DK1969031T3 - Polyglutamat-aminosyre-konjugater og fremgangsmåder - Google Patents

Polyglutamat-aminosyre-konjugater og fremgangsmåder

Info

Publication number
DK1969031T3
DK1969031T3 DK06838728T DK06838728T DK1969031T3 DK 1969031 T3 DK1969031 T3 DK 1969031T3 DK 06838728 T DK06838728 T DK 06838728T DK 06838728 T DK06838728 T DK 06838728T DK 1969031 T3 DK1969031 T3 DK 1969031T3
Authority
DK
Denmark
Prior art keywords
methods
amino acid
acid conjugates
polyglutamate
polyglutamate amino
Prior art date
Application number
DK06838728T
Other languages
Danish (da)
English (en)
Inventor
Lei Yu
Gang Zhao
Sang Van
Zhongling Feng
Xinghe Wang
Sanjib Kumar Das
Xiaoli Fu
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Application granted granted Critical
Publication of DK1969031T3 publication Critical patent/DK1969031T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06838728T 2005-12-05 2006-12-01 Polyglutamat-aminosyre-konjugater og fremgangsmåder DK1969031T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74229105P 2005-12-05 2005-12-05
US75791706P 2006-01-10 2006-01-10
US79073506P 2006-04-10 2006-04-10
PCT/US2006/045915 WO2007067417A1 (en) 2005-12-05 2006-12-01 Polyglutamate-amino acid conjugates and methods

Publications (1)

Publication Number Publication Date
DK1969031T3 true DK1969031T3 (da) 2009-09-14

Family

ID=37909775

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10004160.7T DK2206736T3 (da) 2005-12-05 2006-12-01 Polyglutamat-aminosyre-konjugater og fremgangsmåder
DK06838728T DK1969031T3 (da) 2005-12-05 2006-12-01 Polyglutamat-aminosyre-konjugater og fremgangsmåder

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10004160.7T DK2206736T3 (da) 2005-12-05 2006-12-01 Polyglutamat-aminosyre-konjugater og fremgangsmåder

Country Status (16)

Country Link
US (2) US20070128118A1 (ru)
EP (4) EP1969031B1 (ru)
JP (1) JP5237821B2 (ru)
KR (1) KR20080074207A (ru)
CN (2) CN102125695B (ru)
AT (3) ATE432955T1 (ru)
AU (1) AU2006322254B2 (ru)
BR (1) BRPI0619436A2 (ru)
CA (1) CA2631704A1 (ru)
DE (2) DE602006013893D1 (ru)
DK (2) DK2206736T3 (ru)
ES (1) ES2395461T3 (ru)
HK (3) HK1124627A1 (ru)
RU (1) RU2472812C2 (ru)
TW (1) TW200804461A (ru)
WO (1) WO2007067417A1 (ru)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
ATE432955T1 (de) 2005-12-05 2009-06-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
FR2915748B1 (fr) * 2007-05-03 2012-10-19 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
JP2010526917A (ja) * 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
ES2430380T3 (es) * 2007-05-09 2013-11-20 Nitto Denko Corporation Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
JP2008305262A (ja) * 2007-06-08 2008-12-18 Konica Minolta Business Technologies Inc サーバ及びシンクライアント環境でのプリンタ紹介方法
CA2716662A1 (en) * 2008-03-06 2009-03-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
EP2151249A1 (en) * 2008-07-28 2010-02-10 Canon Kabushiki Kaisha PH-sensitive probe comprising polymer and fluorescent dye
CA2732412C (en) * 2008-07-30 2014-12-09 Lei Yu Retinoid-targeted drug carriers
WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US20130011336A1 (en) * 2008-09-12 2013-01-10 Nitto Denko Corporation Imaging agents of fibrotic diseases
BRPI0920655A2 (pt) 2008-10-07 2019-07-09 Rexahn Pharmaceuticals Inc conjugados e hpma-docetaxel ou gencitabina e usos dos mesmos
EP2358396A2 (en) * 2008-10-15 2011-08-24 Nitto Denko Corporation Method of preparing polyglutamate conjugates
AU2010306917B2 (en) 2009-10-13 2014-11-27 Rexahn Pharmaceuticals, Inc. Polymeric systems for the delivery of anticancer agents
AU2011224374A1 (en) * 2010-03-11 2012-09-27 Nitto Denko Corporation Carbohydrate-polyamino acid-drug conjugates
KR101477194B1 (ko) * 2010-05-27 2014-12-29 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 이중기능 복합체의 화학합성 및 항 종양과 항 종양 전이 작용
TWI449823B (zh) * 2010-10-04 2014-08-21 Far Eastern New Century Corp Superabsorbent antibacterial fiber and its use
AU2012239933B2 (en) * 2011-04-06 2017-01-05 Cedars-Sinai Medical Center Polymalic acid based nanoconjugates for imaging
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
CN102442996B (zh) * 2011-09-16 2014-09-24 中山大学附属第一医院 多胺类小分子显像剂、其生产方法及其应用
CN102391168B (zh) * 2011-09-16 2013-11-27 中山大学附属第一医院 对称性双功能偶联剂及其偶合分子显像剂
ES2677478T3 (es) 2012-04-12 2018-08-02 Nitto Denko Corporation Conjugados de copolímero
EP2846838B1 (en) 2012-05-07 2017-05-03 Nitto Denko Corporation Polymer conjugates with a linker
WO2014085471A1 (en) * 2012-11-28 2014-06-05 Prognosdx Health, Inc. Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation
US9839694B2 (en) 2013-04-26 2017-12-12 Nitto Denko Corporation Reduction of endotoxins from polyanionic polymer conjugates
US9636411B2 (en) 2013-04-26 2017-05-02 Nitto Denko Corporation Large scale process for preparing poly (glutamyl-glutamate) conjugates
CN103724618B (zh) * 2013-12-03 2016-10-26 江南大学 一种光敏性γ-聚谷氨酸接枝共聚物胶束的制备方法
JPWO2015129901A1 (ja) * 2014-02-27 2017-03-30 株式会社セルシード アミノ酸誘導体蛍光ポリマー及びそれを利用した蛍光プローブ
EP3129425B1 (en) * 2014-04-07 2019-04-10 Nitto Denko Corporation Polymer-based hydrotropes for hydrophobic drug delivery
WO2016103867A1 (ja) * 2014-12-26 2016-06-30 日本化薬株式会社 カンプトテシン類高分子誘導体の医薬製剤
WO2018222545A1 (en) * 2017-05-27 2018-12-06 Ecovia Renewables Inc. Poly(amino acid) rheology modifier compositions and methods of use
US20240043615A1 (en) * 2020-12-04 2024-02-08 The Methodist Hospital System Amino acid polymer-platinum anticancer drug conjugates

