ES2186607T3 - Procedimiento de purificacion de l-ascorbilo 2-monofosfato. - Google Patents
Procedimiento de purificacion de l-ascorbilo 2-monofosfato.Info
- Publication number
- ES2186607T3 ES2186607T3 ES00111474T ES00111474T ES2186607T3 ES 2186607 T3 ES2186607 T3 ES 2186607T3 ES 00111474 T ES00111474 T ES 00111474T ES 00111474 T ES00111474 T ES 00111474T ES 2186607 T3 ES2186607 T3 ES 2186607T3
- Authority
- ES
- Spain
- Prior art keywords
- monophosphate
- ascorbyl
- ascorbic acid
- resin
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000746 purification Methods 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 6
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 229960005070 ascorbic acid Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 1
- 239000002211 L-ascorbic acid Substances 0.000 abstract 1
- 150000000996 L-ascorbic acids Chemical class 0.000 abstract 1
- 229930003268 Vitamin C Natural products 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000011033 desalting Methods 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000010525 oxidative degradation reaction Methods 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000011718 vitamin C Substances 0.000 abstract 1
- 235000019154 vitamin C Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Saccharide Compounds (AREA)
- Fodder In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Un procedimiento para separar L-ascorbilo 2-monofosfato, a partir de una mezcla de los productos del desalado de la mezcla de productos obtenida a partir de la fosforilación, bajo condiciones básicas de una sal de ácido L-ascórbico, procedimiento éste el cual se caracteriza por hacer pasar una solución acuosa de la mezcla desalada que contiene, entre otros componentes, el Lascorbilo 2-monofosfato deseado, a través de una columna de una resina intercambiadora de iones, básica, la cual trae como resultado la adsorción de los componentes sobre la resina, desorbiendo, entre otros componentes adsorbidos, el citado Lascorbilo 2-monofosfato, de la resina, utilizando, como eluyente, una solución de hidróxido alcalino, y recogiendo del eluído la fracción que éste contiene, como su principal componente disuelto, el deseado L-ascorbilo 2-monofosfato, en la forma de su apropiada sal monometálica alcalina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99110851 | 1999-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2186607T3 true ES2186607T3 (es) | 2003-05-16 |
Family
ID=8238292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00111474T Expired - Lifetime ES2186607T3 (es) | 1999-06-07 | 2000-05-29 | Procedimiento de purificacion de l-ascorbilo 2-monofosfato. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6288243B1 (es) |
| EP (1) | EP1059298B1 (es) |
| JP (1) | JP4545886B2 (es) |
| KR (1) | KR100647926B1 (es) |
| CN (1) | CN1159325C (es) |
| AT (1) | ATE228525T1 (es) |
| BR (1) | BR0002585B1 (es) |
| CA (1) | CA2310903A1 (es) |
| DE (1) | DE60000844T2 (es) |
| DK (1) | DK1059298T3 (es) |
| ES (1) | ES2186607T3 (es) |
| IN (1) | IN189335B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030046269A (ko) * | 2001-12-05 | 2003-06-12 | 주식회사 엔지켐 | 엘-아스코빌-2-인산에스테르마그네슘의 제조방법 |
| JP3969204B2 (ja) * | 2002-06-18 | 2007-09-05 | コニカミノルタホールディングス株式会社 | 蛍光体前駆体製造装置及び蛍光体前駆体の製造方法 |
| KR100532573B1 (ko) * | 2002-11-21 | 2005-12-01 | 주식회사 엔지켐 | 엘-아스코빌-2-인산에스테르마그네슘염의 제조방법 |
