HK1072259A1 - Indole derivatives useful as histamine h3 antagonists - Google Patents
Indole derivatives useful as histamine h3 antagonistsInfo
- Publication number
- HK1072259A1 HK1072259A1 HK05105092A HK05105092A HK1072259A1 HK 1072259 A1 HK1072259 A1 HK 1072259A1 HK 05105092 A HK05105092 A HK 05105092A HK 05105092 A HK05105092 A HK 05105092A HK 1072259 A1 HK1072259 A1 HK 1072259A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- histamine
- antagonists
- indole derivatives
- derivatives useful
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39098702P | 2002-06-24 | 2002-06-24 | |
PCT/US2003/019619 WO2004000831A1 (en) | 2002-06-24 | 2003-06-20 | Indole derivatives useful as histamine h3 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1072259A1 true HK1072259A1 (en) | 2005-08-19 |
Family
ID=30000654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05105092A HK1072259A1 (en) | 2002-06-24 | 2005-06-18 | Indole derivatives useful as histamine h3 antagonists |
Country Status (22)
Country | Link |
---|---|
US (1) | US6951871B2 (es) |
EP (2) | EP1539742B1 (es) |
JP (1) | JP4326468B2 (es) |
KR (1) | KR20050009757A (es) |
CN (1) | CN100497334C (es) |
AR (1) | AR039718A1 (es) |
AT (1) | ATE344798T1 (es) |
AU (1) | AU2003243709B2 (es) |
CA (1) | CA2489337C (es) |
CY (1) | CY1105986T1 (es) |
DE (1) | DE60309598T2 (es) |
DK (1) | DK1539742T3 (es) |
ES (1) | ES2271644T3 (es) |
HK (1) | HK1072259A1 (es) |
IL (1) | IL165863A0 (es) |
MX (1) | MXPA05000193A (es) |
MY (1) | MY135686A (es) |
NZ (1) | NZ537200A (es) |
PT (1) | PT1539742E (es) |
TW (1) | TW200400031A (es) |
WO (1) | WO2004000831A1 (es) |
ZA (1) | ZA200410213B (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
CA2491079C (en) * | 2002-06-28 | 2011-10-04 | Donald J. Kyle | Therapeutic piperazine derivatives useful for treating pain |
WO2004064730A2 (en) | 2003-01-14 | 2004-08-05 | Cytokinetics, Inc. | Compounds, compositions and methods |
RU2410384C2 (ru) | 2004-06-17 | 2011-01-27 | Цитокинетикс, Инк. | Соединения, композиции и способы их использования |
CA2569611C (en) * | 2004-06-21 | 2012-12-11 | F. Hoffmann-La Roche Ag | Indole derivatives as histamine receptor antagonists |
US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
KR20070100277A (ko) * | 2004-12-06 | 2007-10-10 | 아벤티스 파마 소시에떼아노님 | 치환된 인돌, 그를 함유하는 조성물, 그의 제조 방법 및그의 용도 |
FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
AU2006207712A1 (en) | 2005-01-19 | 2006-07-27 | F. Hoffmann-La Roche Ag | 5-aminoindole derivatives |
WO2007001975A1 (en) | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
CA2609957A1 (en) | 2005-06-20 | 2007-01-04 | Schering Corporation | Carbon-linked substituted piperidines and derivatives thereof useful as histamine h3 antagonists |
EP1909797A4 (en) * | 2005-08-02 | 2013-02-27 | Neurogen Corp | DIPIPERAZINYL KETONE AND RELATED ANALOG |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
EP1931665A1 (en) * | 2005-09-20 | 2008-06-18 | Schering Corporation | 1-[[1-[(2-amin0-6-methyl-4-pyridinyl)methyl]-4-flu0r0-4-piperidinyl,]carbonyl]-4-[2-(2-pyridinyl)-3h-imidaz0[4, 5-b]pyridin-3-yl]piperidine useful as histamine h3 antagonist |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
EP1966199B1 (en) * | 2005-11-18 | 2010-10-20 | F. Hoffmann-La Roche AG | Azaindole-2-carboxamide derivatives |
