DK171534B1 - Fremgangsmåde til fremstilling af bakteriecelleaggregater - Google Patents
Fremgangsmåde til fremstilling af bakteriecelleaggregater Download PDFInfo
- Publication number
- DK171534B1 DK171534B1 DK140883A DK140883A DK171534B1 DK 171534 B1 DK171534 B1 DK 171534B1 DK 140883 A DK140883 A DK 140883A DK 140883 A DK140883 A DK 140883A DK 171534 B1 DK171534 B1 DK 171534B1
- Authority
- DK
- Denmark
- Prior art keywords
- polyamine
- filter cake
- particles
- enzyme
- sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 43
- 230000001580 bacterial effect Effects 0.000 title claims description 31
- 102000004190 Enzymes Human genes 0.000 claims description 56
- 108090000790 Enzymes Proteins 0.000 claims description 56
- 239000002245 particle Substances 0.000 claims description 47
- 239000012065 filter cake Substances 0.000 claims description 40
- 239000010419 fine particle Substances 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 25
- 229920000768 polyamine Polymers 0.000 claims description 25
- 239000011230 binding agent Substances 0.000 claims description 21
- 108700040099 Xylose isomerases Proteins 0.000 claims description 20
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- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 8
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- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 5
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
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- 235000010418 carrageenan Nutrition 0.000 claims description 2
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- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- 230000000379 polymerizing effect Effects 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- 241000894007 species Species 0.000 claims 2
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- 238000005563 spheronization Methods 0.000 description 33
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 17
- 229960002737 fructose Drugs 0.000 description 17
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- 229920001285 xanthan gum Polymers 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 2
- 125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 description 2
- KUGRPPRAQNPSQD-UHFFFAOYSA-N OOOOO Chemical compound OOOOO KUGRPPRAQNPSQD-UHFFFAOYSA-N 0.000 description 2
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
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- XDIYNQZUNSSENW-UUBOPVPUSA-N (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O XDIYNQZUNSSENW-UUBOPVPUSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229920002972 Acrylic fiber Polymers 0.000 description 1
- 241000187844 Actinoplanes Species 0.000 description 1
- 241000193749 Bacillus coagulans Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 241001442654 Percnon planissimum Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 241000187759 Streptomyces albus Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000002519 antifouling agent Substances 0.000 description 1
- 229940054340 bacillus coagulans Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
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- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
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- 244000144992 flock Species 0.000 description 1
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- 238000006317 isomerization reaction Methods 0.000 description 1
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- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
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- 230000035484 reaction time Effects 0.000 description 1
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- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
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- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 239000004753 textile Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36261882A | 1982-03-29 | 1982-03-29 | |
US36261882 | 1982-03-29 | ||
US06/467,851 US4543332A (en) | 1982-03-29 | 1983-02-24 | Method for the preparation of spherical microorganism cell aggregates |
US46785183 | 1983-02-24 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK140883D0 DK140883D0 (da) | 1983-03-28 |
DK140883A DK140883A (da) | 1983-09-30 |
DK171534B1 true DK171534B1 (da) | 1996-12-23 |
Family
ID=27001740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK140883A DK171534B1 (da) | 1982-03-29 | 1983-03-28 | Fremgangsmåde til fremstilling af bakteriecelleaggregater |
Country Status (4)
Country | Link |
---|---|
US (1) | US4543332A (de) |
EP (1) | EP0090276B1 (de) |
DE (1) | DE3367253D1 (de) |
DK (1) | DK171534B1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4760024A (en) * | 1983-08-10 | 1988-07-26 | Miles Inc. | Immobilization of enzymes |
CA1215922A (en) * | 1984-05-25 | 1986-12-30 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4757008A (en) * | 1986-02-24 | 1988-07-12 | Miles Inc. | Enzyme immobilization in a macroporous non-ionic resin |
CU22292A1 (es) * | 1991-05-07 | 1995-01-31 | Cigb | Procedimiento para la obtencion a escala industrial de licores de fructosa-glucosa a partir de sacarosa e instalacion para el mismo |
CA2214088A1 (en) * | 1995-03-03 | 1996-09-12 | Metabolex Inc. | Novel encapsulation process by a gelling polymer |
US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
US6066325A (en) * | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US7435425B2 (en) | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US7871637B2 (en) * | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
US6465227B1 (en) * | 1997-09-09 | 2002-10-15 | Biochemie Gesellschaft M.B.H. | Spherical particles containing microorganism cells having enzyme activity |
DE60212464T2 (de) * | 2002-04-29 | 2007-01-11 | EGIS Gyógyszergyár Rt. | Herstellung von tabletten von pharmazeutisch aktiven substanzen mit ungünstigen tablettierungseigenschaften mit einer mikrokristalline zellulose enthaltenden granulierflüssigkeit |
GB0212825D0 (en) * | 2002-05-31 | 2002-07-10 | Dna Res Innovations Ltd | Methods compositions and kits for cell separation |
WO2004050823A1 (en) * | 2002-12-02 | 2004-06-17 | Council Of Scientific And Industrial Research | Porous vessel bioreactor |
US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
MX2008014847A (es) * | 2006-05-31 | 2009-04-30 | Baxter Int | Metodo para crecimiento interno en la celula dirigido y regeneracion controlada de los tejidos en la cirugia espinal. |
TWI436793B (zh) * | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
CN101842122B (zh) | 2007-10-30 | 2013-12-25 | 巴克斯特国际公司 | 再生性生物功能胶原生物基质用于治疗内脏或腔壁缺损的应用 |
JP5569398B2 (ja) | 2008-02-29 | 2014-08-13 | フェッローサン メディカル ディバイス エー/エス | 止血および/または創傷治癒を促進するための装置 |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
PT2442835E (pt) * | 2009-06-16 | 2015-03-23 | Baxter Healthcare Sa | Esponja hemostática |
KR101811070B1 (ko) | 2009-12-16 | 2017-12-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 스폰지 |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
KR101957625B1 (ko) | 2010-06-01 | 2019-03-12 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
EP2575776B1 (de) | 2010-06-01 | 2018-05-30 | Baxter International Inc | Verfahren zur herstellung trockener und stabiler hämostatischer zusammensetzungen |
US9084728B2 (en) | 2010-06-01 | 2015-07-21 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
JP6195569B2 (ja) | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 止血組成物 |
CA2851338C (en) | 2011-10-11 | 2019-11-05 | Baxter International Inc. | Hemostatic compositions |
DK2771027T3 (en) | 2011-10-27 | 2015-11-02 | Baxter Int | hemostatic compositions |
CA2865349C (en) | 2012-03-06 | 2021-07-06 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
CA2874290C (en) | 2012-06-12 | 2020-02-25 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
CN105358071B (zh) | 2013-06-21 | 2018-07-31 | 弗罗桑医疗设备公司 | 真空膨胀的干组合物和用于保留该干组合物的注射器 |
CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
WO2016058612A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
EP3237041B1 (de) | 2014-12-24 | 2020-01-29 | Ferrosan Medical Devices A/S | Spritze für die enthaltung und die mischung erster und zweiter substanzen |
BR112017027695A2 (pt) | 2015-07-03 | 2018-09-04 | Ferrosan Medical Devices As | seringa para retenção e mistura de primeira e segunda substâncias |
MX2020011866A (es) | 2018-05-09 | 2021-01-20 | Ferrosan Medical Devices As | Metodo para preparar una composicion hemostatica. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1362365A (en) * | 1970-07-28 | 1974-08-07 | Novo Terapeutisk Labor As | Production of enzyme preparations |
US4212943A (en) * | 1978-03-27 | 1980-07-15 | Miles Laboratories, Inc. | Production of bacterial cell aggregate |
US4251632A (en) * | 1978-09-11 | 1981-02-17 | Miles Laboratories, Inc. | Preparation of a bacterial cell aggregate |
-
1983
- 1983-02-24 US US06/467,851 patent/US4543332A/en not_active Expired - Lifetime
- 1983-03-17 DE DE8383102649T patent/DE3367253D1/de not_active Expired
- 1983-03-17 EP EP83102649A patent/EP0090276B1/de not_active Expired
- 1983-03-28 DK DK140883A patent/DK171534B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0090276B1 (de) | 1986-10-29 |
DK140883A (da) | 1983-09-30 |
EP0090276A2 (de) | 1983-10-05 |
DK140883D0 (da) | 1983-03-28 |
EP0090276A3 (en) | 1984-08-22 |
DE3367253D1 (en) | 1986-12-04 |
US4543332A (en) | 1985-09-24 |
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