DK1648505T3 - Quil A-fraktion med lav toksicitet og anvendelse deraf - Google Patents
Quil A-fraktion med lav toksicitet og anvendelse derafInfo
- Publication number
- DK1648505T3 DK1648505T3 DK04749076T DK04749076T DK1648505T3 DK 1648505 T3 DK1648505 T3 DK 1648505T3 DK 04749076 T DK04749076 T DK 04749076T DK 04749076 T DK04749076 T DK 04749076T DK 1648505 T3 DK1648505 T3 DK 1648505T3
- Authority
- DK
- Denmark
- Prior art keywords
- quil
- fraction
- adjuvant
- lps
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301998A SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Quil A fraction with low toxicity and use thereof |
PCT/SE2004/001038 WO2005002620A1 (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1648505T3 true DK1648505T3 (da) | 2009-12-21 |
Family
ID=27731119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04749076T DK1648505T3 (da) | 2003-07-07 | 2004-07-07 | Quil A-fraktion med lav toksicitet og anvendelse deraf |
Country Status (15)
Country | Link |
---|---|
US (8) | US8821881B2 (pt) |
EP (1) | EP1648505B1 (pt) |
JP (1) | JP4731475B2 (pt) |
AT (1) | ATE442164T1 (pt) |
AU (1) | AU2004254152B2 (pt) |
BR (1) | BRPI0412444B8 (pt) |
CA (1) | CA2529363C (pt) |
DE (1) | DE602004023089D1 (pt) |
DK (1) | DK1648505T3 (pt) |
ES (1) | ES2331952T3 (pt) |
NZ (1) | NZ544299A (pt) |
PL (1) | PL1648505T3 (pt) |
SE (1) | SE0301998D0 (pt) |
WO (1) | WO2005002620A1 (pt) |
ZA (1) | ZA200600151B (pt) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69929444T2 (de) * | 1998-08-10 | 2006-09-28 | Antigenics Inc., Woburn | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
CN101107009B (zh) | 2005-01-20 | 2014-08-06 | 伊斯克诺瓦公司 | 包含纤连蛋白结合蛋白或纤连蛋白结合肽的疫苗组合物 |
EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
AU2007231027B2 (en) | 2006-03-24 | 2013-10-03 | Novartis Influenza Vaccines Marburg Gmbh | Storage of influenza vaccines without refrigeration |
PT2054431E (pt) | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
EP1902727A1 (de) * | 2006-09-22 | 2008-03-26 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
WO2008031878A1 (en) * | 2006-09-15 | 2008-03-20 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | A composition for therapy and/or for prophylaxis of hbv-infections and hbv-mediated diseases |
ES2630205T3 (es) * | 2006-11-20 | 2017-08-18 | Duecom | Uso de partículas que contengan lípidos que comprenden saponínas quillaja para el tratamiento del cáncer |
NZ582595A (en) | 2007-06-27 | 2012-07-27 | Novartis Ag | Low-additive influenza vaccines |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
ES2728949T3 (es) | 2008-06-27 | 2019-10-29 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
CN102470168A (zh) * | 2009-07-10 | 2012-05-23 | 伊斯克诺瓦公司 | 新组合物 |
CN103118702A (zh) | 2010-09-20 | 2013-05-22 | 克鲁塞尔荷兰公司 | 活动性结核病的治疗性接种 |
RS57350B1 (sr) | 2011-10-03 | 2018-08-31 | Mx Adjuvac Ab | Nanočestice, postupak dobijanja i njihova primena kao nosača amfipatičnih ili hidrofobnih molekula u medicini, uključujući i terapiju kancera, kao i prehrambenih jedinjenja |
SG11201402633UA (en) | 2011-11-28 | 2014-09-26 | Crucell Holland Bv | Influenza virus vaccines and uses thereof |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
SI2825640T1 (sl) | 2012-03-12 | 2016-08-31 | Crucell Holland B.V. | Šarže rekombinantnega adenovirusa s spremenjenimi konci |
US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
KR102050616B1 (ko) | 2012-03-22 | 2019-12-03 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
ES2959258T3 (es) | 2013-02-07 | 2024-02-22 | Childrens Medical Center | Antígenos proteicos que proporcionan protección contra la colonización y/o la enfermedad neumocócicas |
ES2597832T3 (es) | 2013-03-08 | 2017-01-23 | Janssen Vaccines & Prevention B.V. | Vacuna acelular contra la tosferina |
AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
KR102236497B1 (ko) | 2013-04-25 | 2021-04-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 rsv f 폴리펩타이드 |
CA2913859C (en) | 2013-05-30 | 2021-11-30 | Crucell Holland B.V. | Influenza virus vaccines and uses thereof |
AP2015008893A0 (en) | 2013-06-17 | 2015-12-31 | Crucell Holland Bv | Stabilized soluble pre-fusion rsv f polypeptides |
EP3017040B1 (en) | 2013-07-02 | 2018-06-06 | Janssen Vaccines & Prevention B.V. | Method for preparing virosomes |