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA71763B (en) * 1970-04-13 1972-03-29 Lilly Industries Ltd Erythromycylamines via hydrazones
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
JPS60501759A (ja) * 1983-07-01 1985-10-17 バテル　メモリアル　インステイチユ−ト 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用
US5385738A (en) * 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CS254355B1 (en) * 1985-04-10 1988-01-15 Vladimir Saudek Soluble and biodegradatable copolymeres activated for bond of biologicaly active substances
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US6673347B1 (en) * 1986-04-30 2004-01-06 Gryphon Therapeutics Polypeptide and protein derivatives and process for their preparation
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
IN165717B (ru) * 1986-08-07 1989-12-23 Battelle Memorial Institute
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
EP0526503B1 (en) 1990-04-10 1997-06-04 Imarx Pharmaceutical Corp. Polymers as contrast media for magnetic resonance imaging
US5660822A (en) * 1990-05-14 1997-08-26 University Of Medicine & Dentistry Of N.J. Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
US5372807A (en) 1990-05-14 1994-12-13 University Of Medicine And Dentistry Of New Jersey Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use
US6517824B1 (en) * 1990-05-14 2003-02-11 University Of Medicine & Denistry Of New Jersey Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US6762188B1 (en) * 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP2589431B2 (ja) 1991-05-13 1997-03-12 株式会社ディ・ディ・エス研究所 糖修飾ポリグルタミン酸誘導体及びその製造法
GB9120653D0 (en) 1991-09-27 1991-11-06 Procter & Gamble Dispensing agent
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
FR2695563B1 (fr) * 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
DK0693924T4 (da) * 1993-02-22 2008-08-04 Abraxis Bioscience Inc Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil
US6749868B1 (en) * 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6753006B1 (en) * 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US6441026B1 (en) * 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
US6713045B1 (en) * 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US5980862A (en) 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5762909A (en) * 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
DE19548114C2 (de) * 1995-12-21 2000-04-27 Deutsches Krebsforsch Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
AU735900B2 (en) * 1996-03-12 2001-07-19 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
US6030941A (en) * 1996-05-01 2000-02-29 Avi Biopharma, Inc. Polymer composition for delivering substances in living organisms
US5929198A (en) 1996-07-16 1999-07-27 Nalco Chemical Company Biodegradable poly (amino acid)s, derivatized amino acid polymers and methods for making same
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
WO1998047496A2 (en) 1997-04-18 1998-10-29 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US5965118A (en) 1997-04-18 1999-10-12 Access Pharmaceuticals, Inc. Polymer-platinum compounds
US6251866B1 (en) * 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
US6229009B1 (en) * 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
US6528061B1 (en) * 1997-09-04 2003-03-04 Pasteur Institut Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
JP3390965B2 (ja) * 1997-09-12 2003-03-31 理化学研究所 糖結合スフィンゴシンを含有するポリマー化合物
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US20040170563A1 (en) 1997-10-27 2004-09-02 Meade Thomas J. Magnetic resonance imaging agents for the delivery of therapeutic agents
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
AU2795499A (en) 1998-02-26 1999-09-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Conjugated suramin or derivatives thereof with peg, polyaspartate or polyglutamate for cancer treatment
US5981564A (en) 1998-07-01 1999-11-09 Universite Laval Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
US20030124143A1 (en) * 1998-08-31 2003-07-03 Armelle Phalipon Methods for selecting immunogenic polypeptides
US6143817A (en) 1998-10-07 2000-11-07 National Starch & Chemical Co. Use of derivatives of polyamino acids as emulsifiers stabilizers in aqueous free radical emulsion polymerization
AU1688099A (en) * 1998-12-24 2000-07-31 Kyowa Hakko Kogyo Co. Ltd. Pharmaceutical preparation
EP1031354A3 (en) 1999-01-19 2003-02-05 Rohm And Haas Company Polymeric MRI Contrast agents
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20040121954A1 (en) * 1999-04-13 2004-06-24 Xu Wuhan Jingya Poly(dipeptide) as a drug carrier
US20010041189A1 (en) 1999-04-13 2001-11-15 Jingya Xu Poly(dipeptide) as a drug carrier
WO2000063409A1 (en) 1999-04-21 2000-10-26 Massachusetts Institute Of Technology Endosomolytic agents and cell delivery systems
US7005123B1 (en) 1999-06-17 2006-02-28 Universiteit Gent Functional poly-α-amino-acid derivatives useful for the modification of biologically active materials and their application
US6326021B1 (en) 1999-06-18 2001-12-04 The Ohio State University Research Foundation Biocompatible polymeric delivery systems having functional groups attached to the surface thereof
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
AU781735B2 (en) 1999-10-12 2005-06-09 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
US6136846A (en) 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
US6235264B1 (en) 1999-12-01 2001-05-22 General Electric Company Medical imaging method for characterizing tumor angiogenesis using polymeric contrast agents
US6685915B2 (en) 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US7166733B2 (en) 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
WO2001049696A1 (en) 2000-01-04 2001-07-12 Access Pharmaceuticals, Inc. N,o-amidomalonate platinum complexes
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
IL151685A0 (en) * 2000-03-17 2003-04-10 Cell Therapeutics Inc Polyglutamic acid-camptothecin conjugates, methods for the preparation thereof and pharmaceutical compositons containing the same
US20020183243A1 (en) 2000-03-17 2002-12-05 Cell Therapeutics, Inc. Polyglutamic acid-camptothecin conjugates and methods of preparation
WO2001074399A1 (fr) * 2000-03-30 2001-10-11 Ajinomoto Co., Inc. Medicaments a long temps de conservation dans un tissu
JP2001288097A (ja) 2000-04-07 2001-10-16 Pg-Txl Co Lp 水溶性パクリタキセル誘導体
JP2004501875A (ja) 2000-06-14 2004-01-22 メダレックス，インコーポレイティド トリペプチドプロドラッグ化合物
GB0018240D0 (en) 2000-07-25 2000-09-13 Pharmacia & Upjohn Spa Polymeric conjugates of antitumor agents
CN100344293C (zh) * 2000-09-26 2007-10-24 株式会社东京大学Tlo 包封顺铂的高分子微胶粒及其用途
WO2002026867A2 (en) * 2000-09-29 2002-04-04 The Regents Of The University Of California Dendrimeric support or carrier macromolecule
US6497901B1 (en) 2000-11-02 2002-12-24 Royer Biomedical, Inc. Resorbable matrices for delivery of bioactive compounds
US7070797B2 (en) * 2000-11-07 2006-07-04 Dana Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers
US6916492B2 (en) 2001-03-30 2005-07-12 Council Of Scientific & Industrial Research Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses
WO2002087497A2 (en) 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use
US20030003048A1 (en) 2001-04-26 2003-01-02 Chun Li Diagnostic imaging compositions, their methods of synthesis and use
DE60235812D1 (de) * 2001-06-20 2010-05-12 Nippon Kayaku Kk Blockcopolymer mit verringertem verunreinigungsgehalt, polymerer träger, pharmazeutische zubereitungen in polymerer form und verfahren zur herstellung davon
US20040043030A1 (en) * 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
US20030049253A1 (en) * 2001-08-08 2003-03-13 Li Frank Q. Polymeric conjugates for delivery of MHC-recognized epitopes via peptide vaccines
AU2002359364A1 (en) * 2001-11-09 2003-05-26 Enzon, Inc. Polymeric thiol-linked prodrugs employing benzyl elimination systems
US20030109432A1 (en) * 2001-12-10 2003-06-12 Zuo William W. Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same
US7261875B2 (en) 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
CN1252130C (zh) 2002-04-01 2006-04-19 北京键凯科技有限公司 亲水性聚合物与丹参酮类药物的结合物以及包含该结合物的药物组合物
