DK1663287T3 - Anvendelse af modificerede cyclosporiner til behandling af HCV-sygdomme - Google Patents
Anvendelse af modificerede cyclosporiner til behandling af HCV-sygdommeInfo
- Publication number
- DK1663287T3 DK1663287T3 DK04764762T DK04764762T DK1663287T3 DK 1663287 T3 DK1663287 T3 DK 1663287T3 DK 04764762 T DK04764762 T DK 04764762T DK 04764762 T DK04764762 T DK 04764762T DK 1663287 T3 DK1663287 T3 DK 1663287T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- cyclosporins
- hcv diseases
- hcv
- modified
- Prior art date
Links
- 108010036941 Cyclosporins Proteins 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0320638.0A GB0320638D0 (en) | 2003-09-03 | 2003-09-03 | Organic compounds |
| PCT/EP2004/009804 WO2005021028A1 (fr) | 2003-09-03 | 2004-09-02 | Utilisation de cyclosporines pour le traitement des troubles lies au vhc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1663287T3 true DK1663287T3 (da) | 2009-11-09 |
Family
ID=28686843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04764762T DK1663287T3 (da) | 2003-09-03 | 2004-09-02 | Anvendelse af modificerede cyclosporiner til behandling af HCV-sygdomme |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7968518B2 (fr) |
| EP (2) | EP1797892B1 (fr) |
| JP (1) | JP4688806B2 (fr) |
| KR (1) | KR101116968B1 (fr) |
| CN (1) | CN1842343A (fr) |
| AU (2) | AU2004268382A1 (fr) |
| BR (1) | BRPI0414062B8 (fr) |
| CA (1) | CA2537137C (fr) |
| CY (1) | CY1110506T1 (fr) |
| DE (1) | DE602004022061D1 (fr) |
| DK (1) | DK1663287T3 (fr) |
| ES (1) | ES2328361T3 (fr) |
| GB (1) | GB0320638D0 (fr) |
| HR (1) | HRP20090535T1 (fr) |
| IL (1) | IL173909A (fr) |
| IS (1) | IS2917B (fr) |
| MA (1) | MA28032A1 (fr) |
| MX (1) | MXPA06002394A (fr) |
| NO (1) | NO20061479L (fr) |
| NZ (1) | NZ545495A (fr) |
| PL (1) | PL1663287T3 (fr) |
| PT (1) | PT1663287E (fr) |
| RU (1) | RU2389501C2 (fr) |
| SG (1) | SG149063A1 (fr) |
| SI (1) | SI1663287T1 (fr) |
| TN (1) | TNSN06071A1 (fr) |
| TW (1) | TWI342782B (fr) |
| WO (1) | WO2005021028A1 (fr) |
| ZA (1) | ZA200601550B (fr) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU759480B2 (en) | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
| JP2006524232A (ja) | 2003-03-17 | 2006-10-26 | アルバニー モレキュラー リサーチ インコーポレーティッド | 新規サイクロスポリン |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) * | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| US7671017B2 (en) | 2004-07-14 | 2010-03-02 | Novartis Ag | Use of a combination of cyclosporine and pegylated interferon for treating hepatitis C (HCV) |
| WO2006039164A2 (fr) | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Nouveaux analogues de la cyclosporine et leurs utilisations pharmaceutiques |
| EP1809656A4 (fr) | 2004-09-29 | 2009-03-25 | Amr Technology Inc | Analogues d'alcyne de cyclosporine et utilisations pharmaceutiques de ceux-ci |
| MX2007003387A (es) * | 2004-10-01 | 2007-05-23 | Debiopharm Sa | Uso de [d-meala]3-[etval]4-ciclosporina para el tratamiento de infeccion por hepatitis c y composicion farmaceutica que comprende la [d-meala]3-[etval]4-ciclosporina. |
| US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| CA2583494C (fr) * | 2004-10-01 | 2014-01-21 | Scynexis, Inc. | Derives de cyclosporine 3-ether et 3-thioether substitues utilises dans le traitement et la prevention d'une infection par hepatite c |
| US7361636B2 (en) | 2004-10-06 | 2008-04-22 | Amr Technology, Inc. | Cyclosporin alkynes and their utility as pharmaceutical agents |
| DE602005010607D1 (de) | 2004-11-22 | 2008-12-04 | Astellas Pharma Inc | Zyklosporinanalog |
| KR20070089954A (ko) * | 2004-12-23 | 2007-09-04 | 노파르티스 아게 | 플라비비리대 치료용 화합물 |
| RU2007128099A (ru) | 2004-12-23 | 2009-01-27 | Новартис АГ (CH) | Композиции для лечения гепатита с |
| MX2007016068A (es) | 2005-06-17 | 2008-03-10 | Novartis Ag | Uso de sanglifehrina en hcv. |
| CN101316606B (zh) * | 2005-09-30 | 2015-05-27 | 西尼克斯公司 | 治疗和预防丙型肝炎感染的方法和药物组合物 |
| JP5322647B2 (ja) * | 2005-09-30 | 2013-10-23 | スシネキス インク | ウイルス感染の治療及び予防のためのシクロスポリンaのアリールアルキル及びヘテロアリールアルキル誘導体 |
| JP5517454B2 (ja) * | 2005-09-30 | 2014-06-11 | スシネキス インク | C型肝炎感染の治療及び予防のための方法及び医薬組成物 |
| AU2006306974B2 (en) | 2005-10-26 | 2011-09-22 | Astellas Pharma Inc. | New cyclic peptide compounds |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| ATE502633T1 (de) | 2006-05-19 | 2011-04-15 | Scynexis Inc | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen |
| CN101502196A (zh) * | 2006-06-02 | 2009-08-05 | 克洛德·安妮·佩里西恩 | 激活电子的管理 |
| CN101557819A (zh) * | 2006-10-12 | 2009-10-14 | 诺瓦提斯公司 | 修饰的环孢素的用途 |
| US7576057B2 (en) | 2006-11-20 | 2009-08-18 | Scynexis, Inc. | Cyclic peptides |
| US8450281B2 (en) * | 2007-01-04 | 2013-05-28 | Debiopharm S.A. | Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy |
| ES2396170T3 (es) * | 2007-05-02 | 2013-02-19 | Astellas Pharma Inc. | Nuevos compuestos péptídicos ciclicos |
| EP2193807A4 (fr) * | 2007-08-24 | 2012-09-12 | Univ Sapporo Medical | Protéine de liaison à la cyclosporine a |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| CN102083852A (zh) * | 2008-06-06 | 2011-06-01 | 西尼克斯公司 | 环孢菌素类似物及其在治疗hcv感染中的应用 |
| JP5726733B2 (ja) * | 2008-07-30 | 2015-06-03 | シクロフィリン ファーマシューティカルズ コープ. | 非免疫抑制性シクロスポリン類似体分子 |
| CN102164947A (zh) * | 2008-09-24 | 2011-08-24 | 安斯泰来制药有限公司 | 肽化合物及其制备方法 |
| WO2010052559A1 (fr) * | 2008-11-06 | 2010-05-14 | Debio Recherche Pharmaceutique S.A. | Composés de cycloundeca depsipeptides et leur utilisation comme médicament. |
| JP5780969B2 (ja) * | 2008-12-31 | 2015-09-16 | サイネクシス,インコーポレーテッド | シクロスポリンaの誘導体 |
| US8367618B2 (en) * | 2009-01-30 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US20110117055A1 (en) | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
| CN102869367A (zh) | 2009-12-09 | 2013-01-09 | 西尼克斯公司 | 新颖的环肽 |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| WO2012045704A1 (fr) | 2010-10-05 | 2012-04-12 | Novartis Ag | Nouveaux traitements d'une infection par le virus de l'hépatite c |
| US20130251678A1 (en) | 2010-11-30 | 2013-09-26 | Novartis Ag | Bid dosage regimen for deb025 |
| JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| HRP20190096T1 (hr) | 2010-12-15 | 2019-02-22 | Contravir Pharmaceuticals, Inc. | Molekule analoga ciklosporina modificirani na amino kiselini 1 i 3 |
