DK1899330T3 - Substitueret glycinamid med antithrombotisk og faktor Xa-inhiberende virkning - Google Patents
Substitueret glycinamid med antithrombotisk og faktor Xa-inhiberende virkningInfo
- Publication number
- DK1899330T3 DK1899330T3 DK06763910.4T DK06763910T DK1899330T3 DK 1899330 T3 DK1899330 T3 DK 1899330T3 DK 06763910 T DK06763910 T DK 06763910T DK 1899330 T3 DK1899330 T3 DK 1899330T3
- Authority
- DK
- Denmark
- Prior art keywords
- antithrombotic
- factor
- inhibitory effect
- substituted glycinamide
- glycinamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05014270 | 2005-06-30 | ||
| PCT/EP2006/063611 WO2007003536A1 (de) | 2005-06-30 | 2006-06-28 | Substituierte glycinamide mit antithrombotischer und faktor xa-inhibierender wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1899330T3 true DK1899330T3 (da) | 2011-02-21 |
Family
ID=35907001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06763910.4T DK1899330T3 (da) | 2005-06-30 | 2006-06-28 | Substitueret glycinamid med antithrombotisk og faktor Xa-inhiberende virkning |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US20100216769A1 (da) |
| EP (1) | EP1899330B9 (da) |
| JP (1) | JP4768016B2 (da) |
| KR (1) | KR101321722B1 (da) |
| CN (1) | CN101213195B (da) |
| AR (1) | AR054627A1 (da) |
| AT (1) | ATE489381T1 (da) |
| AU (1) | AU2006265216B2 (da) |
| BR (1) | BRPI0612580A8 (da) |
| CA (1) | CA2613059C (da) |
| CY (1) | CY1111627T1 (da) |
| DE (1) | DE502006008392D1 (da) |
| DK (1) | DK1899330T3 (da) |
| EA (1) | EA015188B1 (da) |
| EC (1) | ECSP078058A (da) |
| ES (1) | ES2357029T3 (da) |
| HK (1) | HK1116190A1 (da) |
| HR (1) | HRP20110044T2 (da) |
| IL (1) | IL188323A (da) |
| MX (1) | MX2007016253A (da) |
| MY (1) | MY145883A (da) |
| NO (1) | NO340670B1 (da) |
| NZ (1) | NZ565440A (da) |
| PE (1) | PE20070171A1 (da) |
| PL (1) | PL1899330T3 (da) |
| PT (1) | PT1899330E (da) |
| RS (1) | RS51572B (da) |
| SG (1) | SG163540A1 (da) |
| SI (1) | SI1899330T1 (da) |
| TW (1) | TWI392495B (da) |
| UA (1) | UA94910C2 (da) |
| WO (1) | WO2007003536A1 (da) |
| ZA (1) | ZA200708525B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799684B1 (en) | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| JP2009543812A (ja) * | 2006-07-20 | 2009-12-10 | キャスケイド・セラピューティクス・インコーポレイテッド | ５−ＨＴ２Ｃリガンドとしてのテトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピン |
| PE20081834A1 (es) * | 2006-12-31 | 2009-01-16 | Boehringer Ingelheim Int | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos |
| EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| WO2009063028A2 (en) * | 2007-11-15 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Substituted amides, manufacturing and use thereof as medicaments |
| JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
| JP5684719B2 (ja) | 2008-12-05 | 2015-03-18 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン |
| EP2398781A1 (en) * | 2009-02-17 | 2011-12-28 | Msd K.K. | 1,4-benzodiazepin-2-on derivatives |
| KR20130075732A (ko) | 2010-03-30 | 2013-07-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
| ES2953393T3 (es) | 2011-09-20 | 2023-11-10 | Icahn School Med Mount Sinai | Vacunas contra el virus de la influenza y sus usos |
| BR112015014482A2 (pt) | 2012-12-18 | 2017-11-21 | Icahn School Med Mount Sinai | vacinas para vírus influenza e seus usos |
| FI3102200T3 (fi) * | 2014-02-07 | 2023-05-31 | Exithera Pharmaceuticals Inc | Terapeuttisia yhdisteitä ja koostumuksia |
| CN105622511B (zh) * | 2014-11-03 | 2018-01-23 | 北京瑞都医药科技有限公司 | 一种减肥药物及其制备方法 |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| WO2020007902A1 (en) | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | Substituted thiophenecarboxamides and analogues as antibacterials agents |
| CN111196772B (zh) * | 2018-11-16 | 2022-09-30 | 沈阳化工研究院有限公司 | 一种芳酰氨基异丁酰衍生物及其应用 |
| BR112022010333A2 (pt) | 2019-12-20 | 2022-08-16 | Bayer Ag | Tieniloxazolonas e análogos |
| EP4240348A1 (en) | 2020-11-06 | 2023-09-13 | Boehringer Ingelheim International GmbH | 2-[thiophen-2-yl)formamido]-n-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855715B1 (en) | 1999-06-14 | 2005-02-15 | Eli Lilly And Company | Serine protease inhibitors |
