ATE408408T1 - Eine die antitumorwirkung verstärkende verbindung und antitumormittel - Google Patents
Eine die antitumorwirkung verstärkende verbindung und antitumormittelInfo
- Publication number
- ATE408408T1 ATE408408T1 AT04719589T AT04719589T ATE408408T1 AT E408408 T1 ATE408408 T1 AT E408408T1 AT 04719589 T AT04719589 T AT 04719589T AT 04719589 T AT04719589 T AT 04719589T AT E408408 T1 ATE408408 T1 AT E408408T1
- Authority
- AT
- Austria
- Prior art keywords
- antitumor
- antitumor effect
- administering
- enhancing
- patient
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003070097 | 2003-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE408408T1 true ATE408408T1 (de) | 2008-10-15 |
Family
ID=32984641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04719589T ATE408408T1 (de) | 2003-03-14 | 2004-03-11 | Eine die antitumorwirkung verstärkende verbindung und antitumormittel |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9611227B2 (de) |
| EP (1) | EP1604991B1 (de) |
| JP (1) | JP4610481B2 (de) |
| KR (1) | KR100812693B1 (de) |
| CN (2) | CN1761665A (de) |
| AT (1) | ATE408408T1 (de) |
| AU (1) | AU2004220205B2 (de) |
| BR (1) | BRPI0408372A (de) |
| CA (1) | CA2518195C (de) |
| CY (1) | CY1108395T1 (de) |
| DE (1) | DE602004016636D1 (de) |
| DK (1) | DK1604991T3 (de) |
| ES (1) | ES2312978T3 (de) |
| MX (1) | MXPA05009781A (de) |
| NZ (1) | NZ542150A (de) |
| PL (1) | PL1604991T3 (de) |
| PT (1) | PT1604991E (de) |
| RU (1) | RU2334517C2 (de) |
| SI (1) | SI1604991T1 (de) |
| TW (1) | TW200503720A (de) |
| WO (1) | WO2004081012A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4956423B2 (ja) * | 2005-04-01 | 2012-06-20 | 大鵬薬品工業株式会社 | 放射線治療増強剤 |
| AU2006231809B2 (en) * | 2005-04-01 | 2011-08-25 | Taiho Pharmaceutical Co., Ltd. | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |
| JPWO2007043531A1 (ja) * | 2005-10-07 | 2009-04-16 | セレスター・レキシコ・サイエンシズ株式会社 | 抗腫瘍剤及び放射線併用療法感受性診断用遺伝子マーカー並びにその利用 |
| WO2009139085A1 (ja) | 2008-05-12 | 2009-11-19 | 静岡県 | 抗腫瘍剤、キット及び癌治療方法 |
| JP5553522B2 (ja) * | 2009-03-31 | 2014-07-16 | 大鵬薬品工業株式会社 | 経口投与用医薬組成物 |
| TW201043237A (en) * | 2009-04-22 | 2010-12-16 | Taiho Pharmaceutical Co Ltd | Method for predicting a therapeutic effect of the chemotherapy for renal cell cancer |
| CN102309491B (zh) * | 2010-07-02 | 2015-06-10 | 天津金耀集团有限公司 | 一种替加氟、吉美斯特复方注射液 |
| CA2836865C (en) * | 2011-05-25 | 2018-02-27 | Taiho Pharmaceutical Co., Ltd. | Dry-coated tablet containing tegafur, gimeracil and oteracil potassium |
| RU2657783C2 (ru) * | 2013-09-30 | 2018-06-15 | Тайхо Фармасьютикал Ко., Лтд. | Комбинированная терапия с использованием азабициклосоединения для ракового заболевания |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| CN106581001B (zh) * | 2016-11-03 | 2018-12-21 | 江苏恒瑞医药股份有限公司 | 一种替吉奥组合物的制备方法 |
| KR102258514B1 (ko) | 2019-09-23 | 2021-05-31 | 연세대학교 산학협력단 | 신규한 다층형 좌약 제제 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL194430C (nl) * | 1989-01-05 | 2002-04-04 | Otsuka Pharma Co Ltd | Niet-injecteerbaar farmaceutisch preparaat met anti-kankerwerking. |
