DK165358C - Renset Bordetella pertussis antigen, vaccine indeholdende et sådant antigen og fremgangsmåde til isolering af et sådant ant - Google Patents

Renset Bordetella pertussis antigen, vaccine indeholdende et sådant antigen og fremgangsmåde til isolering af et sådant ant Download PDF

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Publication number
DK165358C
DK165358C DK198502089A DK208985A DK165358C DK 165358 C DK165358 C DK 165358C DK 198502089 A DK198502089 A DK 198502089A DK 208985 A DK208985 A DK 208985A DK 165358 C DK165358 C DK 165358C
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Prior art keywords
antigen
vaccine
pertussis
amino acid
supernatant
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DK198502089A
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Danish (da)
English (en)
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DK165358B (da
DK208985A (da
DK208985D0 (da
Inventor
Pavel Novotny
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Evans Medical Ltd
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Application filed by Evans Medical Ltd filed Critical Evans Medical Ltd
Publication of DK208985D0 publication Critical patent/DK208985D0/da
Publication of DK208985A publication Critical patent/DK208985A/da
Publication of DK165358B publication Critical patent/DK165358B/da
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK198502089A 1984-05-12 1985-05-10 Renset Bordetella pertussis antigen, vaccine indeholdende et sådant antigen og fremgangsmåde til isolering af et sådant ant DK165358C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848412207A GB8412207D0 (en) 1984-05-12 1984-05-12 Antigenic preparations
GB8412207 1984-05-12

Publications (4)

Publication Number Publication Date
DK208985D0 DK208985D0 (da) 1985-05-10
DK208985A DK208985A (da) 1985-11-13
DK165358B DK165358B (da) 1992-11-16
DK165358C true DK165358C (da) 2000-11-06

Family

ID=10560891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502089A DK165358C (da) 1984-05-12 1985-05-10 Renset Bordetella pertussis antigen, vaccine indeholdende et sådant antigen og fremgangsmåde til isolering af et sådant ant

Country Status (13)

Country Link
US (8) US5648080A (no)
EP (1) EP0162639B1 (no)
JP (3) JPH07116053B2 (no)
AT (1) ATE61937T1 (no)
CA (1) CA1253073A (no)
DE (1) DE3582272D1 (no)
DK (1) DK165358C (no)
ES (1) ES8802275A1 (no)
FI (1) FI81262C (no)
GB (1) GB8412207D0 (no)
LU (1) LU90203I2 (no)
NL (1) NL980006I1 (no)
NO (2) NO165478C (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
FR2597344B1 (fr) * 1986-04-16 1989-06-23 Merieux Inst Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
US4762710A (en) * 1986-06-16 1988-08-09 The United States Of America As Represented By The Department Of Health And Human Services Novel method of preparing toxoid by oxidation and metal ions
SE455946B (sv) * 1986-10-20 1988-08-22 Trion Forskning & Utveckling Nya pertussistoxin-polypeptider och antigener samt testsatser, vacciner och intradermala hudtestkompositioner
FR2606789B1 (fr) * 1986-11-17 1991-05-31 Pasteur Institut Preparations d'adenylate cyclase purifiees, procede d'obtention de ces preparations et leurs applications biologiques
EP0267998A1 (en) * 1986-11-17 1988-05-25 Institut Pasteur Means for protecting against bordetella infections and toxic processes
US5139776A (en) * 1987-04-24 1992-08-18 The Research Foundation For Microbial Diseases Of Osaka University Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine
CA1337859C (en) * 1987-04-24 1996-01-02 Masashi Chazono Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine
EP0338170A1 (en) * 1988-04-19 1989-10-25 Institut Pasteur Immunoprotective antigenic protein against pathogenic bacteria
EP0691348A1 (en) * 1988-04-19 1996-01-10 Institut Pasteur Immunogenic compositions prepared from adenylate cyclase of B. Parapertussis
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
FR2646776B1 (fr) 1989-05-12 1994-06-03 Pasteur Institut Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella
DE69018926T2 (de) * 1989-09-04 1995-08-24 Wellcome Found Vakzine gegen Bordetella.
US5276142A (en) * 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
GB9021004D0 (en) * 1990-09-27 1990-11-07 Wellcome Found Acellular vaccines
US6444211B2 (en) 1991-04-03 2002-09-03 Connaught Laboratories, Inc. Purification of a pertussis outer membrane protein
GB9304399D0 (en) * 1993-03-04 1993-04-21 Smithkline Beecham Biolog Novel process
FR2728170A1 (fr) * 1994-12-15 1996-06-21 Pasteur Institut Vaccin de type acellulaire anti-bordetella
FR2736064B1 (fr) * 1995-06-30 1997-09-05 Pasteur Institut Epitopes protecteurs de l'adenyl cyclase-hemolysine(ac-hty). leur application au traitement ou a la prevention des infections par bordetella
ZA981370B (en) * 1997-02-20 1998-09-07 Cerberus Developments Bv Method and apparatus for continuous flow isoelectric focusing for purifying biological substances
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
MY172181A (en) 2013-03-08 2019-11-15 Janssen Vaccines & Prevention Bv Acellular pertussis vaccine

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141824A (en) * 1961-05-19 1964-07-21 Lilly Co Eli Pertussis antigen
US3395219A (en) * 1964-12-11 1968-07-30 Merck & Co Inc Process for production of pertussis antigen
US3465078A (en) * 1965-10-21 1969-09-02 Sydney Z Spiesel Method of recovering antigens from bordetella pertussis cells
FR2047886A1 (en) * 1969-06-30 1971-03-19 Merieux Inst Non-toxic anti-whooping cough vaccine
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis
GB2014452B (en) * 1978-02-17 1982-07-21 Secr Social Service Brit Producing cell envelope preparations
EP0004137B1 (en) * 1978-02-17 1981-11-11 National Research Development Corporation Immunogenic cell envelope preparations
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
US4551429A (en) * 1983-09-15 1985-11-05 American Home Products Corporation Stimulation of antigen production by Bordetella pertussis
US5237052A (en) * 1984-05-12 1993-08-17 Burroughs Wellcome Company Antigenic preparations and isolation of such preparations
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
FR2606789B1 (fr) * 1986-11-17 1991-05-31 Pasteur Institut Preparations d'adenylate cyclase purifiees, procede d'obtention de ces preparations et leurs applications biologiques
EP0267998A1 (en) * 1986-11-17 1988-05-25 Institut Pasteur Means for protecting against bordetella infections and toxic processes
GB8807860D0 (en) * 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
US5101014A (en) * 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
GB8910570D0 (en) * 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US5276142A (en) * 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007416D0 (en) * 1990-04-02 1990-05-30 Wellcome Found Expression of heterologous protein in yeast
GB9007657D0 (en) 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
EP0484621A3 (en) 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens

Also Published As

Publication number Publication date
ATE61937T1 (de) 1991-04-15
DK165358B (da) 1992-11-16
DK208985A (da) 1985-11-13
EP0162639A2 (en) 1985-11-27
US6048700A (en) 2000-04-11
ES8802275A1 (es) 1988-05-01
FI851859A0 (fi) 1985-05-10
JP2000053585A (ja) 2000-02-22
JPH07116053B2 (ja) 1995-12-13
CA1253073A (en) 1989-04-25
GB8412207D0 (en) 1984-06-20
DK208985D0 (da) 1985-05-10
NO851878L (no) 1985-11-13
JP2000072690A (ja) 2000-03-07
NL980006I1 (nl) 1998-04-01
DE3582272D1 (de) 1991-05-02
NO165478B (no) 1990-11-12
US5648080A (en) 1997-07-15
NO165478C (no) 1991-02-20
JPS60246321A (ja) 1985-12-06
EP0162639A3 (en) 1988-02-03
US20020150595A1 (en) 2002-10-17
FI81262B (fi) 1990-06-29
NO1997010I1 (no) 1997-08-25
US20030077294A1 (en) 2003-04-24
US5438120A (en) 1995-08-01
LU90203I2 (fr) 1998-04-06
US20030108572A1 (en) 2003-06-12
EP0162639B1 (en) 1991-03-27
FI81262C (fi) 1990-10-10
ES543026A0 (es) 1988-05-01
US6210685B1 (en) 2001-04-03
US6127151A (en) 2000-10-03
FI851859L (fi) 1985-11-13

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