ZA898655B - Anti-thrombins - Google Patents

Anti-thrombins

Info

Publication number
ZA898655B
ZA898655B ZA898655A ZA898655A ZA898655B ZA 898655 B ZA898655 B ZA 898655B ZA 898655 A ZA898655 A ZA 898655A ZA 898655 A ZA898655 A ZA 898655A ZA 898655 B ZA898655 B ZA 898655B
Authority
ZA
South Africa
Prior art keywords
gly
glu
cys
asp
indicates
Prior art date
Application number
ZA898655A
Other languages
English (en)
Inventor
Anthony Atkinson
Atkinson Anthony
Asgar Electricwala
Electricwala Asgar
Roy Sawyer
Sawyer Roy
Christopher Powell-Jones
Powell-Jones Christopher
Original Assignee
Biopharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Ltd filed Critical Biopharm Ltd
Publication of ZA898655B publication Critical patent/ZA898655B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
ZA898655A 1988-11-11 1989-11-13 Anti-thrombins ZA898655B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888826428A GB8826428D0 (en) 1988-11-11 1988-11-11 Antithrombin

Publications (1)

Publication Number Publication Date
ZA898655B true ZA898655B (en) 1990-08-29

Family

ID=10646705

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898655A ZA898655B (en) 1988-11-11 1989-11-13 Anti-thrombins

Country Status (16)

Country Link
US (1) US5472942A (xx)
EP (1) EP0373767B1 (xx)
JP (1) JP2865345B2 (xx)
KR (1) KR0153774B1 (xx)
AT (1) ATE111484T1 (xx)
AU (1) AU636857B2 (xx)
CA (1) CA2002924C (xx)
DE (1) DE68918246T2 (xx)
DK (1) DK173077B1 (xx)
FI (1) FI912240A0 (xx)
GB (1) GB8826428D0 (xx)
HU (1) HUT62016A (xx)
IE (1) IE64652B1 (xx)
RU (1) RU2050160C1 (xx)
WO (1) WO1990005143A1 (xx)
ZA (1) ZA898655B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
GB9007879D0 (en) * 1990-04-06 1990-06-06 Biopharm Ltd Treatment of thrombotic events
IL101062A0 (en) * 1991-02-28 1992-11-15 Erba Carlo Spa Anti-thrombin polypeptides and their preparation
US6514730B1 (en) * 1991-03-21 2003-02-04 Consortium für elektrochemische Industrie GmbH Secretion of hirudin derivatives
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
GB9309509D0 (en) * 1993-05-07 1993-06-23 Merck Patent Gmbh Thrombin inhibitors
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US6008320A (en) * 1995-04-27 1999-12-28 Korea Advanced Institute Of Science And Technology Elastase inhibitor and process for preparing the same
US6077825A (en) * 1997-03-13 2000-06-20 Auburn University Antithrombin protein and DNA sequences from black fly
WO2005079474A2 (en) 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US8790711B2 (en) 2012-09-17 2014-07-29 Biopep Solutions, Inc. Treating diabetes with a whole, leech saliva extract
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
GB8504025D0 (en) * 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
US5139944A (en) * 1985-08-10 1992-08-18 Biophram (Uk) Limited Collagen-specific enzyme with platelet aggregation inhibition properties
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity

Also Published As

Publication number Publication date
ATE111484T1 (de) 1994-09-15
GB8826428D0 (en) 1988-12-14
KR0153774B1 (ko) 1998-10-15
AU636857B2 (en) 1993-05-13
HUT62016A (en) 1993-03-29
DE68918246D1 (de) 1994-10-20
FI912240A0 (fi) 1991-05-09
US5472942A (en) 1995-12-05
JPH04502907A (ja) 1992-05-28
CA2002924A1 (en) 1990-05-11
WO1990005143A1 (en) 1990-05-17
DK173077B1 (da) 1999-12-20
IE64652B1 (en) 1995-08-23
HU896934D0 (en) 1991-07-29
EP0373767A1 (en) 1990-06-20
JP2865345B2 (ja) 1999-03-08
DK87891A (da) 1991-06-21
DK87891D0 (da) 1991-05-10
DE68918246T2 (de) 1995-02-16
AU4522589A (en) 1990-05-28
EP0373767B1 (en) 1994-09-14
CA2002924C (en) 1999-08-03
KR900701832A (ko) 1990-12-04
RU2050160C1 (ru) 1995-12-20

Similar Documents

Publication Publication Date Title
ZA898655B (en) Anti-thrombins
HK1008787A1 (en) N-terminally monopegylated polypeptides and process for their preparation.
AU630951B2 (en) Enzymatic removal of a protein amino-terminal sequence
EP0676964A4 (en) NITROSATION OF SH PROTEIN GROUPS AND REMAINING AMINO ACIDS USED AS A THERAPEUTIC MODALITY.
HUP0003314A2 (hu) GLP-1 analógok és származékok alkalmazása elhízás szabályozására használható gyógyszerkészítmények előállítására
AU5707294A (en) 3,3 diphenyl prop-2-yl amino acid derivatives and their use as tachykinin antagonists
DK193887A (da) Peptid med bronchodilartorisk og hypotensiv aktivitet
HUT58764A (en) Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
AU1562988A (en) DNA clone of human thrombomodulin
EP0225020A3 (en) Peptides comprising, in sequence, units selected from the amino-acid residues 17 to 24 of vip
HU895788D0 (en) Process for producing peptides and medical products containing them
EP0257312A3 (en) A new cartilage-derived leukocyte elastase-inhibitor
CA2025070A1 (en) Recombinant aprotinin variants genetically engineered process for the microbial preparation of homgeneously processed aprotinin variants and the therapeutic use thereof
EP0333071A3 (en) Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use
AU9026691A (en) New human recombinant gamma interferon
DK0378432T3 (da) Peptider, deres anvendelse til inhibering af modningen af T-lymfocytter og aktiviteten af makrofager samt fremgangsmåder til deres fremstilling
FI93843C (fi) Menetelmä angiogeenisen tekijän tuottamiseksi
CA2018461A1 (en) Novel polypeptides and their use
AU3934689A (en) New furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
AU4034095A (en) Cyclohexapeptides and their mixtures, a process for preparing them, and their use
CA2247998A1 (en) Fragments of cr1 and their use
AU3327789A (en) Expression of the hiv 24 kda 24 gag protein in methylotrophic yeast
CA2003360A1 (en) Human vascular permeability factor