MX369154B - Composición y vacuna para tratar cáncer de pulmón. - Google Patents
Composición y vacuna para tratar cáncer de pulmón.Info
- Publication number
- MX369154B MX369154B MX2016002151A MX2016002151A MX369154B MX 369154 B MX369154 B MX 369154B MX 2016002151 A MX2016002151 A MX 2016002151A MX 2016002151 A MX2016002151 A MX 2016002151A MX 369154 B MX369154 B MX 369154B
- Authority
- MX
- Mexico
- Prior art keywords
- vaccine
- composition
- lung cancer
- antigens
- relates
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 title abstract 2
- 201000005202 lung cancer Diseases 0.000 title abstract 2
- 208000020816 lung neoplasm Diseases 0.000 title abstract 2
- 102000000763 Survivin Human genes 0.000 abstract 3
- 108010002687 Survivin Proteins 0.000 abstract 3
- 102100033579 Trophoblast glycoprotein Human genes 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 101001036406 Homo sapiens Melanoma-associated antigen C1 Proteins 0.000 abstract 2
- 101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 abstract 2
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 abstract 2
- 102100039447 Melanoma-associated antigen C1 Human genes 0.000 abstract 2
- 102100027252 Melanoma-associated antigen C2 Human genes 0.000 abstract 2
- 102100034256 Mucin-1 Human genes 0.000 abstract 2
- 230000003044 adaptive effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 abstract 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 abstract 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010008707 Mucin-1 Proteins 0.000 abstract 1
- 206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 abstract 1
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 abstract 1
- 101710190034 Trophoblast glycoprotein Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/86—Lung
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a una composición que comprende al menos un ARNm que codifica una combinación de antígenos capaces de inducir una respuesta inmunitaria (adaptiva) en un mamífero, en donde los antígenos se seleccionan del grupo que consiste de 5T4 (Glicoproteína Trofoblástica, TPBG), Survivina (Proteína 5 que contiene la repetición IAP Baculoviral; BIRC5), NY-ESO-1 (Carcinoma 1 de células escamosas esofágicas de Nueva York, CTAG1B), MAGE-C1 (Familia de antígenos de melanoma C1), MAGE-C2 (Familia de antígenos de melanoma C2), y MUC1 (Mucina 1). La invención se refiere adicionalmente a una vacuna que comprende al menos un ARNm que codifica tal combinación de antígenos, y al uso de la composición (para la preparación de una vacuna) y/o de la vacuna para inducir una respuesta inmunitaria (adaptiva) para el tratamiento de cáncer de pulmón, de manera preferente de cáncer de pulmón de células no pequeñas (NSCLC), y enfermedades o trastornos relacionados con el mismo. Finalmente, la invención se refiere a kits, particularmente a kits de partes, que contienen la composición y/o la vacuna.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2013002514 | 2013-08-21 | ||
PCT/EP2014/002299 WO2015024666A1 (en) | 2013-08-21 | 2014-08-21 | Composition and vaccine for treating lung cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016002151A MX2016002151A (es) | 2016-12-14 |
MX369154B true MX369154B (es) | 2019-10-30 |
Family
ID=49003746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016002151A MX369154B (es) | 2013-08-21 | 2014-08-21 | Composición y vacuna para tratar cáncer de pulmón. |
Country Status (23)
Country | Link |
---|---|
US (1) | US20160168227A1 (es) |
JP (1) | JP6678582B2 (es) |
KR (1) | KR20160042935A (es) |
CN (1) | CN105530952A (es) |
AP (1) | AP2016009090A0 (es) |
AU (2) | AU2014310932B2 (es) |
BR (1) | BR112016003400A2 (es) |
CA (1) | CA2914508A1 (es) |
CL (1) | CL2016000388A1 (es) |
DK (1) | DK3035955T3 (es) |
EA (1) | EA037217B1 (es) |
ES (1) | ES2759910T3 (es) |
HK (1) | HK1225987A1 (es) |
HU (1) | HUE046469T2 (es) |
IL (2) | IL243090B (es) |
MX (1) | MX369154B (es) |
MY (1) | MY174677A (es) |
PE (1) | PE20160224A1 (es) |
PH (1) | PH12015502718A1 (es) |
SG (2) | SG11201510748PA (es) |
UA (1) | UA120595C2 (es) |
WO (1) | WO2015024666A1 (es) |
ZA (1) | ZA201508947B (es) |
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MY174677A (en) | 2020-05-06 |
ES2759910T3 (es) | 2020-05-12 |
BR112016003400A2 (pt) | 2017-12-05 |
ZA201508947B (en) | 2020-05-27 |
CA2914508A1 (en) | 2015-02-26 |
HK1225987A1 (zh) | 2017-09-22 |
JP6678582B2 (ja) | 2020-04-08 |
AU2019226125A1 (en) | 2019-09-26 |
KR20160042935A (ko) | 2016-04-20 |
EA037217B1 (ru) | 2021-02-20 |
IL276428A (en) | 2020-09-30 |
JP2016528264A (ja) | 2016-09-15 |
CN105530952A (zh) | 2016-04-27 |
DK3035955T3 (da) | 2019-12-02 |
SG11201510748PA (en) | 2016-03-30 |
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