DK175266B1 - Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin - Google Patents

Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin Download PDF

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Publication number
DK175266B1
DK175266B1 DK198705284A DK528487A DK175266B1 DK 175266 B1 DK175266 B1 DK 175266B1 DK 198705284 A DK198705284 A DK 198705284A DK 528487 A DK528487 A DK 528487A DK 175266 B1 DK175266 B1 DK 175266B1
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Prior art keywords
approx
human insulin
metal ion
ion
insulin precursor
Prior art date
Application number
DK198705284A
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Danish (da)
English (en)
Other versions
DK528487A (da
DK528487D0 (da
Inventor
Bruce Hill Frank
Richard Eugene Heiney
Walter Francis Prouty
Mark Robert Walden
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK528487D0 publication Critical patent/DK528487D0/da
Publication of DK528487A publication Critical patent/DK528487A/da
Application granted granted Critical
Publication of DK175266B1 publication Critical patent/DK175266B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198705284A 1986-10-14 1987-10-09 Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin DK175266B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91793986A 1986-10-14 1986-10-14
US91793986 1986-10-14

Publications (3)

Publication Number Publication Date
DK528487D0 DK528487D0 (da) 1987-10-09
DK528487A DK528487A (da) 1988-04-15
DK175266B1 true DK175266B1 (da) 2004-08-02

Family

ID=25439543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705284A DK175266B1 (da) 1986-10-14 1987-10-09 Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin

Country Status (26)

Country Link
US (1) US5457066A (es)
EP (1) EP0264250B1 (es)
JP (1) JP2634176B2 (es)
KR (1) KR970003519B1 (es)
CN (1) CN1029131C (es)
AR (1) AR243608A1 (es)
AT (1) ATE115962T1 (es)
AU (1) AU595934B2 (es)
CA (1) CA1339955C (es)
CY (1) CY1830A (es)
DE (1) DE3750897T2 (es)
DK (1) DK175266B1 (es)
EG (1) EG18520A (es)
ES (1) ES2065321T3 (es)
GR (1) GR3015143T3 (es)
HK (1) HK39495A (es)
HU (1) HU204572B (es)
IE (1) IE65972B1 (es)
IL (1) IL84110A (es)
MX (1) MX168305B (es)
NZ (1) NZ222082A (es)
PH (1) PH26471A (es)
PT (1) PT85892B (es)
RU (1) RU1829939C (es)
SG (1) SG14795G (es)
ZA (1) ZA877505B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
CZ283234B6 (cs) 1990-09-05 1998-02-18 Hoechst Aktiengesellschaft Enymatický způsob konverse preproinsulinů na insuliny
ZA928916B (en) * 1991-11-26 1994-05-18 Lilly Co Eli Tri-arginine insulins
IL107536A0 (en) * 1992-11-13 1994-02-27 Lilly Co Eli Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6087558A (en) * 1998-07-22 2000-07-11 Prodigene, Inc. Commercial production of proteases in plants
US6395299B1 (en) 1999-02-12 2002-05-28 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
WO2002051428A1 (fr) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Composition de parfum stimulant le systeme sympathique
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
CN100424179C (zh) 2001-11-19 2008-10-08 诺沃挪第克公司 制备胰岛素化合物的方法
CA2485703A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
CA2485698C (en) * 2002-05-24 2012-03-27 Jin Seog Seo Peptide amidation process
EP1531836B1 (en) * 2002-05-24 2010-11-10 Medtronic, Inc. Polypeptide cleavage process
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
ES2380765T3 (es) * 2003-11-21 2012-05-18 Nps Pharmaceuticals, Inc. Producción del péptido 2 de tipo glucagón y análogos
ATE455849T1 (de) * 2003-12-05 2010-02-15 Hoffmann La Roche Rekombinante carboxypeptidase b und ihre aufreinigung
UA91512C2 (ru) 2004-07-19 2010-08-10 Биокон Лимитед Коньюгати олигомеров инсулина, их композиция (варианты) и применение
UA114700C2 (uk) 2007-10-16 2017-07-25 Біокон Лімітед Тверда фармацевтична форма для перорального застосування та процес її виготовлення
WO2010016069A1 (en) * 2008-08-07 2010-02-11 Biocon Limited A process for preparation of insulin compounds
WO2012104099A1 (en) * 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
WO2012115640A1 (en) 2011-02-23 2012-08-30 Elona Biotechnologies Liquid insulin- containing compositions and methods of making the same
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
TW202409070A (zh) 2022-05-18 2024-03-01 美商普羅托莫科技公司 芳族含硼化合物及相關胰島素類似物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5756878A (en) * 1980-09-22 1982-04-05 Sharp Corp Cleaning device
DK149824C (da) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Also Published As

Publication number Publication date
EP0264250A3 (en) 1990-03-21
PT85892A (en) 1987-11-01
IL84110A (en) 1992-11-15
PT85892B (pt) 1990-07-31
CN87107019A (zh) 1988-04-27
AU7952887A (en) 1988-04-21
HU204572B (en) 1992-01-28
EP0264250A2 (en) 1988-04-20
DK528487A (da) 1988-04-15
RU1829939C (ru) 1993-07-23
IE872743L (en) 1988-04-14
ZA877505B (en) 1989-05-30
AU595934B2 (en) 1990-04-12
ES2065321T3 (es) 1995-02-16
EP0264250B1 (en) 1994-12-21
DE3750897T2 (de) 1995-05-18
ATE115962T1 (de) 1995-01-15
JPS63105695A (ja) 1988-05-10
CY1830A (en) 1995-12-01
GR3015143T3 (en) 1995-05-31
MX168305B (es) 1993-05-17
KR970003519B1 (ko) 1997-03-18
CA1339955C (en) 1998-07-14
EG18520A (en) 1993-04-30
NZ222082A (en) 1989-08-29
CN1029131C (zh) 1995-06-28
KR880005262A (ko) 1988-06-28
HUT46363A (en) 1988-10-28
US5457066A (en) 1995-10-10
IE65972B1 (en) 1995-11-29
JP2634176B2 (ja) 1997-07-23
AR243608A1 (es) 1993-08-31
PH26471A (en) 1992-07-27
HK39495A (en) 1995-03-24
DK528487D0 (da) 1987-10-09
SG14795G (en) 1995-06-16
IL84110A0 (en) 1988-03-31
DE3750897D1 (de) 1995-02-02

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