EP3016679B1 (en) | 2013-07-02 | 2019-03-27 | Janssen Vaccines & Prevention B.V. | Method for preparing virosomes |
WO2015042369A2 (en) | 2013-09-19 | 2015-03-26 | Zoetis Llc | Oil-based adjuvants |
DE102014005771A1 (de) | 2014-04-23 | 2015-10-29 | Clariant International Ltd. | Verwendung von wässrigen driftreduzierenden Zusammensetzungen |
BR112017000257A2 (pt) | 2014-07-10 | 2017-10-31 | Janssen Vaccines & Prevention Bv | vacinas contra o vírus da gripe e usos das mesmas |
MX2017005788A (es) | 2014-11-04 | 2017-08-02 | Janssen Vaccines & Prevention Bv | Vacunas terapeuticas contra el vph16. |
PL3244920T3 (pl) | 2015-01-16 | 2023-09-25 | Zoetis Services Llc | Szczepionka przeciw pryszczycy |
EP3283634B1 (en) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
US10456462B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Preventions B.V. | Vaccine against RSV |
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WO2017037196A1 (en) | 2015-09-02 | 2017-03-09 | Janssen Vaccines & Prevention B.V. | Stabilized viral class i fusion proteins |
AU2016315478B2 (en) | 2015-09-03 | 2023-07-13 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
CN108738312A (zh) | 2015-12-23 | 2018-11-02 | 辉瑞公司 | Rsv f蛋白突变体 |
PT3439672T (pt) | 2016-04-05 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Proteína f do rsv pré-fusão solúvel e estabilizada para uso na profilaxia de infeção por rsv |
WO2017174564A1 (en) | 2016-04-05 | 2017-10-12 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
CA3021341A1 (en) | 2016-05-02 | 2017-11-09 | Janssen Vaccine & Prevention B.V. | Therapeutic hpv vaccine combinations |
DE102016207877A1 (de) | 2016-05-09 | 2017-11-09 | Clariant International Ltd | Stabilisatoren für Silikatfarben |
BR112018072865A2 (pt) | 2016-05-12 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
PL3464331T3 (pl) | 2016-05-30 | 2021-04-19 | Janssen Vaccines & Prevention B.V. | Stabilizowane przedfuzyjne białka F RSV |
MX2018015540A (es) | 2016-06-20 | 2019-04-11 | Janssen Vaccines & Prevention Bv | Promotor bidireccional potente y equilibrado. |
WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
CN109906411B (zh) | 2016-11-04 | 2022-12-27 | 卡博特公司 | 含结晶聚酯和有机硅的纳米复合物 |
CA3053212C (en) | 2017-02-09 | 2021-04-13 | Janssen Vaccines & Prevention B.V. | Potent and short promoter for expression of heterologous genes |
CA3061278A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
BR112020004143A2 (pt) | 2017-09-15 | 2020-09-01 | Janssen Vaccines & Prevention B.V. | método para a indução segura de imunidade contra vírus sincicial respiratório (rsv) |
HRP20220980T1 (hr) | 2018-01-23 | 2022-11-11 | Janssen Vaccines & Prevention B.V. | Cjepiva protiv virusa influence i njihova uporaba |
JP7417532B2 (ja) | 2018-03-19 | 2024-01-18 | ノババックス,インコーポレイテッド | 多価インフルエンザナノ粒子ワクチン |
GB201807303D0 (en) | 2018-05-03 | 2018-06-20 | London School Of Hygeine & Tropical Medicine | Glyconjugate vaccines |
CN113286616A (zh) | 2018-05-23 | 2021-08-20 | Adc治疗有限公司 | 分子佐剂 |
CN113164583A (zh) | 2018-11-13 | 2021-07-23 | 扬森疫苗与预防公司 | 稳定的融合前rsv f蛋白 |
EP3959228A1 (en) | 2019-04-25 | 2022-03-02 | Janssen Vaccines & Prevention B.V. | Recombinant influenza antigens |
AU2020275910A1 (en) | 2019-05-15 | 2021-11-04 | Janssen Vaccines & Prevention B.V. | Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine |
WO2020229577A1 (en) | 2019-05-15 | 2020-11-19 | Janssen Vaccines & Prevention B.V. | Co-administration of seasonal influenza vaccine and an adenovirus based respiratory syncytial virus vaccine |
CA3152957A1 (en) | 2019-09-05 | 2021-03-11 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
US11498944B2 (en) | 2020-01-31 | 2022-11-15 | Janssen Pharmaceuticals, Inc. | Compositions and methods for preventing and treating coronavirus infection—SARS-CoV-2 vaccines |
MX2022014167A (es) | 2020-05-11 | 2023-02-14 | Janssen Pharmaceuticals Inc | Replicón de arn que codifica una proteína de espícula del coronavirus estabilizada. |
BR112022022937A2 (pt) | 2020-05-11 | 2022-12-20 | Janssen Pharmaceuticals Inc | Proteínas de fusão estabilizadas de proteína de pico de coronavírus |
EP4149538A1 (en) | 2020-05-11 | 2023-03-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
