DK1686119T3 - Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer - Google Patents

Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer

Info

Publication number
DK1686119T3
DK1686119T3 DK06075890T DK06075890T DK1686119T3 DK 1686119 T3 DK1686119 T3 DK 1686119T3 DK 06075890 T DK06075890 T DK 06075890T DK 06075890 T DK06075890 T DK 06075890T DK 1686119 T3 DK1686119 T3 DK 1686119T3
Authority
DK
Denmark
Prior art keywords
ldl
pyrimidin
derivatives
pla2 inhibitors
inhibitors
Prior art date
Application number
DK06075890T
Other languages
Danish (da)
English (en)
Inventor
Deidre Mary Hickey
Robert John Ife
Colin Andrew Leach
Ivan Leo Pinto
Stephen Allan Smith
Steven James Stanway
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0003636A external-priority patent/GB0003636D0/en
Priority claimed from GB0101437A external-priority patent/GB0101437D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK1686119T3 publication Critical patent/DK1686119T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK06075890T 2000-02-16 2001-02-13 Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer DK1686119T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0003636A GB0003636D0 (en) 2000-02-16 2000-02-16 Novel compounds
GB0101437A GB0101437D0 (en) 2001-01-19 2001-01-19 Novel Compounds
PCT/EP2001/001515 WO2001060805A1 (en) 2000-02-16 2001-02-13 Pyrimidine-4-one derivatives as ldl-pla2 inhibitors

Publications (1)

Publication Number Publication Date
DK1686119T3 true DK1686119T3 (da) 2009-11-09

Family

ID=26243663

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06075890T DK1686119T3 (da) 2000-02-16 2001-02-13 Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer
DK01907522T DK1263740T3 (da) 2000-02-16 2001-02-13 Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01907522T DK1263740T3 (da) 2000-02-16 2001-02-13 Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor

Country Status (32)