| DE19962924A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| EA005893B1 (ru) | 2000-03-21 | 2005-06-30 | Смитклайн Бичам Корпорейшн | Ингибиторы протеаз |
| DE10063008A1 (de) | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| WO2002092563A2 (en) | 2001-05-17 | 2002-11-21 | Smithkline Beecham Corporation | Protease inhibitors |
| JP2004300133A (ja) * | 2002-11-19 | 2004-10-28 | Takeda Chem Ind Ltd | アミン誘導体 |
| AU2003280838A1 (en) | 2002-11-19 | 2004-06-15 | Takeda Pharmaceutical Company Limited | Indole derivatives as somatostatin agonists or antagonists |
| DE10254336A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
| US7250415B2 (en) | 2003-06-04 | 2007-07-31 | Bristol-Myers Squibb Company | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors |
| KR20070012552A (ko) * | 2004-05-13 | 2007-01-25 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 치환된 티오펜카복스아미드, 이의 제조방법 및약제로서의 이의 용도 |
| EP1748996A1 (de) | 2004-05-13 | 2007-02-07 | Boehringer Ingelheim International GmbH | Substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel |
| WO2005111013A1 (de) | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Substituierte thiophen-2-carbonsäureamide, deren herstellung und deren verwendung als arzneimittel |
| DE102004047840A1 (de) | 2004-09-29 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20081834A1 (es) | 2006-12-31 | 2009-01-16 | Boehringer Ingelheim Int | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos |
-
2006
- 2006-06-27 PE PE2006000745A patent/PE20070171A1/es not_active Application Discontinuation
- 2006-06-28 SG SG201004677-9A patent/SG163540A1/en unknown
- 2006-06-28 EA EA200702620A patent/EA015188B1/ru not_active IP Right Cessation
- 2006-06-28 MY MYPI20063092A patent/MY145883A/en unknown
- 2006-06-28 CA CA2613059A patent/CA2613059C/en not_active Expired - Fee Related
- 2006-06-28 US US11/993,426 patent/US20100216769A1/en not_active Abandoned
- 2006-06-28 UA UAA200800769A patent/UA94910C2/ru unknown
- 2006-06-28 PL PL06763910T patent/PL1899330T3/pl unknown
- 2006-06-28 DK DK06763910.4T patent/DK1899330T3/da active
- 2006-06-28 EP EP06763910A patent/EP1899330B9/de active Active
- 2006-06-28 PT PT06763910T patent/PT1899330E/pt unknown
- 2006-06-28 DE DE502006008392T patent/DE502006008392D1/de active Active
- 2006-06-28 AT AT06763910T patent/ATE489381T1/de active
- 2006-06-28 AU AU2006265216A patent/AU2006265216B2/en not_active Ceased
- 2006-06-28 BR BRPI0612580A patent/BRPI0612580A8/pt not_active Application Discontinuation
- 2006-06-28 RS RS20110015A patent/RS51572B/en unknown
- 2006-06-28 JP JP2008517518A patent/JP4768016B2/ja not_active Expired - Fee Related
- 2006-06-28 SI SI200630915T patent/SI1899330T1/sl unknown
- 2006-06-28 MX MX2007016253A patent/MX2007016253A/es active IP Right Grant
- 2006-06-28 NZ NZ565440A patent/NZ565440A/en not_active IP Right Cessation
- 2006-06-28 KR KR1020087002478A patent/KR101321722B1/ko active IP Right Grant
- 2006-06-28 CN CN2006800242678A patent/CN101213195B/zh not_active Expired - Fee Related
- 2006-06-28 ES ES06763910T patent/ES2357029T3/es active Active
- 2006-06-28 WO PCT/EP2006/063611 patent/WO2007003536A1/de active Application Filing
- 2006-06-29 TW TW095123603A patent/TWI392495B/zh not_active IP Right Cessation
- 2006-06-30 AR ARP060102825A patent/AR054627A1/es active IP Right Grant
-
2007
- 2007-10-05 ZA ZA200708525A patent/ZA200708525B/xx unknown
- 2007-10-11 NO NO20075186A patent/NO340670B1/no not_active IP Right Cessation
- 2007-12-20 IL IL188323A patent/IL188323A/en not_active IP Right Cessation
- 2007-12-27 EC EC2007008058A patent/ECSP078058A/es unknown
-
2008
- 2008-10-16 HK HK08111433.4A patent/HK1116190A1/xx not_active IP Right Cessation
-
2011
- 2011-01-21 HR HR20110044T patent/HRP20110044T2/hr unknown
- 2011-02-16 CY CY20111100202T patent/CY1111627T1/el unknown
-
2013
- 2013-03-05 US US13/785,176 patent/US9062034B2/en active Active
-
2015
- 2015-05-19 US US14/716,227 patent/US9676781B2/en active Active
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