DK171526B1 - Anvendelse af ferromagnetiske partikler til fremstilling af et partikkelformigt diagnostisk kontrastmiddel til NMR-billeddannelse - Google Patents

Anvendelse af ferromagnetiske partikler til fremstilling af et partikkelformigt diagnostisk kontrastmiddel til NMR-billeddannelse Download PDF

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Publication number
DK171526B1
DK171526B1 DK528385A DK528385A DK171526B1 DK 171526 B1 DK171526 B1 DK 171526B1 DK 528385 A DK528385 A DK 528385A DK 528385 A DK528385 A DK 528385A DK 171526 B1 DK171526 B1 DK 171526B1
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Prior art keywords
particles
ferromagnetic
use according
ferromagnetic particles
contrast agent
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DK528385A
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Danish (da)
English (en)
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DK528385A (da
DK528385D0 (da
Inventor
Trond Jacobsen
Jo Klaveness
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Nyegaard & Co As
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Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of DK528385A publication Critical patent/DK528385A/da
Publication of DK528385D0 publication Critical patent/DK528385D0/da
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Soft Magnetic Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hard Magnetic Materials (AREA)
  • Compounds Of Iron (AREA)
DK528385A 1984-03-29 1985-11-15 Anvendelse af ferromagnetiske partikler til fremstilling af et partikkelformigt diagnostisk kontrastmiddel til NMR-billeddannelse DK171526B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848408127A GB8408127D0 (en) 1984-03-29 1984-03-29 Contrast agents
GB8408127 1984-03-29
PCT/NO1985/000017 WO1985004330A1 (en) 1984-03-29 1985-03-28 Use of ferromagnetic particles in contrast agents for nmr imaging and contrast agents
NO8500017 1985-03-28

Publications (3)

Publication Number Publication Date
DK528385A DK528385A (da) 1985-11-15
DK528385D0 DK528385D0 (da) 1985-11-15
DK171526B1 true DK171526B1 (da) 1996-12-23

Family

ID=10558866

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528385A DK171526B1 (da) 1984-03-29 1985-11-15 Anvendelse af ferromagnetiske partikler til fremstilling af et partikkelformigt diagnostisk kontrastmiddel til NMR-billeddannelse

Country Status (13)