Country Link
US (10) US20020103213A1 (de)
EP (2) EP1686119B1 (de)
JP (1) JP4095804B2 (de)
KR (1) KR100781425B1 (de)
CN (1) CN1179952C (de)
AR (1) AR030190A1 (de)
AT (2) ATE333446T1 (de)
AU (2) AU2001235466B2 (de)
BG (1) BG66014B1 (de)
BR (1) BRPI0108396B1 (de)
CA (1) CA2400554C (de)
CO (1) CO5271661A1 (de)
CY (2) CY1105649T1 (de)
CZ (1) CZ304450B6 (de)
DE (2) DE60139429D1 (de)
DK (2) DK1686119T3 (de)
ES (2) ES2330552T3 (de)
GC (1) GC0000221A (de)
HK (1) HK1053466A1 (de)
HU (1) HU229479B1 (de)
IL (2) IL151236A (de)
MX (1) MXPA02008062A (de)
MY (1) MY135732A (de)
NO (1) NO324691B1 (de)
NZ (1) NZ520752A (de)
PL (1) PL209824B1 (de)
PT (2) PT1686119E (de)
SI (2) SI1686119T1 (de)
SK (1) SK287296B6 (de)
TW (1) TW550259B (de)
UA (1) UA73762C2 (de)
WO (1) WO2001060805A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229479B1 (en) * 2000-02-16 2014-01-28 Glaxo Group Ltd Pyrimidine-4-one derivatives
GB0024807D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
WO2002032863A1 (en) * 2000-10-20 2002-04-25 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy
GB0119793D0 (en) * 2001-08-14 2001-10-03 Smithkline Beecham Plc Novel compounds
GB0119795D0 (en) * 2001-08-14 2001-10-03 Smithkline Beecham Plc Novel process
GB0127143D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Novel compounds
GB0127141D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Plc Novel compounds
GB0127140D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Novel compounds
GB0127139D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Novel compounds
WO2003057671A1 (fr) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Compose biaryle et son utilisation
US6939863B2 (en) 2002-01-04 2005-09-06 Wei-Jan Chen Prevention of atherosclerosis and restenosis
GB0208280D0 (en) * 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
GB0208279D0 (en) * 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
US20050227974A9 (en) * 2002-08-01 2005-10-13 Euro-Celtique S.A. Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers
JP4366122B2 (ja) * 2003-06-24 2009-11-18 日立オムロンターミナルソリューションズ株式会社 紙葉類搬送装置
GB0320522D0 (en) 2003-09-02 2003-10-01 Glaxo Group Ltd Formulation
CN1875002B (zh) 2003-11-05 2011-08-03 霍夫曼-拉罗奇有限公司 作为ppar激动剂的苯基衍生物
EP1735457A4 (de) 2004-04-16 2007-08-29 Glaxo Group Ltd VERFAHREN ZUR BESTIMMUNG VON Lp-PLA2-AKTIVITÄT UND HEMMUNG VON Lp-PLA2 AKTIVITÄT
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
TW200608976A (en) 2004-05-08 2006-03-16 Neurogen Corp 4,5-disubstituted-2-aryl pyrimidines
DE102004061005A1 (de) * 2004-12-18 2006-06-22 Bayer Healthcare Ag 3-Cycloalkyl-1,2,4-triazin-5(2H)-one
US20080090851A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US20080090852A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US7705005B2 (en) * 2006-10-13 2010-04-27 Glaxo Group Limited Bicyclic heteroaromatic compounds
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
ES2540933T3 (es) * 2007-05-11 2015-07-14 Thomas Jefferson University Métodos de tratamiento y prevención de enfermedades y trastornos neurodegenerativos
EA018101B1 (ru) * 2007-05-11 2013-05-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Способы лечения кожных язв
US8637524B2 (en) 2009-07-28 2014-01-28 Auspex Pharmaceuticals, Inc Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
TW201209043A (en) * 2010-05-17 2012-03-01 Glaxo Group Ltd Novel processes
JP6053675B2 (ja) 2010-06-18 2016-12-27 ホワイトヘッド・インスティチュート・フォア・バイオメディカル・リサーチ 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６
CN104478812A (zh) * 2010-12-06 2015-04-01 葛兰素集团有限公司 用于治疗由Lp-PLA2介导的疾病或病症的嘧啶酮化合物
WO2012075917A1 (en) * 2010-12-06 2012-06-14 Glaxo Group Limited Compounds
TW201307324A (zh) * 2010-12-06 2013-02-16 Glaxo Group Ltd 化合物
WO2012080497A2 (en) 2010-12-17 2012-06-21 Glaxo Group Limited Methods of treatment and prevention of eye diseases
CN102643269B (zh) * 2011-02-21 2014-07-23 天津药物研究院 一类含吡唑结构的磷脂酶a2抑制剂及用途
CN103476414B (zh) * 2011-03-16 2015-07-08 中国科学院上海药物研究所 季铵盐类化合物、其制备方法、药物组合物及用途
WO2012129792A1 (zh) * 2011-03-30 2012-10-04 中国科学院上海药物研究所 嘧啶酮类化合物、其制备方法及药物组合物和用途
WO2013000267A1 (zh) * 2011-06-27 2013-01-03 中国科学院上海药物研究所 唑类杂环化合物、其制备方法、药物组合物和用途
AU2012289492B2 (en) 2011-07-27 2016-02-04 Glaxo Group Limited 2,3-dihydroimidazo[1,2-c] pyrimidin-5(1H)-one compounds use as Lp-PLA2 inhibitors
CN103827116B (zh) * 2011-07-27 2016-08-31 葛兰素集团有限公司 用作LP-PLA2抑制剂的2,3-二氢咪唑并[1,2-c]嘧啶-5(1H)-酮化合物
BR112014001634A2 (pt) 2011-07-27 2017-02-14 Glaxo Group Ltd compostos bicíclicos de pirimidona
WO2014114694A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
JP2016508995A (ja) 2013-01-25 2016-03-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 化合物
WO2014114249A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Bicyclic pyrimidone compounds as inhibitors of lp-pla2
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
WO2015114479A1 (en) 2014-01-28 2015-08-06 Ranbaxy Laboratories Limited Crystalline forms of darapladib oxalate, adipate, succinate, phosphate, sulphate, fumaratetartrate, nitrate and borate
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
CN105777653A (zh) * 2014-12-26 2016-07-20 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物
CN104840963B (zh) * 2015-05-26 2018-02-16 河北东康生物科技有限公司 含脂蛋白相关性磷脂酶a2抑制剂的药物组合物及应用
CN107709314A (zh) * 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途
WO2017106396A1 (en) * 2015-12-16 2017-06-22 Bristol-Myers Squibb Company Heteroarylhydroxypyrimidinones as agonists of the apj receptor
US10878307B2 (en) * 2016-12-23 2020-12-29 Microsoft Technology Licensing, Llc EQ-digital conversation assistant
ES2907130T3 (es) 2017-09-26 2022-04-22 Inst Nat Sante Rech Med Darapladib radiomarcado, análogos del mismo y su uso como compuestos para la obtención de imágenes
CN110746445B (zh) * 2019-10-16 2021-03-16 深圳海关食品检验检疫技术中心 一种头孢哌酮氘代内标物的制备方法
EP4056571A4 (de) 2019-11-09 2024-01-24 Shanghai Simr Biotechnology Co Ltd Trizyklisches dihydroimidazopyrimidonderivat, verfahren zu seiner herstellung, pharmazeutische zusammensetzung und verwendung davon
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
EP4257133A1 (de) 2022-04-05 2023-10-11 Institut Pasteur Oxo-azaheterozyklische derivate zur verwendung bei der behandlung von malaria

