DK175201B1 - Kompositioner omfattende antineoplastiske anthracyclinmidler indkapslet i micellulære phospholipidpartikler og fremgangsmåder til fremstilling deraf - Google Patents

Kompositioner omfattende antineoplastiske anthracyclinmidler indkapslet i micellulære phospholipidpartikler og fremgangsmåder til fremstilling deraf Download PDF

Info

Publication number
DK175201B1
DK175201B1 DK198600988A DK98886A DK175201B1 DK 175201 B1 DK175201 B1 DK 175201B1 DK 198600988 A DK198600988 A DK 198600988A DK 98886 A DK98886 A DK 98886A DK 175201 B1 DK175201 B1 DK 175201B1
Authority
DK
Denmark
Prior art keywords
composition
anthracycline
agent
particles
daunorubicin
Prior art date
Application number
DK198600988A
Other languages
Danish (da)
English (en)
Other versions
DK98886D0 (da
DK98886A (da
Inventor
Eric Forssen
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25141806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175201(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Publication of DK98886D0 publication Critical patent/DK98886D0/da
Publication of DK98886A publication Critical patent/DK98886A/da
Application granted granted Critical
Publication of DK175201B1 publication Critical patent/DK175201B1/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198600988A 1985-10-15 1986-03-04 Kompositioner omfattende antineoplastiske anthracyclinmidler indkapslet i micellulære phospholipidpartikler og fremgangsmåder til fremstilling deraf DK175201B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78753585A 1985-10-15 1985-10-15
US78753585 1985-10-15

Publications (3)

Publication Number Publication Date
DK98886D0 DK98886D0 (da) 1986-03-04
DK98886A DK98886A (da) 1987-04-16
DK175201B1 true DK175201B1 (da) 2004-07-05

Family

ID=25141806

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198600988A DK175201B1 (da) 1985-10-15 1986-03-04 Kompositioner omfattende antineoplastiske anthracyclinmidler indkapslet i micellulære phospholipidpartikler og fremgangsmåder til fremstilling deraf

Country Status (10)

Country Link
US (1) US4769250A (de)
EP (1) EP0219922B2 (de)
JP (1) JPH0761947B2 (de)
KR (1) KR890004689B1 (de)
AT (1) ATE65392T1 (de)
AU (1) AU587232B2 (de)
DE (1) DE3680447D1 (de)
DK (1) DK175201B1 (de)
IE (1) IE58981B1 (de)
NO (1) NO172729C (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5435989A (en) 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5723147A (en) * 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JP2501336B2 (ja) * 1987-07-02 1996-05-29 第一製薬株式会社 安定なリポソ−ム製剤
FI874742A (fi) * 1987-10-28 1989-04-29 K & V Licencing Oy Foerfarande foer framstaellning av liposomer.
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
WO1989006654A1 (en) * 1988-01-19 1989-07-27 Board Of Regents, The University Of Texas System Glycosides, liposomal compositions thereof, and methods for their use
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
DE68916439T2 (de) * 1988-10-05 1994-10-20 Vestar Inc Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US20010051183A1 (en) * 1989-10-20 2001-12-13 Alza Corporation Liposomes with enhanced circulation time and method of treatment
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
US6060080A (en) * 1990-07-16 2000-05-09 Daiichi Pharmaceutical Co., Ltd. Liposomal products
DE4023241A1 (de) * 1990-07-21 1992-01-23 Knoll Ag Stabile wirkstoff-formulierung
AU660288B2 (en) * 1990-07-31 1995-06-22 Transave, Inc. Accumulation of amino acids and peptides into liposomes
JP2599492B2 (ja) * 1990-08-21 1997-04-09 第一製薬株式会社 リポソーム製剤の製造法
DK0592446T3 (da) * 1991-07-03 1996-01-29 Nexstar Pharmaceuticals Inc Fyldningsteknik til fremstilling af lægemiddelholdige liposomer
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
BR9201168A (pt) * 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
US6093391A (en) * 1992-10-08 2000-07-25 Supratek Pharma, Inc. Peptide copolymer compositions
ATE198268T1 (de) * 1992-10-08 2001-01-15 Supratek Pharma Inc Zusammensetzung von in mizellen eingeschlossenen antineoplastischen wirkstoffen
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
CA2176712C (en) * 1993-11-16 2000-05-23 Mantripragada Sankaram Synthetic membrane vesicles with controlled release of encapsulated biologically active substances
EP0664117A1 (de) * 1994-01-25 1995-07-26 F. Hoffmann-La Roche Ag Liposomenlösungen
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US20040208922A1 (en) * 1995-06-07 2004-10-21 The Regents Of The University Of California Method for loading lipid like vesicles with drugs or other chemicals
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
CA2254772C (en) * 1996-05-14 2004-01-27 Stanislaw R. Burzynski Liposomal antineoplaston therapies with markedly improved antineoplastic activity
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
PT1014946E (pt) * 1997-09-18 2010-07-06 Pacira Pharmaceuticals Inc COMPOSIÎES ANESTéSICAS LIPOSSOMAIS DE LIBERTAÆO SUSTENTADA
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
EP1030652B1 (de) * 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Herstellung von multivesikulären liposomen
AU5246900A (en) * 1999-06-14 2001-01-02 Japan Science And Technology Corporation Anticancer emulsions containing anthracycline compounds
US7387790B2 (en) * 2001-06-15 2008-06-17 Cornerstone Pharmaceuticals Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
KR20040063901A (ko) * 2001-09-28 2004-07-14 에스페리온 테라피유틱스 인코포레이티드 고압에서 소포체를 압출하는 방법 및 장치
US8518437B2 (en) * 2001-11-13 2013-08-27 Celator Pharmaceuticals, Inc. Lipid carrier compositions with enhanced blood stability
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
GB2398495B (en) * 2003-01-23 2007-08-22 Kent G Lau A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
US9149543B2 (en) * 2005-12-15 2015-10-06 The Trustees Of The University Of Pennsylvania Methods and models for rapid, widespread delivery of genetic material to the CNS using non-viral, cationic lipid-mediated vectors
EP2224904A2 (de) * 2007-11-30 2010-09-08 Endo Pharmaceuticals Solutions Inc. Intravesikale zusammensetzungen mit valrubicin zur behandlung von blasenkrebs
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
JPS5793909A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Carcinostatic pharmaceutical having directivity to specific internal organ and its preparation
US4419348A (en) * 1981-04-27 1983-12-06 Georgetown University Anthracycline glycoside compositions, their use and preparation
US4427664A (en) * 1981-05-29 1984-01-24 The United States Of America As Represented By The Department Of Health And Human Services 2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin
CA1187434A (en) * 1981-08-11 1985-05-21 Akihiro Yoshimoto Anthracycline antibiotics and their preparation method
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
WO1985000968A1 (en) * 1983-09-06 1985-03-14 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
IL69720A (en) * 1983-09-14 1987-08-31 Univ Ramot Anti-tumor pharmaceutical compositions comprising liposome-bound porphyrins

