DE3680447D1 - In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel. - Google Patents

In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel.

Info

Publication number
DE3680447D1
DE3680447D1 DE8686301513T DE3680447T DE3680447D1 DE 3680447 D1 DE3680447 D1 DE 3680447D1 DE 8686301513 T DE8686301513 T DE 8686301513T DE 3680447 T DE3680447 T DE 3680447T DE 3680447 D1 DE3680447 D1 DE 3680447D1
Authority
DE
Germany
Prior art keywords
particles
micellular
phospholipidic
agents included
anthracycline agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686301513T
Other languages
English (en)
Inventor
Eric Forssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25141806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3680447(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of DE3680447D1 publication Critical patent/DE3680447D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686301513T 1985-10-15 1986-03-04 In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel. Expired - Lifetime DE3680447D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78753585A 1985-10-15 1985-10-15

Publications (1)

Publication Number Publication Date
DE3680447D1 true DE3680447D1 (de) 1991-08-29

Family

ID=25141806

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686301513T Expired - Lifetime DE3680447D1 (de) 1985-10-15 1986-03-04 In mizellulare phospholipidische partikel eingekapselte antineoplastische anthracyclinmittel.

Country Status (10)

Country Link
US (1) US4769250A (de)
EP (1) EP0219922B2 (de)
JP (1) JPH0761947B2 (de)
KR (1) KR890004689B1 (de)
AT (1) ATE65392T1 (de)
AU (1) AU587232B2 (de)
DE (1) DE3680447D1 (de)
DK (1) DK175201B1 (de)
IE (1) IE58981B1 (de)
NO (1) NO172729C (de)

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US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JP2501336B2 (ja) * 1987-07-02 1996-05-29 第一製薬株式会社 安定なリポソ−ム製剤
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IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
ATE107502T1 (de) * 1988-10-05 1994-07-15 Vestar Inc Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US20010051183A1 (en) * 1989-10-20 2001-12-13 Alza Corporation Liposomes with enhanced circulation time and method of treatment
CA2046997C (en) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomal products
US6060080A (en) * 1990-07-16 2000-05-09 Daiichi Pharmaceutical Co., Ltd. Liposomal products
DE4023241A1 (de) * 1990-07-21 1992-01-23 Knoll Ag Stabile wirkstoff-formulierung
DE69120089T2 (de) * 1990-07-31 1996-12-12 Liposome Co Inc Anhäufung von aminosäuren und peptiden in liposomen
JP2599492B2 (ja) * 1990-08-21 1997-04-09 第一製薬株式会社 リポソーム製剤の製造法
DK0592446T3 (da) * 1991-07-03 1996-01-29 Nexstar Pharmaceuticals Inc Fyldningsteknik til fremstilling af lægemiddelholdige liposomer
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
BR9201168A (pt) * 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
US6093391A (en) * 1992-10-08 2000-07-25 Supratek Pharma, Inc. Peptide copolymer compositions
DK0619730T3 (da) * 1992-10-08 2001-01-29 Supratek Pharma Inc Sammensætninger af antineoplastiske midler inkorporeret i miceller
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
PL314485A1 (en) * 1993-11-16 1996-09-16 Depotech Corp Bubbles with controllable release of active substances
EP0664117A1 (de) * 1994-01-25 1995-07-26 F. Hoffmann-La Roche Ag Liposomenlösungen
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US20040208922A1 (en) * 1995-06-07 2004-10-21 The Regents Of The University Of California Method for loading lipid like vesicles with drugs or other chemicals
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
WO1997042939A1 (en) * 1996-05-14 1997-11-20 Burzynski Research Inst Liposomal antineoplaston therapies with markedly improved antineoplastic activity
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
CA2296056A1 (en) * 1997-07-10 1999-01-21 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
EP2198854B1 (de) 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Retardierte Freisetzung Liposomaler Anesthetischer Zusammensetzungen
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
CA2309548A1 (en) * 1997-11-14 1999-05-27 Skyepharma Inc. Production of multivesicular liposomes
WO2000076525A1 (fr) * 1999-06-14 2000-12-21 Meiji Milk Products Co., Ltd. Emulsions anticancereuses contenant des composes d'anthracycline
US7387790B2 (en) * 2001-06-15 2008-06-17 Cornerstone Pharmaceuticals Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
BR0212866A (pt) * 2001-09-28 2004-09-14 Esperion Therapeutics Inc Métodos de produzir uma suspensão de vesìcula e lipossomas e dispositivo para extrudar uma suspensão aquosa de lipìdeos a alta pressão
WO2003041681A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions with enhanced blood stability
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
GB2398495B (en) * 2003-01-23 2007-08-22 Kent G Lau A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
WO2007070705A2 (en) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Cationic lipid-mediated vectors
US20090214634A1 (en) * 2007-11-30 2009-08-27 Indevus Pharmaceuticals, Inc. Compositions and methods for the treatment of bladder cancer
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

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GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
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US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
JPS5793909A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Carcinostatic pharmaceutical having directivity to specific internal organ and its preparation
US4419348A (en) * 1981-04-27 1983-12-06 Georgetown University Anthracycline glycoside compositions, their use and preparation
US4427664A (en) * 1981-05-29 1984-01-24 The United States Of America As Represented By The Department Of Health And Human Services 2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin
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US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
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IL69720A (en) * 1983-09-14 1987-08-31 Univ Ramot Anti-tumor pharmaceutical compositions comprising liposome-bound porphyrins

Also Published As

Publication number Publication date
NO862193L (no) 1987-04-21
EP0219922B1 (de) 1991-07-24
AU5418486A (en) 1987-04-16
IE58981B1 (en) 1993-12-15
ATE65392T1 (de) 1991-08-15
NO862193D0 (no) 1986-06-03
NO172729B (no) 1993-05-24
IE860535L (en) 1987-04-15
US4769250A (en) 1988-09-06
DK175201B1 (da) 2004-07-05
JPS6287514A (ja) 1987-04-22
EP0219922A3 (en) 1987-10-28
NO172729C (no) 1993-09-01
DK98886A (da) 1987-04-16
AU587232B2 (en) 1989-08-10
DK98886D0 (da) 1986-03-04
JPH0761947B2 (ja) 1995-07-05
KR870003775A (ko) 1987-05-04
KR890004689B1 (ko) 1989-11-25
EP0219922B2 (de) 2002-08-28
EP0219922A2 (de) 1987-04-29

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: NEXSTAR PHARMACEUTICALS, INC. (N.D.GES.D.STAATES D

8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: GILEAD SCIENCES, INC., FOSTER CITY, CALIF., US