DK154211C - Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser - Google Patents

Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Info

Publication number
DK154211C
DK154211C DK127480A DK127480A DK154211C DK 154211 C DK154211 C DK 154211C DK 127480 A DK127480 A DK 127480A DK 127480 A DK127480 A DK 127480A DK 154211 C DK154211 C DK 154211C
Authority
DK
Denmark
Prior art keywords
vitamin
compounds
preparation
substituted
fluorous
Prior art date
Application number
DK127480A
Other languages
Danish (da)
English (en)
Other versions
DK127480A (da
DK154211B (da
Inventor
Hector F Deluca
Heinrich K Schnoes
Jr Joseph L Napoli
Bruce L Onisko
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK127480A publication Critical patent/DK127480A/da
Publication of DK154211B publication Critical patent/DK154211B/da
Application granted granted Critical
Publication of DK154211C publication Critical patent/DK154211C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK127480A 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser DK154211C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92827978 1978-07-26
US05/928,279 US4188345A (en) 1978-07-26 1978-07-26 Fluorovitamin D compounds and processes for their preparation
US7900528 1979-07-24
PCT/US1979/000528 WO1980000338A1 (en) 1978-07-26 1979-07-24 Process for preparing side chain fluorinated vitamin d compounds

Publications (3)

Publication Number Publication Date
DK127480A DK127480A (da) 1980-03-25
DK154211B DK154211B (da) 1988-10-24
DK154211C true DK154211C (da) 1989-03-13

Family

ID=25456012

Family Applications (2)

Application Number Title Priority Date Filing Date
DK127580A DK156716C (da) 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser
DK127480A DK154211C (da) 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK127580A DK156716C (da) 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser

Country Status (14)

Country Link
US (1) US4188345A (ja)
JP (2) JPS6312867B2 (ja)
AU (1) AU521131B2 (ja)
BE (1) BE877918A (ja)
CH (2) CH650237A5 (ja)
DK (2) DK156716C (ja)
FR (1) FR2433514B1 (ja)
GB (1) GB2026494B (ja)
IE (1) IE48463B1 (ja)
IL (1) IL57801A (ja)
NL (2) NL7920012A (ja)
NZ (1) NZ190939A (ja)
SE (2) SE8001746L (ja)
WO (2) WO1980000338A1 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4410515A (en) * 1981-04-01 1983-10-18 Massachusetts General Hospital Vitamin D glycosides and a method of use
WO1984000107A1 (en) * 1982-06-30 1984-01-19 Massachusetts Gen Hospital Vitamin d glycosides
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
GB2145091B (en) * 1983-08-18 1987-08-12 Wisconsin Alumni Res Found Vitamin d3 derivatives
US4661294A (en) * 1985-03-18 1987-04-28 The General Hospital Corporation Biologically active 1-thio derivatives of vitamin D
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
TR25295A (tr) * 1992-02-26 1993-01-01 Simfer Dayanikli Tueketim Mamu Kati yakit yakan sobalar icin yanma havasi ön isitma sistemi
US5384314B1 (en) * 1994-03-11 1997-08-05 Hoffmann La Roche 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
EP1021401A1 (en) * 1995-09-21 2000-07-26 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US6100294A (en) 1997-05-16 2000-08-08 Women And Infants Hospital Cyclic ether vitamin D3 compounds, 1α(OH) 3-epi-vitamin D3 compounds and uses thereof
MX2008012114A (es) * 2006-04-06 2009-03-06 Wisconsin Alumni Res Found Analogos 19-nor-vitamina d con anillo 1,2, o 3,2 heterociclico.
JP2009532458A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
WO2007118198A2 (en) * 2006-04-06 2007-10-18 Wisconsin Alumni Research Foundation 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF
NZ570711A (en) 2006-04-06 2012-10-26 Wisconsin Alumni Res Found 2-Substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
JP2009532457A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１８，１９，２１−トリノルビタミンＤ３類縁体およびその使用
US7704981B2 (en) * 2006-04-06 2010-04-27 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof
MX2008012674A (es) * 2006-04-10 2008-10-15 Wisconsin Alumni Res Found Compuestos de 1 a-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitamina d con una cadena lateral 1,1-dimetilpropilo.
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US8814007B2 (en) 2010-12-31 2014-08-26 Medline Industries, Inc. Dispenser with directional flow controlling flange and corresponding systems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives

Also Published As

Publication number Publication date
CH641445A5 (de) 1984-02-29
FR2433514A1 (fr) 1980-03-14
JPS6312867B2 (ja) 1988-03-23
GB2026494A (en) 1980-02-06
JPS55500428A (ja) 1980-07-17
NZ190939A (en) 1982-09-07
AU4920679A (en) 1980-01-31
JPS6312868B2 (ja) 1988-03-23
IE48463B1 (en) 1985-01-23
US4188345A (en) 1980-02-12
BE877918A (fr) 1979-11-16
GB2026494B (en) 1982-12-15
SE8001746L (sv) 1980-03-05
IL57801A0 (en) 1979-11-30
WO1980000339A1 (en) 1980-03-06
DK156716C (da) 1990-02-19
IL57801A (en) 1984-03-30
DK127580A (da) 1980-03-25
DK127480A (da) 1980-03-25
CH650237A5 (de) 1985-07-15
DK156716B (da) 1989-09-25
NL7920012A (nl) 1980-05-30
JPS55500430A (ja) 1980-07-17
DK154211B (da) 1988-10-24
SE8001747L (sv) 1980-03-05
FR2433514B1 (fr) 1986-05-23
IE791496L (en) 1980-01-26
AU521131B2 (en) 1982-03-18
NL7920016A (nl) 1980-05-30
WO1980000338A1 (en) 1980-03-06

Similar Documents

Publication Publication Date Title
DK154211C (da) Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser
BR8107071A (pt) Valvula cardiaca para protese
ES506400A0 (es) Procedimiento para la fabricacion de collares para animales caseros,conteniendo ectoparasiticidas
DK106784A (da) Biokompatible, antithrombotiske materialer, som er velegnede til rekonstruktionskirurgi
ES520985A0 (es) Procedimiento para la preparacion de nuevos 6,11-dihidrodibenzo (b,e)-tiepin-11-n-alcohilnorescopin-eteres cuaternarios.
ES517234A0 (es) Procedimiento para la obtencion de trimeros mixtos de isocianatos organicos.
DK173883D0 (da) Substituerede 8-phenylxanthiner
PT77898B (en) Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
ES485489A0 (es) Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
ES507810A0 (es) Procedimiento para hidroformilar compuestos olefinicamente insaturados.
DK32684A (da) Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
HK15184A (en) Fluor-containing 1,4-dihydrophyridines,pharmaceuticals containing them and process for their preparation
DK8685A (da) Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
ATE124681T1 (de) Arzneimittelzusammensetzungen zur behandlung von psoriasis.
ES241316Y (es) Dispositivo ensanchador para el tratamiento de displasais dela cadera.
IS2902A7 (is) Aðferð til framleiðslu á 1,8-dihydroxy-10-acyl-9-anthrones, sérstaklega til meðferðar á psoriasis
SE8404334L (sv) 16-fluoro-16,17-didehydro-prostanoider och forfarande for deras framstellning
ES538403A0 (es) Procedimiento para la obtencion de antipodas opticos del (+7-1,7-difenil-3-metilaza-7-ciano-8-metil-nonano
DE3373978D1 (en) Composition for the care or treatment of the human skin
DK96379A (da) Fremgangsmaade til fremstilling af disubstituerede 2,3-dihydroimidazo (1,2-c)-pyrimidiner
IT7826282A0 (it) Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi.
ES500419A0 (es) Aparato y su correspondiente procedimiento,para el trata- miento en humedo de cueros
IT7920415A0 (it) Preparazione di ceruletide. procedimento per la
DK306479A (da) N-cyclohexyl-n-methoxyacetoacetamid, fremgangsmaade til fremstilling deraf og anvendelse deraf til fremstilling af o-methyl-n-cyclohexyl-2,5-dimethylfuran-3-hydroxamsyre
DE2963558D1 (en) N-amino-3,4,5-trihydroxypiperidines, methods for their preparation, medicaments containing them, method for the production of the medicaments and animal feedstuff containing said compounds

Legal Events

Date Code Title Description
PBP Patent lapsed