| CN112321640B (zh) * | 2020-10-29 | 2023-12-19 | 宿迁科思化学有限公司 | 一种高品质维生素c磷酸酯钠的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4815605B1 (es) * | 1969-05-16 | 1973-05-16 | ||
| US4179445A (en) | 1976-05-06 | 1979-12-18 | Kansas State University Research Foundation | Method of preparation of 2-phosphate esters of ascorbic acid |
| JPS5951293A (ja) * | 1982-09-14 | 1984-03-24 | Takeda Chem Ind Ltd | Ｌ−アスコルビン酸−２−リン酸エステルの精製法 |
| JPS59106494A (ja) * | 1982-12-09 | 1984-06-20 | Pola Chem Ind Inc | 燐酸化アスコルビン酸の精製方法 |
| JPS6156142A (ja) * | 1984-08-24 | 1986-03-20 | Shikishima Sutaac Kk | フィチン及びフィチン酸の製造法 |
| US4647672A (en) | 1985-06-25 | 1987-03-03 | Kansas State University Research Foundation | Ascorbate 2-polyphosphate esters and method of making same |
| JPS6230791A (ja) * | 1985-08-02 | 1987-02-09 | Showa Denko Kk | Ｌ−アスコルビン酸−２−リン酸エステルの精製法 |
| JPS62103096A (ja) * | 1985-10-29 | 1987-05-13 | Showa Denko Kk | Ｌ−アスコルビン酸−２−リン酸エステルの精製法 |
| JPH02169524A (ja) * | 1988-12-21 | 1990-06-29 | Sumitomo Chem Co Ltd | 有機酸の回収法 |
| DE3909198A1 (de) | 1989-03-21 | 1990-09-27 | Basf Ag | Verfahren zur herstellung von ascorbinsaeure-2-phosphat sowie von 5,6-isorpropyliden-ascorbinsaeure als ausgangsprodukt |
| JP3117949B2 (ja) * | 1989-08-24 | 2000-12-18 | 協和醗酵工業株式会社 | Ｌ−アスコルビン酸−２−リン酸ナトリウム塩の結晶 |
| US5110950A (en) | 1991-06-12 | 1992-05-05 | Kansas State University Research Foundation | Method of preparing 2-phosphorylated compounds of ascorbic acid |
| US5413663A (en) * | 1992-06-11 | 1995-05-09 | Tokyo Electron Limited | Plasma processing apparatus |
| DE4226625A1 (de) | 1992-08-12 | 1994-02-17 | Basf Ag | Verfahren zur Herstellung von Calcium-L-ascorbat-2-phosphat |
| JP3840672B2 (ja) * | 1994-04-28 | 2006-11-01 | 和光純薬工業株式会社 | アスコルビン酸誘導体の製造法 |
| CA2230774C (en) * | 1997-03-18 | 2007-06-26 | F. Hoffmann-La Roche Ag | Manufacture of ascorbyl monophosphates |
| JP4480100B2 (ja) * | 1999-09-20 | 2010-06-16 | 協和発酵バイオ株式会社 | Ｌ−アスコルビン酸−２−リン酸の製造方法 |
-
2000
- 2000-05-29 AT AT00111474T patent/ATE228525T1/de not_active IP Right Cessation
- 2000-05-29 ES ES00111474T patent/ES2186607T3/es not_active Expired - Lifetime
- 2000-05-29 DK DK00111474T patent/DK1059298T3/da active
- 2000-05-29 EP EP00111474A patent/EP1059298B1/en not_active Expired - Lifetime
- 2000-05-29 DE DE60000844T patent/DE60000844T2/de not_active Expired - Lifetime
- 2000-05-31 US US09/583,254 patent/US6288243B1/en not_active Expired - Lifetime
- 2000-06-05 JP JP2000166979A patent/JP4545886B2/ja not_active Expired - Lifetime
- 2000-06-05 IN IN427MA2000 patent/IN189335B/en unknown
- 2000-06-05 KR KR1020000030695A patent/KR100647926B1/ko active IP Right Grant
- 2000-06-05 CA CA002310903A patent/CA2310903A1/en not_active Abandoned
- 2000-06-06 BR BRPI0002585-2A patent/BR0002585B1/pt not_active IP Right Cessation
- 2000-06-07 CN CNB001179918A patent/CN1159325C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1059298A1 (en) | 2000-12-13 |
| CN1276377A (zh) | 2000-12-13 |
| US6288243B1 (en) | 2001-09-11 |
| KR20010049483A (ko) | 2001-06-15 |
| IN189335B (es) | 2003-02-15 |
| CN1159325C (zh) | 2004-07-28 |
| BR0002585A (pt) | 2001-01-02 |
| ATE228525T1 (de) | 2002-12-15 |
| JP2001026595A (ja) | 2001-01-30 |
| BR0002585B1 (pt) | 2011-10-04 |
| DK1059298T3 (da) | 2003-03-24 |
| DE60000844T2 (de) | 2003-09-04 |
| JP4545886B2 (ja) | 2010-09-15 |
| KR100647926B1 (ko) | 2006-11-17 |
| EP1059298B1 (en) | 2002-11-27 |
| CA2310903A1 (en) | 2000-12-07 |
| DE60000844D1 (de) | 2003-01-09 |
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