DK167342B1 - Terapeutisk praeparat til behandling af virussygdomme samt anvendelse af et 9-(fosfonylmetoxyalkyl)adeninderivat til fremstilling af praeparatet - Google Patents

Terapeutisk praeparat til behandling af virussygdomme samt anvendelse af et 9-(fosfonylmetoxyalkyl)adeninderivat til fremstilling af praeparatet Download PDF

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Publication number
DK167342B1
DK167342B1 DK184186A DK184186A DK167342B1 DK 167342 B1 DK167342 B1 DK 167342B1 DK 184186 A DK184186 A DK 184186A DK 184186 A DK184186 A DK 184186A DK 167342 B1 DK167342 B1 DK 167342B1
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Prior art keywords
preparation
compounds
formula
compound
treatment
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DK184186A
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Danish (da)
English (en)
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DK184186D0 (da
DK184186A (da
Inventor
Erik De Clercq
Antonin Holy
Ivan Rosenberg
Original Assignee
Stichting Rega V Z W
Ceskoslovenska Akademie Ved
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Application filed by Stichting Rega V Z W, Ceskoslovenska Akademie Ved filed Critical Stichting Rega V Z W
Publication of DK184186D0 publication Critical patent/DK184186D0/da
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK184186A 1985-04-25 1986-04-22 Terapeutisk praeparat til behandling af virussygdomme samt anvendelse af et 9-(fosfonylmetoxyalkyl)adeninderivat til fremstilling af praeparatet DK167342B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS301885 1985-04-25
CS853018A CS263952B1 (en) 1985-04-25 1985-04-25 Remedy with antiviral effect

Publications (3)

Publication Number Publication Date
DK184186D0 DK184186D0 (da) 1986-04-22
DK184186A DK184186A (da) 1986-10-26
DK167342B1 true DK167342B1 (da) 1993-10-18

Family

ID=5369042

Family Applications (1)

Application Number Title Priority Date Filing Date
DK184186A DK167342B1 (da) 1985-04-25 1986-04-22 Terapeutisk praeparat til behandling af virussygdomme samt anvendelse af et 9-(fosfonylmetoxyalkyl)adeninderivat til fremstilling af praeparatet

Country Status (17)

Country Link
US (1) US4724233A (fr)
EP (1) EP0205826B1 (fr)
JP (1) JPH0692307B2 (fr)
AT (1) ATE73663T1 (fr)
AU (1) AU586860B2 (fr)
CA (1) CA1272956A (fr)
CS (1) CS263952B1 (fr)
DE (1) DE3684363D1 (fr)
DK (1) DK167342B1 (fr)
EG (1) EG18436A (fr)
GR (1) GR861089B (fr)
HK (1) HK217296A (fr)
IL (1) IL78553A (fr)
NZ (1) NZ215939A (fr)
PH (1) PH23112A (fr)
PT (1) PT82457B (fr)
ZA (1) ZA863133B (fr)

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US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
ES2118069T3 (es) * 1990-09-14 1998-09-16 Acad Of Science Czech Republic Profarmacos de fosfonatos.
KR0184530B1 (ko) * 1991-10-11 1999-05-15 카렐 마르티넥 항비루스 비고리 포스포노메톡시알킬치환, 알켄일 및 알킨일 퓨린 및 피리미딘 유도체
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
KR100386685B1 (ko) * 1993-09-17 2003-12-31 길리애드 사이언시즈, 인코포레이티드 뉴클레오타이드동족체류
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
NZ283658A (en) * 1994-04-04 1999-09-29 William R Freeman Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides)
US5468752A (en) * 1994-04-04 1995-11-21 Freeman; William R. Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6635278B1 (en) 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
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NZ535408A (en) 2000-07-21 2006-09-29 Gilead Sciences Inc Method for selecting prodrugs of phosphonate nucleotide analogues
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CA2485597C (fr) * 2002-05-13 2013-07-02 Metabasis Therapeutics, Inc. Procede destine a la preparation de promedicaments cycliques de la pmea et de la pmpa
WO2004037161A2 (fr) * 2002-05-13 2004-05-06 Metabasis Therapeutics, Inc. Nouveaux pro-medicaments de pmea et de ses analogues, a base d'acide phosphonique
KR20050086519A (ko) * 2002-11-12 2005-08-30 티안진 킨슬리 파마슈티컬 컴퍼니 리미티드 새로운 결정 형태를 가진 아데포비어 디피복실 및 그조성물
CN105596356A (zh) 2003-01-14 2016-05-25 吉里德科学公司 用于联合抗病毒治疗的组合物和方法
DK1644389T3 (da) 2003-06-16 2011-05-09 Acad Of Science Czech Republic Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
EP1753762B1 (fr) * 2004-06-08 2014-03-19 Metabasis Therapeutics, Inc. Synthese d'esters cycliques induite par l'acide de lewis
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9－[2－(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
PL216369B1 (pl) 2004-07-27 2014-03-31 Gilead Sciences Pochodne fosfonianowe, kompozycje farmaceutyczne zawierające te pochodne oraz zastosowanie tych pochodnych do wytwarzania leku do hamowania wirusa HIV
US8101745B2 (en) * 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
WO2006130217A2 (fr) * 2005-04-01 2006-12-07 The Regents Of The University Of California Esters de phosphate de phosphonates de nucleosides substitues
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
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WO2014143643A1 (fr) 2013-03-15 2014-09-18 The Regents Of The University Of California, A California Corporation Diesters phosphonates nucléosidiques acycliques
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CS238038B1 (en) * 1983-10-07 1985-11-13 Antonin Holy Medical drug with antivirus effect

Also Published As

Publication number Publication date
CA1272956A (fr) 1990-08-21
NZ215939A (en) 1988-09-29
AU586860B2 (en) 1989-07-27
PT82457B (pt) 1988-03-03
JPS61275218A (ja) 1986-12-05
PT82457A (en) 1986-05-01
ZA863133B (en) 1987-02-25
IL78553A (en) 1989-09-28
EP0205826A2 (fr) 1986-12-30
JPH0692307B2 (ja) 1994-11-16
DE3684363D1 (de) 1992-04-23
DK184186D0 (da) 1986-04-22
GR861089B (en) 1986-08-26
EG18436A (en) 1993-02-28
AU5646886A (en) 1986-10-30
EP0205826A3 (en) 1989-05-10
PH23112A (en) 1989-04-19
ATE73663T1 (de) 1992-04-15
EP0205826B1 (fr) 1992-03-18
CS263952B1 (en) 1989-05-12
IL78553A0 (en) 1986-08-31
DK184186A (da) 1986-10-26
US4724233A (en) 1988-02-09
HK217296A (en) 1996-12-27

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B1 Patent granted (law 1993)
PUP Patent expired