DK175964B1 - Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne - Google Patents

Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne Download PDF

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Publication number
DK175964B1
DK175964B1 DK198604227A DK422786A DK175964B1 DK 175964 B1 DK175964 B1 DK 175964B1 DK 198604227 A DK198604227 A DK 198604227A DK 422786 A DK422786 A DK 422786A DK 175964 B1 DK175964 B1 DK 175964B1
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Prior art keywords
sequence
inhibitor
fibac
dna sequence
vector
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DK198604227A
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Danish (da)
English (en)
Other versions
DK422786D0 (da
DK422786A (da
Inventor
David F Carmichael
David C Anderson
George P Stricklin
Howard G Welgus
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Amgen Inc A Corp Of The State
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Application filed by Amgen Inc A Corp Of The State filed Critical Amgen Inc A Corp Of The State
Publication of DK422786D0 publication Critical patent/DK422786D0/da
Publication of DK422786A publication Critical patent/DK422786A/da
Application granted granted Critical
Publication of DK175964B1 publication Critical patent/DK175964B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK198604227A 1985-02-05 1986-09-04 Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne DK175964B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US69918185A 1985-02-05 1985-02-05
US69918185 1985-02-05
US78431985A 1985-10-04 1985-10-04
US78431985 1985-10-04
PCT/US1986/000302 WO1986004608A1 (en) 1985-02-05 1986-02-05 Metalloproteinase inhibitor sequence recombinant vector system for using same and recombinant-dna method for the manufacture of same
US8600302 1986-02-05

Publications (3)

Publication Number Publication Date
DK422786D0 DK422786D0 (da) 1986-09-04
DK422786A DK422786A (da) 1986-12-05
DK175964B1 true DK175964B1 (da) 2005-09-26

Family

ID=27106361

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198604227A DK175964B1 (da) 1985-02-05 1986-09-04 Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne

Country Status (9)

Country Link
US (3) US6090585A (ko)
EP (1) EP0211077B1 (ko)
JP (1) JPH088870B2 (ko)
KR (1) KR940010862B1 (ko)
AT (1) ATE89005T1 (ko)
AU (2) AU5549386A (ko)
DE (1) DE3688383T2 (ko)
DK (1) DK175964B1 (ko)
WO (1) WO1986004608A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0198014A4 (en) * 1984-10-01 1987-11-23 Sandoz Ltd VECTORS CONTAINING A GENE FOR A PROTEIN HAVING ERYTHROID ACTIVATION ACTIVITY AND A RECOMBINANT DNA PROCESS FOR PRODUCING THE PROTEIN.
EP0188312A3 (en) * 1985-01-07 1988-01-13 Celltech Limited Process for the production of a protein
JPH01213232A (ja) * 1988-02-22 1989-08-28 Fuji Yakuhin Kogyo Kk 新規な皮膚潰瘍治療剤
AU648505B2 (en) * 1989-05-19 1994-04-28 Amgen, Inc. Metalloproteinase inhibitor
US5714465A (en) 1989-05-19 1998-02-03 Amgen Inc. Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor
ATE403714T1 (de) 1996-11-06 2008-08-15 Univ California Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen
AU2002326070A1 (en) * 2001-07-02 2003-01-21 Elan Corporation, Plc Peyers's patch and/or m-celle targeting ligands
JP2010502425A (ja) * 2006-08-30 2010-01-28 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 膜を評価するシステム及び方法並びに膜濾過装置
US8189753B1 (en) 2007-04-12 2012-05-29 Russound/Fmp Incorporated Distributed intercom system with audio bus

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276284A (en) * 1971-07-26 1981-06-30 Brown Stuart I Prevention of collagenase induced disease by treatment with collagenase inhibitors
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
US4361574A (en) * 1981-10-02 1982-11-30 American Home Products Corporation Inhibitors of mammalian collagenase
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (ko) * 1982-12-22 1984-10-02 Genentech Inc
DE122080T1 (de) * 1983-03-25 1985-05-23 Celltech Ltd., Slough, Berkshire Verfahren zur herstellung eines proteins.
US4609667A (en) * 1983-12-19 1986-09-02 American Home Products Corporation Inhibitor of mammalian collagenase and elastase
US4602006A (en) * 1984-05-09 1986-07-22 Syntex (U.S.A.) Inc. Ynenolactone protease inhibitors
EP0198014A4 (en) * 1984-10-01 1987-11-23 Sandoz Ltd VECTORS CONTAINING A GENE FOR A PROTEIN HAVING ERYTHROID ACTIVATION ACTIVITY AND A RECOMBINANT DNA PROCESS FOR PRODUCING THE PROTEIN.
EP0188312A3 (en) * 1985-01-07 1988-01-13 Celltech Limited Process for the production of a protein
GB8500341D0 (en) * 1985-01-07 1985-02-13 Celltech Ltd Production of protein
EP0189784B1 (en) * 1985-01-18 1989-11-08 G.D. Searle & Co. Human natural inhibitor of collagenases
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation

Also Published As

Publication number Publication date
AU636370B2 (en) 1993-04-29
AU5971090A (en) 1990-11-01
DE3688383T2 (de) 1993-08-26
DK422786D0 (da) 1986-09-04
US6090585A (en) 2000-07-18
KR870700096A (ko) 1987-02-28
EP0211077A4 (en) 1987-11-23
JPS62502101A (ja) 1987-08-20
US20030003556A1 (en) 2003-01-02
DE3688383D1 (de) 1993-06-09
AU5549386A (en) 1986-08-26
JPH088870B2 (ja) 1996-01-31
US6342374B1 (en) 2002-01-29
WO1986004608A1 (en) 1986-08-14
ATE89005T1 (de) 1993-05-15
EP0211077B1 (en) 1993-05-05
DK422786A (da) 1986-12-05
US6800732B2 (en) 2004-10-05
KR940010862B1 (ko) 1994-11-18
EP0211077A1 (en) 1987-02-25

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