AR039718A1 - Derivados de indol utiles como antagonistas de la histamina h3 - Google Patents
Derivados de indol utiles como antagonistas de la histamina h3Info
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- AR039718A1 AR039718A1 ARP030102203A ARP030102203A AR039718A1 AR 039718 A1 AR039718 A1 AR 039718A1 AR P030102203 A ARP030102203 A AR P030102203A AR P030102203 A ARP030102203 A AR P030102203A AR 039718 A1 AR039718 A1 AR 039718A1
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- Prior art keywords
- alkyl
- aryl
- independently selected
- alkoxy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Un compuesto representando por la fórmula estructural (1) o una sal o solvato farmacéuticamente aceptable del mismo, en el cual a es de 0 a 3; b es de 0 a 3; n es 1, 2, ó 3; p es 1, 2 ó 3; r es 0, 1, 2 ó 3; X es un enlace o alquileno C1-6; M1 es CH o N; M2 es C(R3) o N; con las salvedades de que cuando M2 es N; p no es 1; y que cuando r es o, M2 es C(R3) y que la suma de p y r es de 1 a 4; Y es -C(=O)-, -C(=S)-, -(CH2)Q-, -C(=O)NR4-, -C(=O)CH2-, -SO1-2-, -C(=N-CN)-NH- o -NH-C(=N-CN)-; con las salvedades de que, cuando M1 es N, Y no es -NR4C(=O)- ni -NH-C(=N-CN)- y cuando M2 es N, Y no es -C(=O)NR4- ni -C(=N-CN)-NH-; q es 1 a 5, siempre que, cuando tanto M1 como M2 son ambos N, q no sea 1; Z es un enlace, alquileno C1-6, alquenileno C2-6, -C(=O)-, -CH(CN)- o -CH2C(=O)NR4-; R1 es un resto seleccionado del grupo de fórmulas (2); Q es -N(R8)-, -S- o -O-; k es 0, 1, 2, 3 ó 4; k1 es 0, 1, 2 ó 3; k2 es 0, 1 ó 2; la línea de puntos representa un enlace doble optativo; R y R7 son independientemente seleccionados entre el grupo que consiste en H, alquilo C1-6, haloalquilo (C1-6), alcoxi C1-6, alcoxi(C1-6)-alquilo(C1-6)-, alcoxi(C1-6)-alcoxi(C1-6)-, alcoxi(C1-6)-alquilo(C1-6)-SO0-2, R32-arilalcoxi (C1-6)-, R32-arilalquilo (C1-6)-, R32-arilo, R32-ariloxi, R32-heteroarilo, cicloalquilo (C1-6), cicloalquil(C3-6)-alquilo(C1-6), cicloalquil(C3-6)-alcoxi(C1-6), cicloalquil(C3-6)-oxi, R37-heterocicloalquilo, N(R30)(R31)-alquilo (C1-6), N(R30)(R31), -NH-alquil(C1-6)-O-alquilo(C1-6), -NHC(O)NH(R29); R22-S(O)0-2-, haloalquil(C1-6)-S(O)0-2-, N(R30)(R31)-alquilo(C1-6)-S(O)0-2-, benzoilo, alcoxi(C1-6)-carbonilo, R37-heterocicloalquil-N(R29)-C(O)-, alquil(C1-6)-N(R29)-C(O)-, alquil(C1-6)-N(alcoxiC1-6)-C(O)-, -C(=NOR36)R36 y -NHC(O)R29 y, cuando no está presente el enlace doble optativo, R7 puede ser OH; R8 es H, alquilo C1-6, halo-alquilo (C1-6), alcoxi(C1-6)-alquilo(C2-6)-, R32-aril-alquilo (C1-6)-, R32-arilo, R32-heteroarilo, R32-heteroaril-alquilo (C1-6)-, cicloalquilo (C3-6), cicloalquil(C3-6)-alquilo(C1-6), R37-heterocicloalquilo, R37-heterocicloalquil-alquilo (C1-6), N(R30)(R31)-alquilo (C2-6)-, R22-S(O)2-, halo-alquilo (C1-6)-S(O)2-, R22-S(O)0-1-alquilo (C2-6)-, halo-alquil(C1-6)-S(O)0-1-alquilo(C2-6)-, alquil(C1-6)-N(R29)-SO2- o R32-heteroaril-SO2; R2 es un anillo de heteroarilo de seis miembros que tiene 1 ó 2 heteroátomos independientemente seleccionados entre N o N-O, siendo los restantes átomos del anillo, de carbono; un anillo de heteroarilo de cinco miembros con 1, 2, 3 ó 4 heteroátomos independientemente seleccionados entre N, O ó S, donde los restantes átomos del anillo de carbono, R32-quinolilo, R32-arilo, un resto de fórmula (3); o heterocicloalquilo; donde dicho anillo de heteroarilo de seis miembros o dicho anillo de heteroarilo de cinco miembros está optativamente sustituidos con R6; R3 es H, halógeno, alquilo C1-6, -OH o alcoxi (C1-6), R4 es independientemente seleccionado entre el grupo que consiste en hidrógeno, alquilo C1-6, cicloalquilo C3-6, cicloalquil(C3-6)-alquilo(C1-6), R33-arilo, R33-aril-alquilo (C1-6) y R32-heteroarilo; R5 es hidrógeno, alquilo C1-6; -C(O)R20, -C(O)2R20, -C(O)N(R20)2, R33-aril-alquilo (C1-6) o alquil(C1-6)-SO2-; R6 representa 1 a 3 sustituyentes independientemente seleccionados entre el grupo que consiste en -OH, halógeno, alquilo C1-6, alcoxi C1-6, -CF3, -NR4R5, -alquil(C1-6)-NR4R5, fenilo, R33-fenilo, NO2, -CO2R4, -CON(R4)2, -NHC(O)N(R4)2, R32-heteroaril-SO2-NH-, R32-aril-alquil(C1-6)-NH, R32-heteroaril-alquilo(C1-6)-NH-, R32-heteroaril-NH-C(O)-NH-, R37-heterocicloalquil-N(R29)-C(O)- y R37-heterocicloalquil-N(R29)-C(O)-NH; R12 es independientemente seleccionado entre el grupo que consiste en alquilo C1-6, hidroxilo, alcoxi C1-6 o flúor, siempre que, cuando R12 es hidroxi o flúor, luego R12 no esté unido a un carbono adyacente a un nitrógeno o R12 forme un puente de alquilo C1-2 desde un carbono del anillo hasta otro carbono del anillo; R13 es independientemente seleccionado entre el grupo que consiste en alquilo C1-6, hidroxilo, alcoxi C1-6 o flúor, siempre que, cuando R13 es hidroxi o flúor, luego R13 no esté unido a un carbono adyacente a un nitrógeno o forme un puente de alquilo C1-2 desde un carbono del anillo hasta otro carbono del anillo; o R13 es =O; R20 es independientemente seleccionado entre el grupo que consiste en hidrógeno, alquilo C1-6, o arilo, donde dicho grupo arilo está optativamente sustituido con 1 a 3 grupos independientemente seleccionados entre halógeno, -CF3, -OCF3-, hidroxilo o metoxi o, cuando hay dos grupos R20 presentes, dichos dos grupos R20 tomados junto con el nitrógeno al cual están unidos, forman un anillo heterocíclico de cinco o seis miembros; R22 es alquilo C1-6, R34-arilo o heterocicloalquilo; R24 es H, alquilo C1-6, -SO2R22 o R34-arilo; R25 es independientemente seleccionado entre el grupo que consiste en alquilo C1-6, halógeno, CN, -CF3, -OH, alcoxi C1-6, alquil(C1-6)-C(O)-, aril-C(O)-, N(R4)(R5)-C(O)-, N(R4)(R5)-S(O)1-2-, halo-alquilo (C1-6)- o halo-alcoxi(C1-6)-alquilo(C1-6)-; R29 es H, alquilo C1-6, R35-arilo o R35-aril-alquilo (C1-6)-; R30 es H, alquilo C1-6-, R35-arilo o R35-aril-alquilo (C1-6)-; R31 es H, alquilo C1-6, R35-arilo, R35-aril-alquilo (C1-6)-; alquil(C1-6)-C(O)-, R35-aril-C(O)-, N(R4)(R5)-C(O)-, alquil(C1-6)-S(O)2- o R35-aril-S(O)2-; o R30 y R31, juntos son -(CH2)4-5-, -(CH2)2-O-(CH2)2- o -(CH2)2-N(R29)-(CH2)2- y forman un anillo con el nitrógeno al cual