US6939538B2 (en) 2002-04-11 2005-09-06 Biomedical Research Models, Inc. Extended release analgesic for pain control
JP2004018494A (ja) 2002-06-19 2004-01-22 Japan Science & Technology Corp ブロック共重合体−薬剤複合体の製造法
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
FR2844514B1 (fr) * 2002-09-16 2007-10-19 Neovacs Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation
US7495099B2 (en) * 2002-10-31 2009-02-24 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins
US20070020272A1 (en) 2003-04-30 2007-01-25 Tayyaba Hasan Indirectly linked photosensitizer immunoconjugates, processes for the production thereof and methods of use thereof
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
JP2007537986A (ja) * 2003-05-30 2007-12-27 セントカー・インコーポレーテツド トランスグルタミナーゼを用いる新規なエリトロポエチン複合体の形成
US6855695B2 (en) * 2003-06-13 2005-02-15 Vion Pharmaceuticals, Inc. Water-soluble SHPs as novel alkylating agents
US20050118718A1 (en) * 2003-09-22 2005-06-02 University Of Utah Research Foundation Stabilization and controlled delivery of ionic biopharmaceuticals
US20050187147A1 (en) * 2003-09-22 2005-08-25 Newman Michael J. Compositions and methods for increasing drug efficiency
SI1695991T1 (sl) 2003-12-10 2010-04-30 Toudai Tlo Ltd Koordinacijski kompleks diaminocikloheksan platine (II) z blok kopolimerom, ki vsebuje segment poli(karboksilne kisline) in antitumorni agens, ki jih vsebuje
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
WO2005079861A2 (en) 2004-02-13 2005-09-01 Safeway Investments Ltd. Polymeric water soluble prodrugs
US20050266067A1 (en) 2004-03-02 2005-12-01 Shiladitya Sengupta Nanocell drug delivery system
US7317070B1 (en) * 2004-03-12 2008-01-08 Sigma-Aldrich Co. Process for the preparation of polyamino acids
AU2005244260B2 (en) 2004-04-09 2010-08-05 3M Innovative Properties Company Methods, compositions, and preparations for delivery of immune response modifiers
KR20050104152A (ko) * 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
US20050271585A1 (en) 2004-06-07 2005-12-08 General Electric Company Extended conjugated polymers
US20050276783A1 (en) 2004-06-10 2005-12-15 Ernest Giralt Lledo Polypeptides with the capacity to entrap drugs and release them in a controlled way
CN100475837C (zh) 2004-06-11 2009-04-08 北京键凯科技有限公司 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
TW200616604A (en) * 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
WO2006041613A2 (en) 2004-10-05 2006-04-20 Nanomega Medical Corporation Nanoparticles for targeting hepatoma cells
AU2005294214A1 (en) 2004-10-07 2006-04-20 Emory University Multifunctional nanoparticles conjugates and their use
ATE485836T1 (de) 2004-12-03 2010-11-15 Univ Utah Res Found Mrt-geführte photodynamische therapie gegen krebs
ATE432955T1 (de) 2005-12-05 2009-06-15 Nitto Denko Corp Polyglutamat-aminosäure-konjugate und verfahren
US20080051603A1 (en) 2006-06-15 2008-02-28 Cell Therapeutics, Inc. Process for the preparation of poly-alpha-glutamic acid and derivatives thereof
US20080181852A1 (en) 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
JP2010526917A (ja) 2007-05-09 2010-08-05 日東電工株式会社 複数種の薬物を有するポリグルタミン酸塩複合体及びポリグルタミン酸塩−アミノ酸複合体
ES2430380T3 (es) 2007-05-09 2013-11-20 Nitto Denko Corporation Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido
CN101730549B (zh) 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
CA2716662A1 (en) 2008-03-06 2009-03-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
CN102131509B (zh) 2008-05-22 2015-01-07 特拉维夫大学拉莫特有限公司 聚合物、二膦酸盐和抗血管生成剂的缀合物及其在治疗和监测骨相关疾病中的用途
US20130011336A1 (en) 2008-09-12 2013-01-10 Nitto Denko Corporation Imaging agents of fibrotic diseases
EP2358396A2 (en) 2008-10-15 2011-08-24 Nitto Denko Corporation Method of preparing polyglutamate conjugates
CN102666566A (zh) 2009-12-16 2012-09-12 日东电工株式会社 聚谷氨酸的受控合成
AU2011224374A1 (en) 2010-03-11 2012-09-27 Nitto Denko Corporation Carbohydrate-polyamino acid-drug conjugates
FR2957692B1 (fr) 2010-03-17 2012-06-08 Delphi Tech Inc Dispositif de commande a commutateur rotatif retro-eclaire par un guide de lumiere
WO2012027204A1 (en) 2010-08-26 2012-03-01 Nitto Denko Corporation End-capped polymers

Also Published As

Publication number Publication date
WO2007067417A1 (en) 2007-06-14
DK2206736T3 (da) 2012-04-23
DE602006013893D1 (de) 2010-06-02
EP1969031B1 (en) 2009-06-03
KR20080074207A (ko) 2008-08-12
ATE432955T1 (de) 2009-06-15
EP2325232A1 (en) 2011-05-25
US20070128118A1 (en) 2007-06-07
ATE465205T1 (de) 2010-05-15
CN102125695B (zh) 2014-02-19
JP2009518511A (ja) 2009-05-07
TW200804461A (en) 2008-01-16
JP5237821B2 (ja) 2013-07-17
EP1969031A1 (en) 2008-09-17
AU2006322254A1 (en) 2007-06-14
EP2077290B1 (en) 2010-04-21
AU2006322254B2 (en) 2012-08-02
EP2206736B1 (en) 2012-02-08
ATE544802T1 (de) 2012-02-15
HK1135421A1 (en) 2010-06-04
ES2395461T3 (es) 2013-02-12
CN102125695A (zh) 2011-07-20
HK1124627A1 (en) 2009-07-17
EP2206736A1 (en) 2010-07-14
RU2472812C2 (ru) 2013-01-20
CA2631704A1 (en) 2007-06-14
DE602006007177D1 (de) 2009-07-16
HK1146075A1 (en) 2011-05-13
EP2077290A1 (en) 2009-07-08
CN101321806B (zh) 2011-01-26
US9855338B2 (en) 2018-01-02
US20170119889A1 (en) 2017-05-04
RU2008120699A (ru) 2010-01-20
CN101321806A (zh) 2008-12-10
BRPI0619436A2 (pt) 2011-10-04

Similar Documents

Publication Publication Date Title
DK2206736T3 (da) Polyglutamat-aminosyre-konjugater og fremgangsmåder
WO2008124735A3 (en) Multi-functional polyglutamate drug carriers
WO2008094834A3 (en) Multi-functional drug carriers
WO2008141110A3 (en) Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
CY1118120T1 (el) Συνθεσεις βασιζομενες σε πεδιο ινωδονεκτινης τυπου iii, μεθοδοι και χρησεις αυτων
CY1114132T1 (el) Γαστροανθεκτικες φαρμακοτεχνικες μορφες που περιεχουν ριφαξιμινη
DE602007014087D1 (de) Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen
FI20051203A (fi) Alifaattisiin biohajoaviin välikeosiin perustuvat vapautettavat polymeerikonjugaatit
WO2007127440A3 (en) Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
DK3404102T3 (da) Knogletilførselskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle
DK1793994T3 (da) Polymælkesyreblæst film og fremgangsmåde til fremstilling deraf
EA200301250A1 (ru) Фармацевтические композиции, содержащие слаборастворимые и/или чувствительные к кислотам лекарственные средства и нейтрализованные кислотные полимеры
DK1799748T3 (da) Bionedbrydelige kationiske polymerer
DK1543063T3 (da) Medikament levering
ATE540996T1 (de) Polymerbasierter serumalbumin-ersatzstoff
NO20083573L (no) Amfifile polymerer for opploseliggjoring og malrettet avgivelse av legemidler
WO2007099397A3 (en) Aliphatic polyester-amide compositions and a process for producing the same
CY1124650T1 (el) Φαρμακευτικο παρασκευασμα που περιεχει ινσουλινη σε κρυσταλλικη μορφη καθως και σε διαλυτοποιημενη μορφη
AR054739A1 (es) Composicion de liberacion sostenida de droga proteica
DE60218061D1 (de) Biologisch abbaubares polymer
ATE326968T1 (de) Pharmazeutische zusammensetzung enthaltend tenatoprazol und einen entzündungshemmer
HUP0500541A2 (hu) Rákellenes antraciklin hatóanyag célterápiára alkalmas pH-érzékeny polimer konjugátjai
DE602006019302D1 (de) Organosilicium-polymer und verfahren zu dessen herstellung
DE602004026747D1 (de) Biologisch abbaubare polyacetale für die in-vivo-abgabe von polynucleotiden
DE602007013759D1 (de) Thermoplastische elastomerzusammensetzung, herstellungsverfahren dafür und gegenstände daraus