genes 0.000 claims 1
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
- 101710118230 Neutrophil collagenase Proteins 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 230000003044 adaptive effect Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108090000440 matrix metalloproteinase 25 Proteins 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75490305P | 2005-12-29 | 2005-12-29 | |
| EP06848187.8A EP1981519B1 (en) | 2005-12-29 | 2006-12-27 | Protease inhibition |
| PCT/US2006/049322 WO2007079096A2 (en) | 2005-12-29 | 2006-12-27 | Protease inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1981519T1 true SI1981519T1 (en) | 2018-05-31 |
Family
ID=38228815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200632240T SI1981519T1 (en) | 2005-12-29 | 2006-12-27 | INHIBITION PROTEAZE |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8828703B2 (enExample) |
| EP (1) | EP1981519B1 (enExample) |
| JP (2) | JP5632126B2 (enExample) |
| AU (1) | AU2006332774A1 (enExample) |
| CA (1) | CA2635589C (enExample) |
| CY (1) | CY1119967T1 (enExample) |
| DK (1) | DK1981519T3 (enExample) |
| ES (1) | ES2663497T3 (enExample) |
| HU (1) | HUE038243T2 (enExample) |
| LT (1) | LT1981519T (enExample) |
| PL (1) | PL1981519T3 (enExample) |
| PT (1) | PT1981519T (enExample) |
| SI (1) | SI1981519T1 (enExample) |
| WO (1) | WO2007079096A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
| EP2386310B1 (en) | 2002-08-28 | 2018-11-07 | Dyax Corp. | Methods for preserving organs and tissues |
| AU2004268145B2 (en) * | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP5362349B2 (ja) | 2005-04-15 | 2013-12-11 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | タンパク質を精製する方法 |
| ES2531372T3 (es) * | 2006-10-13 | 2015-03-13 | Novo Nordisk Healthcare Ag | Enzimas de procesamiento fusionadas a marcadores de proteínas básicas |
| CA2696208A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| WO2009026539A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US20110262396A1 (en) * | 2008-10-22 | 2011-10-27 | Dyax Corp. | Combination treatments comprising protease binding proteins for inflammatory disorders |
| CA2744235A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| AU2010222537B2 (en) * | 2009-03-10 | 2016-06-30 | Med Discovery Sa | Use of serine protease inhibitors in the treatment of neutropenia |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| PL2521568T3 (pl) | 2010-01-06 | 2019-03-29 | Dyax Corp. | Białka wiążące kalikreinę osocza |
| US9597379B1 (en) * | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| KR102502293B1 (ko) | 2011-01-06 | 2023-02-21 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
| CA2897018C (en) | 2013-01-07 | 2021-07-27 | Omniox, Inc. | Polymeric forms of h-nox proteins |
| HUE041332T2 (hu) | 2013-01-20 | 2019-05-28 | Dyax Corp | Bradikinin-közvetített rendellenességek értékelése és kezelése |
| PT3060908T (pt) | 2013-10-21 | 2021-05-27 | Dyax Corp | Diagnóstico e tratamento de doenças autoimunes |
| KR20250066486A (ko) | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| PT3110434T (pt) | 2014-02-24 | 2018-12-19 | Takeda Pharmaceuticals Co | Proteínas da fusão de uti |
| KR20230109785A (ko) | 2014-03-27 | 2023-07-20 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| JP7049832B2 (ja) | 2015-03-17 | 2022-04-07 | オムニオクス， インコーポレイテッド | タンパク質媒介性ｏ２送達による腫瘍免疫のモジュレーション |
| DK3365685T3 (da) | 2015-10-19 | 2021-03-01 | Dyax Corp | Immunoassay til påvisning af spaltet højmolekylært kininogen |
| WO2017100679A1 (en) | 2015-12-11 | 2017-06-15 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| JP6467073B2 (ja) * | 2018-01-04 | 2019-02-06 | オムニオクス， インコーポレイテッド | Ｈ−ｎｏｘタンパク質の重合体形態 |
| KR20200143376A (ko) | 2018-03-13 | 2020-12-23 | 샤이어 휴먼 지네틱 테라피즈 인크. | 혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도 |
| JP2022544393A (ja) * | 2019-08-12 | 2022-10-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | マクロファージ刺激１受容体（ｍｓｔ１ｒ）バリアント及びその使用 |
| CN114667289B (zh) | 2019-09-18 | 2025-08-26 | 武田药品工业有限公司 | 杂芳基血浆激肽释放酶抑制剂 |
| US11787796B2 (en) | 2019-09-18 | 2023-10-17 | Takeda Pharmaceutical Company Limited | Plasma Kallikrein inhibitors and uses thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0332640A1 (en) | 1986-11-17 | 1989-09-20 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
