DK170283B1 - Ascorbat-2-polyphosphatforbindelser og fremgangsmåde til deres fremstilling - Google Patents
Ascorbat-2-polyphosphatforbindelser og fremgangsmåde til deres fremstilling Download PDFInfo
- Publication number
- DK170283B1 DK170283B1 DK092987A DK92987A DK170283B1 DK 170283 B1 DK170283 B1 DK 170283B1 DK 092987 A DK092987 A DK 092987A DK 92987 A DK92987 A DK 92987A DK 170283 B1 DK170283 B1 DK 170283B1
- Authority
- DK
- Denmark
- Prior art keywords
- ascorbate
- ascorbic acid
- reaction
- astp
- reaction mixture
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 18
- 238000000034 method Methods 0.000 title claims description 16
- 229920000388 Polyphosphate Polymers 0.000 title claims description 13
- 239000001205 polyphosphate Substances 0.000 title claims description 13
- 235000011176 polyphosphates Nutrition 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 37
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 10
- 239000001226 triphosphate Substances 0.000 claims description 10
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical class OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 claims description 9
- 239000002585 base Substances 0.000 claims description 9
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
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- 239000007864 aqueous solution Substances 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims description 2
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- SUZJDLRVEPUNJG-UHFFFAOYSA-K tripotassium 2,4,6-trioxido-1,3,5,2lambda5,4lambda5,6lambda5-trioxatriphosphinane 2,4,6-trioxide Chemical compound [K+].[K+].[K+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 SUZJDLRVEPUNJG-UHFFFAOYSA-K 0.000 claims description 2
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- AZSFNUJOCKMOGB-UHFFFAOYSA-K cyclotriphosphate(3-) Chemical compound [O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-K 0.000 description 4
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- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- ZSBGSQHBWLTTMB-NLBXRHDGSA-N pentaazanium [[[(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl]oxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate Chemical compound P([O-])(=O)(OP(=O)([O-])OP(=O)([O-])[O-])OC=1C(=O)O[C@@H](C1[O-])[C@@H](O)CO.[NH4+].[NH4+].[NH4+].[NH4+].[NH4+] ZSBGSQHBWLTTMB-NLBXRHDGSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- CKRORYDHXIRZCH-UHFFFAOYSA-N phosphoric acid;dihydrate Chemical compound O.O.OP(O)(O)=O CKRORYDHXIRZCH-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- PBSRSWFGYPZDAU-FFIPNUABSA-H trimagnesium;[(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2h-furan-4-yl] phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] PBSRSWFGYPZDAU-FFIPNUABSA-H 0.000 description 1
- AIJAJGQAPNYWOW-UHFFFAOYSA-N tris(3-nitrophenyl) phosphate Chemical compound [O-][N+](=O)C1=CC=CC(OP(=O)(OC=2C=C(C=CC=2)[N+]([O-])=O)OC=2C=C(C=CC=2)[N+]([O-])=O)=C1 AIJAJGQAPNYWOW-UHFFFAOYSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/749,081 US4647672A (en) | 1985-06-25 | 1985-06-25 | Ascorbate 2-polyphosphate esters and method of making same |
| US74908185 | 1985-06-25 | ||
| PCT/US1986/001299 WO1987000172A1 (fr) | 1985-06-25 | 1986-06-18 | Esters de 2-polyphosphate d'ascorbate et procede de production |
| US8601299 | 1986-06-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK92987A DK92987A (da) | 1987-02-24 |
| DK92987D0 DK92987D0 (da) | 1987-02-24 |
| DK170283B1 true DK170283B1 (da) | 1995-07-24 |
Family
ID=25012170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK092987A DK170283B1 (da) | 1985-06-25 | 1987-02-24 | Ascorbat-2-polyphosphatforbindelser og fremgangsmåde til deres fremstilling |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4647672A (fr) |
| EP (1) | EP0229154B1 (fr) |
| JP (1) | JPS63500240A (fr) |
| CA (1) | CA1246593A (fr) |
| DE (1) | DE3676671D1 (fr) |
| DK (1) | DK170283B1 (fr) |
| ES (1) | ES8707220A1 (fr) |
| FI (1) | FI82835C (fr) |
| IN (1) | IN163317B (fr) |
| IS (1) | IS1304B6 (fr) |
| PH (1) | PH22988A (fr) |
| SG (1) | SG56193G (fr) |
| WO (1) | WO1987000172A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4814192A (en) * | 1987-11-18 | 1989-03-21 | The United States Of America As Represented By The Secretary Of Agriculture | Process for preserving raw fruits and vegetables using ascorbic acid esters |