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0658205B1 (de) 1993-06-25 2000-03-15 Smithkline Beecham Plc An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
PT673426E (pt) * 1993-10-06 2001-11-30 Icos Corp Acetil-hidrolase do factor activador das plaquetas
GB9421816D0 (en) 1994-10-29 1994-12-14 Smithkline Beecham Plc Novel compounds
AU704407B2 (en) 1994-12-22 1999-04-22 Smithkline Beecham Plc Substituted azetidin-2-ones for treatment of atherosclerosis
CH690264A5 (fr) 1995-06-30 2000-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
TR199701762T1 (xx) 1995-07-01 1998-05-21 Smithkline Beecham P.L.C. Damar t�kanmas� tedavisi i�in azetidinon t�revleri.
EP0859834A2 (de) 1995-09-29 1998-08-26 Smithkline Beecham Plc Paf-acetylhydrolase und ihre therapeutische verwendung
EP0869943A1 (de) 1995-12-08 1998-10-14 Smithkline Beecham Plc Monocyclische beta-lactame zur behandlung von atherosklerose
JP2000505063A (ja) 1995-12-08 2000-04-25 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー アテローム性動脈硬化症の治療のためのアゼチジノン化合物
GB9608649D0 (en) 1996-04-26 1996-07-03 Smithkline Beecham Plc Novel compounds
AU2698697A (en) 1996-04-26 1997-11-19 Smithkline Beecham Plc Azetidinone derivatives for the treatment of atherosclerosis
GB9626615D0 (en) 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626536D0 (en) 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626616D0 (en) 1996-12-20 1997-02-05 Symphar Sa Novel compounds
JP2001522844A (ja) * 1997-11-06 2001-11-20 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ピリミジノン化合物およびそれを含有する医薬組成物
DE69911980T2 (de) 1998-08-21 2004-09-09 Smithkline Beecham P.L.C., Brentford Pyrimidinonderivate zur behandlung von atheroscleros
SI1175408T1 (en) 1999-05-01 2005-04-30 Smithkline Beecham Plc Pyrimidinone compounds
GB9910079D0 (en) 1999-05-01 1999-06-30 Smithkline Beecham Plc Novel compounds
GB9910378D0 (en) 1999-05-05 1999-06-30 Smithkline Beecham Plc Novel compounds
HU229479B1 (en) * 2000-02-16 2014-01-28 Glaxo Group Ltd Pyrimidine-4-one derivatives
GB0024808D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0024807D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
US20120172378A1 (en) 2012-07-05
SI1686119T1 (sl) 2009-12-31
CZ20022768A3 (cs) 2003-05-14
ATE333446T1 (de) 2006-08-15
DK1263740T3 (da) 2006-11-13
CO5271661A1 (es) 2003-04-30
DE60139429D1 (de) 2009-09-10
HUP0204410A2 (en) 2003-05-28
US20070155762A1 (en) 2007-07-05
MY135732A (en) 2008-06-30
US20070123549A1 (en) 2007-05-31
WO2001060805A1 (en) 2001-08-23
US20020103213A1 (en) 2002-08-01
SK11772002A3 (sk) 2003-02-04
PL357382A1 (en) 2004-07-26
US9266841B2 (en) 2016-02-23
US20090170877A1 (en) 2009-07-02
DE60121550T2 (de) 2007-06-21
CA2400554C (en) 2009-04-07
KR100781425B1 (ko) 2007-12-03
EP1263740A1 (de) 2002-12-11
MXPA02008062A (es) 2002-11-29
KR20030011772A (ko) 2003-02-11
IL151236A (en) 2009-02-11
EP1686119B1 (de) 2009-07-29
SK287296B6 (sk) 2010-06-07
US7470694B2 (en) 2008-12-30
AR030190A1 (es) 2003-08-13
CZ304450B6 (cs) 2014-05-14
UA73762C2 (uk) 2005-09-15
BRPI0108396B1 (pt) 2015-05-19
BG66014B1 (bg) 2010-10-29
IL181957A0 (en) 2009-02-11
AU2001235466B2 (en) 2004-04-22
CN1418199A (zh) 2003-05-14
BG107034A (bg) 2003-04-30
DE60121550D1 (de) 2006-08-31
ATE437862T1 (de) 2009-08-15
CY1105649T1 (el) 2010-12-22
US6649619B1 (en) 2003-11-18
HK1053466A1 (en) 2003-10-24
US20090118313A1 (en) 2009-05-07
US8871775B2 (en) 2014-10-28
US20040097525A1 (en) 2004-05-20
NZ520752A (en) 2004-03-26
CY1109484T1 (el) 2014-08-13
US7652019B2 (en) 2010-01-26
US7153861B2 (en) 2006-12-26
ES2267714T3 (es) 2007-03-16
NO324691B1 (no) 2007-12-03
HUP0204410A3 (en) 2003-07-28
CN1179952C (zh) 2004-12-15
PT1686119E (pt) 2009-10-06
JP2003523335A (ja) 2003-08-05
GC0000221A (en) 2006-03-29
AU3546601A (en) 2001-08-27
SI1263740T1 (sl) 2006-12-31
EP1263740B1 (de) 2006-07-19
CA2400554A1 (en) 2001-08-23
NO20023828D0 (no) 2002-08-13
JP4095804B2 (ja) 2008-06-04
ES2330552T3 (es) 2009-12-11
BR0108396A (pt) 2003-03-11
PL209824B1 (pl) 2011-10-31
PT1263740E (pt) 2006-11-30
HU229479B1 (en) 2014-01-28
US20150045375A1 (en) 2015-02-12
US20100144765A1 (en) 2010-06-10
US7638520B2 (en) 2009-12-29
EP1686119A1 (de) 2006-08-02
TW550259B (en) 2003-09-01
NO20023828L (no) 2002-09-30

