IL78553A - Therapeutic compositions of phosphonylmethoxyalkyl adenines - Google Patents
Therapeutic compositions of phosphonylmethoxyalkyl adeninesInfo
- Publication number
- IL78553A IL78553A IL78553A IL7855386A IL78553A IL 78553 A IL78553 A IL 78553A IL 78553 A IL78553 A IL 78553A IL 7855386 A IL7855386 A IL 7855386A IL 78553 A IL78553 A IL 78553A
- Authority
- IL
- Israel
- Prior art keywords
- phosphonylmethoxyalkyl
- adenines
- therapeutic compositions
- salts
- human
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS853018A CS263952B1 (en) | 1985-04-25 | 1985-04-25 | Remedy with antiviral effect |
Publications (2)
Publication Number | Publication Date |
---|---|
IL78553A0 IL78553A0 (en) | 1986-08-31 |
IL78553A true IL78553A (en) | 1989-09-28 |
Family
ID=5369042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL78553A IL78553A (en) | 1985-04-25 | 1986-04-21 | Therapeutic compositions of phosphonylmethoxyalkyl adenines |
Country Status (17)
Country | Link |
---|---|
US (1) | US4724233A (xx) |
EP (1) | EP0205826B1 (xx) |
JP (1) | JPH0692307B2 (xx) |
AT (1) | ATE73663T1 (xx) |
AU (1) | AU586860B2 (xx) |
CA (1) | CA1272956A (xx) |
CS (1) | CS263952B1 (xx) |
DE (1) | DE3684363D1 (xx) |
DK (1) | DK167342B1 (xx) |
EG (1) | EG18436A (xx) |
GR (1) | GR861089B (xx) |
HK (1) | HK217296A (xx) |
IL (1) | IL78553A (xx) |
NZ (1) | NZ215939A (xx) |
PH (1) | PH23112A (xx) |
PT (1) | PT82457B (xx) |
ZA (1) | ZA863133B (xx) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
US5650510A (en) * | 1986-11-18 | 1997-07-22 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives |
NZ222553A (en) * | 1986-11-18 | 1991-07-26 | Bristol Myers Co | Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions |
US5284837A (en) * | 1988-05-06 | 1994-02-08 | Medivir Ab | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
EP0353955A3 (en) * | 1988-08-02 | 1991-08-14 | Beecham Group Plc | Novel compounds |
US5688778A (en) * | 1989-05-15 | 1997-11-18 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Nucleoside analogs |
US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
EP0481214B1 (en) * | 1990-09-14 | 1998-06-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Prodrugs of phosphonates |
ATE151432T1 (de) * | 1991-10-11 | 1997-04-15 | Acad Of Science Czech Republic | Antivirale acyclische phosphonomethoxyalkyl substituierte, alkenyl und alkynyl purin und pyrimidin-derivate |
US6057305A (en) | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
US5514798A (en) * | 1993-06-02 | 1996-05-07 | Gilead Sciences, Inc. | Method and cyclic carbonates for nucleotide analogues |
US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
KR100386685B1 (ko) * | 1993-09-17 | 2003-12-31 | 길리애드 사이언시즈, 인코포레이티드 | 뉴클레오타이드동족체류 |
EP0754046A1 (en) * | 1994-04-04 | 1997-01-22 | FREEMAN, William R. | Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure |
US5468752A (en) * | 1994-04-04 | 1995-11-21 | Freeman; William R. | Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines |
US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
US6093816A (en) | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
TWI230618B (en) * | 1998-12-15 | 2005-04-11 | Gilead Sciences Inc | Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same |
US6635278B1 (en) | 1998-12-15 | 2003-10-21 | Gilead Sciences, Inc. | Pharmaceutical formulations |