AU2006319235A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
EP1959960B1 (en) | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
WO2007078815A2 (en) | 2005-12-16 | 2007-07-12 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
WO2007078839A2 (en) * | 2005-12-19 | 2007-07-12 | Cytokinetics, Inc. | Compounds, compositions and methods |
WO2007075555A2 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Combination of an h3 antagonist/inverse agonist and an appetite suppressant |
WO2007075629A2 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists |
PE20071136A1 (es) * | 2005-12-21 | 2007-12-29 | Schering Corp | Derivados de anilina sustituida como antagonistas de la histamina h3 |
JP2010519171A (ja) * | 2006-02-17 | 2010-06-03 | メモリー・ファーマシューティカルズ・コーポレイション | 5−ht6受容体親和性を有する化合物 |
US7514433B2 (en) * | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
US8153660B2 (en) * | 2006-10-27 | 2012-04-10 | Boehringer Ingelheim International Gmbh | Piperidyl-propane-thiol CCR3 modulators |
EP2079731B1 (en) * | 2006-10-27 | 2011-09-14 | Boehringer Ingelheim International GmbH | Novel substituted piperidyl-propane-thiols |
KR20100053626A (ko) * | 2007-08-15 | 2010-05-20 | 메모리 파마슈티칼스 코포레이션 | 5-ht6 수용체 친화성을 나타내는 3'-치환된 화합물 |
CA2956278C (en) * | 2008-01-04 | 2022-03-01 | Schabar Research Associates Llc | Unit oral dose compositions composed of ibuprofen and famotidine and applications thereof |
CN102137858B (zh) | 2008-05-23 | 2014-07-23 | 潘米拉制药有限责任公司 | 5-脂氧合酶-活化蛋白抑制剂 |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100035862A1 (en) * | 2008-06-25 | 2010-02-11 | Abbott Laboratories | Novel aza-cyclic indole-2-carboxamides and methods of use thereof |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
EP2318387A1 (en) * | 2008-07-23 | 2011-05-11 | Schering Corporation | Bicyclic heterocycle derivatives as histamine h3 receptor antagonists |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
EP2556068B1 (en) | 2010-04-08 | 2019-01-23 | Respivert Limited | P38 map kinase inhibitors |
NZ604035A (en) | 2010-06-04 | 2015-02-27 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Fxr有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
EP3797769A1 (fr) | 2019-09-25 | 2021-03-31 | Fontès, M. Michel | Composition a usage therapeutique |
CN116194102A (zh) | 2020-07-15 | 2023-05-30 | 沙巴研究联合有限责任公司 | 用于治疗急性疼痛和降低胃灼热的严重程度和/或风险的包含布洛芬和法莫替丁的单位口服剂量组合物 |
US11324727B2 (en) | 2020-07-15 | 2022-05-10 | Schabar Research Associates, Llc | Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0730037B2 (ja) | 1987-03-13 | 1995-04-05 | 第一製薬株式会社 | ピリミジニルプロピオン酸誘導体 |
DK181190D0 (da) | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
US5352707A (en) * | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
US5217986A (en) * | 1992-03-26 | 1993-06-08 | Harbor Branch Oceanographic Institution, Inc. | Anti-allergy agent |
US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
WO1998006394A1 (en) | 1996-08-16 | 1998-02-19 | Schering Corporation | Treatment of upper airway allergic responses with a combination of histamine receptor antagonists |
SK68399A3 (en) * | 1996-11-25 | 2000-07-11 | Procter & Gamble | 2-imidazolinylaminoindole compound, pharmaceutical composition containing the same and use thereof |