Similar Documents

Publication Publication Date Title
DK1686119T3 (da) Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer
BR0010220A (pt) Compostos de pirimidinona
CY1112442T1 (el) Παραγωγα πυριδινονης για θεραπεια αθηροσκληρωσης
DK1864975T3 (da) Nikotinamid-derivater anvendelige som P38-inhibitorer
EE200300227A (et) P38 kinaasiga seotud haigusseisundite ravimeetodid ja kinaasi inhibiitoritena kasulikud pürrolotriasiiniühendid
NO20023614L (no) Pyrimidin-karboksamider som er anvendelige som inhibitorer for PDE4-isoenzymer
DK1475377T3 (da) Indol-derivater og deres anvendelse som inhibitorer for phosphodiesterase 4
DK1070056T3 (da) Phthalazinon-PDE III/IV-inhibitorer
EE200300361A (et) PDE4 isosüümide inhibiitoritena kasutatavad eetriderivaadid
PT1465864E (pt) Inibidores de factor xa e outras serina proteases envolvidos na cascata da coagulacao
PT1294724E (pt) Compostos pirrolo (2,3-d ) pirimidina como agentes imunosupressivos
DK1268480T3 (da) 8-Quinolinxanthin- og 8-isoquinolinxanthinderivater som PDE5-inhibitorer
ATE495736T1 (de) Verwendung von derivaten der 2-oxothiazolidin-4- corbonsäure als prä-abschuppungsmittel
NO20033288D0 (no) Anilinderivater som kan anvendes som fosfodiesterase 4- inhibitorer
DK1100797T3 (da) Heterocycliske forbindelser som inhibitorer af rotamaseenzymer
BR0209149A (pt) Ftalazinonas
DK1060178T3 (da) Heterocyklisk forbindelser som inhibitorer af rotamase enzymer
DE60318826D1 (de) Alkoxypyridinderivate
MXPA04004372A (es) Derivados heterociclicos de glicinamida y su uso medico.
SE0103710D0 (sv) Compounds
EE200100315A (et) Amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
NO20034434D0 (no) Indolinoner substituert i 6-stilling og deres anvendelse som kinase-inhibitorer
BR0109512A (pt) Imidazopiridinas tricìclicas
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
NO20035206D0 (no) Pyrimidin-derivater anvendelige som selektive COX-2- inhibitorer