DK168567B1 - Analogifremgangsmåde til fremstilling af 2-substituerede-3-hydroxy-1,4-naphthoquinoner - Google Patents

Analogifremgangsmåde til fremstilling af 2-substituerede-3-hydroxy-1,4-naphthoquinoner Download PDF

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Publication number
DK168567B1
DK168567B1 DK459782A DK459782A DK168567B1 DK 168567 B1 DK168567 B1 DK 168567B1 DK 459782 A DK459782 A DK 459782A DK 459782 A DK459782 A DK 459782A DK 168567 B1 DK168567 B1 DK 168567B1
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DK
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Prior art keywords
formula
compound
hydroxy
trans
process according
Prior art date
Application number
DK459782A
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Danish (da)
English (en)
Other versions
DK459782A (da
Inventor
Alan Thomas Hudson
Anthony Winchester Randall
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK459782A publication Critical patent/DK459782A/da
Application granted granted Critical
Publication of DK168567B1 publication Critical patent/DK168567B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/12—Naphthoquinones, i.e. C10H6O2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/22—Unsaturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK459782A 1981-10-16 1982-10-15 Analogifremgangsmåde til fremstilling af 2-substituerede-3-hydroxy-1,4-naphthoquinoner DK168567B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8131206 1981-10-16
GB8131206 1981-10-16
GB8220680 1982-07-16
GB8220680 1982-07-16

Publications (2)

Publication Number Publication Date
DK459782A DK459782A (da) 1983-04-17
DK168567B1 true DK168567B1 (da) 1994-04-25

Family

ID=26280983

Family Applications (1)

Application Number Title Priority Date Filing Date
DK459782A DK168567B1 (da) 1981-10-16 1982-10-15 Analogifremgangsmåde til fremstilling af 2-substituerede-3-hydroxy-1,4-naphthoquinoner

Country Status (14)

Country Link
US (1) US4485116A (fi)
EP (1) EP0077550B1 (fi)
KR (2) KR890000374B1 (fi)
CA (1) CA1205082A (fi)
DE (1) DE3264682D1 (fi)
DK (1) DK168567B1 (fi)
DZ (1) DZ466A1 (fi)
FI (2) FI78677C (fi)
GB (1) GB2111047B (fi)
HU (1) HU196354B (fi)
IL (1) IL66999A0 (fi)
OA (1) OA07231A (fi)
PH (1) PH20784A (fi)
ZW (1) ZW21982A1 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310140D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Antiprotozoal agents
US5053432A (en) * 1983-04-14 1991-10-01 Burroughs Wellcome Co. Naphthoquinone derivatives
GB8500292D0 (en) * 1985-01-07 1985-02-13 Wellcome Found Treatment of babesiosis
US5225184A (en) * 1988-08-16 1993-07-06 Burroughs Wellcome Co. Medicaments
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
GB9207517D0 (en) * 1992-04-06 1992-05-20 Wellcome Found Heterocyclic compounds
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) * 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
CN1102568C (zh) * 1995-01-10 2003-03-05 英国技术集团国际有限公司 农药化合物
KR970042464A (ko) * 1995-12-26 1997-07-24 김준웅 나프타퀴논의 제조방법
US5831118A (en) * 1996-06-18 1998-11-03 Katayama Seiyakusyo Co., Ltd. Epimerization of 2- or 4- substituted cyclohexanecarboxylic acids
CN103450141B (zh) * 2013-08-23 2015-08-26 山东鲁抗舍里乐药业有限公司 一种苯并吡喃酮类化合物、其制备方法及其应用
CN103483176A (zh) * 2013-08-23 2014-01-01 山东鲁抗舍里乐药业有限公司 一种布帕伐醌的制备方法
CN114276231A (zh) * 2021-12-30 2022-04-05 江苏云朴医药新材料科技有限公司 一种4-叔丁基环己基乙酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
US3347742A (en) * 1965-05-28 1967-10-17 Merck & Co Inc 2-(4-cyclohexylcyclohexyl)-3-hydroxy-1, 4-naphthoquinone in controlling coccidiosis in poultry
US3393211A (en) * 1965-09-14 1968-07-16 Merck & Co Inc Naphthoquinone compounds
US3578686A (en) * 1968-04-26 1971-05-11 Sterling Drug Inc 2-hydroxy - 3 -((3,3,5-trimethylcyclohexyl)-alkyl) - 1,4-naphthoquinones and their preparation
US3682991A (en) * 1970-10-19 1972-08-08 Sterling Drug Inc 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids
GB1553424A (en) * 1976-02-10 1979-09-26 Wellcome Found Method of treating protozal diseases
US4110473A (en) * 1977-07-14 1978-08-29 E. I. Du Pont De Nemours And Company Miticidal ethers
EG14152A (en) * 1977-11-22 1983-12-31 Wellcome Found Antitheilerial naphtoquinone derivatives

Also Published As

Publication number Publication date
KR900002683A (ko) 1990-02-28
EP0077550A3 (en) 1983-09-28
GB2111047B (en) 1985-10-23
CA1205082A (en) 1986-05-27
FI823531A0 (fi) 1982-10-15
FI78677B (fi) 1989-05-31
DE3264682D1 (en) 1985-08-14
EP0077550A2 (en) 1983-04-27
PH20784A (en) 1987-04-14
ZW21982A1 (en) 1984-12-26
IL66999A0 (en) 1983-02-23
KR890000374B1 (ko) 1989-03-15
FI78678B (fi) 1989-05-31
OA07231A (en) 1984-04-30
GB2111047A (en) 1983-06-29
FI78678C (fi) 1989-09-11
HU196354B (en) 1988-11-28
US4485116A (en) 1984-11-27
FI823531L (fi) 1983-04-17
FI78677C (fi) 1989-09-11
DZ466A1 (fr) 2004-09-13
FI862616A (fi) 1986-06-18
FI862616A0 (fi) 1986-06-18
DK459782A (da) 1983-04-17
EP0077550B1 (en) 1985-07-10
KR840001944A (ko) 1984-06-07
KR900001287B1 (ko) 1990-03-05

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)