DK1520175T3 - Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer - Google Patents

Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer

Info

Publication number
DK1520175T3
DK1520175T3 DK03737795T DK03737795T DK1520175T3 DK 1520175 T3 DK1520175 T3 DK 1520175T3 DK 03737795 T DK03737795 T DK 03737795T DK 03737795 T DK03737795 T DK 03737795T DK 1520175 T3 DK1520175 T3 DK 1520175T3
Authority
DK
Denmark
Prior art keywords
neoplasms
agents
oncolytic viruses
phenotype determination
phenotype
Prior art date
Application number
DK03737795T
Other languages
Danish (da)
English (en)
Inventor
Bradley G Thompson
Matthew C Coffey
Original Assignee
Oncolytics Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncolytics Biotech Inc filed Critical Oncolytics Biotech Inc
Application granted granted Critical
Publication of DK1520175T3 publication Critical patent/DK1520175T3/da

Links

Classifications

    • G01N33/575—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G01N33/57575—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
DK03737795T 2002-06-28 2003-06-25 Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer DK1520175T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39203102P 2002-06-28 2002-06-28
US44318803P 2003-01-29 2003-01-29
PCT/CA2003/000951 WO2004003562A2 (en) 2002-06-28 2003-06-25 Oncolytic viruses as phenotyping agents for neoplasms

Publications (1)

Publication Number Publication Date
DK1520175T3 true DK1520175T3 (da) 2008-02-11

Family

ID=30003222

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03737795T DK1520175T3 (da) 2002-06-28 2003-06-25 Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer
DK07021569.4T DK1890151T3 (da) 2002-06-28 2003-06-25 Onkolytiske vira som midler til fænotypebestemmelse for neoplasmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07021569.4T DK1890151T3 (da) 2002-06-28 2003-06-25 Onkolytiske vira som midler til fænotypebestemmelse for neoplasmer

Country Status (19)

Country Link
US (3) US7306902B2 (de)
EP (2) EP1520175B1 (de)
JP (1) JP2005531306A (de)
CN (1) CN1666105B (de)
AR (1) AR039768A1 (de)
AT (2) ATE377754T1 (de)
AU (2) AU2003245760B2 (de)
BR (1) BR0311983A (de)
CA (1) CA2487824C (de)
DE (1) DE60317331T2 (de)
DK (2) DK1520175T3 (de)
ES (2) ES2385845T3 (de)
IL (2) IL165498A0 (de)
MX (1) MXPA04012414A (de)
NZ (1) NZ537116A (de)
PT (1) PT1890151E (de)
SI (1) SI1890151T1 (de)
TW (3) TWI334444B (de)
WO (1) WO2004003562A2 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
US8491884B2 (en) * 2000-05-03 2013-07-23 Oncolytics Biotech Inc. Virus clearance of neoplastic cells from mixed cellular compositions
US7306902B2 (en) * 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
US20040115170A1 (en) * 2001-11-30 2004-06-17 Brown Earl Garnet Oncolytic virus
EP1523333A4 (de) 2002-07-24 2007-01-24 Univ Arizona Verwendung des vaccinia-virus mit deletion des e3l-gens als vakzine-vektor
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
WO2005007824A2 (en) * 2003-07-08 2005-01-27 Arizona Board Of Regents Mutants of vaccinia virus as oncolytic agents
WO2005111200A1 (en) * 2004-05-17 2005-11-24 Universite De Montreal Novel strains of reoviruses and methods of uses thereof
US10668119B2 (en) 2005-08-01 2020-06-02 Virocure, Inc. Attenuated reovirus
EP1917351A4 (de) 2005-08-01 2009-12-16 Univ Technologies Int Abgeschwächtes reovirus
ATE516370T1 (de) * 2005-12-22 2011-07-15 Sloan Kettering Inst Cancer Verfahren zur erfassung von krebszellen unter verwendung eines virus
DK1984007T3 (en) * 2006-02-13 2015-12-07 Oncolytics Biotech Inc Application of Low-dose local immunosuppression for amplification of viral oncolytic therapy
US10369171B2 (en) 2007-03-13 2019-08-06 Virocure, Inc. Attenuated reoviruses for selection of cell populations
WO2008144067A1 (en) * 2007-05-21 2008-11-27 Board Of Regents, University Of Texas System Methods and compositions for treatment of cancer using oncolytic rsv activity
CN102124335B (zh) * 2008-05-22 2014-07-30 第一药品株式会社 基于肿瘤抑制因子的过度增生细胞对溶瘤病毒疗法的敏感性
MX339014B (es) * 2008-05-27 2016-05-09 Oncolytics Biotech Inc Modulacion de presion intersticial y suministro y distribucion viral oncolitica.
CN102065873A (zh) * 2008-05-27 2011-05-18 昂科利蒂克斯生物科技公司 在溶瘤呼肠孤病毒治疗中消除促炎细胞因子的产生
US8481297B2 (en) * 2009-01-08 2013-07-09 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
EP2670426B1 (de) 2011-01-31 2017-05-10 The General Hospital Corporation Multimodale trail-moleküle und ihre verwendungen in zelltherapien
US8859256B2 (en) 2011-10-05 2014-10-14 Genelux Corporation Method for detecting replication or colonization of a biological therapeutic
US20140087362A1 (en) 2012-03-16 2014-03-27 Aladar A. Szalay Methods for assessing effectiveness and monitoring oncolytic virus treatment
WO2013158265A1 (en) 2012-04-20 2013-10-24 Genelux Corporation Imaging methods for oncolytic virus therapy
EP3473708B1 (de) 2012-07-24 2021-01-27 The General Hospital Corporation Onkolytische virustherapie für resistente tumore
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
WO2014055960A1 (en) 2012-10-05 2014-04-10 Genelux Corporation Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes
US20160303174A1 (en) * 2013-12-11 2016-10-20 The General Hospital Corporation Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors
WO2015103438A2 (en) 2014-01-02 2015-07-09 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
CA2964317C (en) 2014-10-14 2021-10-05 Halozyme, Inc. Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
EP3261669B1 (de) 2015-02-25 2022-08-03 Memorial Sloan Kettering Cancer Center Verwendung von inaktiviertem nichtreplizierendem modified-vaccinia-ankara-virus (mva) als monoimmunotherapie oder in kombination mit immun-checkpoint-blockierungsmitteln für solide tumoren
CN116173193A (zh) 2015-04-17 2023-05-30 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
AU2017222687B2 (en) 2016-02-25 2022-02-24 Memorial Sloan Kettering Cancer Center Recombinant MVA or MVADELE3L expressing human Flt3L and use thereof as immuno-therapeutic agents against solid tumors
BR112018016949A2 (pt) 2016-02-25 2019-01-08 Memorial Sloan Kettering Cancer Center vírus vaccinia atenuado competente em relação à replicação como deleção de timidina quinase com ou sem a expressão de flt3l ou gm-csf humano para imunoterapia de câncer
JP7527758B2 (ja) 2016-04-15 2024-08-05 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｄ８０バリアント免疫調節タンパク質およびその使用
KR102824067B1 (ko) 2016-04-15 2025-06-23 알파인 이뮨 사이언시즈, 인코포레이티드 Icos 리간드 변이체 면역조절 단백질 및 그의 용도
US10842835B2 (en) 2016-05-25 2020-11-24 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic vaccinia virus mutants and using same for cancer treatment
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
WO2018022946A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
EP4019029A1 (de) * 2016-09-27 2022-06-29 Sator Therapeutics LLC Rekombinante onkolytische viren und verwendungen davon
WO2018075978A1 (en) 2016-10-20 2018-04-26 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
JP2020507349A (ja) 2017-02-09 2020-03-12 インダプタ セラピューティクス インコーポレイテッド 操作されたナチュラルキラー（ｎｋ）細胞ならびにその組成物および方法
