DK173509B1 - Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf - Google Patents

Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf Download PDF

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Publication number
DK173509B1
DK173509B1 DK198603384A DK338486A DK173509B1 DK 173509 B1 DK173509 B1 DK 173509B1 DK 198603384 A DK198603384 A DK 198603384A DK 338486 A DK338486 A DK 338486A DK 173509 B1 DK173509 B1 DK 173509B1
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DK
Denmark
Prior art keywords
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thr
ile
lys
Prior art date
Application number
DK198603384A
Other languages
Danish (da)
English (en)
Other versions
DK338486A (da
DK338486D0 (da
Inventor
Dominique Tripier
Martin Kramer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853525428 external-priority patent/DE3525428A1/de
Priority claimed from DE19863601032 external-priority patent/DE3601032A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK338486D0 publication Critical patent/DK338486D0/da
Publication of DK338486A publication Critical patent/DK338486A/da
Application granted granted Critical
Publication of DK173509B1 publication Critical patent/DK173509B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/141—Feedstock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198603384A 1985-07-17 1986-07-16 Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf DK173509B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19853525428 DE3525428A1 (de) 1985-07-17 1985-07-17 Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3525428 1985-07-17
DE19863601032 DE3601032A1 (de) 1986-01-16 1986-01-16 Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3601032 1986-01-16

Publications (3)

Publication Number Publication Date
DK338486D0 DK338486D0 (da) 1986-07-16
DK338486A DK338486A (da) 1987-01-18
DK173509B1 true DK173509B1 (da) 2001-01-15

Family

ID=25834067

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198603384A DK173509B1 (da) 1985-07-17 1986-07-16 Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf

Country Status (16)

Country Link
US (1) US4791100A (es)
EP (1) EP0209061B1 (es)
JP (1) JPH0764875B2 (es)
KR (1) KR940000758B1 (es)
AU (1) AU593820B2 (es)
CA (1) CA1340102C (es)
DE (1) DE3689525D1 (es)
DK (1) DK173509B1 (es)
ES (1) ES2000216A6 (es)
FI (1) FI862950A (es)
GR (1) GR861837B (es)
HU (1) HUT41418A (es)
IE (1) IE61569B1 (es)
IL (1) IL79424A (es)
NO (1) NO862876L (es)
PT (1) PT82993B (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
FI96956C (fi) * 1985-04-11 1996-09-25 Hoechst Ag Menetelmä terapeuttisesti käyttökelpoisen hirudiinijohdannaisen valmistamiseksi
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
FR2607517B2 (fr) * 1986-12-01 1989-12-22 Transgene Sa Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
DE68919848T2 (de) * 1988-05-27 1995-05-04 Philadelphia Children Hospital Amphiphile peptide und deren verwendung.
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same
IL87004A (en) * 1988-07-06 1992-08-18 Technion Res & Dev Foundation Method and apparatus for bioaffinity separation
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5187155A (en) * 1989-06-23 1993-02-16 Board Of Regents, The University Of Texas System Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides
DE3939801A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue proteine und ihre herstellung
DE4001238A1 (de) * 1990-01-18 1991-07-25 Basf Ag Verfahren zur anreicherung bzw. reinigung von biomolekuelen
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
EP0514464A4 (en) * 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
EP0559647A1 (en) * 1990-06-27 1993-09-15 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
US5428009A (en) * 1990-07-16 1995-06-27 Merck & Co., Inc. Lipopeptide derivatives
CA2047527A1 (en) * 1990-07-24 1992-01-25 Christopher Dunwiddie Method for administering a therapeutic anticoagulant
DE4031731A1 (de) * 1990-10-06 1992-04-09 Basf Ag Protein aus hirudo medicinalis
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
US5385884A (en) * 1991-08-27 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
CA2120337A1 (en) * 1991-10-16 1993-04-17 Michael A. Zasloff Composition and treatment with biologically active peptides and antibiotic
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
US5824641A (en) * 1993-04-09 1998-10-20 Bio-Technology General Corp Method of treating of preventing influenza
ATE213155T1 (de) * 1993-04-09 2002-02-15 Bio Technology General Corp Herstellung eines rekombinanten inhibitors des faktors xa des blutegels hirudo medicinalis
GB9309509D0 (en) * 1993-05-07 1993-06-23 Merck Patent Gmbh Thrombin inhibitors
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) * 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE69624087T2 (de) 1996-01-31 2003-06-05 Sumitomo Bakelite Co Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
CA2370782A1 (en) 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
CA2744145A1 (en) * 2008-11-19 2010-05-27 Avantor Performance Materials, Inc. New chromatographic media based on phenoxy alkyl and alkoxy-or phenoxy-phenyl alkyl ligands
CN102373216B (zh) * 2011-10-28 2013-06-05 元昊 一种含有医用水蛭素基因的重组真核汉逊酵母工程菌株的构建及重组水蛭素的生产工艺
CN113956339B (zh) * 2021-10-28 2023-02-24 中国药科大学 宽体金线蛭抗凝血因子XIa多肽及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
ATE78294T1 (de) * 1984-03-27 1992-08-15 Transgene Sa Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

Also Published As

Publication number Publication date
KR870001237A (ko) 1987-03-12
EP0209061B1 (de) 1994-01-12
IE61569B1 (en) 1994-11-16
HUT41418A (en) 1987-04-28
KR940000758B1 (ko) 1994-01-29
PT82993A (de) 1986-08-01
EP0209061A3 (en) 1989-03-15
AU593820B2 (en) 1990-02-22
FI862950A0 (fi) 1986-07-15
NO862876D0 (no) 1986-07-16
GR861837B (en) 1986-11-11
ES2000216A6 (es) 1988-01-16
JPS6222799A (ja) 1987-01-30
IE861902L (en) 1987-01-17
NO862876L (no) 1987-01-19
PT82993B (pt) 1989-01-30
DE3689525D1 (de) 1994-02-24
US4791100A (en) 1988-12-13
JPH0764875B2 (ja) 1995-07-12
IL79424A0 (en) 1986-10-31
DK338486A (da) 1987-01-18
DK338486D0 (da) 1986-07-16
CA1340102C (en) 1998-10-27
IL79424A (en) 1992-02-16
EP0209061A2 (de) 1987-01-21
AU6023386A (en) 1987-01-22
FI862950A (fi) 1987-01-18

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired