DK169404B1 - Substitueret phenylamidforbindelse, fremgangsmåde til fremstilling deraf, anvendelse deraf til brug som farmaceutisk middel og farmaceutisk præparat indeholdende forbindelsen - Google Patents

Substitueret phenylamidforbindelse, fremgangsmåde til fremstilling deraf, anvendelse deraf til brug som farmaceutisk middel og farmaceutisk præparat indeholdende forbindelsen Download PDF

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Publication number
DK169404B1
DK169404B1 DK413987A DK413987A DK169404B1 DK 169404 B1 DK169404 B1 DK 169404B1 DK 413987 A DK413987 A DK 413987A DK 413987 A DK413987 A DK 413987A DK 169404 B1 DK169404 B1 DK 169404B1
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DK
Denmark
Prior art keywords
compound
formula
alkyl
salt
compound according
Prior art date
Application number
DK413987A
Other languages
Danish (da)
English (en)
Other versions
DK413987D0 (da
DK413987A (da
Inventor
Peter Thaddeus Gallagher
Terence Alan Hicks
Graham Walter Mullier
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of DK413987D0 publication Critical patent/DK413987D0/da
Publication of DK413987A publication Critical patent/DK413987A/da
Application granted granted Critical
Publication of DK169404B1 publication Critical patent/DK169404B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK413987A 1986-08-08 1987-08-07 Substitueret phenylamidforbindelse, fremgangsmåde til fremstilling deraf, anvendelse deraf til brug som farmaceutisk middel og farmaceutisk præparat indeholdende forbindelsen DK169404B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868619432A GB8619432D0 (en) 1986-08-08 1986-08-08 Pharmaceutical compounds
GB8619432 1986-08-08

Publications (3)

Publication Number Publication Date
DK413987D0 DK413987D0 (da) 1987-08-07
DK413987A DK413987A (da) 1988-02-09
DK169404B1 true DK169404B1 (da) 1994-10-24

Family

ID=10602473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK413987A DK169404B1 (da) 1986-08-08 1987-08-07 Substitueret phenylamidforbindelse, fremgangsmåde til fremstilling deraf, anvendelse deraf til brug som farmaceutisk middel og farmaceutisk præparat indeholdende forbindelsen

Country Status (23)

Country Link
US (1) US4892963A (fr)
EP (1) EP0257882B1 (fr)
JP (1) JPS63239259A (fr)
KR (2) KR880002815A (fr)
CN (1) CN1015256B (fr)
AR (2) AR244660A1 (fr)
AT (1) ATE65494T1 (fr)
AU (1) AU604737B2 (fr)
CA (1) CA1317964C (fr)
DE (1) DE3771611D1 (fr)
DK (1) DK169404B1 (fr)
EG (1) EG18269A (fr)
ES (1) ES2031510T3 (fr)
GB (1) GB8619432D0 (fr)
GR (1) GR3002714T3 (fr)
HU (1) HU197559B (fr)
IL (1) IL83432A (fr)
MX (1) MX174371B (fr)
NZ (1) NZ221352A (fr)
PH (1) PH22821A (fr)
PT (1) PT85476B (fr)
RU (1) RU1771472C (fr)
ZA (1) ZA875813B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4975462A (en) * 1988-07-29 1990-12-04 Bristol-Myers Company Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
DD297328A5 (de) * 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
JPH04211048A (ja) * 1990-03-05 1992-08-03 Mitsubishi Kasei Corp チオカルバモイルアセトニトリル誘導体
EP0527736B1 (fr) * 1990-05-18 1997-04-16 Hoechst Aktiengesellschaft Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf History of 3-cycloalkyl-prop-2-anamide
ATE128353T1 (de) * 1991-10-23 1995-10-15 Hoechst Ag N-phenyl-2-cyano-3-hydroxycrotonsäureamidderiva e und deren verwendung als arzneimittel mit immunmodulatorischer eigenschaft.
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
TW314467B (fr) * 1993-03-31 1997-09-01 Hoechst Ag
WO1994024095A1 (fr) * 1993-04-16 1994-10-27 Abbott Laboratories Agents immunosuppresseurs
GB9320299D0 (en) * 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
EP0787491B1 (fr) * 1994-10-17 2000-07-26 Aventis Pharma Ltd. Composition preventive et remede pour les maladies allergiques de type i
DE19702988A1 (de) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
AU779931B2 (en) * 1999-12-16 2005-02-17 Teva Pharmaceutical Industries Ltd. Novel processes for making- and a new crystalline form of- leflunomide
SK12992002A3 (sk) 2000-02-15 2003-05-02 Teva Pharmaceutical Industries Ltd. Spôsob syntézy leflunomidu
DE10311763A1 (de) * 2003-03-18 2004-10-07 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
MX2016006678A (es) 2013-11-22 2016-09-13 Genzyme Corp Nuevos metodos para tratar enfermedades neurodegenerativas.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DK545976A (da) * 1975-12-11 1977-06-12 Hoechst Ag Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser
DE2654797A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Verfahren zur herstellung von isoxazolderivaten
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
IL60269A (en) * 1979-06-11 1983-12-30 Ciba Geigy Alpha-carbamoyl-pyrrolpropionitriles,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE3771611D1 (de) 1991-08-29
EP0257882B1 (fr) 1991-07-24
MX174371B (es) 1994-05-11
JPS63239259A (ja) 1988-10-05
AR244660A1 (es) 1993-11-30
RU1771472C (ru) 1992-10-23
KR880002815A (ko) 1988-05-11
PT85476B (pt) 1990-06-29
CN1015256B (zh) 1992-01-01
IL83432A (en) 1992-06-21
EP0257882A1 (fr) 1988-03-02
AR247876A1 (es) 1995-04-28
ATE65494T1 (de) 1991-08-15
IL83432A0 (en) 1988-01-31
CN87105516A (zh) 1988-02-24
DK413987D0 (da) 1987-08-07
PH22821A (en) 1989-01-19
PT85476A (en) 1987-09-01
AU604737B2 (en) 1991-01-03
GR3002714T3 (en) 1993-01-25
CA1317964C (fr) 1993-05-18
DK413987A (da) 1988-02-09
ZA875813B (en) 1989-04-26
MX7668A (es) 1993-08-01
NZ221352A (en) 1989-10-27
ES2031510T3 (es) 1992-12-16
KR880002823A (ko) 1988-05-11
HUT44523A (en) 1988-03-28
EG18269A (en) 1992-12-30
HU197559B (en) 1989-04-28
AU7668187A (en) 1988-02-11
GB8619432D0 (en) 1986-09-17
US4892963A (en) 1990-01-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed