DK173077B1 - Polypeptid, der specifikt inhiberer thrombin, dets anvendelse til fremstilling af et lægemiddel samt farmaceutisk præparat - Google Patents

Polypeptid, der specifikt inhiberer thrombin, dets anvendelse til fremstilling af et lægemiddel samt farmaceutisk præparat Download PDF

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Publication number
DK173077B1
DK173077B1 DK199100878A DK87891A DK173077B1 DK 173077 B1 DK173077 B1 DK 173077B1 DK 199100878 A DK199100878 A DK 199100878A DK 87891 A DK87891 A DK 87891A DK 173077 B1 DK173077 B1 DK 173077B1
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Denmark
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gly
asp
cys
ser
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DK199100878A
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Danish (da)
English (en)
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DK87891A (da
DK87891D0 (da
Inventor
Anthony Atkinson
Asgar Electricwala
Roy Sawyer
Christopher Powell-Jones
Original Assignee
Biopharm Ltd
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Application filed by Biopharm Ltd filed Critical Biopharm Ltd
Publication of DK87891D0 publication Critical patent/DK87891D0/da
Publication of DK87891A publication Critical patent/DK87891A/da
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Publication of DK173077B1 publication Critical patent/DK173077B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DK199100878A 1988-11-11 1991-05-10 Polypeptid, der specifikt inhiberer thrombin, dets anvendelse til fremstilling af et lægemiddel samt farmaceutisk præparat DK173077B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888826428A GB8826428D0 (en) 1988-11-11 1988-11-11 Antithrombin
GB8826428 1988-11-11
PCT/GB1989/001345 WO1990005143A1 (en) 1988-11-11 1989-11-13 Anti-thrombins
GB8901345 1989-11-13

Publications (3)

Publication Number Publication Date
DK87891D0 DK87891D0 (da) 1991-05-10
DK87891A DK87891A (da) 1991-06-21
DK173077B1 true DK173077B1 (da) 1999-12-20

Family

ID=10646705

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199100878A DK173077B1 (da) 1988-11-11 1991-05-10 Polypeptid, der specifikt inhiberer thrombin, dets anvendelse til fremstilling af et lægemiddel samt farmaceutisk præparat

Country Status (16)

Country Link
US (1) US5472942A (hu)
EP (1) EP0373767B1 (hu)
JP (1) JP2865345B2 (hu)
KR (1) KR0153774B1 (hu)
AT (1) ATE111484T1 (hu)
AU (1) AU636857B2 (hu)
CA (1) CA2002924C (hu)
DE (1) DE68918246T2 (hu)
DK (1) DK173077B1 (hu)
FI (1) FI912240A0 (hu)
GB (1) GB8826428D0 (hu)
HU (1) HUT62016A (hu)
IE (1) IE64652B1 (hu)
RU (1) RU2050160C1 (hu)
WO (1) WO1990005143A1 (hu)
ZA (1) ZA898655B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
GB9007879D0 (en) * 1990-04-06 1990-06-06 Biopharm Ltd Treatment of thrombotic events
IL101062A0 (en) * 1991-02-28 1992-11-15 Erba Carlo Spa Anti-thrombin polypeptides and their preparation
US6514730B1 (en) * 1991-03-21 2003-02-04 Consortium für elektrochemische Industrie GmbH Secretion of hirudin derivatives
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
GB9309509D0 (en) * 1993-05-07 1993-06-23 Merck Patent Gmbh Thrombin inhibitors
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US6008320A (en) * 1995-04-27 1999-12-28 Korea Advanced Institute Of Science And Technology Elastase inhibitor and process for preparing the same
US6077825A (en) 1997-03-13 2000-06-20 Auburn University Antithrombin protein and DNA sequences from black fly
WO2005079474A2 (en) * 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
GB8504025D0 (en) * 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
US5139944A (en) * 1985-08-10 1992-08-18 Biophram (Uk) Limited Collagen-specific enzyme with platelet aggregation inhibition properties
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.

Also Published As

Publication number Publication date
RU2050160C1 (ru) 1995-12-20
CA2002924C (en) 1999-08-03
ATE111484T1 (de) 1994-09-15
CA2002924A1 (en) 1990-05-11
WO1990005143A1 (en) 1990-05-17
ZA898655B (en) 1990-08-29
JP2865345B2 (ja) 1999-03-08
GB8826428D0 (en) 1988-12-14
EP0373767A1 (en) 1990-06-20
AU4522589A (en) 1990-05-28
DE68918246T2 (de) 1995-02-16
IE64652B1 (en) 1995-08-23
HUT62016A (en) 1993-03-29
DK87891A (da) 1991-06-21
FI912240A0 (fi) 1991-05-09
DK87891D0 (da) 1991-05-10
US5472942A (en) 1995-12-05
AU636857B2 (en) 1993-05-13
KR900701832A (ko) 1990-12-04
JPH04502907A (ja) 1992-05-28
HU896934D0 (en) 1991-07-29
DE68918246D1 (de) 1994-10-20
EP0373767B1 (en) 1994-09-14
KR0153774B1 (ko) 1998-10-15

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