Country Link
US (1) US4863715A (nl)
EP (1) EP0177545B2 (nl)
JP (1) JPH066538B2 (nl)
AT (1) ATE61001T1 (nl)
AU (1) AU568740B2 (nl)
DE (1) DE3581871D1 (nl)
DK (1) DK171526B1 (nl)
FI (1) FI85442C (nl)
GB (1) GB8408127D0 (nl)
HK (1) HK18094A (nl)
NL (1) NL960016I2 (nl)
NO (2) NO173429C (nl)
WO (1) WO1985004330A1 (nl)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US5720939A (en) * 1985-08-15 1998-02-24 Nycomed Imaging As Method of contrast enhanced magnetic resonance imaging using magnetically responsive-particles
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
PT81498B (pt) * 1984-11-23 1987-12-30 Schering Ag Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas
US5186922A (en) * 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
DE3700911C2 (de) * 1986-01-17 2001-05-17 West Pharm Serv Drug Res Ltd System zur Zuführung eines Arzneimittels oder eines Diagnostikums
US5055288A (en) * 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US5160726A (en) * 1990-02-15 1992-11-03 Advanced Magnetics Inc. Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US4827945A (en) * 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US5248492A (en) * 1986-07-03 1993-09-28 Advanced Magnetics, Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US5102652A (en) * 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5342607A (en) * 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5314679A (en) * 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
FR2612400A1 (fr) * 1987-03-16 1988-09-23 Centre Nat Rech Scient Microcapsules contenant un marqueur radioactif et/ou paramagnetique sous forme de chelate, et leur utilisation dans le domaine de l'imagerie medicale
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
US5154179A (en) * 1987-07-02 1992-10-13 Medical Magnetics, Inc. Device construction and method facilitating magnetic resonance imaging of foreign objects in a body
DE3723310A1 (de) * 1987-07-15 1989-01-26 John Urquhart Pharmazeutisches praeparat und verfahren zu seiner herstellung
GB8808305D0 (en) * 1988-04-08 1988-05-11 Nycomed As Compositions
JPH076765B2 (ja) * 1988-06-23 1995-01-30 株式会社日立メディコ 非破壊断面形状検査装置
GB8817137D0 (en) * 1988-07-19 1988-08-24 Nycomed As Compositions
WO1990001295A1 (en) 1988-08-04 1990-02-22 Advanced Magnetics, Incorporated Receptor mediated endocytosis type mri contrast agents
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8916780D0 (en) 1989-07-21 1989-09-06 Nycomed As Compositions
US5393525A (en) * 1989-07-21 1995-02-28 Nycomed Imaging As Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration
GB8916782D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
DE69118367T2 (de) 1990-02-15 1996-08-08 Advanced Magnetics Inc FILTERSTERILISATION ZUR HERSTELLUNG VON KOLLOIDALEN SUPERPARAMAGNETISCHEN MR-KONTRASTMITTELN und ihre Verwendung
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
US5358702A (en) * 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
JPH05506227A (ja) * 1990-04-10 1993-09-16 イマルクス　ファーマシューティカル　コーポレーション 磁気共鳴画像用造影剤としてのポリマー
US5948384A (en) * 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
GB9120508D0 (en) * 1991-09-26 1991-11-06 Nycomed As Diagnostic agents
CA2121681A1 (en) * 1991-11-19 1993-05-27 Evan C. Unger Gel particle contrast media for improved diagnostic imaging
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
DE69207589T2 (de) * 1992-06-01 1996-05-23 Basf Ag Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln
ES2130406T5 (es) * 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
US5323780A (en) * 1992-08-07 1994-06-28 University Of Florida Research Foundation, Inc. Artifact-free imaging contrast agent
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
JPH08508721A (ja) * 1993-03-17 1996-09-17 シリカゲル ゲス．エム．ビー．エイチ 超常磁性粒子、その製法及びその用途
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US5728079A (en) * 1994-09-19 1998-03-17 Cordis Corporation Catheter which is visible under MRI
NL9401518A (nl) * 1994-09-19 1996-05-01 Cordis Europ MR-zichtbare catheter met in uitgehard materiaal opgenomen deeltjesvormig magnetiseerbaar materiaal.
DE19516323C2 (de) * 1995-04-27 1997-02-27 Dirk Dipl Chem Guenther Verfahren zur Herstellung von magnetisierbaren Dispersionen und deren Verwendung
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
ATE291439T1 (de) 1996-01-10 2005-04-15 Amersham Health As Kontrastmittel
US5855868A (en) * 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
CA2262685C (en) * 1996-08-05 2008-09-23 Schering Aktiengesellschaft Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device
WO1999012578A1 (en) * 1997-09-10 1999-03-18 Yale University Radiation dosimetry with magnetic resonance detectable compounds
WO1999052564A1 (en) * 1998-04-09 1999-10-21 Nycomed Imaging A.S Method
EP1078263B1 (en) 1998-05-11 2009-07-22 Miltenyi Biotec GmbH Method of direct selection of antigen-specific t cells
US6315709B1 (en) * 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
US6296604B1 (en) * 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6355225B1 (en) 1999-10-05 2002-03-12 Wm. Marsh Rice University Tda Research, Inc. Fullerene contrast agent for magnetic resonance imaging and spectroscopy
