DK1601363T3 - Anvendelse som lægemiddel af derivater af cholest-4-en-3-on, farmaceutiske sammensætninger indeholdende disse og nye derivater - Google Patents

Anvendelse som lægemiddel af derivater af cholest-4-en-3-on, farmaceutiske sammensætninger indeholdende disse og nye derivater

Info

Publication number
DK1601363T3
DK1601363T3 DK04717660.7T DK04717660T DK1601363T3 DK 1601363 T3 DK1601363 T3 DK 1601363T3 DK 04717660 T DK04717660 T DK 04717660T DK 1601363 T3 DK1601363 T3 DK 1601363T3
Authority
DK
Denmark
Prior art keywords
derivatives
cholest
drug
pharmaceutical compositions
compositions containing
Prior art date
Application number
DK04717660.7T
Other languages
English (en)
Inventor
Cyrille Drouot
Bruno Buisson
Thierry Bordet
Original Assignee
Trophos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0302992A external-priority patent/FR2852246B1/fr
Priority claimed from FR0311324A external-priority patent/FR2860159B1/fr
Application filed by Trophos filed Critical Trophos
Application granted granted Critical
Publication of DK1601363T3 publication Critical patent/DK1601363T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DK04717660.7T 2003-03-11 2004-03-05 Anvendelse som lægemiddel af derivater af cholest-4-en-3-on, farmaceutiske sammensætninger indeholdende disse og nye derivater DK1601363T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0302992A FR2852246B1 (fr) 2003-03-11 2003-03-11 Utilisation de l'oxime de cholest-4-en-3-one dans le traitement des affections du motoneurone
FR0311324A FR2860159B1 (fr) 2003-09-26 2003-09-26 Utilisation de l'oxime de cholest-4-en-3-one en tant que medicament neuroprotecteur
PCT/FR2004/000532 WO2004082581A2 (fr) 2003-03-11 2004-03-05 Application a titre de medicaments de derives de cholest-4-en-3- one, compositions pharmaceutiques les renfermant et nouveaux derives

Publications (1)

Publication Number Publication Date
DK1601363T3 true DK1601363T3 (da) 2012-09-03

Family

ID=33031360

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04717660.7T DK1601363T3 (da) 2003-03-11 2004-03-05 Anvendelse som lægemiddel af derivater af cholest-4-en-3-on, farmaceutiske sammensætninger indeholdende disse og nye derivater

Country Status (12)

