DK155367C - Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater - Google Patents

Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater

Info

Publication number
DK155367C
DK155367C DK366678A DK366678A DK155367C DK 155367 C DK155367 C DK 155367C DK 366678 A DK366678 A DK 366678A DK 366678 A DK366678 A DK 366678A DK 155367 C DK155367 C DK 155367C
Authority
DK
Denmark
Prior art keywords
nitroimidazold
derivatives
preparation
analogy procedure
analogy
Prior art date
Application number
DK366678A
Other languages
Danish (da)
English (en)
Other versions
DK155367B (da
DK366678A (da
Inventor
Carey Ernest Smithen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK366678A publication Critical patent/DK366678A/da
Publication of DK155367B publication Critical patent/DK155367B/da
Application granted granted Critical
Publication of DK155367C publication Critical patent/DK155367C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK366678A 1977-08-19 1978-08-18 Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater DK155367C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB3490877 1977-08-19
GB3490877 1977-08-19
GB1953478 1978-05-15
GB1953478 1978-05-15

Publications (3)

Publication Number Publication Date
DK366678A DK366678A (da) 1979-02-20
DK155367B DK155367B (da) 1989-04-03
DK155367C true DK155367C (da) 1989-08-14

Family

ID=26254111

Family Applications (1)

Application Number Title Priority Date Filing Date
DK366678A DK155367C (da) 1977-08-19 1978-08-18 Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater

Country Status (26)

Country Link
US (1) US4241060A (fi)
EP (1) EP0000928B1 (fi)
JP (1) JPS5444671A (fi)
AR (3) AR218325A1 (fi)
AT (1) AT364829B (fi)
AU (1) AU516443B2 (fi)
CA (1) CA1104133A (fi)
DE (2) DE2836073A1 (fi)
DK (1) DK155367C (fi)
ES (3) ES472661A1 (fi)
FI (1) FI70576C (fi)
FR (1) FR2400512A1 (fi)
GB (1) GB2003154A (fi)
GR (1) GR73055B (fi)
HU (1) HU179983B (fi)
IE (1) IE47132B1 (fi)
IL (1) IL55351A (fi)
IT (1) IT1098042B (fi)
MC (1) MC1210A1 (fi)
NL (1) NL7808597A (fi)
NO (1) NO151240C (fi)
NZ (1) NZ188140A (fi)
PH (1) PH16364A (fi)
PT (1) PT68441A (fi)
SE (1) SE7808773L (fi)
YU (1) YU41317B (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4494547A (en) * 1981-03-30 1985-01-22 North Carolina Central University 2H-isoindolediones, their synthesis and use as radiosensitizers
US4605744A (en) * 1982-03-18 1986-08-12 Hoffmann-La Roche Inc. Imidazole derivatives
US4537969A (en) * 1982-03-18 1985-08-27 Hoffmann-La Roche Inc. Imidazole derivatives
US4581368A (en) * 1982-05-27 1986-04-08 National Research Development Corporation Aziridino containing nitro imidazoles and pharmaceutical compositions
CA1227211A (en) * 1982-05-27 1987-09-22 Israr Ahmed Nitro imidazolyl aziridino propanols
US4742050B1 (en) * 1982-08-17 1994-06-28 Alpha Therapeutic Corp Sensitization of hypoxic tumor cells and control of growth thereof
CH665952A5 (de) * 1982-08-17 1988-06-30 Sun Tech Inc Cyclische perfluorverbindungen enthaltende waessrige pharmazeutische zusammensetzung.
US4889525A (en) * 1982-08-17 1989-12-26 Adamantech, Inc. Sensitization of hypoxic tumor cells and control of growth thereof
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
JP2848602B2 (ja) * 1987-06-24 1999-01-20 京都大学長 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
DE3854645T2 (de) * 1987-12-04 1996-05-02 British Tech Group Nitro substituierte aromatische und heteroaromatische Verbindungen für Krebsbehandlungen.
US5086068A (en) * 1988-02-26 1992-02-04 Alberta Cancer Board Immunochemical detection of hypoxia in normal and tumor tissue
US5194624A (en) * 1988-05-23 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Intermediates for the preparation of compounds of antimicrobial activity
US5073639A (en) * 1988-11-25 1991-12-17 Warner-Lambert Company Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
US5036089A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
JPH02146288A (ja) * 1988-11-25 1990-06-05 Ebara Corp 内部圧縮を持つ容積型圧縮機
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
JP2799368B2 (ja) * 1990-01-10 1998-09-17 ポーラ化成工業株式会社 抗原虫剤
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US6252087B1 (en) 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
CA2149770C (en) * 1992-11-19 2009-01-06 Cameron J. Koch Detection of hypoxia
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
US5741800A (en) * 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
EP1838305A1 (en) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer formulations comprising nitrohistidine derivatives
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
MD4150C1 (ro) * 2011-10-11 2012-09-30 Институт Химии Академии Наук Молдовы Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) * 2012-02-27 2013-02-28 Институт Химии Академии Наук Молдовы Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
KR20160030537A (ko) * 2013-07-16 2016-03-18 코닝 인코포레이티드 얇은 유리를 구부리기 위한 방법 및 기기
CN108203411A (zh) * 2016-12-19 2018-06-26 曾舟华 一种高压合成甲硝唑的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA746007A (en) * 1966-11-08 W. Henry David 1-substituted-2-sulfonyl-5-nitroimidazoles
US3255201A (en) * 1965-04-09 1966-06-07 Hoffmann La Roche 2-nitroimidazoles
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
CH512492A (de) * 1966-06-10 1971-09-15 Hoffmann La Roche Verfahren zur Herstellung von Imidazolderivaten
US3646057A (en) * 1969-04-06 1972-02-29 Hoffmann La Roche 2-nitroimidazoles
FR2260996A1 (en) * 1974-02-15 1975-09-12 Hoffmann La Roche (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents
DE2410749A1 (de) * 1974-03-06 1975-09-11 Hoffmann La Roche 2-nitroimidazole
US4038410A (en) * 1974-03-14 1977-07-26 Schering Aktiengesellschaft Nitroimidazole derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
FI70576B (fi) 1986-06-06
AU516443B2 (en) 1981-06-04
EP0000928B1 (de) 1981-03-18
NL7808597A (nl) 1979-02-21
NO151240C (no) 1985-03-06
AR220216A1 (es) 1980-10-15
MC1210A1 (fr) 1979-05-18
IL55351A (en) 1982-07-30
IT1098042B (it) 1985-08-31
ES478052A1 (es) 1979-10-16
AR218325A1 (es) 1980-05-30
IE781453L (en) 1979-02-19
PT68441A (fi) 1978-09-01
AT364829B (de) 1981-11-25
GR73055B (fi) 1984-01-26
IE47132B1 (en) 1983-12-28
FR2400512B1 (fi) 1980-07-04
NO782813L (no) 1979-02-20
US4241060A (en) 1980-12-23
YU41317B (en) 1987-02-28
FI782530A (fi) 1979-02-20
JPS5444671A (en) 1979-04-09
SE7808773L (sv) 1979-02-20
GB2003154A (en) 1979-03-07
JPS6220187B2 (fi) 1987-05-06
AR218553A1 (es) 1980-06-13
DK155367B (da) 1989-04-03
IL55351A0 (en) 1978-10-31
ATA601078A (de) 1981-04-15
YU195378A (en) 1983-01-21
CA1104133A (en) 1981-06-30
IT7826792A0 (it) 1978-08-16
EP0000928A1 (de) 1979-03-07
ES478051A1 (es) 1979-10-16
FR2400512A1 (fr) 1979-03-16
FI70576C (fi) 1986-09-24
AU3891578A (en) 1980-02-21
HU179983B (en) 1983-01-28
DE2860546D1 (en) 1981-04-16
DE2836073A1 (de) 1979-03-01
ES472661A1 (es) 1979-02-16
NO151240B (no) 1984-11-26
DK366678A (da) 1979-02-20
PH16364A (en) 1983-09-08
NZ188140A (en) 1981-01-23

