DK1539742T3 - Indolderivater, der er nyttige som histamin H3-antagonister - Google Patents

Indolderivater, der er nyttige som histamin H3-antagonister

Info

Publication number
DK1539742T3
DK1539742T3 DK03761216T DK03761216T DK1539742T3 DK 1539742 T3 DK1539742 T3 DK 1539742T3 DK 03761216 T DK03761216 T DK 03761216T DK 03761216 T DK03761216 T DK 03761216T DK 1539742 T3 DK1539742 T3 DK 1539742T3
Authority
DK
Denmark
Prior art keywords
histamine
antagonists
indole derivatives
derivatives useful
useful
Prior art date
Application number
DK03761216T
Other languages
Danish (da)
English (en)
Inventor
Robert G Aslanian
Michael Y Berlin
Pietro Mangiaracina
Kevin D Mccormick
Mwangi W Mutahi
Stuart B Rosenblum
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1539742T3 publication Critical patent/DK1539742T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
DK03761216T 2002-06-24 2003-06-20 Indolderivater, der er nyttige som histamin H3-antagonister DK1539742T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39098702P 2002-06-24 2002-06-24

Publications (1)

Publication Number Publication Date
DK1539742T3 true DK1539742T3 (da) 2006-12-27

Family

ID=30000654

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03761216T DK1539742T3 (da) 2002-06-24 2003-06-20 Indolderivater, der er nyttige som histamin H3-antagonister

Country Status (22)

Country Link
US (1) US6951871B2 (pt)
EP (2) EP1777223A1 (pt)
JP (1) JP4326468B2 (pt)
KR (1) KR20050009757A (pt)
CN (1) CN100497334C (pt)
AR (1) AR039718A1 (pt)
AT (1) ATE344798T1 (pt)
AU (1) AU2003243709B2 (pt)
CA (1) CA2489337C (pt)
CY (1) CY1105986T1 (pt)
DE (1) DE60309598T2 (pt)
DK (1) DK1539742T3 (pt)
ES (1) ES2271644T3 (pt)
HK (1) HK1072259A1 (pt)
IL (1) IL165863A0 (pt)
MX (1) MXPA05000193A (pt)
MY (1) MY135686A (pt)
NZ (1) NZ537200A (pt)
PT (1) PT1539742E (pt)
TW (1) TW200400031A (pt)
WO (1) WO2004000831A1 (pt)
ZA (1) ZA200410213B (pt)

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KR20070100277A (ko) * 2004-12-06 2007-10-10 아벤티스 파마 소시에떼아노님 치환된 인돌, 그를 함유하는 조성물, 그의 제조 방법 및그의 용도
BRPI0606502A2 (pt) 2005-01-19 2009-06-30 Hoffmann La Roche compostos; processo para a fabricação de compostos; composições farmacêuticas; método para o tratamento ou prevenção de doenças que são associadas com a modulação de receptores h3; método para o tratamento ou prevenção de obesidade em um ser humano ou animal; método de tratamento ou prevenção de diabetes tipo ii em um ser humano ou animal e usos de compostos
MX2007016523A (es) * 2005-06-20 2008-03-06 Schering Corp Piperidinas sustituidas ligadas a carbono y derivados de las mismas utiles como antagonistas de hsitamina h3.
US7635705B2 (en) 2005-06-20 2009-12-22 Schering Corporation Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists
EP1909797A4 (en) * 2005-08-02 2013-02-27 Neurogen Corp DIPIPERAZINYL KETONE AND RELATED ANALOG
US7538223B2 (en) 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
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KR101007489B1 (ko) * 2005-11-18 2011-01-12 에프. 호프만-라 로슈 아게 아자인돌-2-카복스아마이드 유도체
DE602006014022D1 (de) * 2005-11-30 2010-06-10 Hoffmann La Roche 5-substituierte indol-2-carbonsäureamidderivate
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
WO2007070683A2 (en) * 2005-12-15 2007-06-21 Cytokinetics, Inc. Certain chemical entities, compositions and methods
EP1959962A2 (en) 2005-12-16 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
US7989455B2 (en) 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
MX2008008337A (es) * 2005-12-21 2008-09-03 Schering Corp Fenoxipiperidinas y sus analogos utiles como antagonistas de histamina h3.
JP2009521445A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション H3アンタゴニスト/逆アゴニストと食欲抑制剤との組み合わせ
PE20071136A1 (es) * 2005-12-21 2007-12-29 Schering Corp Derivados de anilina sustituida como antagonistas de la histamina h3
US7696229B2 (en) * 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
US7514433B2 (en) * 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US8153660B2 (en) * 2006-10-27 2012-04-10 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol CCR3 modulators
US8148403B2 (en) 2006-10-27 2012-04-03 Boehringer Ingelheim International Gmbh Substituted piperidyl-propane-thiols
MX2010001576A (es) * 2007-08-15 2010-09-14 Memory Pharm Corp Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6).
EP2240018B1 (en) 2008-01-04 2016-05-25 Schabar Research Associates LLC Composition comprising an analgesic and an antihistamine
JP5791500B2 (ja) 2008-05-23 2015-10-07 パンミラ ファーマシューティカルズ,エルエルシー. 5−リポキシゲナーゼ活性化タンパク質阻害剤
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
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Also Published As

Publication number Publication date
PT1539742E (pt) 2007-01-31
EP1539742A1 (en) 2005-06-15
ATE344798T1 (de) 2006-11-15
ZA200410213B (en) 2005-10-20
KR20050009757A (ko) 2005-01-25
AU2003243709A1 (en) 2004-01-06
US6951871B2 (en) 2005-10-04
CN100497334C (zh) 2009-06-10
IL165863A0 (en) 2006-01-15
MY135686A (en) 2008-06-30
DE60309598D1 (de) 2006-12-21
CN1662524A (zh) 2005-08-31
AU2003243709B2 (en) 2007-01-18
EP1777223A1 (en) 2007-04-25
MXPA05000193A (es) 2005-04-08
CA2489337C (en) 2010-05-25
CA2489337A1 (en) 2003-12-31
EP1539742B1 (en) 2006-11-08
US20040019099A1 (en) 2004-01-29
NZ537200A (en) 2007-09-28
TW200400031A (en) 2004-01-01
JP4326468B2 (ja) 2009-09-09
DE60309598T2 (de) 2007-09-13
JP2005531615A (ja) 2005-10-20
HK1072259A1 (en) 2005-08-19
CY1105986T1 (el) 2011-04-06
AR039718A1 (es) 2005-03-09
ES2271644T3 (es) 2007-04-16
WO2004000831A1 (en) 2003-12-31

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