US7205404B1 (en) * | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
AU3540101A (en) * | 2000-01-07 | 2001-07-16 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
CN1291994C (zh) | 2000-07-21 | 2006-12-27 | 吉里德科学公司 | 核苷酸膦酸酯类似物前药及其筛选和制备方法 |
CA2452036C (en) | 2001-06-29 | 2009-09-29 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | 6-'2-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity |
EP1504014B1 (en) * | 2002-05-13 | 2015-12-02 | Metabasis Therapeutics, Inc. | Process for preparation of cyclic prodrugs of pmea and pmpa |
AU2003299492B2 (en) * | 2002-05-13 | 2010-06-10 | Metabasis Therapeutics, Inc. | Cyclic prodrugs of PMEA one of its analogues |
GB2413556B (en) * | 2002-11-12 | 2007-03-14 | Tianjin Kinsly Pharmaceutical | A new crystal form of adefovir dipivoxil and its composition |
KR20090053867A (ko) | 2003-01-14 | 2009-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 복합 항바이러스 치료를 위한 조성물 및 방법 |
EA011948B1 (ru) | 2003-06-16 | 2009-06-30 | Инститьют Оф Оргэник Кемистри Энд Байокемистри, Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик | Фосфонатзамещенные пиримидиновые соединения (варианты), способ их получения (варианты), фармацевтическая композиция на их основе и способ лечения вирусной инфекции |
JP5142716B2 (ja) * | 2004-06-08 | 2013-02-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | サイクリックエステルのルイス酸介在合成法 |
CN100338080C (zh) * | 2004-06-16 | 2007-09-19 | 山东中科泰斗化学有限公司 | 9-[2-(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法 |
ES2363160T3 (es) | 2004-07-27 | 2011-07-22 | Gilead Sciences, Inc. | Conjugados de fosfonato nucelosidico como agentes anti-vih. |
EP1831235B1 (en) | 2004-12-16 | 2013-02-20 | The Regents of The University of California | Lung-targeted drugs |
WO2006130217A2 (en) * | 2005-04-01 | 2006-12-07 | The Regents Of The University Of California | Substituted phosphate esters of nucleoside phosphonates |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
FR2908133B1 (fr) * | 2006-11-08 | 2012-12-14 | Centre Nat Rech Scient | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
EP2514750B1 (en) | 2007-06-18 | 2013-11-20 | Sunshine Lake Pharma Co., Ltd | Bromo-phenyl substituted thiazolyl dihydropyrimidines |
TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
TW201639852A (zh) | 2008-12-09 | 2016-11-16 | 吉李德科學股份有限公司 | 用於製備可用作類鐸受體調節劑之化合物的中間體化合物 |
US9169257B2 (en) | 2009-03-26 | 2015-10-27 | Daewoong Pharmaceutical Co., Ltd. | Crystal forms of adefovir dipivoxil and processes for preparing the same |
US20110223131A1 (en) | 2010-02-24 | 2011-09-15 | Gilead Sciences, Inc. | Antiviral compounds |
MX2013006127A (es) | 2010-12-10 | 2013-09-26 | Sigmapharm Lab Llc | Composiciones sumamente estables de analogos nucleotidicoas oralmente activos o profarmacos analogos nucleotidicos oralmente activos. |
EP3401320B1 (en) | 2013-03-15 | 2020-05-13 | The Regents of the University of California | Acyclic nucleoside phosphonate diesters for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia |
WO2015038421A1 (en) | 2013-09-10 | 2015-03-19 | Dow Corning Corporation | Wear-resistant silicon eutectic alloy components and methods of making the same |
AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
WO2015195538A1 (en) | 2014-06-17 | 2015-12-23 | Dow Corning Corporation | Decorative shape-cast articles made from silicon eutectic alloys, and methods for producing the same |