Similar Documents

Publication Publication Date Title
DK148280C (da) Analogifremgangsmaade til fremstilling af thienothiazinderivater
DK155367C (da) Analogifremgangsmaade til fremstilling af 2-nitroimidazolderivater
DK63178A (da) Fremgangsmaade til fremstilling af pyrrodinderivater
DK536178A (da) Fremgangsmaade til fremstilling af stilbenderivater
DK110778A (da) Fremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer
DK149954C (da) Analogifremgangsmaade til fremstilling af 18-umaettede prostacyklinderivater
DK149858C (da) Analogifremgangsmaade til fremstilling af morfinderivater
DK146962C (da) Analogifremgangsmaade til fremstilling af indolizinderivater
DK155669C (da) Analogifremgangsmaade til fremstilling af pleuromutilinderivater
DK158984C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK153482C (da) Analogifremgangsmaade til fremstilling af 5-cyano-prostacyklinderivater
DK154137C (da) Analogifremgangsmaade til fremstilling af meta-sulfonamido-benzamidderivater
DK156643C (da) Analogifremgangsmaade til fremstilling af naphthalensulfonamidderivater
DK30578A (da) Fremgangsmaade til fremstilling af aminoalkoxyphenylderivater
DK156568C (da) Analogifremgangsmaade til fremstilling af 3-indolderivater
DK145701C (da) Fremgangsmaade til fremstilling af ergotalkaloider
DK50778A (da) Fremgangsmaade til fremstilling af oxadiazolopyrimidinderivater
DK149753C (da) Analogifremgangsmaade til fremstilling af morfinderivater
DK154970C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK154949C (da) Fremgangsmaade til fremstilling af trifluormethylphenoler
DK154434C (da) Analogifremgangsmaade til fremstilling af tripeptidderivater
DK50878A (da) Fremgangsmaade til fremstilling af oxadiazolopyrimidinderivater
DK246878A (da) Fremgangsmaade til fremstilling af acylderivater
DK61778A (da) Fremgangsmaade til fremstilling af everninominderivater
DK150156C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater

Legal Events

Date Code Title Description
PBP Patent lapsed