| US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US4966852A (en) | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| IL87172A (en) | 1987-07-23 | 1994-12-29 | Univ Washington | Method of isolating highly purified tissue factor inhibitor |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US7078383B2 (en) | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| US5378614A (en) | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| IL104327A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| IL104314A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| US5212091A (en) | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
| US6063764A (en) | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| EP0739355B1 (en) | 1994-01-11 | 2004-09-08 | Dyax Corporation | Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| US6008196A (en) * | 1994-06-02 | 1999-12-28 | Hoechst Marion Roussel, Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
| US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| WO1996004377A1 (en) | 1994-08-05 | 1996-02-15 | Chiron Corporation | Production of tissue factor pathway inhibitor |
| US5648331A (en) | 1994-08-26 | 1997-07-15 | G.D. Searle & Co. | Method of inhibiting tissue ischemia and reperfusion injury |
| US5914316A (en) | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
| ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US5780265A (en) | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| JP3469584B2 (ja) | 1996-03-11 | 2003-11-25 | バイエル コーポレイション | ヒト ビクニン |
| AU6042298A (en) | 1997-01-31 | 1998-08-25 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
| US6180607B1 (en) | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
| US6544760B2 (en) * | 1999-12-22 | 2003-04-08 | Zymogenetics, Inc. | Kunitz domain polypeptide Zkun11 |
| US20020102703A1 (en) | 1999-12-29 | 2002-08-01 | Sheppard Paul O. | Kunitz domain polypeptide zkun10 |
| AU2001249074A1 (en) | 2000-03-13 | 2001-09-24 | Eli Lilly And Company | Human hepatocyte growth factor activator inhibitor homologue |
| US20040152633A1 (en) | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
| US20030129659A1 (en) | 2001-12-03 | 2003-07-10 | Whelihan E. Fayelle | Library screening |
| NZ534310A (en) * | 2002-02-07 | 2008-03-28 | Novozymes Delta Ltd | Albumin-fused anti-angiogenesis peptides |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| CA2535859A1 (en) | 2003-08-14 | 2005-03-03 | Dyax Corp. | Endotheliase-2 ligands |
| US20070020252A1 (en) * | 2003-08-29 | 2007-01-25 | Ladner Robert C | Modified protease inhibitors |
| AU2004268145B2 (en) * | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| US20050164945A1 (en) * | 2003-10-21 | 2005-07-28 | Andrew Nixon | Endotheliase-1 ligands |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| EP1835926A4 (en) * | 2004-11-22 | 2009-04-01 | Dyax Corp | PLASMINE-INHIBITING THERAPIES |
-
2006
- 2006-12-27 JP JP2008548690A patent/JP5632126B2/ja active Active
- 2006-12-27 SI SI200632240T patent/SI1981519T1/en unknown
- 2006-12-27 LT LTEP06848187.8T patent/LT1981519T/lt unknown
- 2006-12-27 CA CA2635589A patent/CA2635589C/en active Active
- 2006-12-27 HU HUE06848187A patent/HUE038243T2/hu unknown
- 2006-12-27 WO PCT/US2006/049322 patent/WO2007079096A2/en not_active Ceased
- 2006-12-27 DK DK06848187.8T patent/DK1981519T3/en active
- 2006-12-27 ES ES06848187.8T patent/ES2663497T3/es active Active
- 2006-12-27 US US11/646,148 patent/US8828703B2/en active Active
- 2006-12-27 PT PT68481878T patent/PT1981519T/pt unknown
- 2006-12-27 PL PL06848187T patent/PL1981519T3/pl unknown
- 2006-12-27 AU AU2006332774A patent/AU2006332774A1/en not_active Abandoned
- 2006-12-27 EP EP06848187.8A patent/EP1981519B1/en active Active
-
2012
- 2012-09-06 JP JP2012196306A patent/JP2012235793A/ja active Pending
-
2018
- 2018-02-09 CY CY20181100165T patent/CY1119967T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1981519T3 (pl) | 2018-07-31 |
| CY1119967T1 (el) | 2018-12-12 |
| CA2635589A1 (en) | 2007-07-12 |
| DK1981519T3 (en) | 2018-02-19 |
| JP2009521926A (ja) | 2009-06-11 |
| JP5632126B2 (ja) | 2014-11-26 |
| LT1981519T (lt) | 2018-04-25 |
| HUE038243T2 (hu) | 2018-10-29 |
| US20080255025A1 (en) | 2008-10-16 |
| EP1981519B1 (en) | 2017-12-27 |
| EP1981519A2 (en) | 2008-10-22 |
| ES2663497T3 (es) | 2018-04-13 |
| WO2007079096A2 (en) | 2007-07-12 |
| CA2635589C (en) | 2017-01-17 |
| AU2006332774A1 (en) | 2007-07-12 |
| WO2007079096A3 (en) | 2008-02-14 |
| EP1981519A4 (en) | 2010-01-06 |
| JP2012235793A (ja) | 2012-12-06 |
| PT1981519T (pt) | 2018-02-23 |
| US8828703B2 (en) | 2014-09-09 |
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