DK1720544T3 - Nye azabicykliske derivater, fremstillingsmetode hertil og farmaceutiske sammensætninger indeholdende disse - Google Patents

Nye azabicykliske derivater, fremstillingsmetode hertil og farmaceutiske sammensætninger indeholdende disse

Info

Publication number
DK1720544T3
DK1720544T3 DK05717646T DK05717646T DK1720544T3 DK 1720544 T3 DK1720544 T3 DK 1720544T3 DK 05717646 T DK05717646 T DK 05717646T DK 05717646 T DK05717646 T DK 05717646T DK 1720544 T3 DK1720544 T3 DK 1720544T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
azabicyclic derivatives
new
Prior art date
Application number
DK05717646T
Other languages
Danish (da)
English (en)
Inventor
Patrick Casara
Anne-Marie Chollet
Alain Dhainaut
Lionel Bert
Pierre Lestage
Brian Lockhart
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1720544T3 publication Critical patent/DK1720544T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK05717646T 2004-02-20 2005-02-18 Nye azabicykliske derivater, fremstillingsmetode hertil og farmaceutiske sammensætninger indeholdende disse DK1720544T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401690A FR2866647B1 (fr) 2004-02-20 2004-02-20 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2005/000382 WO2005089747A1 (fr) 2004-02-20 2005-02-18 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK1720544T3 true DK1720544T3 (da) 2008-07-21

Family

ID=34833930

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05717646T DK1720544T3 (da) 2004-02-20 2005-02-18 Nye azabicykliske derivater, fremstillingsmetode hertil og farmaceutiske sammensætninger indeholdende disse

Country Status (30)

Country Link
US (1) US7576120B2 (zh)
EP (1) EP1720544B1 (zh)
JP (1) JP4519861B2 (zh)
KR (1) KR100885104B1 (zh)
CN (2) CN101230033B (zh)
AR (3) AR047685A1 (zh)
AT (1) ATE389398T1 (zh)
AU (1) AU2005224129B2 (zh)
BR (1) BRPI0507830A (zh)
CA (1) CA2555216C (zh)
CY (1) CY1108529T1 (zh)
DE (1) DE602005005456T2 (zh)
DK (1) DK1720544T3 (zh)
EA (1) EA010300B1 (zh)
ES (1) ES2303233T3 (zh)
FR (1) FR2866647B1 (zh)
GE (1) GEP20094578B (zh)
HK (1) HK1123789A1 (zh)
HR (1) HRP20080184T5 (zh)
MA (1) MA28342A1 (zh)
ME (1) ME01400B (zh)
MY (1) MY137282A (zh)
NO (1) NO337013B1 (zh)
NZ (1) NZ548898A (zh)
PL (1) PL1720544T3 (zh)
PT (1) PT1720544E (zh)
RS (1) RS50577B (zh)
SI (1) SI1720544T1 (zh)
WO (1) WO2005089747A1 (zh)
ZA (1) ZA200606558B (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1717234A1 (en) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
EP1717235A3 (en) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
TW200900072A (en) * 2007-03-22 2009-01-01 Arete Therapeutics Inc Soluble epoxide hydrolase inhibitors
FR2932479A1 (fr) 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2937251B1 (fr) * 2008-10-16 2011-03-18 Servier Lab Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil
FR2953514B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-3-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953513B1 (fr) * 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-6-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953515B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953521B1 (fr) * 2009-12-09 2011-11-18 Servier Lab Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2974729B1 (fr) * 2011-05-02 2013-04-19 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR2976286B1 (fr) * 2011-06-08 2013-05-24 Servier Lab 4-{3-[trans-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, son procede de preparation et les compositions pharmaceutiques qui le contiennent
FR2976285B1 (fr) * 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
SG11201402963TA (en) 2011-12-08 2014-09-26 Taisho Pharmaceutical Co Ltd Phenylpyrrole derivative
FR2983732B1 (fr) * 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent
TW201343636A (zh) * 2011-12-27 2013-11-01 大正製藥股份有限公司 苯基三唑衍生物
CN103183632A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种3-氮杂双环辛烷盐酸盐的提纯方法
FR2999179A1 (fr) * 2012-12-07 2014-06-13 Servier Lab Procede de synthese d'un sel d'addition a un acide pharmaceutiquement acceptable du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, ainsi que les formes cristallines associees
FR3003466B1 (fr) 2013-03-22 2015-08-07 Servier Lab Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques
EP3594206A1 (en) * 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
CN111377911B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种吗啉苯甲酰胺类化合物及其应用
CN111377846B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种哌嗪苯甲酰胺类衍生物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962496A (en) * 1957-01-28 1960-11-29 Geschickter Fund Med Res Nu-substituted-3-azabicyclooctanes [3: 3: 0] and salts thereof
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US7034182B2 (en) * 2000-06-30 2006-04-25 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
JP4516717B2 (ja) * 2000-07-13 2010-08-04 アボット・ラボラトリーズ ヒスタミン−３受容体リガンドとしての１，３−二置換ピロリジン及び１，３，３−三置換ピロリジン並びにそれらの治療的応用
FR2827288B1 (fr) * 2001-07-12 2003-10-31 Servier Lab Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
KR100885104B1 (ko) 2009-02-20
ZA200606558B (en) 2008-01-08
CN1921848A (zh) 2007-02-28
CA2555216A1 (fr) 2005-09-29
CA2555216C (fr) 2011-10-11
HRP20080184T3 (en) 2008-05-31
CY1108529T1 (el) 2014-04-09
EA010300B1 (ru) 2008-08-29
AU2005224129A1 (en) 2005-09-29
GEP20094578B (en) 2009-01-12
PL1720544T3 (pl) 2008-05-30
WO2005089747A1 (fr) 2005-09-29
SI1720544T1 (sl) 2008-06-30
JP4519861B2 (ja) 2010-08-04
KR20060114382A (ko) 2006-11-06
CN101230033B (zh) 2011-03-09
JP2007523135A (ja) 2007-08-16
CN101230033A (zh) 2008-07-30
ATE389398T1 (de) 2008-04-15
DE602005005456D1 (de) 2008-04-30
FR2866647A1 (fr) 2005-08-26
US7576120B2 (en) 2009-08-18
DE602005005456T2 (de) 2009-04-09
HK1123789A1 (en) 2009-06-26
EP1720544A1 (fr) 2006-11-15
AR089451A2 (es) 2014-08-27
AR047685A1 (es) 2006-02-01
AU2005224129B2 (en) 2010-08-12
BRPI0507830A (pt) 2007-07-10
HRP20080184T5 (en) 2008-10-31
EP1720544B1 (fr) 2008-03-19
US20070197625A1 (en) 2007-08-23
PT1720544E (pt) 2008-05-08
MY137282A (en) 2009-01-30
NO20064160L (no) 2006-09-14
NO337013B1 (no) 2015-12-21
RS50577B (sr) 2010-05-07
MA28342A1 (fr) 2006-12-01
AR094601A2 (es) 2015-08-12
ES2303233T3 (es) 2008-08-01
ME01400B (en) 2013-12-20
NZ548898A (en) 2010-06-25
FR2866647B1 (fr) 2006-10-27
CN100577160C (zh) 2010-01-06
EA200601512A1 (ru) 2007-02-27