| KR0146952B1 (ko) * | 1990-09-07 | 1998-08-17 | 고바야시 유끼오 | 항종양효과증강제 및 항종양제 |
| ES2124257T4 (es) * | 1991-05-27 | 2012-03-23 | Taiho Pharmaceutical Co., Ltd. | Composición, método y equipo para la estimulación de la actividad antitumoral y para el tratamiento de tumores. |
| CH683262A5 (it) * | 1992-01-22 | 1994-02-15 | Applied Pharma Res | Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico). |
| WO2001066102A2 (en) * | 2000-03-08 | 2001-09-13 | Bristol-Myers Squibb Company | Oral dosage form for administration of the combination of tegafur, uracil, folinic acid, and oxaliplatin and method of using the same |
| WO2002076459A1 (en) | 2001-03-06 | 2002-10-03 | Bristol-Myers Squibb Company | Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin |
| DE60235088D1 (de) * | 2001-07-05 | 2010-03-04 | Taiho Pharmaceutical Co Ltd | Dna-arrays zur messung der empfindlichkeit gegenüber einem antikrebsmittel |
-
2004
- 2004-03-11 US US10/548,655 patent/US9611227B2/en active Active
- 2004-03-11 ES ES04719589T patent/ES2312978T3/es not_active Expired - Lifetime
- 2004-03-11 CA CA002518195A patent/CA2518195C/en not_active Expired - Fee Related
- 2004-03-11 PT PT04719589T patent/PT1604991E/pt unknown
- 2004-03-11 MX MXPA05009781A patent/MXPA05009781A/es active IP Right Grant
- 2004-03-11 EP EP04719589A patent/EP1604991B1/de not_active Expired - Lifetime
- 2004-03-11 RU RU2005131839/15A patent/RU2334517C2/ru active
- 2004-03-11 DK DK04719589T patent/DK1604991T3/da active
- 2004-03-11 AU AU2004220205A patent/AU2004220205B2/en not_active Ceased
- 2004-03-11 PL PL04719589T patent/PL1604991T3/pl unknown
- 2004-03-11 KR KR1020057017150A patent/KR100812693B1/ko active IP Right Grant
- 2004-03-11 WO PCT/JP2004/003189 patent/WO2004081012A1/ja active IP Right Grant
- 2004-03-11 CN CNA2004800069779A patent/CN1761665A/zh active Pending
- 2004-03-11 JP JP2005503567A patent/JP4610481B2/ja not_active Expired - Lifetime
- 2004-03-11 SI SI200430955T patent/SI1604991T1/sl unknown
- 2004-03-11 NZ NZ542150A patent/NZ542150A/xx not_active IP Right Cessation
- 2004-03-11 BR BRPI0408372-5A patent/BRPI0408372A/pt not_active Application Discontinuation
- 2004-03-11 CN CNA2008101445581A patent/CN101357134A/zh active Pending
- 2004-03-11 DE DE602004016636T patent/DE602004016636D1/de not_active Expired - Lifetime
- 2004-03-11 AT AT04719589T patent/ATE408408T1/de active
- 2004-03-12 TW TW093106702A patent/TW200503720A/zh not_active IP Right Cessation
-
2008
- 2008-10-06 CY CY20081101101T patent/CY1108395T1/el unknown
-
2017
- 2017-02-17 US US15/435,493 patent/US9814724B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004081012A1 (ja) | 2004-09-23 |
| TW200503720A (en) | 2005-02-01 |
| NZ542150A (en) | 2009-09-25 |
| TWI295173B (de) | 2008-04-01 |
| CY1108395T1 (el) | 2014-02-12 |
| DK1604991T3 (da) | 2009-01-05 |
| EP1604991A4 (de) | 2006-05-03 |
| PT1604991E (pt) | 2008-10-27 |
| PL1604991T3 (pl) | 2009-02-27 |
| SI1604991T1 (sl) | 2009-02-28 |
| CA2518195A1 (en) | 2004-09-23 |
| ES2312978T3 (es) | 2009-03-01 |
| BRPI0408372A (pt) | 2006-03-21 |
| CA2518195C (en) | 2009-07-07 |
| KR20050106119A (ko) | 2005-11-08 |
| EP1604991B1 (de) | 2008-09-17 |
| AU2004220205B2 (en) | 2010-06-17 |
| US9814724B2 (en) | 2017-11-14 |
| US20170157131A1 (en) | 2017-06-08 |
| US9611227B2 (en) | 2017-04-04 |
| RU2005131839A (ru) | 2006-02-10 |
| DE602004016636D1 (de) | 2008-10-30 |
| US20060116345A1 (en) | 2006-06-01 |
| KR100812693B1 (ko) | 2008-03-13 |
| JP4610481B2 (ja) | 2011-01-12 |
| EP1604991A1 (de) | 2005-12-14 |
| AU2004220205A1 (en) | 2004-09-23 |
| RU2334517C2 (ru) | 2008-09-27 |
| JPWO2004081012A1 (ja) | 2006-06-08 |
| CN101357134A (zh) | 2009-02-04 |
| MXPA05009781A (es) | 2005-10-26 |
| CN1761665A (zh) | 2006-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1108395T1 (el) | Ουσια επαυξησης της δρασης εναντι ογκων και παραγοντας εναντι ογκων | |
| TW200637828A (en) | Novel cis-imidazolines | |
| ATE428411T1 (de) | Hdl-verstärkende kombinationstherapie-komplexe | |
| WO2007075554A3 (en) | Combination of igfr inhibitor and anti-cancer agent | |
| EA200501849A1 (ru) | Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ | |
| MXPA04002537A (es) | Alquinos como inhibidores de metaloproteinasa de matriz. | |
| TW200728276A (en) | Oxindole derivatives | |
| ATE411022T1 (de) | Pyridylpyrrol-derivate als wirksame kinase-hemmer | |
| DE60312715D1 (de) | Verwendung von dem quinazolin derivat zd6474 kombiniert mit gemcitabin und gegebenenfalls ionisierender strahlung für die behandlung von krebs | |
| ATE396986T1 (de) | Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken | |
| IS6925A (is) | Aðferð og skömmtunarform til meðhöndlunar æxla með gjöf tegafúrs, úracíls, fólínsýru, paclítaxels og karbóplatíns | |
| WO2005065266A3 (en) | Di-substituted pyrrolotriazine compounds | |
| IL162384A0 (en) | Composition inhibiting matrix-metallproteinases for the treatment of neoplastic diseases | |
| WO2004110151A8 (en) | Treatment of cancer with active vitamin d compounds in combination with radiotherapeutic agents and treatments | |
| WO2005123068A3 (en) | Methods of dealying alzheimer’s disease progression using a beta-amyloid precursor protein inhibitor and a hmg coa reductase inhibitor | |
| MY140563A (en) | Antitumor effect potentiator, antitumor preparation | |
| EA200701813A1 (ru) | Новые амидозамещенные 6-фенилфенантридины | |
| RU2007143434A (ru) | 4-анилино-3-хинолинкарбонитрилы, подходящие для лечения раковых заболеваний | |
| BRPI0408238A (pt) | anticorpo, método de detectar cáncer, conjunto para detecção de cáncer, e, composição farmacêutica para tratar cáncer | |
| JOP20220038A1 (ar) | عوامل مضادة للملاريا | |
| HK1080768A1 (en) | Use of epothilone derivatives for the treatment ofhyperparathyroidism | |
| WO2005035500A3 (en) | Therapeutic agents useful for treating pain | |
| ATE346080T1 (de) | Steroid-verbindungen mit anti-tumoraler wirkung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1604991 Country of ref document: EP |