DK1678130T3 - Amidomethyl-substitueret 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H chromen-6-yl derivater og medikamenter indeholdende disse forbindelser - Google Patents

Amidomethyl-substitueret 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H chromen-6-yl derivater og medikamenter indeholdende disse forbindelser

Info

Publication number
DK1678130T3
DK1678130T3 DK04817204T DK04817204T DK1678130T3 DK 1678130 T3 DK1678130 T3 DK 1678130T3 DK 04817204 T DK04817204 T DK 04817204T DK 04817204 T DK04817204 T DK 04817204T DK 1678130 T3 DK1678130 T3 DK 1678130T3
Authority
DK
Denmark
Prior art keywords
chromomen
amidomethyl
sulphonylamino
dihydro
hydroxy
Prior art date
Application number
DK04817204T
Other languages
Danish (da)
English (en)
Inventor
David Sykes
Brian Moloney
Lester Marrison
Dieter Ziegler
Michael Mlinaric
Christiane Boecker
Reinhard Brueckner
Michael Weske
Klaus Witte
Yvan Fischer
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Application granted granted Critical
Publication of DK1678130T3 publication Critical patent/DK1678130T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK04817204T 2003-10-17 2004-10-14 Amidomethyl-substitueret 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H chromen-6-yl derivater og medikamenter indeholdende disse forbindelser DK1678130T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10348298A DE10348298A1 (de) 2003-10-17 2003-10-17 Amidomethyl-substituierte 2-(4-Sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-ylderivade, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP2004/052539 WO2005037780A2 (de) 2003-10-17 2004-10-14 Amidomethyl-substituierte 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromen-6-yl-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DK1678130T3 true DK1678130T3 (da) 2008-12-01

Family

ID=34442032

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04817204T DK1678130T3 (da) 2003-10-17 2004-10-14 Amidomethyl-substitueret 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H chromen-6-yl derivater og medikamenter indeholdende disse forbindelser

Country Status (25)

Country Link
EP (1) EP1678130B1 (zh)
JP (1) JP4791968B2 (zh)
KR (1) KR20060129170A (zh)
CN (1) CN100532375C (zh)
AR (1) AR046106A1 (zh)
AT (1) ATE405547T1 (zh)
AU (1) AU2004281195B2 (zh)
BR (1) BRPI0415523A (zh)
CA (1) CA2542813C (zh)
DE (3) DE10348298A1 (zh)
DK (1) DK1678130T3 (zh)
ES (1) ES2313126T3 (zh)
HK (1) HK1096960A1 (zh)
HR (1) HRP20080602T3 (zh)
IL (1) IL174950A (zh)
MX (1) MXPA06003958A (zh)
NO (1) NO20062202L (zh)
PL (1) PL1678130T3 (zh)
PT (1) PT1678130E (zh)
RU (1) RU2355685C2 (zh)
SI (1) SI1678130T1 (zh)
TW (1) TWI321564B (zh)
UA (1) UA82907C2 (zh)
WO (1) WO2005037780A2 (zh)
ZA (1) ZA200602788B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006016420D1 (de) * 2005-04-12 2010-10-07 Abbott Products Gmbh Aminoalkylamidomethylsubstituierte 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2h-cromen-6-yl derivate und ihre verwendung als kaliumkanalblocker
US7714150B2 (en) 2005-04-12 2010-05-11 Solvay Pharmaceuticals Gmbh Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
CA2615440A1 (en) * 2005-07-22 2007-02-08 Merck & Co., Inc. Potassium channel inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
NO3175985T3 (zh) 2011-07-01 2018-04-28
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ282172B6 (cs) * 1992-11-30 1997-05-14 Smithkline Beecham Plc Benzpyranové analogy pro léčení úzkosti, mánie, deprese nebo symptomů po přerušení podávání drog nebo léčiv, způsob přípravy těchto sloučenin, jejich použití a farmaceutický prostředek obsahující tyto sloučeniny
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
CA2341678C (en) * 1998-09-01 2009-10-13 Bristol-Myers Squibb Company Potassium channel inhibitors and method
JP2000336085A (ja) * 1999-03-25 2000-12-05 Nissan Chem Ind Ltd クロマン誘導体
AU2830800A (en) * 1999-03-25 2000-10-16 Nissan Chemical Industries Ltd. Chroman derivatives
EP1240147A1 (en) * 1999-12-21 2002-09-18 Icagen, Inc. Potassium channel inhibitors

Also Published As

Publication number Publication date
UA82907C2 (en) 2008-05-26
IL174950A0 (en) 2006-08-20
KR20060129170A (ko) 2006-12-15
AU2004281195A1 (en) 2005-04-28
JP4791968B2 (ja) 2011-10-12
TW200523259A (en) 2005-07-16
CN100532375C (zh) 2009-08-26
HRP20080602T3 (en) 2008-12-31
PT1678130E (pt) 2008-10-08
EP1678130A2 (de) 2006-07-12
DE10348298A1 (de) 2005-05-19
BRPI0415523A (pt) 2006-12-26
EP1678130B1 (de) 2008-08-20
AU2004281195B2 (en) 2010-12-16
TWI321564B (en) 2010-03-11
MXPA06003958A (es) 2006-07-05
DE502004007916D1 (de) 2008-10-02
RU2006116629A (ru) 2007-11-27
SI1678130T1 (sl) 2008-12-31
IL174950A (en) 2010-06-30
CA2542813A1 (en) 2005-04-28
CN1894233A (zh) 2007-01-10
ES2313126T3 (es) 2009-03-01
AU2004281195A2 (en) 2005-04-28
NO20062202L (no) 2006-07-03
DE112004001659D2 (de) 2006-08-10
WO2005037780A3 (de) 2007-10-18
ZA200602788B (en) 2008-01-30
RU2355685C2 (ru) 2009-05-20
HK1096960A1 (en) 2007-06-15
JP2007516235A (ja) 2007-06-21
CA2542813C (en) 2011-08-30
PL1678130T3 (pl) 2009-01-30
AR046106A1 (es) 2005-11-23
ATE405547T1 (de) 2008-09-15
WO2005037780A2 (de) 2005-04-28

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