WO2016001907A1 (en) | 2014-07-02 | 2016-01-07 | Prendergast Patrick T | Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents. |
EP3164136A4 (en) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
MX2017000026A (es) | 2014-07-11 | 2017-05-01 | Gilead Sciences Inc | Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih). |
RS63250B1 (sr) | 2014-09-15 | 2022-06-30 | Univ California | Nukleotidni analozi |
US10377782B2 (en) | 2015-09-15 | 2019-08-13 | The Regents Of The University Of California | Nucleotide analogs |
CA2997955A1 (en) | 2015-09-15 | 2017-03-23 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
EP3372227A1 (en) | 2017-03-06 | 2018-09-12 | MH10 Spolka z ograniczona odpowiedzialnoscia | Tablet formulation of adefovir dipivoxil |
AU2019207625A1 (en) | 2018-01-09 | 2020-07-30 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
JPS52105195A (en) * | 1976-03-01 | 1977-09-03 | Wellcome Found | Substituted purine |
US4230708A (en) * | 1977-10-20 | 1980-10-28 | Stichting Rega V.Z.W. | Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents |
CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
CS238038B1 (en) * | 1983-10-07 | 1985-11-13 | Antonin Holy | Medical drug with antivirus effect |
-
1985
- 1985-04-25 CS CS853018A patent/CS263952B1/cs not_active IP Right Cessation
-
1986
- 1986-04-21 IL IL78553A patent/IL78553A/xx not_active IP Right Cessation
- 1986-04-21 US US06/854,087 patent/US4724233A/en not_active Expired - Lifetime
- 1986-04-22 DK DK184186A patent/DK167342B1/da not_active IP Right Cessation
- 1986-04-22 AU AU56468/86A patent/AU586860B2/en not_active Ceased
- 1986-04-24 EG EG241/86A patent/EG18436A/xx active
- 1986-04-24 PH PH33699A patent/PH23112A/en unknown
- 1986-04-24 GR GR861089A patent/GR861089B/el unknown
- 1986-04-24 PT PT82457A patent/PT82457B/pt unknown
- 1986-04-24 CA CA000507510A patent/CA1272956A/en not_active Expired - Lifetime
- 1986-04-24 NZ NZ215939A patent/NZ215939A/xx unknown
- 1986-04-25 JP JP61097811A patent/JPH0692307B2/ja not_active Expired - Lifetime
- 1986-04-25 ZA ZA863133A patent/ZA863133B/xx unknown
- 1986-04-25 EP EP86105776A patent/EP0205826B1/en not_active Expired - Lifetime
- 1986-04-25 DE DE8686105776T patent/DE3684363D1/de not_active Expired - Lifetime
- 1986-04-25 AT AT86105776T patent/ATE73663T1/de not_active IP Right Cessation
-
1996
- 1996-12-19 HK HK217296A patent/HK217296A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK184186D0 (da) | 1986-04-22 |
ZA863133B (en) | 1987-02-25 |
PH23112A (en) | 1989-04-19 |
PT82457A (en) | 1986-05-01 |
NZ215939A (en) | 1988-09-29 |
DK167342B1 (da) | 1993-10-18 |
JPS61275218A (ja) | 1986-12-05 |
CA1272956A (en) | 1990-08-21 |
EG18436A (en) | 1993-02-28 |
IL78553A0 (en) | 1986-08-31 |
GR861089B (en) | 1986-08-26 |
EP0205826A2 (en) | 1986-12-30 |
CS263952B1 (en) | 1989-05-12 |
HK217296A (en) | 1996-12-27 |
AU586860B2 (en) | 1989-07-27 |
EP0205826A3 (en) | 1989-05-10 |
US4724233A (en) | 1988-02-09 |
PT82457B (pt) | 1988-03-03 |
ATE73663T1 (de) | 1992-04-15 |
AU5646886A (en) | 1986-10-30 |
EP0205826B1 (en) | 1992-03-18 |
DK184186A (da) | 1986-10-26 |
JPH0692307B2 (ja) | 1994-11-16 |
DE3684363D1 (de) | 1992-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
HP | Change in proprietorship | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |