DK1604991T3 - Antitumorvirkningsforstærker og antitumormiddel - Google Patents
Antitumorvirkningsforstærker og antitumormiddelInfo
- Publication number
- DK1604991T3 DK1604991T3 DK04719589T DK04719589T DK1604991T3 DK 1604991 T3 DK1604991 T3 DK 1604991T3 DK 04719589 T DK04719589 T DK 04719589T DK 04719589 T DK04719589 T DK 04719589T DK 1604991 T3 DK1604991 T3 DK 1604991T3
- Authority
- DK
- Denmark
- Prior art keywords
- antitumor
- tumor
- antitumor effect
- agent
- administering
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 8
- 239000002246 antineoplastic agent Substances 0.000 title abstract 4
- 239000003623 enhancer Substances 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 abstract 1
- ZPLQIPFOCGIIHV-UHFFFAOYSA-N Gimeracil Chemical compound OC1=CC(=O)C(Cl)=CN1 ZPLQIPFOCGIIHV-UHFFFAOYSA-N 0.000 abstract 1
- IAPCTXZQXAVYNG-UHFFFAOYSA-M Potassium 2,6-dihydroxytriazinecarboxylate Chemical compound [K+].[O-]C(=O)C1=NC(=O)NC(=O)N1 IAPCTXZQXAVYNG-UHFFFAOYSA-M 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
- 235000008191 folinic acid Nutrition 0.000 abstract 1
- 239000011672 folinic acid Substances 0.000 abstract 1
- 229950009822 gimeracil Drugs 0.000 abstract 1
- 229960001691 leucovorin Drugs 0.000 abstract 1
- 229950000193 oteracil Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 abstract 1
- 229960001674 tegafur Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003070097 | 2003-03-14 | ||
| PCT/JP2004/003189 WO2004081012A1 (ja) | 2003-03-14 | 2004-03-11 | 抗腫瘍効果増強剤及び抗腫瘍剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1604991T3 true DK1604991T3 (da) | 2009-01-05 |
Family
ID=32984641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04719589T DK1604991T3 (da) | 2003-03-14 | 2004-03-11 | Antitumorvirkningsforstærker og antitumormiddel |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9611227B2 (enExample) |
| EP (1) | EP1604991B1 (enExample) |
| JP (1) | JP4610481B2 (enExample) |
| KR (1) | KR100812693B1 (enExample) |
| CN (2) | CN101357134A (enExample) |
| AT (1) | ATE408408T1 (enExample) |
| AU (1) | AU2004220205B2 (enExample) |
| BR (1) | BRPI0408372A (enExample) |
| CA (1) | CA2518195C (enExample) |
| CY (1) | CY1108395T1 (enExample) |
| DE (1) | DE602004016636D1 (enExample) |
| DK (1) | DK1604991T3 (enExample) |
| ES (1) | ES2312978T3 (enExample) |
| MX (1) | MXPA05009781A (enExample) |
| NZ (1) | NZ542150A (enExample) |
| PL (1) | PL1604991T3 (enExample) |
| PT (1) | PT1604991E (enExample) |
| RU (1) | RU2334517C2 (enExample) |
| SI (1) | SI1604991T1 (enExample) |
| TW (1) | TW200503720A (enExample) |
| WO (1) | WO2004081012A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090137640A1 (en) * | 2005-04-01 | 2009-05-28 | Taiho Pharmaceutical Co.Ltd | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |
| EP1864683B1 (en) * | 2005-04-01 | 2010-09-01 | Taiho Pharmaceutical Co., Ltd. | Radiotherapy enhancer |
| JPWO2007043531A1 (ja) * | 2005-10-07 | 2009-04-16 | セレスター・レキシコ・サイエンシズ株式会社 | 抗腫瘍剤及び放射線併用療法感受性診断用遺伝子マーカー並びにその利用 |
| WO2009139085A1 (ja) * | 2008-05-12 | 2009-11-19 | 静岡県 | 抗腫瘍剤、キット及び癌治療方法 |
| JP5553522B2 (ja) * | 2009-03-31 | 2014-07-16 | 大鵬薬品工業株式会社 | 経口投与用医薬組成物 |
| JP5566376B2 (ja) * | 2009-04-22 | 2014-08-06 | 大鵬薬品工業株式会社 | 腎細胞癌に対する化学療法の治療効果予測方法 |
| CN102309491B (zh) * | 2010-07-02 | 2015-06-10 | 天津金耀集团有限公司 | 一种替加氟、吉美斯特复方注射液 |
| BR112013030093B1 (pt) * | 2011-05-25 | 2019-12-10 | Taiho Pharmaceutical Co Ltd | comprimido revestido seco de desintegração oral contendo tegafur, gimeracilo e oteracilo potássico |
| EP3053578B1 (en) * | 2013-09-30 | 2020-12-23 | Taiho Pharmaceutical Co., Ltd. | Combination cancer therapy using azabicyclo compound |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| CN106581001B (zh) * | 2016-11-03 | 2018-12-21 | 江苏恒瑞医药股份有限公司 | 一种替吉奥组合物的制备方法 |