están unidos; R32 representa 1 a 3 sustituyentes independientemente seleccionados entre el grupo que consiste en H, -OH, halógeno, alquilo C1-6, alcoxi C1-6, R35-aril-O-, SR22, -CF3, -OCF3, -OCHF2, -NR4R5, fenilo, R33-fenilo, -NO2, -CO2R4, -CON(R4)2, -S(O)2R22, -S(O)2N(R20)2, -N(R24)S(O)2R22, -CN, hidroxi-alquilo (C1-6)-, -OCH2CH2OR22 y R35-aril-alquil(C1-6)-O-, donde dicho grupo arilo está optativamente sustituido con 1 a 3 halógenos independientemente seleccionados; R33 representa 1 a 3 sustituyentes independientemente seleccionados entre el grupo que consiste en alquilo C1-6, halógeno, -CN, -NO2, -OCHF2 y O-alquilo (C1-6)-; R34 representa 1 a 3 sustituyentes independientemente seleccionados entre el grupo que consiste en H, halógeno, -CF3, -OCF3, -OH y -OCH3; R35 representa 1 a 3 sustituyentes independientemente seleccionados entre el grupo que consiste en hidrógeno, halo, alquilo C1-6, hidroxi, alcoxi C1-6, fenoxi, -CF3, -N(R36)2, -COOR20 y -NO2; R36 es independientemente seleccionado entre el grupo que consiste en H y alquilo C1-6; y R37 es independientemente seleccionado entre el grupo que consiste en H, alquilo C1-6 y alcoxicarbonilo (C1-6). Reivindicación 13: Una composición farmacéutica que comprende una cantidad efectiva de un compuesto de acuerdo con la reivindicación 1 y un vehículo farmacéuticamente aceptable. Reivindicación 14: El uso de un compuesto de acuerdo con la reivindicación 1 para la preparación de un medicamento para el tratamiento de alergia, respuestas de las vías respiratorias inducidas por alergia, congestión, hipotensión, enfermedad cardiovascular, enfermedades del tracto GI, híper e hipomotilidad y secreción ácida del tracto gastrointestinal, obesidad, trastornos del sueno, perturbaciones del sistema nervioso central, trastorno de hiperactividad y déficit de la atención, hipo e hiperactividad del sistema nervioso central, enfermedad de Alzheimer, esquizofrenia y migrana. Reivindicación 15: Una composición farmacéutica que comprende una cantidad efectiva de un compuesto de acuerdo con al reivindicación 1, y una cantidad efectiva de un antagonista del receptor H1 y un vehículo farmacéuticamente aceptable. Reivindicación 16: El uso de un compuesto de acuerdo con la reivindicación para la preparación de un medicamento para usar en combinación con un antagonista del receptor H1 para el tratamiento de alergia, respuestas de las vías respiratorias inducidas por alergias y congestión.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39098702P | 2002-06-24 | 2002-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039718A1 true AR039718A1 (es) | 2005-03-09 |
Family
ID=30000654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030102203A AR039718A1 (es) | 2002-06-24 | 2003-06-20 | Derivados de indol utiles como antagonistas de la histamina h3 |
Country Status (22)
Country | Link |
---|---|
US (1) | US6951871B2 (es) |
EP (2) | EP1777223A1 (es) |
JP (1) | JP4326468B2 (es) |
KR (1) | KR20050009757A (es) |
CN (1) | CN100497334C (es) |
AR (1) | AR039718A1 (es) |
AT (1) | ATE344798T1 (es) |
AU (1) | AU2003243709B2 (es) |
CA (1) | CA2489337C (es) |
CY (1) | CY1105986T1 (es) |
DE (1) | DE60309598T2 (es) |
DK (1) | DK1539742T3 (es) |
ES (1) | ES2271644T3 (es) |
HK (1) | HK1072259A1 (es) |
IL (1) | IL165863A0 (es) |
MX (1) | MXPA05000193A (es) |
MY (1) | MY135686A (es) |
NZ (1) | NZ537200A (es) |
PT (1) | PT1539742E (es) |
TW (1) | TW200400031A (es) |
WO (1) | WO2004000831A1 (es) |
ZA (1) | ZA200410213B (es) |
Families Citing this family (45)
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US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US8110595B2 (en) | 2004-06-17 | 2012-02-07 | Cytokinetics, Inc. | Ureas and their use in the treatment of heart failure |
RU2382778C2 (ru) * | 2004-06-21 | 2010-02-27 | Ф.Хоффманн-Ля Рош Аг | Производные индола в качестве антагонистов гистаминовых рецепторов |
US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
JP2008532926A (ja) * | 2004-12-06 | 2008-08-21 | アバンテイス・フアルマ・エス・アー | 置換インドール化合物、それを含有する組成物、この製造方法およびこの使用 |
FR2878849B1 (fr) | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
WO2006077024A2 (en) | 2005-01-19 | 2006-07-27 | F. Hoffmann-La Roche Ag | 5-aminoindole derivatives |
US7408066B2 (en) | 2005-06-20 | 2008-08-05 | Schering Corproation | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
CN101243072A (zh) | 2005-06-20 | 2008-08-13 | 先灵公司 | 用作组胺h3拮抗剂的哌啶衍生物 |
WO2007016496A2 (en) * | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7332604B2 (en) * | 2005-09-20 | 2008-02-19 | Schering Corporation | 1-[[1-[(2-Amino-6-methyl-4-pyridinyl)methyl]-4-fluoro-4-piperidinyl]carbonyl]-4-[2-(2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]piperidine |
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US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
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ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
US7825120B2 (en) * | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
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US20040019099A1 (en) | 2004-01-29 |
ZA200410213B (en) | 2005-10-20 |
DE60309598D1 (de) | 2006-12-21 |
JP4326468B2 (ja) | 2009-09-09 |
ATE344798T1 (de) | 2006-11-15 |
IL165863A0 (en) | 2006-01-15 |
CA2489337A1 (en) | 2003-12-31 |
DK1539742T3 (da) | 2006-12-27 |
US6951871B2 (en) | 2005-10-04 |
DE60309598T2 (de) | 2007-09-13 |
MXPA05000193A (es) | 2005-04-08 |
EP1777223A1 (en) | 2007-04-25 |
CN1662524A (zh) | 2005-08-31 |
AU2003243709A1 (en) | 2004-01-06 |
AU2003243709B2 (en) | 2007-01-18 |
MY135686A (en) | 2008-06-30 |
EP1539742B1 (en) | 2006-11-08 |
CN100497334C (zh) | 2009-06-10 |
KR20050009757A (ko) | 2005-01-25 |
ES2271644T3 (es) | 2007-04-16 |
NZ537200A (en) | 2007-09-28 |
JP2005531615A (ja) | 2005-10-20 |
CY1105986T1 (el) | 2011-04-06 |
PT1539742E (pt) | 2007-01-31 |
TW200400031A (en) | 2004-01-01 |
WO2004000831A1 (en) | 2003-12-31 |
CA2489337C (en) | 2010-05-25 |
HK1072259A1 (en) | 2005-08-19 |
EP1539742A1 (en) | 2005-06-15 |
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