DK1828378T3 - Deacylering af LPS i gram-negative bakterier - Google Patents

Deacylering af LPS i gram-negative bakterier

Info

Publication number
DK1828378T3
DK1828378T3 DK05815467.5T DK05815467T DK1828378T3 DK 1828378 T3 DK1828378 T3 DK 1828378T3 DK 05815467 T DK05815467 T DK 05815467T DK 1828378 T3 DK1828378 T3 DK 1828378T3
Authority
DK
Denmark
Prior art keywords
deacylation
lps
gram
negative bacteria
bacteria
Prior art date
Application number
DK05815467.5T
Other languages
Danish (da)
English (en)
Inventor
Johannes Petrus Maria Tommassen
Der Ley Peter Andre Van
Jeroen Johannes Gerardus Geurtsen
Original Assignee
Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheit Welzijn En Sport
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheit Welzijn En Sport filed Critical Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheit Welzijn En Sport
Application granted granted Critical
Publication of DK1828378T3 publication Critical patent/DK1828378T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK05815467.5T 2004-12-17 2005-12-16 Deacylering af LPS i gram-negative bakterier DK1828378T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04078445 2004-12-17
PCT/NL2005/050081 WO2006065139A2 (en) 2004-12-17 2005-12-16 Deacylation of lps in gram negative bacteria

Publications (1)

Publication Number Publication Date
DK1828378T3 true DK1828378T3 (da) 2014-09-01

Family

ID=34928754

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05815467.5T DK1828378T3 (da) 2004-12-17 2005-12-16 Deacylering af LPS i gram-negative bakterier

Country Status (15)

Country Link
US (1) US8048433B2 (https=)
EP (1) EP1828378B1 (https=)
JP (1) JP5378685B2 (https=)
CN (1) CN101203605B (https=)
AU (1) AU2005317304B2 (https=)
BR (1) BRPI0519923A8 (https=)
CA (1) CA2590906C (https=)
DK (1) DK1828378T3 (https=)
ES (1) ES2493440T3 (https=)
MX (1) MX2007007288A (https=)
NO (1) NO340331B1 (https=)
NZ (1) NZ555889A (https=)
PL (1) PL1828378T3 (https=)
PT (1) PT1828378E (https=)
WO (1) WO2006065139A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2393682T3 (es) * 2007-03-26 2012-12-27 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Vacunas mejoradas contra Bordotella pertussis basadas en mutantes de glicosiltransferasa LPS
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013301312A1 (en) 2012-08-06 2015-03-19 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against RSV and B. pertussis
US11052142B2 (en) 2013-06-04 2021-07-06 Petr G. Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)
US20160120967A1 (en) 2013-06-04 2016-05-05 Petr Gennadievich Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)
MX2016001695A (es) 2013-08-05 2016-05-02 Glaxosmithkline Biolog Sa Composiciones inmunogenas de combinacion.
WO2015179270A2 (en) 2014-05-19 2015-11-26 Board Of Regents, The University Of Texas System Combinatorial platform for the display of surface adjuvants and antigens
CN104388368B (zh) * 2014-10-30 2017-02-15 四川农业大学 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法
US11389520B2 (en) * 2016-01-28 2022-07-19 Intravacc B.V. Modified tetra-acylated neisserial LPS
CN105567620B (zh) * 2016-01-29 2019-03-19 江南大学 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用
CN105695540A (zh) * 2016-03-18 2016-06-22 辽宁成大生物股份有限公司 一种革兰氏阴性菌胞壁抗原的制备方法
ES2992907T3 (en) * 2017-03-13 2024-12-19 Intravacc B V Bordetella vaccines comprising lps with reduced reactogenicity
CA3063419A1 (en) * 2017-05-15 2018-11-22 University Of Maryland, Baltimore Live salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
KR102822764B1 (ko) * 2017-12-04 2025-06-19 인트라백 비.브이. 외막 소포의 생성을 위한 개선된 방법
EP4150101A2 (en) * 2020-05-14 2023-03-22 Merck Patent GmbH Methods and compositions for purifying adeno associated virus particles or adenoviruses
US20250263447A1 (en) 2020-09-04 2025-08-21 Intravacc B.V. Ompa mutations enhance omv production in bordetella pertussis
EP4169513A1 (en) 2021-10-19 2023-04-26 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising sting agonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH650681A5 (en) 1981-08-14 1985-08-15 Dso Pharmachim Whooping cough vaccine
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
JPH08500734A (ja) * 1992-08-18 1996-01-30 デュファル インターナショナル リサーチ ベスローテン フェンノートシャップ 気管支敗血症菌（Ｂｏｒｄｅｔｅｌｌａ ｂｒｏｎｃｈｉｓｅｐｔｉｃａ）ワクチン
ATE496634T1 (de) * 1995-05-04 2011-02-15 Sanofi Pasteur Ltd Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
US6887483B2 (en) 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
CN1326564C (zh) * 1997-04-01 2007-07-18 科里克萨有限公司 单磷酰基脂质a的水性免疫佐剂组合物
CA2264970A1 (en) 1998-03-10 1999-09-10 American Cyanamid Company Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria
AU762369B2 (en) * 1998-11-03 2003-06-26 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur LPS with reduced toxicity from genetically modified gram negative bacteria
US6531131B1 (en) * 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
AU2002307448A1 (en) * 2001-04-20 2002-11-05 President And Fellows Of Harvard College Methods and compositions for the modulation of biofilm formation

Also Published As

Publication number Publication date
MX2007007288A (es) 2008-02-25
ES2493440T3 (es) 2014-09-11
WO2006065139A2 (en) 2006-06-22
NO20073088L (no) 2007-09-17
PT1828378E (pt) 2014-10-10
US20080274145A1 (en) 2008-11-06
JP2008523805A (ja) 2008-07-10
AU2005317304A1 (en) 2006-06-22
EP1828378B1 (en) 2014-06-11
AU2005317304B2 (en) 2011-06-23
NZ555889A (en) 2009-07-31
WO2006065139A3 (en) 2006-10-19
CN101203605B (zh) 2016-01-27
PL1828378T3 (pl) 2014-10-31
JP5378685B2 (ja) 2013-12-25
NO340331B1 (no) 2017-04-03
CN101203605A (zh) 2008-06-18
CA2590906A1 (en) 2006-06-22
EP1828378A2 (en) 2007-09-05
BRPI0519923A8 (pt) 2018-01-23
CA2590906C (en) 2017-01-03
US8048433B2 (en) 2011-11-01
BRPI0519923A2 (pt) 2009-08-11

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