Also Published As

Publication number Publication date
NO172729B (no) 1993-05-24
ATE65392T1 (de) 1991-08-15
AU587232B2 (en) 1989-08-10
KR890004689B1 (ko) 1989-11-25
KR870003775A (ko) 1987-05-04
JPS6287514A (ja) 1987-04-22
US4769250A (en) 1988-09-06
EP0219922A2 (de) 1987-04-29
NO172729C (no) 1993-09-01
DK98886D0 (da) 1986-03-04
EP0219922A3 (en) 1987-10-28
EP0219922B2 (de) 2002-08-28
AU5418486A (en) 1987-04-16
DK98886A (da) 1987-04-16
NO862193L (no) 1987-04-21
IE860535L (en) 1987-04-15
JPH0761947B2 (ja) 1995-07-05
DE3680447D1 (de) 1991-08-29
EP0219922B1 (de) 1991-07-24
IE58981B1 (en) 1993-12-15
NO862193D0 (no) 1986-06-03

Similar Documents

Publication Publication Date Title
DK175201B1 (da) Kompositioner omfattende antineoplastiske anthracyclinmidler indkapslet i micellulære phospholipidpartikler og fremgangsmåder til fremstilling deraf
EP0191824B1 (de) Einkapseln antineoplastischer mittel in liposomen
US4857319A (en) Method for preserving liposomes
US5194266A (en) Amphotericin B/cholesterol sulfate composition and method
EP0632719B1 (de) Verfahren zur behandlung infizierter gewebe
EP0303683B1 (de) Amphotericin b/cholesterolsulfat-zusammensetzung und -verfahren
Maruyama et al. Enhanced delivery of doxorubicin to tumor by long-circulating thermosensitive liposomes and local hyperthermia
JP2958774B2 (ja) アンホテリシンbリポソームの改良調整法
EP0278465B1 (de) Antineoplastika verkapselnde Liposomen
EP0077377B1 (de) Anticyclinglukosidzusammensetzungen, deren verwendung und herstellung
US5032582A (en) Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
US9005655B2 (en) Non-pegylated long-circulating liposomes
JPH0768119B2 (ja) 単一相中で調製された脂質小胞類
Chandraprakash et al. Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice
US4863739A (en) Liposome compositions of anthracycline derivatives
EP0069399B1 (de) Pharmazeutische Zusammensetzung, die die Ubidecarenone enthaltende Liposome enthält
Arica et al. Characterization, in vitro and in vivo studies on primaquine diphosphate liposomes
US20120207821A1 (en) Liposomal formulation and use thereof
JP5355842B2 (ja) 非ペギレート化長循環性リポソーム
CA1272686A (en) Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles and methods for using same for tumor therapy
JP3499604B2 (ja) スフィンゴ糖脂質ミセルからなる薬物担体
JPH1029930A (ja) 閉鎖小胞の製造方法
JPH0625008A (ja) リピッドa単糖類縁体含有リポソーム製剤
GS et al. Enhanced Tumor Targeting and Antitumor Activity of Gemcitabine Encapsulated Stealth Liposomes

Legal Events

Date Code Title Description
PUP Patent expired