| KR102258514B1 (ko) | 2019-09-23 | 2021-05-31 | 연세대학교 산학협력단 | 신규한 다층형 좌약 제제 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0443028B1 (en) * | 1989-01-05 | 1993-09-29 | Otsuka Pharmaceutical Co., Ltd. | Non-injection carcinostatic agent for suppressing occurrence of inflammation due to 5-fluorouracil and method for curing cancer |
| DE69121551T2 (de) * | 1990-09-07 | 1997-01-02 | Taiho Pharmaceutical Co Ltd | Antineoplastisch wirkender und den antineoplastischen effekt verstärkender wirkstoff |
| KR0148589B1 (ko) * | 1991-05-27 | 1998-11-02 | 고바야시 유끼오 | 항종양 효과의 상승 및 종양의 치료를 위한 조성물 및 키트 |
| CH683262A5 (it) * | 1992-01-22 | 1994-02-15 | Applied Pharma Res | Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico). |
| WO2001066102A2 (en) * | 2000-03-08 | 2001-09-13 | Bristol-Myers Squibb Company | Oral dosage form for administration of the combination of tegafur, uracil, folinic acid, and oxaliplatin and method of using the same |
| EP1368034A1 (en) | 2001-03-06 | 2003-12-10 | Bristol-Myers Squibb Company | Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin |
| JPWO2003004640A1 (ja) * | 2001-07-05 | 2004-10-28 | 大鵬薬品工業株式会社 | 抗癌剤感受性測定用ｄｎａアレイ |
-
2004
- 2004-03-11 MX MXPA05009781A patent/MXPA05009781A/es active IP Right Grant
- 2004-03-11 PL PL04719589T patent/PL1604991T3/pl unknown
- 2004-03-11 EP EP04719589A patent/EP1604991B1/en not_active Expired - Lifetime
- 2004-03-11 SI SI200430955T patent/SI1604991T1/sl unknown
- 2004-03-11 KR KR1020057017150A patent/KR100812693B1/ko not_active Expired - Lifetime
- 2004-03-11 NZ NZ542150A patent/NZ542150A/xx not_active IP Right Cessation
- 2004-03-11 CN CNA2008101445581A patent/CN101357134A/zh active Pending
- 2004-03-11 CN CNA2004800069779A patent/CN1761665A/zh active Pending
- 2004-03-11 DK DK04719589T patent/DK1604991T3/da active
- 2004-03-11 WO PCT/JP2004/003189 patent/WO2004081012A1/ja not_active Ceased
- 2004-03-11 DE DE602004016636T patent/DE602004016636D1/de not_active Expired - Lifetime
- 2004-03-11 BR BRPI0408372-5A patent/BRPI0408372A/pt not_active Application Discontinuation
- 2004-03-11 CA CA002518195A patent/CA2518195C/en not_active Expired - Fee Related
- 2004-03-11 AT AT04719589T patent/ATE408408T1/de active
- 2004-03-11 PT PT04719589T patent/PT1604991E/pt unknown
- 2004-03-11 AU AU2004220205A patent/AU2004220205B2/en not_active Ceased
- 2004-03-11 ES ES04719589T patent/ES2312978T3/es not_active Expired - Lifetime
- 2004-03-11 US US10/548,655 patent/US9611227B2/en not_active Expired - Fee Related
- 2004-03-11 RU RU2005131839/15A patent/RU2334517C2/ru active
- 2004-03-11 JP JP2005503567A patent/JP4610481B2/ja not_active Expired - Lifetime
- 2004-03-12 TW TW093106702A patent/TW200503720A/zh not_active IP Right Cessation
-
2008
- 2008-10-06 CY CY20081101101T patent/CY1108395T1/el unknown
-
2017
- 2017-02-17 US US15/435,493 patent/US9814724B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1604991B1 (en) | 2008-09-17 |
| DE602004016636D1 (de) | 2008-10-30 |
| CN101357134A (zh) | 2009-02-04 |
| JP4610481B2 (ja) | 2011-01-12 |
| ATE408408T1 (de) | 2008-10-15 |
| RU2005131839A (ru) | 2006-02-10 |
| TW200503720A (en) | 2005-02-01 |
| US9611227B2 (en) | 2017-04-04 |
| NZ542150A (en) | 2009-09-25 |
| JPWO2004081012A1 (ja) | 2006-06-08 |
| AU2004220205A1 (en) | 2004-09-23 |
| KR100812693B1 (ko) | 2008-03-13 |
| MXPA05009781A (es) | 2005-10-26 |
| US20060116345A1 (en) | 2006-06-01 |
| TWI295173B (enExample) | 2008-04-01 |
| PT1604991E (pt) | 2008-10-27 |
| RU2334517C2 (ru) | 2008-09-27 |
| WO2004081012A1 (ja) | 2004-09-23 |
| KR20050106119A (ko) | 2005-11-08 |
| AU2004220205B2 (en) | 2010-06-17 |
| SI1604991T1 (sl) | 2009-02-28 |
| ES2312978T3 (es) | 2009-03-01 |
| EP1604991A1 (en) | 2005-12-14 |
| US20170157131A1 (en) | 2017-06-08 |
| BRPI0408372A (pt) | 2006-03-21 |
| CA2518195A1 (en) | 2004-09-23 |
| US9814724B2 (en) | 2017-11-14 |
| CA2518195C (en) | 2009-07-07 |
| EP1604991A4 (en) | 2006-05-03 |
| PL1604991T3 (pl) | 2009-02-27 |
| CN1761665A (zh) | 2006-04-19 |
| CY1108395T1 (el) | 2014-02-12 |
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