| KR20140007927A (ko) | 2011-03-31 | 2014-01-20 | 노파르티스 아게 | C형 간염 바이러스 감염을 치료하기 위한 알리스포리비르 |
| BR112013024809A2 (pt) | 2011-04-01 | 2016-09-06 | Novartis Ag | tratamento para infecção com vírus de hepatite b sozinho ou em combinação com vírus de hepatite delta e doenças do fígado associadas |
| SG10201602184TA (en) | 2011-04-13 | 2016-04-28 | Novartis Ag | Treatment of hepatitis c virus infection with alisporivir |
| CA2850052A1 (fr) | 2011-09-27 | 2013-04-04 | Novartis Ag | Alisporivir destine au traitement d'une infection par le virus de l'hepatite c |
| WO2013169616A1 (fr) | 2012-05-07 | 2013-11-14 | Novartis Ag | Modulation pharmacocinétique par de l'alisporivir |
| JP2015519368A (ja) | 2012-06-01 | 2015-07-09 | アラーガン インコーポレイテッドAllergan,Incorporated | シクロスポリンa類似体 |
| US8906853B2 (en) | 2012-11-28 | 2014-12-09 | Enanta Pharmaceuticals, Inc. | [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection |
| WO2015008223A1 (fr) | 2013-07-17 | 2015-01-22 | Novartis Ag | Traitement du virus de l'hépatite c avec l'alisporivir et la ribavirine |
| WO2015031381A1 (fr) | 2013-08-26 | 2015-03-05 | Enanta Pharmaceuticals, Inc. | Analogues de cyclosporine pour prévenir ou traiter une hépatite c |
| WO2015136455A1 (fr) | 2014-03-13 | 2015-09-17 | Novartis Ag | Nouveaux traitements d'une infection par le virus de l'hépatite c |
| US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| WO2016112321A1 (fr) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Dérivés de cyclosporine dans lesquels la chaîne latérale mebmt a été cyclisée |
| WO2022043678A1 (fr) * | 2020-08-24 | 2022-03-03 | Nanomerics Limited | Inhibiteurs viraux |
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| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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| KR0148748B1 (ko) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| DE69124459T3 (de) * | 1990-11-02 | 2001-05-31 | Novartis Ag, Basel | Zyklosporine |
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| FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757520B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent |
| FR2757522B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
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| AU759480B2 (en) | 1998-07-01 | 2003-04-17 | Debiopharm S.A. | Novel cyclosporin with improved activity profile |
| BR0112484A (pt) | 2000-07-13 | 2003-09-23 | Sankyo Co | Composto ou um seu sal, éster ou outro derivado farmacologicamente aceitável, composição farmacêutica, uso de um composto ou de um seu sal, éster ou outro derivado farmacologicamente aceitável, e, processo para a preparação do mesmo |
| AU8533101A (en) | 2000-08-31 | 2002-03-13 | Merck & Co Inc | Phosphate derivatives as immunoregulatory agents |
| JP4232866B2 (ja) | 2000-10-19 | 2009-03-04 | 有限会社 ケアティス | 細胞障害抑制剤 |
| JP2002125683A (ja) * | 2000-10-27 | 2002-05-08 | Tokyoto Igaku Kenkyu Kiko | インターフェロンの有効性を予測する方法並びにそれに用いられるプライマー及びプローブ |
| JP4012823B2 (ja) | 2001-03-26 | 2007-11-21 | ノバルティス アクチエンゲゼルシャフト | 2−アミノ−誘導体 |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| BRPI0212894B8 (pt) | 2001-09-27 | 2021-05-25 | Kyorin Seiyaku Kk | composto ou sal do mesmo farmaceuticamente aceitável e composição farmacêutica |
| DE60235900D1 (de) | 2001-09-27 | 2010-05-20 | Kyorin Seiyaku Kk | Osuppressivum |
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| GB0313444D0 (en) | 2003-06-11 | 2003-07-16 | Midland Medical Technologies L | Modular dysplasia cup |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| MX2007003387A (es) | 2004-10-01 | 2007-05-23 | Debiopharm Sa | Uso de [d-meala]3-[etval]4-ciclosporina para el tratamiento de infeccion por hepatitis c y composicion farmaceutica que comprende la [d-meala]3-[etval]4-ciclosporina. |
| RU2007128099A (ru) | 2004-12-23 | 2009-01-27 | Новартис АГ (CH) | Композиции для лечения гепатита с |
-
2003
- 2003-09-03 GB GBGB0320638.0A patent/GB0320638D0/en not_active Ceased
-
2004
- 2004-09-02 TW TW093126578A patent/TWI342782B/zh not_active IP Right Cessation
- 2004-09-02 US US10/570,097 patent/US7968518B2/en active Active
- 2004-09-02 JP JP2006525712A patent/JP4688806B2/ja not_active Expired - Fee Related
- 2004-09-02 DK DK04764762T patent/DK1663287T3/da active
- 2004-09-02 NZ NZ545495A patent/NZ545495A/en not_active IP Right Cessation
- 2004-09-02 ES ES04764762T patent/ES2328361T3/es not_active Expired - Lifetime
- 2004-09-02 SG SG200809555-6A patent/SG149063A1/en unknown
- 2004-09-02 EP EP06125649.1A patent/EP1797892B1/fr not_active Expired - Lifetime
- 2004-09-02 CA CA2537137A patent/CA2537137C/fr not_active Expired - Fee Related
- 2004-09-02 PT PT04764762T patent/PT1663287E/pt unknown
- 2004-09-02 WO PCT/EP2004/009804 patent/WO2005021028A1/fr not_active Ceased
- 2004-09-02 MX MXPA06002394A patent/MXPA06002394A/es active IP Right Grant
- 2004-09-02 RU RU2006110533/15A patent/RU2389501C2/ru not_active IP Right Cessation
- 2004-09-02 DE DE602004022061T patent/DE602004022061D1/de not_active Expired - Lifetime
- 2004-09-02 HR HR20090535T patent/HRP20090535T1/hr unknown
- 2004-09-02 SI SI200431200T patent/SI1663287T1/sl unknown
- 2004-09-02 PL PL04764762T patent/PL1663287T3/pl unknown
- 2004-09-02 EP EP04764762A patent/EP1663287B1/fr not_active Expired - Lifetime
- 2004-09-02 CN CNA2004800246044A patent/CN1842343A/zh active Pending
- 2004-09-02 BR BRPI0414062A patent/BRPI0414062B8/pt not_active IP Right Cessation
- 2004-09-02 KR KR1020067004342A patent/KR101116968B1/ko not_active Expired - Fee Related
- 2004-09-02 AU AU2004268382A patent/AU2004268382A1/en not_active Abandoned
-
2006
- 2006-02-22 ZA ZA200601550A patent/ZA200601550B/en unknown
- 2006-02-23 IL IL173909A patent/IL173909A/en active IP Right Grant
- 2006-03-02 TN TNP2006000071A patent/TNSN06071A1/en unknown
- 2006-03-10 MA MA28865A patent/MA28032A1/fr unknown
- 2006-03-24 IS IS8371A patent/IS2917B/is unknown
- 2006-03-31 NO NO20061479A patent/NO20061479L/no not_active Application Discontinuation
-
2008
- 2008-07-09 AU AU2008203031A patent/AU2008203031B2/en not_active Ceased
-
2009
- 2009-09-16 CY CY20091100955T patent/CY1110506T1/el unknown
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