MX2023000024A (es) | 2020-06-29 | 2023-04-12 | Janssen Vaccines & Prevention Bv | Combinación vacunal contra la infección por el virus respiratorio sincicial. |
CN115916804A (zh) | 2020-07-06 | 2023-04-04 | 杨森制药公司 | 稳定的冠状病毒刺突蛋白融合蛋白 |
JP2022060169A (ja) | 2020-10-02 | 2022-04-14 | ファイザー・インク | Rsv fタンパク質生産のための細胞培養工程 |
WO2022175479A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
JP2024509756A (ja) | 2021-02-19 | 2024-03-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定化された融合前rsv fb抗原 |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
CA3214415A1 (en) | 2021-04-01 | 2022-10-06 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2023196634A2 (en) | 2022-04-08 | 2023-10-12 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2024017682A1 (en) | 2022-07-18 | 2024-01-25 | Janssen Vaccines & Prevention B.V. | Rsv immunogens |
WO2024030856A2 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2024104947A2 (en) | 2022-11-14 | 2024-05-23 | Janssen Vaccines & Prevention B.V. | Influenza b virus vaccines and uses thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5839376B2 (ja) * | 1978-10-30 | 1983-08-30 | 富士通株式会社 | イオン注入法 |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
ES2039229T3 (es) * | 1986-01-14 | 1993-09-16 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos. |
CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
US6231859B1 (en) * | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
US6558670B1 (en) * | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
SE0202110D0 (sv) * | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
-
2003
- 2003-07-07 SE SE0301998A patent/SE0301998D0/xx unknown
-
2004
- 2004-07-07 NZ NZ544299A patent/NZ544299A/en unknown
- 2004-07-07 EP EP04749076A patent/EP1648505B1/en not_active Expired - Lifetime
- 2004-07-07 US US10/562,866 patent/US8821881B2/en active Active
- 2004-07-07 WO PCT/SE2004/001038 patent/WO2005002620A1/en active Application Filing
- 2004-07-07 DE DE602004023089T patent/DE602004023089D1/de not_active Expired - Lifetime
- 2004-07-07 AU AU2004254152A patent/AU2004254152B2/en not_active Expired
- 2004-07-07 CA CA2529363A patent/CA2529363C/en not_active Expired - Lifetime
- 2004-07-07 ES ES04749076T patent/ES2331952T3/es not_active Expired - Lifetime
- 2004-07-07 BR BRPI0412444A patent/BRPI0412444B8/pt active IP Right Grant
- 2004-07-07 AT AT04749076T patent/ATE442164T1/de not_active IP Right Cessation
- 2004-07-07 DK DK04749076T patent/DK1648505T3/da active
- 2004-07-07 JP JP2006518582A patent/JP4731475B2/ja not_active Expired - Lifetime
- 2004-07-07 PL PL04749076T patent/PL1648505T3/pl unknown
-
2006
- 2006-01-06 ZA ZA200600151A patent/ZA200600151B/en unknown
-
2014
- 2014-07-29 US US14/445,690 patent/US20140335049A1/en not_active Abandoned
-
2015
- 2015-05-18 US US14/714,664 patent/US20150320858A1/en not_active Abandoned
-
2016
- 2016-02-26 US US15/054,801 patent/US20160184427A1/en not_active Abandoned
-
2018
- 2018-01-18 US US15/874,262 patent/US20180369368A1/en not_active Abandoned
-
2019
- 2019-12-03 US US16/701,948 patent/US20200345840A1/en not_active Abandoned
-
2021
- 2021-09-17 US US17/477,739 patent/US20220241408A1/en not_active Abandoned
-
2023
- 2023-10-04 US US18/376,666 patent/US20240024468A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2529363A1 (en) | 2005-01-13 |
US20180369368A1 (en) | 2018-12-27 |
ES2331952T3 (es) | 2010-01-21 |
BRPI0412444B1 (pt) | 2016-06-14 |
US20140335049A1 (en) | 2014-11-13 |
ATE442164T1 (de) | 2009-09-15 |
WO2005002620A1 (en) | 2005-01-13 |
NZ544299A (en) | 2009-03-31 |
US20240024468A1 (en) | 2024-01-25 |
EP1648505A1 (en) | 2006-04-26 |
SE0301998D0 (sv) | 2003-07-07 |
US8821881B2 (en) | 2014-09-02 |
JP4731475B2 (ja) | 2011-07-27 |
CA2529363C (en) | 2013-04-02 |
AU2004254152B2 (en) | 2009-10-29 |
JP2007527386A (ja) | 2007-09-27 |
US20060239963A1 (en) | 2006-10-26 |
ZA200600151B (en) | 2007-01-31 |
EP1648505B1 (en) | 2009-09-09 |
BRPI0412444A (pt) | 2006-09-19 |
BRPI0412444B8 (pt) | 2021-05-25 |
DE602004023089D1 (de) | 2009-10-22 |
US20160184427A1 (en) | 2016-06-30 |
US20150320858A1 (en) | 2015-11-12 |
US20220241408A1 (en) | 2022-08-04 |
PL1648505T3 (pl) | 2010-02-26 |
AU2004254152A1 (en) | 2005-01-13 |
US20200345840A1 (en) | 2020-11-05 |
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