DK1537093T3 - Taxanderivater, som er funktionaliseret i 14-positionen, samt en fremgangsmåde til fremstilling deraf - Google Patents

Taxanderivater, som er funktionaliseret i 14-positionen, samt en fremgangsmåde til fremstilling deraf

Info

Publication number
DK1537093T3
DK1537093T3 DK03747971T DK03747971T DK1537093T3 DK 1537093 T3 DK1537093 T3 DK 1537093T3 DK 03747971 T DK03747971 T DK 03747971T DK 03747971 T DK03747971 T DK 03747971T DK 1537093 T3 DK1537093 T3 DK 1537093T3
Authority
DK
Denmark
Prior art keywords
group
hydrogen
preparation
functionalized
alcohol
Prior art date
Application number
DK03747971T
Other languages
Danish (da)
English (en)
Inventor
Arturo Battaglia
Andrea Guerrini
Gabriele Fontana
Eleonora Baldelli
Maria Luisa Gelmi
Giacomo Carenzi
Donato Pocar
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1537093T3 publication Critical patent/DK1537093T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK03747971T 2002-09-10 2003-09-05 Taxanderivater, som er funktionaliseret i 14-positionen, samt en fremgangsmåde til fremstilling deraf DK1537093T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001921A ITMI20021921A1 (it) 2002-09-10 2002-09-10 Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
PCT/EP2003/009866 WO2004024706A2 (en) 2002-09-10 2003-09-05 Taxane derivatives functionalized at the 14- position and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
DK1537093T3 true DK1537093T3 (da) 2008-10-27

Family

ID=31986024

Family Applications (4)

Application Number Title Priority Date Filing Date
DK09155673.8T DK2077264T3 (da) 2002-09-10 2003-09-05 Taxanderivater og fremgangsmåde til fremstilling heraf
DK03747971T DK1537093T3 (da) 2002-09-10 2003-09-05 Taxanderivater, som er funktionaliseret i 14-positionen, samt en fremgangsmåde til fremstilling deraf
DK10177326.5T DK2298754T3 (da) 2002-09-10 2003-09-05 Fremstilling af taxanderivater
DK10177329.9T DK2264019T3 (da) 2002-09-10 2003-09-05 Mellemforbindelser til fremstilling af taxanderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09155673.8T DK2077264T3 (da) 2002-09-10 2003-09-05 Taxanderivater og fremgangsmåde til fremstilling heraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10177326.5T DK2298754T3 (da) 2002-09-10 2003-09-05 Fremstilling af taxanderivater
DK10177329.9T DK2264019T3 (da) 2002-09-10 2003-09-05 Mellemforbindelser til fremstilling af taxanderivater

Country Status (20)

Country Link
US (1) US7498452B2 (es)
EP (6) EP1980557A3 (es)
JP (2) JP4690039B2 (es)
KR (1) KR101096918B1 (es)
CN (1) CN1681799A (es)
AT (1) ATE398113T1 (es)
AU (1) AU2003267049B8 (es)
CA (1) CA2498277C (es)
DE (1) DE60321577D1 (es)
DK (4) DK2077264T3 (es)
ES (4) ES2398324T3 (es)
IL (5) IL167336A (es)
IT (1) ITMI20021921A1 (es)
NO (3) NO332250B1 (es)
PL (4) PL402333A1 (es)
PT (4) PT2264019E (es)
RU (1) RU2320652C2 (es)
SG (1) SG164282A1 (es)
SI (4) SI2264019T1 (es)
WO (1) WO2004024706A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504222A (en) 1993-08-20 1996-04-02 The Scripps Research Institute Transformations of taxol
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IL127599A (en) 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
US5719177A (en) 1994-11-04 1998-02-17 Pharmacia S.P.A. Taxane derivatives
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
JP2004506069A (ja) * 2000-08-04 2004-02-26 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド 水性環境中での検体検出
IT1318678B1 (it) 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato

Also Published As

Publication number Publication date
EP2298754B1 (en) 2013-08-07
ATE398113T1 (de) 2008-07-15
WO2004024706A2 (en) 2004-03-25
CA2498277C (en) 2011-07-05
ES2307965T3 (es) 2008-12-01
PL402332A1 (pl) 2013-04-02
IL167336A (en) 2009-11-18
EP2077264A2 (en) 2009-07-08
PL402333A1 (pl) 2013-04-02
IL214431A0 (en) 2011-09-27
EP2298754B9 (en) 2013-12-18
ES2432024T3 (es) 2013-11-29
RU2005106361A (ru) 2005-10-10
ITMI20021921A1 (it) 2004-03-11
PL402323A1 (pl) 2013-04-02
KR101096918B1 (ko) 2011-12-22
SG164282A1 (en) 2010-09-29
SI2077264T1 (sl) 2013-03-29
DK2077264T3 (da) 2013-03-04
EP1537093B1 (en) 2008-06-11
RU2320652C2 (ru) 2008-03-27
DK2298754T3 (da) 2013-11-04
EP2281820A2 (en) 2011-02-09
PT1537093E (pt) 2008-09-02
IL214431A (en) 2014-05-28
NO332366B1 (no) 2012-09-03
AU2003267049A1 (en) 2004-04-30
WO2004024706A3 (en) 2004-07-08
PT2298754E (pt) 2013-11-07
EP2077264B1 (en) 2012-11-14
IL197815A (en) 2013-02-28
EP2264019A1 (en) 2010-12-22
JP4690039B2 (ja) 2011-06-01
PT2077264E (pt) 2013-01-29
IL214430A0 (en) 2011-09-27
EP2281820A3 (en) 2011-05-04
SI2264019T1 (sl) 2013-10-30
JP2010270145A (ja) 2010-12-02
DE60321577D1 (de) 2008-07-24
SI1537093T1 (sl) 2008-10-31
IL214432A (en) 2014-05-28
NO332367B1 (no) 2012-09-03
KR20050035540A (ko) 2005-04-18
EP1980557A3 (en) 2008-12-31
EP1980557A2 (en) 2008-10-15
SI2298754T1 (sl) 2013-11-29
CN1681799A (zh) 2005-10-12
EP1537093A2 (en) 2005-06-08
EP2264019B1 (en) 2013-07-24
ES2398324T3 (es) 2013-03-15
NO20110781L (no) 2005-05-10
NO20051774L (no) 2005-05-10
AU2003267049B2 (en) 2010-02-11
US20060122258A1 (en) 2006-06-08
IL214432A0 (en) 2011-09-27
CA2498277A1 (en) 2004-03-25
NO20110782L (no) 2005-05-10
EP2077264A3 (en) 2009-09-16
EP2298754A1 (en) 2011-03-23
US7498452B2 (en) 2009-03-03
NO332250B1 (no) 2012-08-06
ES2433580T3 (es) 2013-12-11
AU2003267049B8 (en) 2010-03-04
DK2264019T3 (da) 2013-10-28
PT2264019E (pt) 2013-10-28
PL375625A1 (en) 2005-12-12
JP2006503030A (ja) 2006-01-26

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