DK171758B1 - Implantat til styret frigørelse af et makromolekylært lægemiddel og fremgangsmåde til fremstiling af implantatet - Google Patents

Implantat til styret frigørelse af et makromolekylært lægemiddel og fremgangsmåde til fremstiling af implantatet Download PDF

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Publication number
DK171758B1
DK171758B1 DK243886A DK243886A DK171758B1 DK 171758 B1 DK171758 B1 DK 171758B1 DK 243886 A DK243886 A DK 243886A DK 243886 A DK243886 A DK 243886A DK 171758 B1 DK171758 B1 DK 171758B1
Authority
DK
Denmark
Prior art keywords
coating
drug
water
polymer
implant
Prior art date
Application number
DK243886A
Other languages
Danish (da)
English (en)
Other versions
DK243886D0 (da
DK243886A (da
Inventor
Mohamad D Shalati
Kallidaikuric Sivaramakrishnan
Original Assignee
Int Minerals & Chem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Minerals & Chem Corp filed Critical Int Minerals & Chem Corp
Publication of DK243886D0 publication Critical patent/DK243886D0/da
Publication of DK243886A publication Critical patent/DK243886A/da
Application granted granted Critical
Publication of DK171758B1 publication Critical patent/DK171758B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/07—Microporous membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Graft Or Block Polymers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK243886A 1985-05-24 1986-05-23 Implantat til styret frigørelse af et makromolekylært lægemiddel og fremgangsmåde til fremstiling af implantatet DK171758B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73762985 1985-05-24
US06/737,629 US4666704A (en) 1985-05-24 1985-05-24 Controlled release delivery system for macromolecules

Publications (3)

Publication Number Publication Date
DK243886D0 DK243886D0 (da) 1986-05-23
DK243886A DK243886A (da) 1986-11-25
DK171758B1 true DK171758B1 (da) 1997-05-12

Family

ID=24964638

Family Applications (1)

Application Number Title Priority Date Filing Date
DK243886A DK171758B1 (da) 1985-05-24 1986-05-23 Implantat til styret frigørelse af et makromolekylært lægemiddel og fremgangsmåde til fremstiling af implantatet

Country Status (15)

Country Link
US (1) US4666704A (es)
EP (1) EP0204476B1 (es)
JP (1) JP2755298B2 (es)
KR (1) KR940000001B1 (es)
CN (1) CN1020851C (es)
AT (1) ATE78155T1 (es)
AU (1) AU590565B2 (es)
CA (1) CA1277237C (es)
DE (1) DE3685992T2 (es)
DK (1) DK171758B1 (es)
ES (1) ES8707666A1 (es)
IE (1) IE59684B1 (es)
IL (1) IL78895A (es)
PT (1) PT82635B (es)
ZA (1) ZA863867B (es)

Families Citing this family (52)

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US4786501A (en) * 1985-07-15 1988-11-22 International Minerals & Chemical Corp. Cylindrical implants for the controlled release of growth hormones
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
EP0270575A4 (en) * 1986-05-16 1988-10-20 Victoria State BIO-COMPATIBLE IMPLANTS.
US5342622A (en) * 1986-05-16 1994-08-30 The State Of Victoria Subdermal biocompatible implants
AU601443B2 (en) * 1986-05-16 1990-09-13 Monash Medical Centre Biocompatible implants
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US4863736A (en) 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5073381A (en) * 1988-08-15 1991-12-17 University Of Akron Amphiphilic networks
SE8803822D0 (sv) * 1988-10-26 1988-10-26 Novel dosage form
US5030452A (en) * 1989-01-12 1991-07-09 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
US5108756A (en) * 1989-01-12 1992-04-28 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
US5141748A (en) * 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
ATE90203T1 (de) * 1989-03-17 1993-06-15 Pitman Moore Inc Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
CH679207A5 (es) * 1989-07-28 1992-01-15 Debiopharm Sa
US5225205A (en) * 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
DK0474098T3 (da) * 1990-08-30 1994-05-02 Senju Pharma Co Middel til kontrolleret lægemiddelfrigivelse
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
GB2306325B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US20060025726A1 (en) * 1996-06-04 2006-02-02 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with pharmacologically active layer
US20060030826A1 (en) * 1996-06-04 2006-02-09 Vance Products Incorporated,d/b/a Cook Urological Incorporated Implantable medical device with anti-neoplastic drug
US20060052757A1 (en) * 1996-06-04 2006-03-09 Vance Products Incorporated, D/B/A Cook Urological Incorporated Implantable medical device with analgesic or anesthetic
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
KR20000022894A (ko) * 1998-09-05 2000-04-25 이승진 생분해성 고분자 미립자형 제제 및 그 제조방법
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6730349B2 (en) * 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
AU2000255261A1 (en) * 2000-05-26 2001-12-11 C.T.P. Cable Technology Procurement Ag Means for maintenance and/or correction of glucose concentration in blood
EP1408876A4 (en) * 2001-06-22 2004-09-22 Durect Corp ZERO ORDER COAXIAL IMPLANTS WITH EXTENDED RELEASE
JP4727987B2 (ja) 2002-07-12 2011-07-20 クック インコーポレイテッド コーティングされた医療装置
US8750983B2 (en) 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
CA2586846C (en) * 2004-11-10 2013-12-31 Qlt Usa Inc. A stabilized polymeric delivery system
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
MX2008012683A (es) * 2006-04-06 2009-01-07 Nupathe Inc Implantes para el tratamiento de estados asociados con dopamina.
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CN110022794A (zh) * 2016-10-05 2019-07-16 泰坦医药品公司 具有减少的突释的用于药物递送的可植入装置
EP3691618A1 (en) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
BR112020023983A2 (pt) 2018-05-24 2021-02-23 Celanese Eva Performance Polymers Llc dispositivo implantável para liberação prolongada de um composto de fármaco macromolecular
WO2019226519A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound

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US2987445A (en) * 1958-10-10 1961-06-06 Rohm & Haas Drug composition
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
DE2010416B2 (de) * 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
AR206692A1 (es) * 1972-12-27 1976-08-13 Alza Corp Agente dispensador de liberacion sostenida de substancias activas
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4127127A (en) * 1977-05-23 1978-11-28 Alza Corporation Therapeutic systems made from certain segmented copolyesters
US4148871A (en) * 1977-10-11 1979-04-10 Pitt Colin G Sustained subdermal delivery ofdrugs using poly(ε-caprolactone) and its copolymers
IN152178B (es) * 1978-05-08 1983-11-05 Pfizer
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
EP0013131A3 (en) * 1978-12-27 1981-01-07 Mundipharma A.G. Pharmaceutical composition in solid dosage form, and process for its production
JPS593963B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
JPS593962B2 (ja) * 1980-06-24 1984-01-27 日東電工株式会社 徐放性酵素製剤
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same

Also Published As

Publication number Publication date
CN1020851C (zh) 1993-05-26
CA1277237C (en) 1990-12-04
PT82635B (pt) 1988-07-29
DE3685992T2 (de) 1992-12-24
IE861370L (en) 1986-11-24
DE3685992D1 (de) 1992-08-20
AU590565B2 (en) 1989-11-09
IL78895A (en) 1991-01-31
IL78895A0 (en) 1986-09-30
AU5767286A (en) 1986-11-27
PT82635A (en) 1986-06-01
CN86104226A (zh) 1987-02-25
KR940000001B1 (ko) 1994-01-05
JPS61277629A (ja) 1986-12-08
EP0204476B1 (en) 1992-07-15
ATE78155T1 (de) 1992-08-15
ES555277A0 (es) 1987-08-16
EP0204476A1 (en) 1986-12-10
US4666704A (en) 1987-05-19
JP2755298B2 (ja) 1998-05-20
ZA863867B (en) 1987-01-28
IE59684B1 (en) 1994-03-23
DK243886D0 (da) 1986-05-23
KR860008776A (ko) 1986-12-18
DK243886A (da) 1986-11-25
ES8707666A1 (es) 1987-08-16

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed