DK153542C - Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer - Google Patents

Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer

Info

Publication number
DK153542C
DK153542C DK110879A DK110879A DK153542C DK 153542 C DK153542 C DK 153542C DK 110879 A DK110879 A DK 110879A DK 110879 A DK110879 A DK 110879A DK 153542 C DK153542 C DK 153542C
Authority
DK
Denmark
Prior art keywords
arginal
ornithin
alfa
analogy
branched
Prior art date
Application number
DK110879A
Other languages
Danish (da)
English (en)
Other versions
DK153542B (da
DK110879A (da
Inventor
Mackenzie Walser
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of DK110879A publication Critical patent/DK110879A/da
Publication of DK153542B publication Critical patent/DK153542B/da
Application granted granted Critical
Publication of DK153542C publication Critical patent/DK153542C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK110879A 1978-03-17 1979-03-16 Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer DK153542C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders
US88757078 1978-03-17

Publications (3)

Publication Number Publication Date
DK110879A DK110879A (da) 1979-09-18
DK153542B DK153542B (da) 1988-07-25
DK153542C true DK153542C (da) 1988-12-05

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK110879A DK153542C (da) 1978-03-17 1979-03-16 Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer

Country Status (17)

Country Link
US (1) US4228099A (cg-RX-API-DMAC10.html)
JP (1) JPS5838421B2 (cg-RX-API-DMAC10.html)
AU (1) AU517505B2 (cg-RX-API-DMAC10.html)
BE (1) BE874900A (cg-RX-API-DMAC10.html)
CA (1) CA1115729A (cg-RX-API-DMAC10.html)
DE (1) DE2910221A1 (cg-RX-API-DMAC10.html)
DK (1) DK153542C (cg-RX-API-DMAC10.html)
ES (1) ES478710A1 (cg-RX-API-DMAC10.html)
FI (1) FI72118C (cg-RX-API-DMAC10.html)
FR (1) FR2419723A1 (cg-RX-API-DMAC10.html)
GB (1) GB2017094B (cg-RX-API-DMAC10.html)
IE (1) IE48336B1 (cg-RX-API-DMAC10.html)
IT (1) IT1202904B (cg-RX-API-DMAC10.html)
LU (1) LU81057A1 (cg-RX-API-DMAC10.html)
NL (1) NL7902136A (cg-RX-API-DMAC10.html)
NO (1) NO151119C (cg-RX-API-DMAC10.html)
SE (1) SE446724B (cg-RX-API-DMAC10.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FR2615734B1 (fr) * 1987-05-27 1989-12-01 Synthelabo Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
FR2618331B1 (fr) * 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
CN1136764A (zh) 1994-10-07 1996-11-27 弗门尼舍有限公司 风味组合物及其制备方法
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
WO2002081020A2 (en) * 2001-04-04 2002-10-17 Critical Therapeutics, Inc. Method for preventing acute renal failure
JP4778913B2 (ja) * 2004-11-15 2011-09-21 協和発酵バイオ株式会社 Ｌ−オルニチン結晶およびその製造方法
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
PL1824563T3 (pl) * 2004-11-26 2010-07-30 Ucl Business Plc Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej
SMT201700601T1 (it) 2009-04-03 2018-03-08 Ocera Therapeutics Inc L-ornitina fenilacetato e metodi per la sua fabbricazione
MX2011013129A (es) 2009-06-08 2012-03-14 Ucl Business Plc Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.
CN103502203B (zh) 2010-10-06 2016-09-07 欧塞拉治疗有限公司 制备l-鸟氨酸苯基乙酸盐的方法
ES2769000T3 (es) 2014-11-24 2020-06-24 Ucl Business Ltd Tratamiento de enfermedades asociadas con la activación de células estrelladas hepáticas utilizando terapias reductoras de amoníaco
AU2016308641B2 (en) 2015-08-18 2022-02-03 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
EP3621947A4 (en) 2017-05-11 2021-03-10 Ocera Therapeutics, Inc. L-ORNITHINE PHENYLACETATE MANUFACTURING PROCESSES
EP3716966A4 (en) 2017-11-29 2021-08-18 Hull, Edgar, L., Jr. ALPHA-KETO ACID COMPOSITIONS FOR THE TREATMENT OF HYPOALBUMINEMIA
US12109254B2 (en) 2017-11-29 2024-10-08 Edgar Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) * 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Also Published As

Publication number Publication date
CA1115729A (en) 1982-01-05
NO151119B (no) 1984-11-05
FR2419723A1 (fr) 1979-10-12
NO151119C (no) 1985-02-13
BE874900A (fr) 1979-07-16
ES478710A1 (es) 1980-01-16
DK153542B (da) 1988-07-25
FI790901A7 (fi) 1979-09-18
DE2910221A1 (de) 1979-09-20
DE2910221C2 (cg-RX-API-DMAC10.html) 1988-04-28
US4228099A (en) 1980-10-14
LU81057A1 (fr) 1979-09-07
SE446724B (sv) 1986-10-06
GB2017094A (en) 1979-10-03
GB2017094B (en) 1982-07-07
FI72118C (fi) 1987-04-13
IT1202904B (it) 1989-02-15
FI72118B (fi) 1986-12-31
SE7902401L (sv) 1979-10-16
FR2419723B1 (cg-RX-API-DMAC10.html) 1982-10-29
AU517505B2 (en) 1981-08-06
DK110879A (da) 1979-09-18
IT7921071A0 (it) 1979-03-16
NL7902136A (nl) 1979-09-19
JPS54163518A (en) 1979-12-26
AU4515479A (en) 1979-09-20
JPS5838421B2 (ja) 1983-08-23
IE790993L (en) 1979-09-17
NO790903L (no) 1979-09-18
IE48336B1 (en) 1984-12-12

Similar Documents

Publication Publication Date Title
DK153542C (da) Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer
DK158788C (da) Analogifremgangsmaade til fremstilling af tetrazolylalkoxycarbostyrilderivater
DK158225C (da) Analogifremgangsmaade til fremstilling af carbostyrilderivater
DK153540C (da) Analogifremgangsmaade til fremstilling af platin-diamin-komplekser
DK156779A (da) Fremgangsmaade til fremstilling af cycloalkyltriazoler
DK129879A (da) Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer
DK149773C (da) Analogifremgangsmaade til fremstilling af 3-quinolincarboxylsyrederivater
DK163580C (da) Analogifremgangsmaade til fremstilling af cyclohexancarboxylsyrederivater
DK123679A (da) Fremgangsmaade til fremstilling af carboxylpersyrer
DK366379A (da) Fremgangsmaade til fremstilling af alkyl-eller arylthiomethylphenoler
DK324979A (da) Fremgangsmaade til fremstilling af imidazoquinoxaliner eller salte deraf
DK20279A (da) Fremgangsmaade til fremstilling af 4-pyridon-3-carboxylsyrederivater
DK415379A (da) Fremgangsmaade til fremstilling af chromanolderivater
DK331679A (da) Fremgangsmaade til fremstilling af phenylalkansyrederivater
DK257779A (da) Fremgangsmaade til fremstilling af chlor-styryl-cyclopropan-carboxylsyrederivater
DK215079A (da) Fremgangsmaade til fremstilling af phenylaminothiothiopheneddikesyrer
DK73379A (da) Fremgangsmaade til fremstilling af halogensubstituerede mercaptoacylaminsyrer
DK267779A (da) Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner
DK150471C (da) Fremgangsmaade til fremstilling af trifluormethylphenoler
DK160485C (da) Fremgangsmaade til fremstilling af arylglyoxylsyrer
DK508881A (da) Fremgangsmaade til fremstilling af oploesninger af 7-amincophelosporansyrer
DK186279A (da) Fremgangsmaade til fremstilling af alkylcarbapenemderivater
DK233379A (da) Fremgangsmaade til fremstilling af arylglyoxylsyrer
DK156399C (da) Analogifremgangsmaade til fremstilling af spiro-quinolylhydantoin-derivater
DK431479A (da) Fremgagnsmaade til fremstilling af 3-exomethylencepham-sulfoxider

Legal Events

Date Code Title Description
PUP Patent expired