DK1776460T3 - Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdet - Google Patents
Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdetInfo
- Publication number
- DK1776460T3 DK1776460T3 DK05768791T DK05768791T DK1776460T3 DK 1776460 T3 DK1776460 T3 DK 1776460T3 DK 05768791 T DK05768791 T DK 05768791T DK 05768791 T DK05768791 T DK 05768791T DK 1776460 T3 DK1776460 T3 DK 1776460T3
- Authority
- DK
- Denmark
- Prior art keywords
- altering
- gene expression
- modulating gene
- cpg content
- relates
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000013604 expression vector Chemical class 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Electrotherapy Devices (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Control Of Electric Motors In General (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004037611A DE102004037611B4 (de) | 2004-08-03 | 2004-08-03 | Induzierbare Genexpression |
DE200410037652 DE102004037652B4 (de) | 2004-08-03 | 2004-08-03 | Verfahren zur Modulation der Genexpression durch Änderung des CpG Gehalts |
PCT/EP2005/008423 WO2006015789A2 (de) | 2004-08-03 | 2005-08-03 | Verfahren zur modulation der genexpression durch änderung des cpg gehalts |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1776460T3 true DK1776460T3 (da) | 2010-04-12 |
Family
ID=35839637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05768791T DK1776460T3 (da) | 2004-08-03 | 2005-08-03 | Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdet |
Country Status (14)
Country | Link |
---|---|
US (4) | US8859275B2 (da) |
EP (1) | EP1776460B8 (da) |
JP (1) | JP4550115B2 (da) |
KR (1) | KR101222628B1 (da) |
AT (1) | ATE453716T1 (da) |
AU (1) | AU2005270430B2 (da) |
BR (1) | BRPI0513081A (da) |
CA (1) | CA2575490A1 (da) |
DE (1) | DE502005008794D1 (da) |
DK (1) | DK1776460T3 (da) |
HK (1) | HK1100089A1 (da) |
IL (1) | IL180786A (da) |
MX (1) | MX2007001292A (da) |
WO (1) | WO2006015789A2 (da) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE502005008794D1 (de) * | 2004-08-03 | 2010-02-11 | Geneart Ag | Verfahren zur modulation der genexpression durch änderung des cpg gehalts |
NZ569541A (en) | 2006-01-13 | 2012-05-25 | Us Gov Health & Human Serv | Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
WO2008069663A1 (en) | 2006-12-07 | 2008-06-12 | Publiekrechtelijke Rechtspersoon Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | Use of a varicellovirus tap-inhibitor for the induction of tumor- or virus-specific immunity against teipp |
JP5575636B2 (ja) | 2007-05-07 | 2014-08-20 | メディミューン,エルエルシー | 抗icos抗体ならびに、腫瘍、移植および自己免疫疾患の治療におけるその使用 |
EP2019134A1 (en) * | 2007-07-26 | 2009-01-28 | Vision 7 GmbH | Gene therapy of chronic granulomatous disease |
AU2008279883B2 (en) | 2007-07-26 | 2013-12-05 | Uniqure Ip B.V. | Baculoviral vectors comprising repeated coding sequences with differential codon biases |
WO2010087709A1 (en) | 2009-01-30 | 2010-08-05 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Alanine-glyoxylate aminotransferase therapeutics |
WO2011100369A2 (en) * | 2010-02-09 | 2011-08-18 | The Trustees Of Columbia University In The City Of New York | Methods for altering polypeptide expression and solubility |
EP2646795B1 (en) | 2010-11-29 | 2019-02-20 | Dako Denmark A/S | Methods for analyzing images of specimens processed by a programmable quantitative assay |
DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
EP2751729B1 (en) | 2011-09-01 | 2020-10-21 | Genome Compiler Corporation | System for polynucleotide construct design, visualization and transactions to manufacture the same |
