DK168015B1 - (1r,5s,6s)-2-(substitueret thio)-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater eller et farmakologisk acceptabelt salt deraf, fremgangsmaade til deres fremstilling samt deres anvendelse til fremstilling af antibakterielle laegemidler og laegemidler indeholdende dem - Google Patents

(1r,5s,6s)-2-(substitueret thio)-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater eller et farmakologisk acceptabelt salt deraf, fremgangsmaade til deres fremstilling samt deres anvendelse til fremstilling af antibakterielle laegemidler og laegemidler indeholdende dem Download PDF

Info

Publication number
DK168015B1
DK168015B1 DK192488A DK192488A DK168015B1 DK 168015 B1 DK168015 B1 DK 168015B1 DK 192488 A DK192488 A DK 192488A DK 192488 A DK192488 A DK 192488A DK 168015 B1 DK168015 B1 DK 168015B1
Authority
DK
Denmark
Prior art keywords
compound
formula
carbapenem
methyl
acceptable salt
Prior art date
Application number
DK192488A
Other languages
Danish (da)
English (en)
Other versions
DK192488A (da
DK192488D0 (da
Inventor
Toshio Kumagai
Hiroshi Matsunaga
Yoshisuke Machida
Yunosuke Nagase
Muneo Hikida
Yoshimitsu Nagao
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of DK192488D0 publication Critical patent/DK192488D0/da
Publication of DK192488A publication Critical patent/DK192488A/da
Application granted granted Critical
Publication of DK168015B1 publication Critical patent/DK168015B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK192488A 1987-04-11 1988-04-08 (1r,5s,6s)-2-(substitueret thio)-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater eller et farmakologisk acceptabelt salt deraf, fremgangsmaade til deres fremstilling samt deres anvendelse til fremstilling af antibakterielle laegemidler og laegemidler indeholdende dem DK168015B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8901687 1987-04-11
JP8901687 1987-04-11
JP63031033A JPS6425779A (en) 1987-04-11 1988-02-15 (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
JP3103388 1988-02-15

Publications (3)

Publication Number Publication Date
DK192488D0 DK192488D0 (da) 1988-04-08
DK192488A DK192488A (da) 1988-10-12
DK168015B1 true DK168015B1 (da) 1994-01-17

Family

ID=26369486

Family Applications (1)

Application Number Title Priority Date Filing Date
DK192488A DK168015B1 (da) 1987-04-11 1988-04-08 (1r,5s,6s)-2-(substitueret thio)-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater eller et farmakologisk acceptabelt salt deraf, fremgangsmaade til deres fremstilling samt deres anvendelse til fremstilling af antibakterielle laegemidler og laegemidler indeholdende dem

Country Status (12)

Country Link
EP (1) EP0289801B1 (no)
JP (1) JPS6425779A (no)
KR (1) KR960002850B1 (no)
AU (1) AU613356B2 (no)
CA (1) CA1340274C (no)
DE (1) DE3860977D1 (no)
DK (1) DK168015B1 (no)
ES (1) ES2019674B3 (no)
FI (1) FI86729C (no)
GR (1) GR3001347T3 (no)
IL (1) IL85985A (no)
NO (1) NO167862C (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059679T3 (es) * 1988-11-08 1994-11-16 Daiichi Seiyaku Co Derivados de carbapenem.
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
JP2771637B2 (ja) * 1989-10-17 1998-07-02 シーアイ化成株式会社 作物栽培用被覆フイルム及びそれを用いる栽培方法
WO1991009860A1 (en) * 1989-12-28 1991-07-11 Banyu Pharmaceutical Co., Ltd. New carbapenem derivative
US5227376A (en) * 1990-02-14 1993-07-13 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds and their production
US5241073A (en) * 1990-10-12 1993-08-31 Lederle (Japan) Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
ES2093010T3 (es) * 1990-10-12 1996-12-16 Lederle Japan Ltd Procedimiento para preparar (1r,5s,6s)-2-((6,7-dihidro-5h-pirazolo(1,2-a)(1,2,4)triazolio-6-il)tio)-6-((r)-1-hidroxietil)-1-metil-carbapenem-3-carboxilato y sus materiales de partida.
US5286721A (en) * 1990-10-15 1994-02-15 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
TW264475B (no) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
WO1993019072A1 (en) * 1992-03-17 1993-09-30 Yamanouchi Pharmaceutical Co., Ltd. Carbapenem derivative
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
CA2268820A1 (en) * 1996-10-28 1998-05-07 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
CA2302009A1 (en) * 1997-09-09 1999-03-18 Merck & Co., Inc. 3-(iodophenoxymethyl) carbapenem antibacterials
KR100476672B1 (ko) * 2001-08-16 2005-03-17 한국과학기술연구원 티올 유도체 및 이를 치환기로 갖는 1-베타-메틸-카바페넴유도체
JP2008303143A (ja) * 2005-08-19 2008-12-18 Shionogi & Co Ltd 連続化反応によるカルバぺネム誘導体の製法
TW200815442A (en) 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics
CN103159789B (zh) * 2011-12-16 2015-11-25 四川科伦药物研究有限公司 一种比阿培南结晶体及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008514B1 (en) * 1978-08-25 1982-01-20 Beecham Group Plc Beta-lactam anti-bacterials, compositions containing them and a process for their preparation
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4644061A (en) * 1982-09-28 1987-02-17 Bristol-Myers Company Carbapenem antibiotics
CA1273012A (en) * 1984-07-02 1990-08-21 Burton G. Christensen 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent
DE3617626A1 (de) * 1986-05-26 1987-12-03 Bayer Ag Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung
EP0597821A1 (en) * 1988-04-01 1994-05-18 Sankyo Company Limited 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics

Also Published As

Publication number Publication date
IL85985A (en) 1993-07-08
CA1340274C (en) 1998-12-15
NO881534D0 (no) 1988-04-08
NO167862C (no) 1991-12-18
EP0289801B1 (en) 1990-11-07
KR880012604A (ko) 1988-11-28
AU613356B2 (en) 1991-08-01
AU1442888A (en) 1988-10-13
GR3001347T3 (en) 1992-08-31
DK192488A (da) 1988-10-12
IL85985A0 (en) 1988-09-30
DE3860977D1 (en) 1990-12-13
NO881534L (no) 1988-10-12
ES2019674B3 (es) 1991-07-01
JPH0438756B2 (no) 1992-06-25
JPS6425779A (en) 1989-01-27
FI86729B (fi) 1992-06-30
KR960002850B1 (ko) 1996-02-27
EP0289801A1 (en) 1988-11-09
FI86729C (fi) 1992-10-12
DK192488D0 (da) 1988-04-08
NO167862B (no) 1991-09-09
FI881644A0 (fi) 1988-04-08
FI881644A (fi) 1988-10-12

Similar Documents

Publication Publication Date Title
DK168015B1 (da) (1r,5s,6s)-2-(substitueret thio)-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater eller et farmakologisk acceptabelt salt deraf, fremgangsmaade til deres fremstilling samt deres anvendelse til fremstilling af antibakterielle laegemidler og laegemidler indeholdende dem
EP0072710B1 (en) Carbapenem derivatives, their preparation and compositions containing them
US4866171A (en) (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
FI96863C (fi) Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
NO164980B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive karbapenemderivater.
US5153187A (en) 1-methylcarbapenem derivatives and process for preparation thereof
EP1612211A1 (en) Novel carbapenem compounds
JPS63152383A (ja) ２−オキサ−イソセフエム誘導体
DK168047B1 (da) (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
US5153188A (en) Piperidylthiocarbapenem derivatives
US4997936A (en) 2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US6479478B1 (en) Carbapenem compounds
FR2587704A1 (fr) Antibiotiques a base de carbapenem
JP2654077B2 (ja) 結晶形態の１−メチル−カルバペネム化合物
JP2003183282A (ja) カルバペネム化合物
EP0358085A1 (en) (1R,5S,6S)-6-[(R)-1-Hydroxyethyl]-1-methyl-2-[(1-alkyl-1,2,4-triazolium-2-yl)alkyl]-thio-carbapenem-3-carboxylic acid derivatives
JPS63255280A (ja) （１ｒ，５ｓ，６ｓ）−２−置換−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボン酸誘導体
US4837215A (en) Penem derivatives
JPH08134075A (ja) 新規なカルバペネム誘導体
JPH07196660A (ja) ２−（ヘテロシクロアルケニルアルキル）チオカルバペネム誘導体
JPH0770139A (ja) ２−（モノ又はジ置換−６，７−ジヒドロ−５Ｈ−ピラゾロ［１，２−ａ］ピラゾリウム−６−イル）チオ−カルバペネム誘導体
JPS63255283A (ja) （１ｒ，５ｓ，６ｓ）−２−〔（３−置換イミダゾリニウム−１−イル）アルキル〕チオ−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボキシレ−ト
JPS63255282A (ja) （１ｒ，５ｓ，６ｓ）−２−〔（チアゾリウム−２−イル）または（イミダゾリウム−２−イル）メチル〕チオ−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボキシレ−ト
JP2000086667A (ja) カルバペネム化合物
JPH05255346A (ja) カルバペネム化合物

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK