DK1678119T3 - Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere - Google Patents
Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestereInfo
- Publication number
- DK1678119T3 DK1678119T3 DK04790277.0T DK04790277T DK1678119T3 DK 1678119 T3 DK1678119 T3 DK 1678119T3 DK 04790277 T DK04790277 T DK 04790277T DK 1678119 T3 DK1678119 T3 DK 1678119T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid esters
- sup
- dihalogenacyl
- dihalogenmethyl
- pyrazole
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10349500A DE10349500A1 (de) | 2003-10-23 | 2003-10-23 | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
| PCT/EP2004/011376 WO2005042468A1 (de) | 2003-10-23 | 2004-10-12 | Verfahren zum herstellen von 2-dihalogenacyl-3-amino-acrylsäureestern und 3-dihalogenmethyl-pyrazol-4-carbonsäureestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1678119T3 true DK1678119T3 (da) | 2011-05-02 |
Family
ID=34529740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04790277.0T DK1678119T3 (da) | 2003-10-23 | 2004-10-12 | Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7358387B2 (enExample) |
| EP (1) | EP1678119B1 (enExample) |
| JP (1) | JP4725977B2 (enExample) |
| KR (1) | KR101116686B1 (enExample) |
| CN (1) | CN100422141C (enExample) |
| AT (1) | ATE494274T1 (enExample) |
| BR (1) | BRPI0415855B1 (enExample) |
| DE (2) | DE10349500A1 (enExample) |
| DK (1) | DK1678119T3 (enExample) |
| IL (1) | IL175024A (enExample) |
| IN (1) | IN2006DE01793A (enExample) |
| MX (1) | MXPA06004339A (enExample) |
| TW (1) | TWI363050B (enExample) |
| WO (1) | WO2005042468A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023450A1 (ja) | 2003-08-28 | 2005-03-17 | Universal Can Corporation | ボトル缶の製造装置 |
| DE10352082A1 (de) * | 2003-10-23 | 2005-05-25 | Bayer Cropscience Ag | Hexylcarboxanilide |
| DE102006039909A1 (de) * | 2006-08-25 | 2008-03-13 | Bayer Cropscience Ag | Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten |
| WO2008081711A1 (ja) * | 2006-12-28 | 2008-07-10 | Mitsui Chemicals Agro, Inc. | ２－含フッ素アシル－３－アミノアクリロニトリル誘導体及びその製造方法 |
| JP5260636B2 (ja) * | 2007-05-31 | 2013-08-14 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | ピラゾールを生産するプロセス |
| EP1997808A1 (en) * | 2007-05-31 | 2008-12-03 | Syngeta Participations AG | Process for the production of pyrazoles |
| UA99460C2 (ru) | 2007-06-01 | 2012-08-27 | Басф Се | Способ получения n-замещенных (3-дигалометил-1-метилпиразол-4-ил)карбоксамидов |
| CA2690460A1 (en) * | 2007-06-15 | 2008-12-18 | Markus Nett | Method for producing difluoromethyl-substituted pyrazole compounds |
| EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
| EP2042482A1 (de) * | 2007-09-26 | 2009-04-01 | Bayer CropScience AG | Verfahren zur Herstellung von 2-Dihalogenacyl-3-amino-acrylsäure-Derivaten |
| EP2072497A1 (de) * | 2007-12-21 | 2009-06-24 | Bayer CropScience AG | Verfahren zum Herstellen von 2-Fluoracyl-3-amino-acrylsäure-Derivaten |
| EP2133341A1 (de) * | 2008-02-25 | 2009-12-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten |
| EP2100883A1 (de) | 2008-03-10 | 2009-09-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten |
| WO2009116435A1 (ja) * | 2008-03-18 | 2009-09-24 | 三井化学アグロ株式会社 | 含フッ素アシル酢酸誘導体の製造方法、含フッ素ピラゾールカルボン酸エステル誘導体の製造方法及び含フッ素ピラゾールカルボン酸誘導体の製造方法 |
| JP2009227643A (ja) * | 2008-03-25 | 2009-10-08 | Mitsui Chemicals Agro Inc | 含フッ素アルキルカルボン酸誘導体を利用した含フッ素ピラゾール誘導体の製造方法 |
| BRPI0911897A2 (pt) * | 2008-05-02 | 2015-07-28 | Basf Se | Processo para a preparação de compostos, e, composto |
| AR073932A1 (es) * | 2008-05-02 | 2010-12-15 | Basf Se | Compuestos de esteres de acido 2-(aminometiliden)-4,4-difluoro-3- oxobutirico y procedimiento para su preparacion |
| AU2009243550B2 (en) * | 2008-05-05 | 2014-06-26 | Basf Se | Method for preparing 1,3,4-substituted pyrazol compounds |
| US7601864B1 (en) * | 2008-05-08 | 2009-10-13 | Ufc Corporation | Method for synthesizing 4,4-dihalogen-2-(dialkylamino)methylene-3-oxy-alkylbutyrate and derivatives thereof |
| KR20110031501A (ko) * | 2008-07-21 | 2011-03-28 | 바스프 에스이 | 1,3-이치환된 피라졸카르복실산 에스테르의 제조 방법 |
| KR101700267B1 (ko) | 2008-07-25 | 2017-01-26 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
| JP5228817B2 (ja) * | 2008-11-12 | 2013-07-03 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| PT3617194T (pt) | 2008-12-11 | 2023-11-27 | Shionogi & Co | Processos e intermediários para inibidores carbamoilpiridona da integrase do vih |
| CA2744019C (en) | 2008-12-11 | 2017-03-14 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| BR112012001990B1 (pt) * | 2009-07-28 | 2021-02-23 | Syngenta Participations Ag | processos relacionados à alquilação de pirazóis |
| JP2013510112A (ja) | 2009-11-05 | 2013-03-21 | ビーエーエスエフ ソシエタス・ヨーロピア | アミナールの調製方法及び１，３−二置換ピラゾール化合物を調製するためのその使用 |
| EP2496560B1 (en) * | 2009-11-05 | 2015-04-22 | Basf Se | Process for preparing 1,3-disubstituted pyrazole compounds |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| KR101788794B1 (ko) * | 2010-08-10 | 2017-10-20 | 신젠타 파티서페이션즈 아게 | ３―할로알킬피라졸의 제조방법 |
| JP5605104B2 (ja) * | 2010-09-10 | 2014-10-15 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| JP5915004B2 (ja) * | 2011-06-22 | 2016-05-11 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| US9012657B2 (en) | 2011-06-22 | 2015-04-21 | Central Glass Company, Limited | Method for producing pyrazole compound |
| JP5793983B2 (ja) * | 2011-06-22 | 2015-10-14 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| JP5790195B2 (ja) * | 2011-06-22 | 2015-10-07 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| JP5830957B2 (ja) * | 2011-06-22 | 2015-12-09 | セントラル硝子株式会社 | ピラゾール化合物の製造方法 |
| EP2623496A1 (de) | 2012-02-01 | 2013-08-07 | Bayer CropScience AG | Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen |
| CN102731402A (zh) * | 2012-06-29 | 2012-10-17 | 上海康鹏化学有限公司 | 3-三氟甲基吡唑-4-羧酸和3-二氟甲基吡唑-4-羧酸的制备方法 |
| US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
| WO2014187773A1 (en) | 2013-05-22 | 2014-11-27 | Bayer Cropscience Ag | PROCESS FOR PREPARING 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES |
| JP6518654B2 (ja) | 2013-05-22 | 2019-05-22 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ３，５−ビス（フルオロアルキル）ピラゾール誘導体の製造方法 |
| TWI647215B (zh) * | 2013-11-11 | 2019-01-11 | 德商拜耳作物科學股份有限公司 | 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法 |
| CN104379551B (zh) | 2013-12-09 | 2017-03-08 | 金凯有限责任公司 | 3‑二氟甲基‑1‑甲基‑1h‑吡唑‑4‑羧酸烷基酯及其类似物的制备方法 |
| EP3093284A4 (en) | 2014-01-10 | 2017-02-22 | Asahi Glass Company, Limited | Ethereal oxygen-containing perfluoroalkyl group-substituted pyrazole compound and production method therefor |
| EP3015458A1 (en) | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| JP6431088B2 (ja) * | 2014-03-24 | 2018-11-28 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | α，α−ジハロアミン類およびケチミン類からの３，５−ビス（ハロアルキル）ピラゾール誘導体の製造方法 |
| MX377282B (es) | 2014-06-11 | 2025-03-07 | Bayer Cropscience Ag | Proceso para preparar derivados de 3,5-bis(haloalquil)pirazol por medio de la acilación de hidrazonas. |
| MX383114B (es) | 2014-06-11 | 2025-03-13 | Bayer Cropscience Ag | Proceso para la preparación de 3,5-bis(haloalquil)pirazoles por medio de la acilación de cetiminas. |
| EP2987782A1 (en) | 2014-08-22 | 2016-02-24 | Solvay SA | Distillation process comprising at least two distillation steps to obtain purified halogenated carboxylic acid halide, and use of the purified halogenated carboxylic acid halide |
| US20170340986A1 (en) | 2014-11-17 | 2017-11-30 | Solvay Sa | Distillation process comprising at least two distillation steps to obtain purified halogenated carboxylic acid halide, and use of the purified halogenated carboxylic acid halide |
| CN104529899A (zh) * | 2014-12-19 | 2015-04-22 | 浙江泰达作物科技有限公司 | 高区域选择性制备1-烷基-3-卤代烷基吡唑衍生物的方法 |
| CN105541716B (zh) * | 2015-03-26 | 2024-02-23 | Ａｇｃ株式会社 | 吡唑衍生物的制造方法 |
| KR20160120009A (ko) | 2015-04-07 | 2016-10-17 | (주)부흥산업사 | 4,4-디플루오로-((2-디알킬아미노)메틸렌)-3-옥소부탄산 알킬에스테르의 새로운 제조방법 |
| JP2018520142A (ja) | 2015-06-26 | 2018-07-26 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | α，α−ジハロアルキルアミンとケチミンからハロアルコキシ基及びハロアルキルチオ基を含んでいる置換ピラゾール類を調製する方法 |
| EP3178813A1 (en) | 2015-12-09 | 2017-06-14 | Basf Se | Method for preparing halogenated 3-oxocarboxylates carrying a 2-alkoxymethylidene or a 2-dialkylaminomethylidene group |
| JP2019515938A (ja) * | 2016-05-10 | 2019-06-13 | ソルヴェイ（ソシエテ アノニム） | ３−（ハロアルキルまたはホルミル）−１ｈ−ピラゾール−４−カルボン酸またはエステルを含む組成物、その製造、およびカルボキサミド調製のためのその使用 |
| MX2019003255A (es) | 2016-09-21 | 2019-07-18 | Bayer Cropscience Ag | Proceso para la preparacion de 3-fluoroalquil-5-pirazolcarboxilato s y acidos 3-fluoroalquil-5-pirazolcarboxilicos. |
| US20200407304A1 (en) | 2017-09-04 | 2020-12-31 | Solvay Sa | Process and intermediate for the manufacture of difluoroacetyl chloride |
| CN111116364B (zh) * | 2019-12-30 | 2022-11-11 | 浙江本立科技股份有限公司 | 2-多卤代乙酰基-3-烷氧基丙烯酸酯的制备方法 |
| CN113912541A (zh) * | 2021-10-29 | 2022-01-11 | 南通宝凯药业有限公司 | 一种3-二氟甲基-1-甲基-1h-吡唑-4-羧酸的制备方法 |
| CN114195715B (zh) * | 2021-12-31 | 2024-05-10 | 福建永晶科技股份有限公司 | 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法 |
| CN117447401B (zh) * | 2023-12-26 | 2024-04-19 | 山东国邦药业有限公司 | 一种二氟吡唑酸的合成方法 |
| CN120118034A (zh) * | 2025-05-14 | 2025-06-10 | 辽宁龙田化工科技有限公司 | 一种3-二氟甲基-1-甲基吡唑-4-羧酸的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093347A (en) * | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| US5223526A (en) * | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
| US5498624A (en) * | 1995-05-03 | 1996-03-12 | Monsanto Company | Selected pyrazolyl derivatives |
| KR20000035081A (ko) * | 1998-11-10 | 2000-06-26 | 마크 에스. 아들러 | 2-(트리할로아세틸)-3-(치환된 아미노)-2-프로페노에이트 제조방법 |
| CN1308044A (zh) * | 2000-01-28 | 2001-08-15 | 住友化学工业株式会社 | 二卤代化合物和制备维生素a衍生物的方法 |
| DE10161978A1 (de) * | 2001-12-17 | 2003-06-26 | Bayer Ag | Verfahren zur Herstellung von 2-Halogenacyl-3-amino-acrylsäure-derivate |
-
2003
- 2003-10-23 DE DE10349500A patent/DE10349500A1/de not_active Withdrawn
-
2004
- 2004-10-12 AT AT04790277T patent/ATE494274T1/de active
- 2004-10-12 WO PCT/EP2004/011376 patent/WO2005042468A1/de not_active Ceased
- 2004-10-12 DK DK04790277.0T patent/DK1678119T3/da active
- 2004-10-12 MX MXPA06004339A patent/MXPA06004339A/es active IP Right Grant
- 2004-10-12 DE DE502004012095T patent/DE502004012095D1/de not_active Expired - Lifetime
- 2004-10-12 US US10/576,059 patent/US7358387B2/en not_active Expired - Lifetime
- 2004-10-12 BR BRPI0415855-5B1A patent/BRPI0415855B1/pt not_active IP Right Cessation
- 2004-10-12 EP EP04790277A patent/EP1678119B1/de not_active Expired - Lifetime
- 2004-10-12 KR KR1020067009068A patent/KR101116686B1/ko not_active Expired - Lifetime
- 2004-10-12 JP JP2006535992A patent/JP4725977B2/ja not_active Expired - Lifetime
- 2004-10-12 CN CNB2004800312031A patent/CN100422141C/zh not_active Expired - Lifetime
- 2004-10-22 TW TW093132065A patent/TWI363050B/zh not_active IP Right Cessation
-
2006
- 2006-04-03 IN IN1793DE2006 patent/IN2006DE01793A/en unknown
- 2006-04-20 IL IL175024A patent/IL175024A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP4725977B2 (ja) | 2011-07-13 |
| BRPI0415855B1 (pt) | 2013-11-05 |
| KR101116686B1 (ko) | 2012-02-22 |
| EP1678119B1 (de) | 2011-01-05 |
| TW200526550A (en) | 2005-08-16 |
| JP2007509850A (ja) | 2007-04-19 |
| IL175024A (en) | 2011-05-31 |
| CN1871204A (zh) | 2006-11-29 |
| WO2005042468A1 (de) | 2005-05-12 |
| US20060252944A1 (en) | 2006-11-09 |
| US7358387B2 (en) | 2008-04-15 |
| BRPI0415855A (pt) | 2007-01-09 |
| IN2006DE01793A (enExample) | 2007-08-10 |
| DE502004012095D1 (de) | 2011-02-17 |
| KR20060109901A (ko) | 2006-10-23 |
| CN100422141C (zh) | 2008-10-01 |
| EP1678119A1 (de) | 2006-07-12 |
| DE10349500A1 (de) | 2005-06-02 |
| TWI363050B (en) | 2012-05-01 |
| IL175024A0 (en) | 2006-08-20 |
| ATE494274T1 (de) | 2011-01-15 |
| MXPA06004339A (es) | 2006-06-05 |
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