DK1677797T3 - Salte og polymorfer af en virkningsfuld antidiabetisk forbindelse - Google Patents
Salte og polymorfer af en virkningsfuld antidiabetisk forbindelseInfo
- Publication number
- DK1677797T3 DK1677797T3 DK04794053.1T DK04794053T DK1677797T3 DK 1677797 T3 DK1677797 T3 DK 1677797T3 DK 04794053 T DK04794053 T DK 04794053T DK 1677797 T3 DK1677797 T3 DK 1677797T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymorphs
- salts
- compound
- antidiabetic compound
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50847003P | 2003-10-03 | 2003-10-03 | |
| PCT/US2004/032552 WO2005033074A2 (en) | 2003-10-03 | 2004-10-04 | Salts and polymorphs of a potent antidiabetic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1677797T3 true DK1677797T3 (da) | 2012-06-04 |
Family
ID=34421741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04794053.1T DK1677797T3 (da) | 2003-10-03 | 2004-10-04 | Salte og polymorfer af en virkningsfuld antidiabetisk forbindelse |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7223761B2 (da) |
| EP (1) | EP1677797B1 (da) |
| JP (2) | JP5426813B2 (da) |
| KR (1) | KR101156277B1 (da) |
| CN (1) | CN1886134A (da) |
| AT (1) | ATE546142T1 (da) |
| AU (1) | AU2004278416B2 (da) |
| BR (1) | BRPI0414957A (da) |
| CA (1) | CA2540536C (da) |
| DK (1) | DK1677797T3 (da) |
| EA (1) | EA013367B1 (da) |
| ES (1) | ES2386670T3 (da) |
| IL (1) | IL174728A (da) |
| IS (1) | IS8378A (da) |
| MX (1) | MXPA06003313A (da) |
| NO (1) | NO333002B1 (da) |
| NZ (1) | NZ546783A (da) |
| WO (1) | WO2005033074A2 (da) |
| ZA (1) | ZA200602669B (da) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| AU6118001A (en) | 2000-05-03 | 2001-11-12 | Tularik Inc | Combination therapeutic compositions and methods of use |
| US20030171399A1 (en) * | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| BRPI0620268B8 (pt) * | 2005-12-22 | 2021-05-25 | Oakwood Laboratories LLC | composição eficaz como sistema de fornecimento para liberação controlada, seu uso, seu método de fabricação, e método para proteger um agente biologicamente ativo |
| MX2009002905A (es) * | 2006-09-21 | 2009-06-19 | Piramal Life Sciences Ltd | Derivados de 3-amino-piridina para el tratamiento de trastornos metabolicos. |
| US20130245024A1 (en) * | 2008-03-06 | 2013-09-19 | Dennis Lanfear | Combination of PPARy Agonist and a Dipeptidyl Peptidase-Inhibitor for the Treatment of Diabetes and Obesity |
| WO2010040055A2 (en) * | 2008-10-03 | 2010-04-08 | Intekrin Therapeutics, Inc. | Oral pharmaceutical formulations for antidiabetic compounds |
| WO2011017488A2 (en) * | 2009-08-05 | 2011-02-10 | Intekrin Therapeutics, Inc. | Combination of a selective ppar-gamma modulator and an incretin for the treatment of diabetes and obesity |
| JP6084926B2 (ja) * | 2010-09-21 | 2017-02-22 | インテクリン・セラピユーテイクス・インコーポレイテツド | 抗糖尿病固体医薬組成物 |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| AU2014212740B2 (en) * | 2013-01-30 | 2015-12-24 | Intekrin Therapeutics, Inc. | PPARy agonists for treatment of multiple sclerosis |
| KR20220070057A (ko) | 2015-03-09 | 2022-05-27 | 인테크린 테라퓨틱스, 아이엔씨. | 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법 |
| WO2017178408A1 (en) | 2016-04-15 | 2017-10-19 | Syngenta Participations Ag | Microbiocidal silicon containing aryl derivatives |
| AU2017313842A1 (en) * | 2016-08-18 | 2019-03-07 | Intekrin Therapeutics, Inc. | PPARgamma AGONIST FOR TREATMENT OF BONE DISORDERS |
| CN110461329A (zh) * | 2016-08-18 | 2019-11-15 | 因特克林治疗股份有限公司 | 治疗血癌的PPARγ激动剂 |
| KR20190064583A (ko) * | 2016-09-13 | 2019-06-10 | 인테크린 테라퓨틱스, 아이엔씨. | Chs-131로 다발성 경화증의 치료 |
| EP3570841A4 (en) * | 2017-01-18 | 2020-08-19 | Coherus Biosciences, Inc. | PPARY AGONIST FOR TREATMENT OF HUNTINGTON'S DISEASE |
| MX2019011867A (es) | 2017-04-03 | 2020-01-09 | Coherus Biosciences Inc | Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva. |
| CN109651208B (zh) * | 2017-10-10 | 2022-01-04 | 中国科学院上海药物研究所 | N-芳基磺酰胺类化合物，其药物组合物及其用途 |
| EP3906022A1 (en) | 2018-12-31 | 2021-11-10 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2020205027A1 (en) | 2019-04-02 | 2020-10-08 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2020205026A1 (en) | 2019-04-04 | 2020-10-08 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2020205023A1 (en) | 2019-04-04 | 2020-10-08 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| US20220288054A1 (en) | 2019-04-04 | 2022-09-15 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| EP3946335A1 (en) | 2019-04-04 | 2022-02-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| US20220202804A1 (en) | 2019-05-30 | 2022-06-30 | Coherus Biosciences, Inc. | Compositions and methods to treat cancer |
| EP4045042A1 (en) | 2019-10-15 | 2022-08-24 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2022051321A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
| WO2022051316A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
| WO2022051319A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a dpp-4 inhibitor |
| WO2022051323A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a ppar agonist |
| WO2022051318A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a thyroid receptor beta agonist |
| JP2022104747A (ja) * | 2020-12-29 | 2022-07-11 | 国立研究開発法人国立がん研究センター | 抗ウイルス剤 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2407309A (en) | 1942-02-04 | 1946-09-10 | Squibb & Sons Inc | Chemotherapeutic agents of the sulphonamide type |
| CH361275A (de) | 1957-09-10 | 1962-04-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Arylsulfonarylamiden |
| US3174901A (en) | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| NL138933B (nl) | 1969-03-26 | 1973-05-15 | Erba Carlo Spa | Werkwijze voor het bereiden van benzeensulfonylureumderivaten met bloedsuikerspiegelverlagende werking. |
| US3700773A (en) | 1969-06-25 | 1972-10-24 | Merck & Co Inc | Substituted phenylsulfamyl salicyclic acids and derivatives thereof in the treatment of inflammation |
| US3686192A (en) | 1971-01-04 | 1972-08-22 | Minnesota Mining & Mfg | Substituted pyridine derivatives |
| US4061642A (en) | 1972-06-22 | 1977-12-06 | Cassella Farbwerke Mainkur Ag | 2,4,6-Trisubstituted-3-pyridine carboxamides |
| US4062950A (en) | 1973-09-22 | 1977-12-13 | Bayer Aktiengesellschaft | Amino sugar derivatives |
| US4003734A (en) | 1974-01-22 | 1977-01-18 | The Dow Chemical Company | Substituted pyridinyloxy(thio)phenyl-acetamides, -ureas and urea derivatives and herbicidal compositions and methods containing said compounds |
| CH592411A5 (en) | 1974-04-18 | 1977-10-31 | Ciba Geigy Ag | Phenoxymethyl- and phenylthiomethyl-pyridine derivs - with insecticidal, acaricidal and plant-growth regulating activity |
| US4013621A (en) | 1975-04-29 | 1977-03-22 | Ciba-Geigy Corporation | Substituted sulfonamide derivatives of hindered phenols and stabilized compositions |
| GB2009146B (en) | 1977-11-29 | 1982-03-24 | Ishihara Sangyo Kaisha | Sulphonanilide copmouds and herbicidal compositions therof |
| US4289876A (en) | 1978-11-24 | 1981-09-15 | Bristol-Myers Company | Antisecretory agents |
| JPS5579369A (en) | 1978-12-13 | 1980-06-14 | Ishihara Sangyo Kaisha Ltd | Urea compound, its preparation, and insecticide comprising it |
| EP0069585B1 (en) | 1981-07-06 | 1985-07-03 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Color-forming sulfonamidodiphenylamines, photographic elements containing them and corresponding sulfonimide dyes |
| US4499304A (en) | 1981-07-06 | 1985-02-12 | Eastman Kodak Company | Color-forming sulfonamidodiphenylamines and corresponding sulfonimide dyes |
| US4577028A (en) | 1981-10-20 | 1986-03-18 | Ciba-Geigy Corporation | 5-Haloalkyl-pyridines |
| US4565568A (en) | 1982-06-18 | 1986-01-21 | The Dow Chemical Company | Pyridyl(oxy/thio)phenoxy compounds, herbicidal compositions and methods |
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US4731090A (en) | 1983-12-23 | 1988-03-15 | Ciba-Geigy Corporation | Process for protecting keratinous material from attack by insects feed on keratin with pyridyloxytrifluoromethanesulfonanilides |
| US4549901A (en) | 1984-02-16 | 1985-10-29 | Stauffer Chemical Company | 2-[4-(Substituted aryl)phenoxy]-N-substituted-phenylsulfonyl propionamides having herbicidal properties |
| US4851419A (en) | 1985-10-16 | 1989-07-25 | Fisons Plc | Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity |
| DE3545570A1 (de) | 1985-12-21 | 1987-06-25 | Hoechst Ag | Neue pyridin-derivate und deren n-oxide, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte |
| US4866079A (en) | 1986-03-19 | 1989-09-12 | Ciba-Geigy Corporation | N-pyridyloxyphenylisothioureas and the use thereof in pest control |
| US5202336A (en) | 1986-09-24 | 1993-04-13 | Bayer Aktiengesellschaft | Antiflammatory quinolin methoxy phenylsulphonamides |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| WO1988002367A1 (en) | 1986-09-27 | 1988-04-07 | Fisons Plc | Compounds |
| JPS646245A (en) | 1987-02-20 | 1989-01-10 | Sumitomo Chemical Co | Benzylamine derivative, production thereof and germicide containing said derivative as active ingredient |
| US4670045A (en) | 1987-04-07 | 1987-06-02 | The Dow Chemical Company | Fungicidal control employing ester derivatives of 4,6-disubstituted 2-pyridinols |
| GB8724252D0 (en) | 1987-10-15 | 1987-11-18 | Ici Plc | Fungicides |
| JPS646245U (da) | 1987-06-30 | 1989-01-13 | ||
| JPH01156953A (ja) | 1987-09-01 | 1989-06-20 | Hokko Chem Ind Co Ltd | ベンゼンスルホンアニリド誘導体および農園芸用殺菌剤 |
| DE3852621D1 (de) | 1987-12-07 | 1995-02-09 | Ciba Geigy Ag | 3-Aminobenzoylphenylharnstoffe. |
| DE3823318A1 (de) | 1988-07-09 | 1990-02-22 | Bayer Ag | (hetero)aryloxynaphthaline mit ueber schwefel gebundenen substituenten |
| GB8820115D0 (en) | 1988-08-24 | 1988-09-28 | Ici Plc | Insecticidal compounds |
| DE3905075A1 (de) | 1989-02-18 | 1990-08-30 | Hoechst Ag | Benzolsulfonamide und verfahren zu ihrer herstellung |
| ZA913760B (en) | 1990-05-24 | 1992-02-26 | Sumitomo Chemical Co | Pyridine derivatives,their production processes and their compounds for control of insect pests |
| GB9015658D0 (en) | 1990-07-17 | 1990-09-05 | Shell Int Research | Herbicidal compounds |
| ATE167473T1 (de) | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| NZ239846A (en) | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| JP3188286B2 (ja) | 1991-08-20 | 2001-07-16 | 塩野義製薬株式会社 | フェニルメトキシイミノ化合物およびそれを用いる農業用殺菌剤 |
| US5204354A (en) | 1992-02-14 | 1993-04-20 | Merck & Co., Inc. | Substituted quinazolinones as neurotensin antagonists useful in the treatment of CNS disorders |
| US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
| JPH06199047A (ja) | 1993-01-08 | 1994-07-19 | New Oji Paper Co Ltd | 感熱記録体 |
| US5643914A (en) | 1993-03-02 | 1997-07-01 | Smithkline Beecham Corporation | Pharmaceutical pyridine compounds |
| US5776951A (en) | 1993-06-30 | 1998-07-07 | Glaxo Wellcome Inc. | Anti-atherosclerotic diaryl compounds |
| US5716993A (en) | 1993-12-27 | 1998-02-10 | Eisai Co., Ltd. | Anthranilic acid derivatives |
| US5545669A (en) | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
| US5684195A (en) | 1994-07-14 | 1997-11-04 | G. D. Searle & Co. | Method of preparing sulfmonamides from sulfones |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (da) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
| US5780483A (en) | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| US5814646A (en) | 1995-03-02 | 1998-09-29 | Eli Lilly And Company | Inhibitors of amyloid beta-protein production |
| US5624937A (en) | 1995-03-02 | 1997-04-29 | Eli Lilly And Company | Chemical compounds as inhibitors of amyloid beta protein production |
| US6022897A (en) | 1995-04-25 | 2000-02-08 | The Salk Institute For Biological Studies | Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof |
| US5939442A (en) | 1995-06-07 | 1999-08-17 | The Salk Institute For Biological Studies | Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof |
| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| EP0778267A4 (en) | 1995-06-21 | 2000-04-05 | Otsuka Kagaku Kk | SULFONAMIDE DERIVATIVES INCLUDING INSECTICIDES, MITICIDES AND NEMATICIDES |
| WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| CA2244785C (en) | 1996-02-22 | 2003-12-02 | Tularik, Inc. | Pentafluorobenzenesulfonamides and analogs |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| JPH09255656A (ja) | 1996-03-28 | 1997-09-30 | Hiroyoshi Hidaka | スルフォンアミド誘導体及びこれを含有する医薬 |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| US6294559B1 (en) | 1996-05-02 | 2001-09-25 | Merck & Co., Inc. | Antiproliferative agents associated with peroxisome proliferator activated receptors gamma1 and gamma2 |
| CN1230185A (zh) | 1996-07-13 | 1999-09-29 | 葛兰素集团有限公司 | 双环芳杂环化合物用作蛋白质酪氨酸激酶的抑制剂 |
| JP3243733B2 (ja) | 1996-08-07 | 2002-01-07 | 雪印乳業株式会社 | 新規イソキノリン誘導体 |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| RU2203272C2 (ru) | 1997-02-21 | 2003-04-27 | Байер Акциенгезелльшафт | Замещенные бициклические соединения, исходные и промежуточные продукты для их получения и фармацевтическая композиция на их основе |
| DE69809827D1 (de) | 1997-03-31 | 2003-01-16 | Korea Res Inst Chem Tech | Chinolinische Sulfid-Derivate als NMDA Rezeptor-Antagonisten und Verfahren zu ihrer Herstellung |
| PH11998001072B1 (en) | 1997-05-07 | 2006-11-21 | Univ Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US5981586A (en) | 1997-05-23 | 1999-11-09 | Pershadsingh; Harrihar A. | Methods for treating proliferative and inflammatory skin diseases |
| RU2199532C2 (ru) | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| FR2773075B1 (fr) | 1997-12-31 | 2000-05-05 | Cird Galderma | Utilisation d'activateurs de ppar-gamma en dermatologie |
| US6583157B2 (en) | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| JP4253126B2 (ja) | 1998-01-29 | 2009-04-08 | アムジェン インコーポレイテッド | Ｐｐａｒ−ガンマ調節剤 |
| JP4327915B2 (ja) | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| DE19837627A1 (de) | 1998-08-19 | 2000-02-24 | Bayer Ag | Neue Aminosäureester von Arylsulfonamiden und Analoga |
| HN1998000027A (es) | 1998-08-19 | 1999-06-02 | Bayer Ip Gmbh | Arilsulfonamidas y analagos |
| US6586475B1 (en) | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| US6204288B1 (en) | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| SG148834A1 (en) * | 1999-06-30 | 2009-01-29 | Japan Tobacco Inc | Compounds for the modulation of ppary activity |
| US7041691B1 (en) * | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| CA2325358C (en) | 1999-11-10 | 2005-08-02 | Pfizer Products Inc. | 7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein b |
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| TW533656B (en) | 2000-04-07 | 2003-05-21 | Mirae Corp | Cooling control system of linear motor |
| AU6118001A (en) | 2000-05-03 | 2001-11-12 | Tularik Inc | Combination therapeutic compositions and methods of use |
| BRPI0112115B8 (pt) * | 2000-06-28 | 2021-05-25 | Japan Tobacco Inc | compostos moduladores ppar-gamma de quinolinil e benzotiazolil |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| EP1344525A4 (en) | 2000-12-22 | 2005-05-25 | Ishihara Sangyo Kaisha | ANILINE DERIVATIVES OR ITS SALTS AND CYTOKINE PRODUCTION INHIBITORS CONTAINING THEM |
| GB2373725A (en) | 2001-03-30 | 2002-10-02 | Novartis Ag | Use of a PPAR gamma agonist in the production of a medicament for the prevention or treatment of diseases associated with IL-10 production |
| US7223761B2 (en) * | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| EP1722789A2 (en) | 2004-03-08 | 2006-11-22 | Amgen Inc. | Therapeutic modulation of ppar (gamma) activity |
-
2004
- 2004-10-01 US US10/956,251 patent/US7223761B2/en active Active
- 2004-10-04 WO PCT/US2004/032552 patent/WO2005033074A2/en active Application Filing
- 2004-10-04 CA CA2540536A patent/CA2540536C/en active Active
- 2004-10-04 JP JP2006534205A patent/JP5426813B2/ja not_active Expired - Fee Related
- 2004-10-04 ES ES04794053T patent/ES2386670T3/es active Active
- 2004-10-04 KR KR1020067008440A patent/KR101156277B1/ko not_active IP Right Cessation
- 2004-10-04 DK DK04794053.1T patent/DK1677797T3/da active
- 2004-10-04 BR BRPI0414957-2A patent/BRPI0414957A/pt not_active IP Right Cessation
- 2004-10-04 NZ NZ546783A patent/NZ546783A/en not_active IP Right Cessation
- 2004-10-04 ZA ZA200602669A patent/ZA200602669B/en unknown
- 2004-10-04 CN CNA2004800346697A patent/CN1886134A/zh active Pending
- 2004-10-04 MX MXPA06003313A patent/MXPA06003313A/es active IP Right Grant
- 2004-10-04 EP EP04794053A patent/EP1677797B1/en active Active
- 2004-10-04 EA EA200600701A patent/EA013367B1/ru not_active IP Right Cessation
- 2004-10-04 AT AT04794053T patent/ATE546142T1/de active
- 2004-10-04 AU AU2004278416A patent/AU2004278416B2/en not_active Ceased
-
2006
- 2006-03-27 IS IS8378A patent/IS8378A/is unknown
- 2006-04-02 IL IL174728A patent/IL174728A/en active IP Right Review Request
- 2006-05-03 NO NO20061974A patent/NO333002B1/no not_active IP Right Cessation
-
2007
- 2007-05-24 US US11/807,208 patent/US8003665B2/en active Active
-
2011
- 2011-12-02 JP JP2011264219A patent/JP2012097090A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1677797A4 (en) | 2009-03-25 |
| NO20061974L (no) | 2006-07-03 |
| EP1677797B1 (en) | 2012-02-22 |
| IS8378A (is) | 2006-03-27 |
| JP5426813B2 (ja) | 2014-02-26 |
| IL174728A (en) | 2011-06-30 |