WO2014153188A2 (en) | 2013-03-14 | 2014-09-25 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
CN107058059B (zh) | 2011-09-26 | 2020-08-07 | 基因技术股份公司 | 高效的小体积核酸合成 |
WO2013152220A2 (en) | 2012-04-04 | 2013-10-10 | Life Technologies Corporation | Tal-effector assembly platform, customized services, kits and assays |
CN105637097A (zh) | 2013-08-05 | 2016-06-01 | 特韦斯特生物科学公司 | 从头合成的基因文库 |
EP3461498A1 (en) * | 2013-08-21 | 2019-04-03 | CureVac AG | Rabies vaccine |
EP3574916A1 (en) * | 2013-08-21 | 2019-12-04 | CureVac AG | Composition and vaccine for treating lung cancer |
MX369154B (es) * | 2013-08-21 | 2019-10-30 | Curevac Ag | Composición y vacuna para tratar cáncer de pulmón. |
EP3586871A3 (en) * | 2013-08-21 | 2020-03-11 | CureVac AG | Respiratory syncytial virus (rsv) vaccine |
RU2712743C2 (ru) | 2013-08-21 | 2020-01-30 | Куревак Аг | Вакцина против бешенства |
BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
KR20160043103A (ko) * | 2013-08-21 | 2016-04-20 | 큐어백 아게 | 전립선암 치료를 위한 조성물 및 백신 |
US20170362627A1 (en) | 2014-11-10 | 2017-12-21 | Modernatx, Inc. | Multiparametric nucleic acid optimization |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
EP3557262B1 (en) | 2014-12-09 | 2022-08-10 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
DK3294885T3 (da) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | Fremgangsmåde til at fremstille rna |
CN107873055B (zh) | 2015-05-29 | 2021-09-17 | 库瑞瓦格房地产有限公司 | 包括至少一个切向流过滤步骤的产生和纯化rna的方法 |
US10844373B2 (en) | 2015-09-18 | 2020-11-24 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
CN115920796A (zh) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
EP3500672A4 (en) | 2016-08-22 | 2020-05-20 | Twist Bioscience Corporation | NOVO SYNTHESIZED NUCLEIC ACID BANKS |
KR102217487B1 (ko) | 2016-09-21 | 2021-02-23 | 트위스트 바이오사이언스 코포레이션 | 핵산 기반 데이터 저장 |
WO2018087285A1 (en) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Or10h1 antigen binding proteins and uses thereof |
KR102514213B1 (ko) | 2016-12-16 | 2023-03-27 | 트위스트 바이오사이언스 코포레이션 | 면역 시냅스의 변이체 라이브러리 및 그의 합성 |
SG11201907713WA (en) | 2017-02-22 | 2019-09-27 | Twist Bioscience Corp | Nucleic acid based data storage |
WO2018170169A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
WO2018195339A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
SG11201912057RA (en) | 2017-06-12 | 2020-01-30 | Twist Bioscience Corp | Methods for seamless nucleic acid assembly |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
WO2019051501A1 (en) | 2017-09-11 | 2019-03-14 | Twist Bioscience Corporation | PROTEINS BINDING TO GPCR AND METHODS OF SYNTHESIS |
JP7066840B2 (ja) | 2017-10-20 | 2022-05-13 | ツイスト バイオサイエンス コーポレーション | ポリヌクレオチド合成のための加熱されたナノウェル |
EP3735459A4 (en) | 2018-01-04 | 2021-10-06 | Twist Bioscience Corporation | DNA-BASED DIGITAL INFORMATION STORAGE |
EP3508499A1 (en) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
EP3768858A1 (en) | 2018-03-19 | 2021-01-27 | Modernatx, Inc. | Assembly and error reduction of synthetic genes from oligonucleotides |
KR20210013128A (ko) | 2018-05-18 | 2021-02-03 | 트위스트 바이오사이언스 코포레이션 | 핵산 하이브리드화를 위한 폴리뉴클레오타이드, 시약 및 방법 |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
CN113766930A (zh) | 2019-02-26 | 2021-12-07 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
EP3989994A4 (en) * | 2019-06-30 | 2023-08-09 | John Fraser Wright | RECOMBINANT AAV VECTORS WITH ALTERED IMMUNOGENICITY AND METHODS FOR THEIR PRODUCTION |
US20220372138A1 (en) | 2019-07-05 | 2022-11-24 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
US20240010720A1 (en) | 2020-07-06 | 2024-01-11 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
EP3992205A1 (en) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Sars coronavirus-2 spike protein binding compounds |
WO2022096536A1 (en) | 2020-11-03 | 2022-05-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
WO2022106205A1 (en) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Corona virus spike protein binding compounds |
EP4301402A1 (en) | 2021-03-03 | 2024-01-10 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Bispecific antibodies enhancing cell mediated immune responses |
CA3228365A1 (en) * | 2021-08-11 | 2023-02-16 | Solid Biosciences Inc. | Treatment of muscular dystrophy |
WO2024067780A1 (zh) * | 2022-09-30 | 2024-04-04 | 南京金斯瑞生物科技有限公司 | 一种降低外源核酸免疫原性的密码子优化 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050131267A1 (en) * | 1995-06-07 | 2005-06-16 | Talmadge Karen D. | System and method for delivering a therapeutic agent for bone disease |
EP1003531B1 (en) * | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
DE60022665T2 (de) * | 1999-09-25 | 2006-06-22 | Coley Pharmaceutical Gmbh | Immunstimulierende nukeinsäuren |
AU2001247445B2 (en) | 2000-03-15 | 2006-09-21 | Gaussia L.L.C. | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
EP1156112B1 (en) * | 2000-05-18 | 2006-03-01 | Geneart GmbH | Synthetic gagpol genes and their uses |
US6919204B2 (en) * | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
DE10053781B4 (de) | 2000-10-30 | 2008-07-03 | Geneart Ag | Kernexportreportersystem |
AU2002242872B2 (en) | 2001-04-05 | 2006-12-14 | Emd Millipore Corporation | Improved gene expression |
WO2002099105A2 (en) | 2001-06-05 | 2002-12-12 | Cellectis | Methods for modifying the cpg content of polynucleotides |
US7569553B2 (en) * | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7605138B2 (en) * | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
ATE505476T1 (de) * | 2002-07-16 | 2011-04-15 | VGX Pharmaceuticals LLC | Codon-optimierte synthetische plasmide |
DE10260805A1 (de) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
US8224574B2 (en) | 2004-05-12 | 2012-07-17 | Northrop Grumman Guidance And Electronics Company, Inc. | System for multiple navigation components |
DE502005008794D1 (de) | 2004-08-03 | 2010-02-11 | Geneart Ag | Verfahren zur modulation der genexpression durch änderung des cpg gehalts |
DE102004037611B4 (de) * | 2004-08-03 | 2013-10-02 | Geneart Ag | Induzierbare Genexpression |
DE102007052344B3 (de) * | 2007-11-02 | 2009-03-12 | Geneart Ag | Selektion kodierender Nukleinsäure-Konstrukte auf Abwesenheit von Frameshift-Mutationen |
EP2970965A2 (en) * | 2013-03-15 | 2016-01-20 | Pronai Therapeutics, Inc. | Dnai for the modulation of genes |
-
2005
- 2005-08-03 DE DE200550008794 patent/DE502005008794D1/de active Active
- 2005-08-03 US US11/659,315 patent/US8859275B2/en active Active
- 2005-08-03 AT AT05768791T patent/ATE453716T1/de active
- 2005-08-03 WO PCT/EP2005/008423 patent/WO2006015789A2/de active Application Filing
- 2005-08-03 JP JP2007524277A patent/JP4550115B2/ja active Active
- 2005-08-03 AU AU2005270430A patent/AU2005270430B2/en not_active Ceased
- 2005-08-03 CA CA 2575490 patent/CA2575490A1/en not_active Abandoned
- 2005-08-03 DK DK05768791T patent/DK1776460T3/da active
- 2005-08-03 MX MX2007001292A patent/MX2007001292A/es not_active Application Discontinuation
- 2005-08-03 KR KR1020077004967A patent/KR101222628B1/ko active IP Right Grant
- 2005-08-03 EP EP20050768791 patent/EP1776460B8/de active Active