Country Link
US (4) US7858603B2 (da)
EP (1) EP1601363B1 (da)
JP (1) JP4970932B2 (da)
AU (1) AU2004222540B2 (da)
BR (1) BRPI0408240A (da)
CA (1) CA2517893C (da)
DK (1) DK1601363T3 (da)
ES (1) ES2388669T3 (da)
IL (1) IL170348A (da)
PL (1) PL1601363T3 (da)
PT (1) PT1601363E (da)
WO (1) WO2004082581A2 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874923B1 (fr) * 2004-09-07 2006-10-27 Trophos Sa Application a titre de medicaments de derives du 3, 5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
FR2894968B1 (fr) * 2005-12-20 2008-02-22 Trophos Sa Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
FR2899108B1 (fr) * 2006-03-31 2012-02-03 Trophos Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur
FR2907783A1 (fr) * 2006-10-30 2008-05-02 Trophos Sa Nouveaux composes chimiques, leurs procedes de synthese et leur utilisation a titre de medicament, particulierement a titre de medicament cytoprotecteur, neuroprotecteur ou cardioprotecteur
FR2914188B1 (fr) * 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
AR061892A1 (es) * 2007-07-11 2008-10-01 Consejo Nac Invest Cient Tec Un compuesto que presenta actividad antiinflamatoria y actividad antiviral, composiciones farmaceuticas que lo comprenden, un procedimiento para su obtencion y uso del mismo en el tratamiento de la queratoconjuntivitis epidemica y de la queratitis estromal herpetica
FR2919180B1 (fr) * 2007-07-25 2009-11-27 Trophos Utilisation d'au moins un derive oxime de la cholest-4-en-3-one comme antioxydants
US20100310674A1 (en) * 2007-10-30 2010-12-09 Trophos Novel composition for treating the side effects of anticancer treatments
US9527881B2 (en) * 2008-02-26 2016-12-27 Emory University Steroid analogues for neuroprotection
FR2934596B1 (fr) * 2008-07-30 2015-04-10 Trophos Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
CN101619089B (zh) * 2009-07-28 2011-07-20 陈大刚 抗肿瘤药物cl168、其合成方法及应用
ES2742213T3 (es) 2010-04-09 2020-02-13 The Research Foundation Of The State Univ Of New York Inhibidores de SHIP y uso de los mismos
WO2012069150A2 (en) 2010-11-22 2012-05-31 Powerpore Gmbh Cytoprotectant agents for the prevention of drug-associated side-effects
FR2979239A1 (fr) 2011-08-25 2013-03-01 Trophos Liposome comprenant au moins un derive de cholesterol
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2015023593A1 (en) * 2013-08-12 2015-02-19 Emory University Progesterone phosphate analogs and uses related thereto
US10758548B2 (en) * 2015-05-20 2020-09-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for treating peripheral demyelinating diseases
EP3373972B1 (en) 2015-11-12 2024-03-20 F. Hoffmann-La Roche AG Compositions for treating spinal muscular atrophy
CN109152788A (zh) * 2016-06-03 2019-01-04 豪夫迈·罗氏有限公司 Sma的新型治疗
WO2018073141A1 (en) 2016-10-18 2018-04-26 F. Hoffmann-La Roche Ag New composition for treating sma
CN108938648A (zh) * 2018-06-21 2018-12-07 中山大学 胆甾-3,6-二酮用于神经元损伤的治疗

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52116456A (en) * 1976-03-25 1977-09-29 Takasago Corp Preparation of 3-keto- #4-steroid
DE4004920C1 (da) * 1990-02-16 1991-09-19 Kanoldt Arzneimittel Gmbh, 8884 Hoechstaedt, De
US5264428A (en) * 1990-02-16 1993-11-23 Kanoldt Arzneimittel Gmbh Use of stigmasta-4-en-3-one in the treatment of androgen dependent diseases
JPH0748397A (ja) * 1993-08-05 1995-02-21 Taisho Pharmaceut Co Ltd ステロイド化合物
ZA953976B (en) * 1994-05-19 1996-01-19 Akzo Nobel Nv 11,21-bisphenyl-19-norpregnane derivatives
JP2001031572A (ja) * 1999-07-22 2001-02-06 Kyorin Pharmaceut Co Ltd ジクチオステロールを有効成分とする中枢神経細胞突起再生薬
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
JP2002030096A (ja) * 2000-07-11 2002-01-29 Kyorin Pharmaceut Co Ltd 神経細胞突起再生剤及びその製造方法

Also Published As

Publication number Publication date
US8354395B2 (en) 2013-01-15
US20060217358A1 (en) 2006-09-28
BRPI0408240A (pt) 2006-03-01
AU2004222540B2 (en) 2009-10-01
US20120316141A1 (en) 2012-12-13
US20100216752A1 (en) 2010-08-26
WO2004082581A2 (fr) 2004-09-30
US20120309721A1 (en) 2012-12-06
JP2006519819A (ja) 2006-08-31
EP1601363B1 (fr) 2012-06-20
PT1601363E (pt) 2012-08-17
US8283341B2 (en) 2012-10-09
EP1601363A2 (fr) 2005-12-07
PL1601363T3 (pl) 2012-11-30
IL170348A (en) 2014-02-27
US7858603B2 (en) 2010-12-28
JP4970932B2 (ja) 2012-07-11
WO2004082581A3 (fr) 2004-10-28
CA2517893A1 (fr) 2004-09-30
US8575138B2 (en) 2013-11-05
AU2004222540A1 (en) 2004-09-30
ES2388669T3 (es) 2012-10-17
CA2517893C (fr) 2012-05-15

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