CA3053804C (en) 2017-03-16 2025-09-23 Alpine Immune Sciences, Inc. Immunomodulatory Proteins of PD-L1 Variants and Associated Uses
MX2019010887A (es) 2017-03-16 2019-10-15 Alpine Immune Sciences Inc Proteinas inmunomoduladoras de cb80 variante y usos de estas.
US11732022B2 (en) 2017-03-16 2023-08-22 Alpine Immune Sciences, Inc. PD-L2 variant immunomodulatory proteins and uses thereof
WO2018209315A1 (en) 2017-05-12 2018-11-15 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
TWI899046B (zh) 2017-10-18 2025-10-01 美商艾爾潘免疫科學有限公司 變異型icos 配位體免疫調節蛋白及相關組合物及方法
SG11202006148UA (en) 2018-01-03 2020-07-29 Alpine Immune Sciences Inc Multi-domain immunomodulatory proteins and methods of use thereof
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy
ES2966045T3 (es) 2018-06-04 2024-04-18 Calidi Biotherapeutics Inc Vehículos basados en células para la potenciación de la terapia viral
WO2019241758A1 (en) 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
WO2020047161A2 (en) 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
SG11202102439WA (en) 2018-09-15 2021-04-29 Memorial Sloan Kettering Cancer Center Recombinant poxviruses for cancer immunotherapy
CN113271955A (zh) 2018-11-06 2021-08-17 卡利迪生物治疗有限公司 用于细胞介导的溶瘤病毒疗法的增强的系统
JP7541516B2 (ja) 2018-11-21 2024-08-28 インダプタ セラピューティクス インコーポレイテッド ナチュラルキラー（ｎｋ）細胞サブセットの増大のための方法ならびに関連する組成物および方法
KR20210135987A (ko) 2018-11-30 2021-11-16 알파인 이뮨 사이언시즈, 인코포레이티드 Cd86 변이체 면역조절 단백질 및 그의 용도
CA3176660A1 (en) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
AU2021258194A1 (en) 2020-04-22 2022-11-24 Indapta Therapeutics, Inc. Natural killer (NK) cell compositions and methods for generating same
TW202241479A (zh) 2020-12-30 2022-11-01 美商安迅生物製藥公司 遞送外來抗原之溶瘤病毒及表現靶向外來抗原之嵌合受體之經工程化免疫細胞之組合療法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5670330A (en) * 1992-09-29 1997-09-23 Mcgill University Anti-tumor agent assay using PKR
PT931830E (pt) 1993-02-16 2001-08-30 Onyx Pharma Inc Virus citopaticos para terapia e profilaxia de neoplasia
US5801029A (en) * 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
DE69435118D1 (de) 1993-04-30 2008-08-28 Wellstat Biologics Corp Gereinigte Zusammensetzungen von Newcastle-Krankheitvirus
CA2178902A1 (en) * 1993-12-14 1995-06-22 Drew Pardoll Controlled release of pharmaceutically active substances for immunotherapy
WO1995032300A1 (en) * 1994-05-23 1995-11-30 University Of Medicine & Dentistry Of New Jersey Selective biological destruction of tumor cells
US5585096A (en) * 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US6777177B1 (en) * 1997-10-10 2004-08-17 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
CA2508238C (en) 1997-08-13 2008-01-15 Oncolytics Biotech Inc. Reovirus for the treatment of neoplasia
US6136307A (en) * 1997-08-13 2000-10-24 Oncolytics Biotech Inc. Reovirus for the treatment of cellular proliferative disorders
US6110461A (en) 1997-08-13 2000-08-29 Oncolytics Biotech Inc. Reovirus for the treatment of neoplasia
AU9603898A (en) * 1997-10-09 1999-05-03 Pro-Virus, Inc. Treatment of neoplasms with viruses
US7780962B2 (en) * 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US6475481B2 (en) * 1997-11-18 2002-11-05 Canji Inc Purging of stem cell products
CA2323067A1 (en) 1998-03-12 1999-09-16 The Trustees Of The University Of Pennsylvania Producer cells for replication selective viruses in the treatment of malignancy
WO2000012103A1 (en) * 1998-08-31 2000-03-09 Ambrus Julian L Method for removal of hiv and other viruses from blood
HUP0302278A3 (en) 1999-04-15 2011-01-28 Pro Virus Treatment of neoplasms with viruses
DE19934788B4 (de) * 1999-07-27 2004-05-27 T-Mobile Deutschland Gmbh Verfahren zur automatischen Anpassung von Daten an die Fähigkeiten einer Nutzer-Software
EP1716858B9 (de) 1999-09-17 2009-08-12 Wellstat Biologics Corporation Onkolytisches Virus
BR0015491A (pt) * 1999-11-12 2002-10-15 Oncolytics Biotech Inc Métodos para tratar um distúrbio proliferativo celular mediado por ras em um mamìfero, para tratar um neoplasma tendo uma via-ras ativada em um humano, para inibir metástase de um neoplasma tendo uma via-ras ativada em um mamìfero, e para tratar um neoplasma suspeito de ter uma via-ras ativada em um mamìfero, composição farmacêutica, kit, e, método para tratar uma população de células compreendendo um neoplasma suspeito de ter uma via-ras ativada in vitro
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
AR028040A1 (es) 2000-05-03 2003-04-23 Oncolytics Biotech Inc Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas
US7306902B2 (en) * 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
AR028039A1 (es) * 2000-05-03 2003-04-23 Oncolytics Biotech Inc Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas
HK1052950B (en) * 2000-06-26 2005-06-24 Wellstat Biologics Corporation Purging of cells using viruses
WO2002004596A2 (en) 2000-07-07 2002-01-17 President And Fellows Of Harvard College Diagnosing and treating cancer cells using mutant viruses
MXPA03004029A (es) 2000-11-09 2004-02-12 Oncolytics Biotech Inc Metodos para tratamiento de trastornos proliferativos celulares.
US20030138405A1 (en) * 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways

Also Published As

Publication number Publication date
JP2005531306A (ja) 2005-10-20
AU2008207579B2 (en) 2011-10-20
DK1890151T3 (da) 2012-06-18
PT1890151E (pt) 2012-05-25
DE60317331D1 (de) 2007-12-20
WO2004003562A3 (en) 2004-05-06
AU2003245760A1 (en) 2004-01-19
HK1112509A1 (en) 2008-09-05
ATE555388T1 (de) 2012-05-15
EP1520175B1 (de) 2007-11-07
AR039768A1 (es) 2005-03-09
IL165498A0 (en) 2006-01-15
US8222036B2 (en) 2012-07-17
US20080014577A1 (en) 2008-01-17
TW200940709A (en) 2009-10-01
US20040029112A1 (en) 2004-02-12
TW201005097A (en) 2010-02-01
EP1890151B1 (de) 2012-04-25
BR0311983A (pt) 2005-04-26
TWI327167B (en) 2010-07-11
ES2385845T3 (es) 2012-08-01
SI1890151T1 (sl) 2012-08-31
CN1666105A (zh) 2005-09-07
ES2292981T3 (es) 2008-03-16
IL220139A0 (en) 2012-07-31
DE60317331T2 (de) 2008-08-21
MXPA04012414A (es) 2005-04-19
TWI402345B (zh) 2013-07-21
NZ537116A (en) 2008-04-30
US7306902B2 (en) 2007-12-11
US20100105122A1 (en) 2010-04-29
EP1890151A1 (de) 2008-02-20
AU2003245760B2 (en) 2008-07-03
TWI334444B (en) 2010-12-11
ATE377754T1 (de) 2007-11-15
EP1520175A2 (de) 2005-04-06
CA2487824C (en) 2013-08-20
AU2008207579A1 (en) 2008-09-18
WO2004003562A2 (en) 2004-01-08
CA2487824A1 (en) 2004-01-08
TW200401032A (en) 2004-01-16
CN1666105B (zh) 2015-11-25
IL220139A (en) 2013-03-24
HK1069877A1 (en) 2005-06-03

Similar Documents

Publication Publication Date Title
DK1520175T3 (da) Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer
DK1423391T3 (da) Pyrrolopyrimidiner som midler til inhibering af cysteinproteaser
ATE506104T1 (de) Hepatitis-c-virus-hemmer
DK1730110T3 (da) Svovlforbindelser som inhibitorer af hepatitis C-virus NS3-serinprotease
NO20043642L (no) Heterocykiske tripeptider som hepatitt C inhibitorer
IS8476A (is) Lifrarbólgu C-veirutálmar
IS8475A (is) Lifrarbólgu C-veirutálmar
DK3395338T3 (da) Hurtigt opløsende formulering af cinacalcet-hcl
DE602005011795D1 (de) Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
DK1402075T3 (da) Udvikling af egnede mutationer til svækkelse af dengue-vira samt kimære dengue-vira
DK1562589T3 (da) Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
NO20023283D0 (no) Flammestopper
DK1802579T3 (da) Derivater af 3-arylaminopyridin
DK1504126T3 (da) Fremgangsmåde til regulering af genekspression
DK1542977T3 (da) 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
DK2060570T3 (da) Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater
IS2761B (is) Ný amínóbensófenónefnasambönd
DK1660090T3 (da) Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
EP1788874A4 (de) Salze von 5-azacytidin
DE602004025775D1 (de) Innengekühltes strömungsleitendes Komponent
DK1840125T3 (da) Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
ATE398450T1 (de) Derivate von aryl-chinazolin/aryl-2amino-phenyl- methanon zurförderung der freisetzung von parathormon
EP1723238A4 (de) Modifizierte onkolytische viren
DK1948176T3 (da) Diarylurinstoffer til behandling af pulmonær hypertension