| WO2005033074A3 (en) | 2005-06-16 |
| NZ546783A (en) | 2008-11-28 |
| EA013367B1 (ru) | 2010-04-30 |
| KR101156277B1 (ko) | 2012-07-05 |
| BRPI0414957A (pt) | 2006-11-07 |
| JP2007507537A (ja) | 2007-03-29 |
| MXPA06003313A (es) | 2006-06-08 |
| AU2004278416A1 (en) | 2005-04-14 |
| ES2386670T3 (es) | 2012-08-24 |
| EA200600701A1 (ru) | 2006-10-27 |
| CA2540536C (en) | 2013-07-02 |
| ATE546142T1 (de) | 2012-03-15 |
| US20070293536A1 (en) | 2007-12-20 |
| CA2540536A1 (en) | 2005-04-14 |
| ZA200602669B (en) | 2007-07-25 |
| US8003665B2 (en) | 2011-08-23 |
| US20050143416A1 (en) | 2005-06-30 |
| JP2012097090A (ja) | 2012-05-24 |
| CN1886134A (zh) | 2006-12-27 |
| AU2004278416B2 (en) | 2010-04-15 |
| EP1677797A2 (en) | 2006-07-12 |
| KR20060097121A (ko) | 2006-09-13 |
| WO2005033074A2 (en) | 2005-04-14 |
| US7223761B2 (en) | 2007-05-29 |
| NO333002B1 (no) | 2013-02-11 |
| IL174728A0 (en) | 2006-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1677797T3 (da) | Salte og polymorfer af en virkningsfuld antidiabetisk forbindelse | |
| EA200700757A1 (ru) | Замещённые дипиперидиновые антагонисты ccr2 | |
| CY1109529T1 (el) | 2-(αμινο-υποκατεστημενες)-4-αρυλο πυραμιδινες και σχετικες ενωσεις που χρησιμευουν στην αγωγη φλεγμονωδων νοσηματων | |
| MX2009001327A (es) | Compuestos de indol. | |
| DK1532974T3 (da) | Sammensætning, der omfatter 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthsyre, til behandling af dermatologiske lidelser | |
| ECSP045081A (es) | Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y trastornos relacionados | |
| DK1861100T3 (da) | 3,11B-cis-dihydrotetrabenazin til behandling af en profilerativ sygdom eller en inflammation | |
| NO20082594L (no) | Pyrimidinylbenzotiofenforbindelser | |
| CL2008002042A1 (es) | Compuestos derivados de heterociclos nitrogenados enlazados; y su uso en el tratamiento de la diabetes y desordenes metabolicos. | |
| CL2012002526A1 (es) | Uso de compuestos inhibidores de dpp iv de formula (i) o (ii) o una de sus sales, para el tratamiento de falla cardiaca. | |
| WO2005112921A3 (en) | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | |
| ATE546439T1 (de) | Heterocyclische modulatoren der glucocorticoidrezeptor-, ap-1- und/oder nf-kb- aktivität und deren verwendung | |
| PA8555401A1 (es) | Derivados de quinolina | |
| IN2015DN00502A (da) | ||
| NI200700221A (es) | Antagonistas receptor pgd2 para el tratamiento de enfermedades inflamatorias | |
| DK2380584T3 (da) | Immunstimulerende fremgangsmåde | |
| CY1113314T1 (el) | (3-αρυλ-πιπεραζιν-1-υλ) παραγωγα της 6,7-διαλκοξυκιναζολινης, 6,7-διαλκοξυφθαλαζινης και 6,7-διαλκοξυϊσοκινολινης | |
| ECSP066883A (es) | Derivados de heteroarilaminopirazol utiles para el tratamiento de la diabetes | |
| DK1959988T3 (da) | Anvendelse af bovint lactoferrin til behandling af destruktiv inflammation af slimhinder | |
| BRPI0417858A (pt) | composto, composição farmacêutica, e, uso de uma composição farmacêutica | |
| WO2010040055A3 (en) | Oral pharmaceutical formulations for antidiabetic compounds | |
| NO20053714L (no) | Aminosyre fenoksyestere | |
| CO6321285A2 (es) | Uso de 3,11b-cis- dihidrotetrabenazina en el tratamiento de la esclerosis multiple y la mielitis autoinmunitaria | |
| DK1871380T3 (da) | Kombineret anvendelse af prostaglandinforbindelse og protonpumpeinhibitor til behandlingen af gastrointestinale lidelser | |
| UY28098A1 (es) | Derivados de anilinopirazol útiles en el tratamiento de la diabetes |