US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
WO2001046181A1 (en) | 1999-12-20 | 2001-06-28 | Eli Lilly And Company | Indole derivatives for the treatment of depression and anxiety |
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
ES2172436B1 (es) | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
JP2004529117A (ja) * | 2001-02-08 | 2004-09-24 | シェーリング コーポレイション | 認知欠陥障害の処置における二重のh3/m2アンタゴニストの使用 |
JP4522651B2 (ja) | 2001-03-13 | 2010-08-11 | シェーリング コーポレイション | 新規非イミダゾール化合物 |
-
2003
- 2003-06-20 IL IL16586303A patent/IL165863A0/xx unknown
- 2003-06-20 JP JP2004516072A patent/JP4326468B2/ja not_active Expired - Fee Related
- 2003-06-20 EP EP03761216A patent/EP1539742B1/en not_active Expired - Lifetime
- 2003-06-20 CN CNB038147173A patent/CN100497334C/zh not_active Expired - Fee Related
- 2003-06-20 ES ES03761216T patent/ES2271644T3/es not_active Expired - Lifetime
- 2003-06-20 MX MXPA05000193A patent/MXPA05000193A/es active IP Right Grant
- 2003-06-20 NZ NZ537200A patent/NZ537200A/en unknown
- 2003-06-20 TW TW092116874A patent/TW200400031A/zh unknown
- 2003-06-20 MY MYPI20032323A patent/MY135686A/en unknown
- 2003-06-20 DK DK03761216T patent/DK1539742T3/da active
- 2003-06-20 DE DE60309598T patent/DE60309598T2/de not_active Expired - Lifetime
- 2003-06-20 AR ARP030102203A patent/AR039718A1/es unknown
- 2003-06-20 CA CA2489337A patent/CA2489337C/en not_active Expired - Fee Related
- 2003-06-20 AT AT03761216T patent/ATE344798T1/de not_active IP Right Cessation
- 2003-06-20 PT PT03761216T patent/PT1539742E/pt unknown
- 2003-06-20 EP EP06020215A patent/EP1777223A1/en not_active Withdrawn
- 2003-06-20 AU AU2003243709A patent/AU2003243709B2/en not_active Ceased
- 2003-06-20 US US10/600,674 patent/US6951871B2/en not_active Expired - Fee Related
- 2003-06-20 WO PCT/US2003/019619 patent/WO2004000831A1/en active IP Right Grant
- 2003-06-20 KR KR10-2004-7020914A patent/KR20050009757A/ko not_active Application Discontinuation
-
2004
- 2004-12-17 ZA ZA200410213A patent/ZA200410213B/en unknown
-
2005
- 2005-06-18 HK HK05105092A patent/HK1072259A1/xx not_active IP Right Cessation
-
2007
- 2007-02-05 CY CY20071100153T patent/CY1105986T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
MY135686A (en) | 2008-06-30 |
DK1539742T3 (da) | 2006-12-27 |
AU2003243709B2 (en) | 2007-01-18 |
CN100497334C (zh) | 2009-06-10 |
CA2489337C (en) | 2010-05-25 |
TW200400031A (en) | 2004-01-01 |
ATE344798T1 (de) | 2006-11-15 |
JP4326468B2 (ja) | 2009-09-09 |
CN1662524A (zh) | 2005-08-31 |
US6951871B2 (en) | 2005-10-04 |
AU2003243709A1 (en) | 2004-01-06 |
NZ537200A (en) | 2007-09-28 |
KR20050009757A (ko) | 2005-01-25 |
CY1105986T1 (el) | 2011-04-06 |
EP1539742A1 (en) | 2005-06-15 |
MXPA05000193A (es) | 2005-04-08 |
DE60309598T2 (de) | 2007-09-13 |
WO2004000831A1 (en) | 2003-12-31 |
DE60309598D1 (de) | 2006-12-21 |
ZA200410213B (en) | 2005-10-20 |
IL165863A0 (en) | 2006-01-15 |
EP1777223A1 (en) | 2007-04-25 |
JP2005531615A (ja) | 2005-10-20 |
US20040019099A1 (en) | 2004-01-29 |
AR039718A1 (es) | 2005-03-09 |
PT1539742E (pt) | 2007-01-31 |
EP1539742B1 (en) | 2006-11-08 |
CA2489337A1 (en) | 2003-12-31 |
ES2271644T3 (es) | 2007-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110620 |