Similar Documents

Publication Publication Date Title
DK1720544T3 (da) Nye azabicykliske derivater, fremstillingsmetode hertil og farmaceutiske sammensætninger indeholdende disse
DK1523488T3 (da) Nye thiophenglycosidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
DK1620429T3 (da) Nye heterocykliske forbindelser anvendelige til behandling af inflammatoriske og allergiske sygdomme, fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger indeholdende disse
DK1896364T3 (da) Pulverformet kalksammensætning, fremgangsmåde til fremstilling deraf og anvendelse deraf
IS7543A (is) Bensóþíadíasepínafleiður, aðferðir til framleiðslu þeirra og lyfjablöndur sem innihalda þær
NO20054765D0 (no) Nye probiotiske sammensetninger og fremgangsmater for anvendelse derav
DK1490062T3 (da) Glukokortikoidmimetika, fremgangsmåder til fremstilling deraf, farmaceutiske sammensætninger og anvendelser deraf
DK1913001T3 (da) (r)-n-methylnaltrexon, fremgangsmåder til syntese og farmaceutisk anvendelse heraf
DK1862158T5 (da) Farmaceutisk sammensætning til behandling af depression og fremgangsmåde til fremstilling deraf
DK2617714T3 (da) Kemiske derivater af jasmonat, farmaceutiske præparater og fremgangsmåder til anvendelse deraf
DK1642897T3 (da) Alfa-krystalform af strontiumranelat, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
DK2107055T3 (da) Dosmetinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
NO20065279L (no) Sproytepose, emne for fremstilling av sproytepose, og fremgangsmate for fremstilling av sproytepose
DK1601363T3 (da) Anvendelse som lægemiddel af derivater af cholest-4-en-3-on, farmaceutiske sammensætninger indeholdende disse og nye derivater
DK1558612T3 (da) Imidazopyridinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
DK1707564T3 (da) Indanyl-piperazinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
DK1560826T3 (da) Pyridopyrimidinonderivater, fremgangsmåde til fremstiling heraf og farmaceutiske sammensætninger indeholdende disse
DK1655030T3 (da) Benzothiadiazinforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse
GB0608398D0 (en) Pharmaceutical composition and method of using same
DK2083007T3 (da) Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
IS8164A (is) Hringtengdar amínafleiður, aðferðir til að framleiða þær og lyfjablöndur sem innihalda þær
DK1783105T3 (da) Mørtelsammensætning, fremgangsmåde til fremstilling og anvendelse deraf
IS7424A (is) Oxasólídínónafleiður, aðferðir til að framleiða þær og lyfjablöndur sem innihalda þær
DK2067779T3 (da) Tiotropiumsalte, fremgangsmåde til deres fremstilling og lægemiddelformuleringer indeholdende disse
DK1957490T3 (da) Hidtil ukendte indolizinderivater, fremgangsmåde til fremstilling deraf og terapeutiske sammensætninger, der omfatter samme