NO20004795D0 (no) * 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
US20020177769A1 (en) * 2001-04-23 2002-11-28 The Regents Of The University Of California Method and apparatus for locating cells in the body by measuring magnetic moments
US7018849B2 (en) * 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
US20040225213A1 (en) 2002-01-22 2004-11-11 Xingwu Wang Magnetic resonance imaging coated assembly
US7162302B2 (en) 2002-03-04 2007-01-09 Nanoset Llc Magnetically shielded assembly
GB0215185D0 (en) 2002-07-01 2002-08-07 Genovision As Binding a target substance
WO2004004786A1 (en) * 2002-07-02 2004-01-15 Universitair Medisch Centrum Utrecht Scanning suspension comprising a particle with a diameter of at least 1 micrometer
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US7803352B2 (en) * 2003-03-07 2010-09-28 John Steele Fisher Method for continuous visualization of a blood clot or plaque in body lumen
US20040175329A1 (en) * 2003-03-07 2004-09-09 Fisher John Steele Method for continuous visualization of a body lumen
US7962194B2 (en) * 2003-04-15 2011-06-14 Polyvalor, Limited Partnership Method and system for propelling and controlling displacement of a microrobot in a blood vessel
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
EP1557151A1 (en) * 2004-01-22 2005-07-27 F. Hoffmann-La Roche Ag Solid dosage form
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
JP4322781B2 (ja) * 2004-11-08 2009-09-02 富士フイルム株式会社 撮像装置
US8669236B2 (en) 2005-05-12 2014-03-11 The General Hospital Corporation Biotinylated compositions
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization
US9149545B2 (en) * 2005-11-02 2015-10-06 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same
US20070098641A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
TW200738752A (en) 2006-01-31 2007-10-16 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
WO2008016431A2 (en) 2006-07-29 2008-02-07 Robert Lamar Bjork Bi-specific monoclonal antibody (specific for both cd3 and cd11b) therapeutic drug
EP3124497B1 (en) 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2277181B1 (en) * 2008-04-16 2017-08-30 StemCell Technologies Inc. Magnetic particles
GB0820309D0 (en) * 2008-11-06 2008-12-17 Middlesex University Higher Ed Detection of cancer
EP2390661B1 (en) 2010-05-02 2015-06-24 Miltenyi Biotec GmbH An anchoring/capturing means for selecting or analyzing a CHO cell according to a product secreted by the CHO cell
AU2013308519A1 (en) 2012-08-31 2015-04-09 The General Hospital Corporation Biotin complexes for treatment and diagnosis of Alzheimer's disease
SG11201507287SA (en) 2013-03-15 2015-10-29 Univ California Peptides having reduced toxicity that stimulate cholesterol efflux
EP2955521A1 (en) 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Methods for separating cells
EP3412303A1 (en) 2017-06-08 2018-12-12 Medizinische Universität Innsbruck Improved pharmacokinetics and cholecystokinin-2 receptor (cck2r) targeting for diagnosis and therapy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592185A (en) * 1967-04-18 1971-07-13 Yeda Res & Dev Ferromagnetic contrast media and method of use
GB1339537A (en) * 1969-12-03 1973-12-05 Yeda Res & Dev Diagnostic and/or therapeutic compositions
SE431214B (sv) * 1977-06-02 1984-01-23 Klaus H Mosbach Sett att framstella magnetiska polymerpartiklar som berare av en foretredesvis biologiskt aktiv substans
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4501726A (en) * 1981-11-12 1985-02-26 Schroeder Ulf Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
SE8201972L (sv) * 1982-03-29 1983-09-30 Gambro Lundia Ab Magnetiskt paverkbara kristalliserade kolhydrat sferer eller partiklar att anvendas tillsammans med bioadsorberande material
NO155316C (no) * 1982-04-23 1987-03-11 Sintef Fremgangsmaate for fremstilling av magnetiske polymerpartikler.
DE3219832A1 (de) * 1982-05-26 1983-12-01 Bruker Medizintechnik Gmbh, 7512 Rheinstetten Verfahren zur nicht-invasiven ermittlung von messwerten innerhalb eines lebenden koerpers
CA1244082A (en) * 1983-01-10 1988-11-01 Robert T. Gordon Method for enhancing nmr imaging; and diagnostic use
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
SE463651B (sv) † 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents

Also Published As

Publication number Publication date
NL960016I2 (nl) 1996-12-02
WO1985004330A1 (en) 1985-10-10
NO1994016I1 (no) 1994-09-05
NO854765L (no) 1985-11-28
NL960016I1 (nl) 1996-10-01
FI85442C (fi) 1992-04-27
FI854488A (fi) 1985-11-14
JPH066538B2 (ja) 1994-01-26
DK528385A (da) 1985-11-15
HK18094A (en) 1994-03-11
NO173429B (no) 1993-09-06
EP0177545B2 (en) 2002-10-23
ATE61001T1 (de) 1991-03-15
FI854488A0 (fi) 1985-11-14
JPS61501633A (ja) 1986-08-07
US4863715A (en) 1989-09-05
NO173429C (no) 1993-12-22
DE3581871D1 (de) 1991-04-04
DK528385D0 (da) 1985-11-15
AU568740B2 (en) 1988-01-07
EP0177545A1 (en) 1986-04-16
AU4215185A (en) 1985-11-01
EP0177545B1 (en) 1991-02-27
GB8408127D0 (en) 1984-05-10
FI85442B (fi) 1992-01-15

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