| US4975293A (en) * | 1988-01-11 | 1990-12-04 | The United States Of America As Represented By The Secretary Of Agriculture | Process for preserving raw fruit and vegetable juices using cyclodextrins and compositions thereof |
| JP2747001B2 (ja) * | 1989-04-18 | 1998-05-06 | 昭和電工株式会社 | Ｌ―アスコルビン酸―２―リン酸エステル類の製造法 |
| UA19385A1 (uk) * | 1989-04-27 | 1997-12-25 | Сендзю Фармасьютікал Ко. Лтд. | Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів |
| US5118817A (en) * | 1989-10-31 | 1992-06-02 | Takeda Chemical Industries, Ltd. | Process for production of 2-phosphated esters of ascorbic acid |
| US5149829A (en) * | 1991-01-14 | 1992-09-22 | Hoffmann-La Roche Inc. | Method of preparing dry, concentrated salts of ascorbate 2-polyphosphate |
| DE59206973D1 (de) * | 1991-04-10 | 1996-10-02 | Hoffmann La Roche | Trocknungsverfahren zur Herstellung von Ascorbinsäure-2-Monophosphaten |
| US5110950A (en) * | 1991-06-12 | 1992-05-05 | Kansas State University Research Foundation | Method of preparing 2-phosphorylated compounds of ascorbic acid |
| WO1994000595A1 (fr) * | 1992-06-25 | 1994-01-06 | Diversey Corporation | Analyse de phosphate |
| CN1208041A (zh) * | 1995-11-28 | 1999-02-17 | 北京市潮白河新技术研究所 | 抗坏血酸衍生物 |
| US5937790A (en) * | 1996-12-18 | 1999-08-17 | Showa Denko Kabushiki Kaisha | Anti-stress agent for animals and a method of reducing stress in animals |
| CA2230774C (fr) * | 1997-03-18 | 2007-06-26 | F. Hoffmann-La Roche Ag | Fabrication de monophosphates d'ascorbyle |
| DE19831056A1 (de) * | 1998-07-13 | 2000-01-20 | Basf Ag | Verfahren zur Herstellung von Salzen von Ascorbyl-2-phosphorsäureestern |
| ES2186607T3 (es) | 1999-06-07 | 2003-05-16 | Hoffmann La Roche | Procedimiento de purificacion de l-ascorbilo 2-monofosfato. |
| US7704515B2 (en) * | 2002-04-02 | 2010-04-27 | Ganado Research, L.L.C. | Composition and method to improve quality and yield of meat products |
| WO2005020704A1 (fr) * | 2003-09-02 | 2005-03-10 | Dsm Ip Assets B.V. | Procede pour stabiliser l'ascorbyl phosphate et ses sels |
| US8275866B2 (en) * | 2007-11-13 | 2012-09-25 | At&T Intellectual Property I, L.P. | Assigning telecommunications nodes to community of interest clusters |
| EP2948003B1 (fr) | 2013-01-23 | 2020-03-18 | Bottled Science Limited | Composition de boisson améliorant la peau |
| CN103396442B (zh) * | 2013-08-21 | 2015-09-09 | 安徽天寅生物技术有限公司 | 水溶性维生素c偏磷酸钠钙及其制备方法 |
| CN103554070A (zh) * | 2013-11-08 | 2014-02-05 | 李玉成 | 抗坏血酸氧铋、其制备方法及应用 |
| US20170202210A1 (en) * | 2014-05-30 | 2017-07-20 | Sbi Pharmaceuticals Co., Ltd. | Organ preservation solution |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179445A (en) * | 1976-05-06 | 1979-12-18 | Kansas State University Research Foundation | Method of preparation of 2-phosphate esters of ascorbic acid |
-
1985
- 1985-06-25 US US06/749,081 patent/US4647672A/en not_active Expired - Lifetime
-
1986
- 1986-06-11 IS IS3109A patent/IS1304B6/is unknown
- 1986-06-11 IN IN449/MAS/86A patent/IN163317B/en unknown
- 1986-06-12 CA CA000511388A patent/CA1246593A/fr not_active Expired
- 1986-06-18 JP JP61503565A patent/JPS63500240A/ja active Granted
- 1986-06-18 DE DE8686904521T patent/DE3676671D1/de not_active Expired - Lifetime
- 1986-06-18 EP EP86904521A patent/EP0229154B1/fr not_active Expired - Lifetime
- 1986-06-18 WO PCT/US1986/001299 patent/WO1987000172A1/fr active IP Right Grant
- 1986-06-24 PH PH33940A patent/PH22988A/en unknown
- 1986-06-24 ES ES556503A patent/ES8707220A1/es not_active Expired
-
1987
- 1987-02-23 FI FI870763A patent/FI82835C/fi not_active IP Right Cessation
- 1987-02-24 DK DK092987A patent/DK170283B1/da not_active IP Right Cessation
-
1993
- 1993-05-03 SG SG561/93A patent/SG56193G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS1304B6 (is) | 1987-11-25 |
| IN163317B (fr) | 1988-09-03 |
| EP0229154B1 (fr) | 1990-12-27 |
| FI82835C (fi) | 1991-04-25 |
| DE3676671D1 (de) | 1991-02-07 |
| JPH0521114B2 (fr) | 1993-03-23 |
| CA1246593A (fr) | 1988-12-13 |
| EP0229154A4 (fr) | 1987-10-06 |
| IS3109A7 (is) | 1986-12-26 |
| US4647672A (en) | 1987-03-03 |
| JPS63500240A (ja) | 1988-01-28 |
| DK92987A (da) | 1987-02-24 |
| FI870763A (fi) | 1987-02-23 |
| PH22988A (en) | 1989-02-24 |
| SG56193G (en) | 1993-07-09 |
| DK92987D0 (da) | 1987-02-24 |
| ES556503A0 (es) | 1987-07-16 |
| ES8707220A1 (es) | 1987-07-16 |
| FI82835B (fi) | 1991-01-15 |
| WO1987000172A1 (fr) | 1987-01-15 |
| EP0229154A1 (fr) | 1987-07-22 |
| FI870763A0 (fi) | 1987-02-23 |
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