- 2005-08-03 BR BRPI0513081-6A patent/BRPI0513081A/pt not_active IP Right Cessation
-
2007
- 2007-01-18 IL IL180786A patent/IL180786A/en active IP Right Grant
- 2007-07-23 HK HK07107945A patent/HK1100089A1/xx not_active IP Right Cessation
-
2014
- 2014-09-10 US US14/483,142 patent/US10273486B2/en active Active
-
2019
- 2019-03-11 US US16/298,715 patent/US20190270999A1/en not_active Abandoned
-
2020
- 2020-10-26 US US17/080,333 patent/US20210155940A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE502005008794D1 (de) | 2010-02-11 |
AU2005270430A1 (en) | 2006-02-16 |
WO2006015789A2 (de) | 2006-02-16 |
IL180786A0 (en) | 2007-06-03 |
AU2005270430B2 (en) | 2008-06-12 |
BRPI0513081A (pt) | 2008-04-22 |
EP1776460B1 (de) | 2009-12-30 |
US20150104832A1 (en) | 2015-04-16 |
US20210155940A1 (en) | 2021-05-27 |
US10273486B2 (en) | 2019-04-30 |
WO2006015789A3 (de) | 2006-06-01 |
US20190270999A1 (en) | 2019-09-05 |
HK1100089A1 (en) | 2007-09-07 |
IL180786A (en) | 2013-08-29 |
EP1776460B8 (de) | 2014-02-26 |
MX2007001292A (es) | 2007-07-04 |
CA2575490A1 (en) | 2006-02-16 |
EP1776460A2 (de) | 2007-04-25 |
US20090324546A1 (en) | 2009-12-31 |
JP4550115B2 (ja) | 2010-09-22 |
ATE453716T1 (de) | 2010-01-15 |
KR20070041605A (ko) | 2007-04-18 |
KR101222628B1 (ko) | 2013-01-16 |
JP2008507986A (ja) | 2008-03-21 |
EP1776460B2 (de) | 2013-12-25 |
US8859275B2 (en) | 2014-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1776460T3 (da) | Fremgangsmåde til modulering af genekspression ved ændring af CpG-indholdet | |
DK1200580T3 (da) | Modulering af oligonukleotid-CpG-medieret immunstimulering ved positionel modifikation | |
ATE512228T1 (de) | Induzierbare expressionssysteme | |
DE60332820D1 (de) | Verfahren und mittel zur überwachung und modulation des gen-silencing | |
WO2004044181A3 (en) | Antisense modulation of apolipoprotein b expression | |
DE60132170D1 (de) | Modulierung der durch cpg-oligonukleotide verursachte immunstimulierung durch positionsbedingte veränderung von nukleosiden | |
WO2004005460A3 (en) | Antisense modulation of hmg-coa reductase expression | |
EP1417351A4 (en) | ANTISENSE MODULATION OF THE EXPRESSION OF APOLIPOPROTEIN (A) | |
MX2007006610A (es) | Metodo para simplificar acidos nucleicos microbianos por modificacion quimica de citosinas. | |
DE60143901D1 (de) | Antisense-modulation der clusterinexpression | |
WO2003011887A3 (en) | Antisense modulation of apolipoprotein b expression | |
WO2002036743A3 (en) | Antisense modulation of calreticulin expression | |
WO2003097662A8 (en) | Antisense modulation of apolipoprotein b expression | |
DK1117672T3 (da) | Antisense-modulation af survivin-ekpression | |
BRPI0413969A (pt) | modulação da transcrição ativada por -catenina/tcf | |
WO2007014077A3 (en) | Rnai modulation of the rho-a gene and uses thereof | |
WO2003046132A3 (en) | Antisense modulation of myd88 expression | |
WO2009135810A8 (en) | Plants having enhanced yield-related traits and a method for making the same | |
WO2009016212A3 (en) | Plants having enhanced yield-related traits and a method for making the same | |
EP1814597A4 (en) | RNAI MODULATION OF BCR-ABL FUSION GENE AND APPLICATIONS THEREOF | |
WO2001083513A3 (en) | Antisense modulation of inhibitor of dna binding-1 expression | |
WO2009100254A3 (en) | Protein tyrosine phosphatase inhibitors | |
WO2007005840A3 (en) | Compositions, kits and methods pertaining to stability modulation of pna oligomer/nucleic acid complexes | |
WO2004003201A3 (en) | Antisense modulation of lrh1 expression | |
WO2003106645A3 (en) | ANTISENSE MODULATION OF SMRT COREPRESSOR EXPRESSION |