DK151884C - Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK151884C
DK151884C DK042580A DK42580A DK151884C DK 151884 C DK151884 C DK 151884C DK 042580 A DK042580 A DK 042580A DK 42580 A DK42580 A DK 42580A DK 151884 C DK151884 C DK 151884C
Authority
DK
Denmark
Prior art keywords
imidazolylalkyl
incidental
analogue
preparation
acid addition
Prior art date
Application number
DK042580A
Other languages
Danish (da)
English (en)
Other versions
DK42580A (da
DK151884B (da
Inventor
Peter Edward Cross
Roger Peter Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK42580A publication Critical patent/DK42580A/da
Publication of DK151884B publication Critical patent/DK151884B/da
Application granted granted Critical
Publication of DK151884C publication Critical patent/DK151884C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK042580A 1979-03-07 1980-01-31 Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf DK151884C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07
GB7908123 1979-03-07

Publications (3)

Publication Number Publication Date
DK42580A DK42580A (da) 1980-09-08
DK151884B DK151884B (da) 1988-01-11
DK151884C true DK151884C (da) 1988-06-13

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK042580A DK151884C (da) 1979-03-07 1980-01-31 Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (36)

Country Link
US (1) US4273782A (pl)
JP (1) JPS55133380A (pl)
KR (1) KR850000760B1 (pl)
AR (1) AR227015A1 (pl)
AT (1) AT375366B (pl)
AU (1) AU516957B2 (pl)
BE (1) BE882113A (pl)
CA (1) CA1120479A (pl)
CH (1) CH649546A5 (pl)
CS (1) CS253702B2 (pl)
DD (1) DD149525A5 (pl)
DE (1) DE3008632A1 (pl)
DK (1) DK151884C (pl)
ES (2) ES489220A0 (pl)
FI (1) FI66860C (pl)
FR (1) FR2450832A1 (pl)
GR (1) GR67237B (pl)
HK (1) HK89884A (pl)
HU (1) HU184727B (pl)
IE (1) IE49542B1 (pl)
IL (1) IL59524A (pl)
IT (1) IT1218420B (pl)
KE (1) KE3467A (pl)
LU (1) LU82224A1 (pl)
MY (1) MY8500285A (pl)
NL (1) NL182959C (pl)
NO (1) NO152217C (pl)
NZ (1) NZ193052A (pl)
PH (1) PH15198A (pl)
PL (1) PL128296B1 (pl)
PT (1) PT70914A (pl)
SE (1) SE440778B (pl)
SG (1) SG67284G (pl)
SU (1) SU1277894A3 (pl)
YU (1) YU41911B (pl)
ZA (1) ZA801328B (pl)

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US4414159A (en) * 1980-09-26 1983-11-08 E. I. Du Pont De Nemours & Co. Vinyl ether monomers and polymers therefrom
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
KR840000529A (ko) * 1981-07-07 1984-02-25 콘스탄틴 루이스 클레멘트 인돌 유도체의 제조방법
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
US4436746A (en) 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 Ｎ―フタルイシド誘導体及びその製造法
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
WO1990012009A1 (fr) * 1989-03-31 1990-10-18 Kyoto Pharmaceutical Industries, Ltd. Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
PT98927A (pt) * 1990-09-13 1992-07-31 Beecham Group Plc Processo para a preparacao de piridil-indolil-ureias
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
ES2090956T3 (es) * 1991-12-18 1996-10-16 Schering Corp Imidazolil o imidazolilalquil sustituido con un anillo heterociclico de cuatro o cinco miembros que contiene nitrogeno.
EP0597112A4 (en) * 1992-03-27 1994-06-22 Kyoto Pharma Ind Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor.
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
ES2224632T3 (es) * 1998-03-31 2005-03-01 The Institutes For Pharmaceutical Discovery, Inc. Acidos indolalcanoicos sustituidos.
ES2268480T3 (es) * 2002-12-10 2007-03-16 Wyeth Derivados del acido 3-alquilo- y 3-arilalquilo-1h-indol-1-il-acetico sustituidos como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1).
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
CA2583667A1 (en) * 2004-10-12 2006-04-27 Jasbir Singh Sulfonamide peri-substituted bicyclics for occlusive artery disease
US7803828B2 (en) * 2005-08-25 2010-09-28 Schering-Plough Corporation Functionally selective alpha2C adrenoreceptor agonists
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
EP2027117A2 (en) * 2006-05-16 2009-02-25 Decode Genetics EHF Process for preparing 7-(acryloyl)-indoles
SI2046740T1 (sl) 2006-07-22 2012-12-31 Oxagen Limited Spojine s crth2 antagonistiäśno aktivnostjo
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
EP2543368A1 (en) 2007-12-11 2013-01-09 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
KR101644170B1 (ko) 2008-01-18 2016-08-01 옥사겐 리미티드 씨알티에이치2 길항제 활성을 갖는 화합물
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US20100022613A1 (en) * 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
US8168673B2 (en) * 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity
US20110160249A1 (en) * 2008-05-23 2011-06-30 Schaab Kevin Murray 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
JP2014518223A (ja) * 2011-06-20 2014-07-28 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド 化合物とその治療用途
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
US11530186B2 (en) * 2018-03-29 2022-12-20 H. Lee Moffitt Cancer Center and Research Center Institute, Inc. Inhibitors for the β-catenin / T-cell factor protein-protein interaction

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NL125443C (pl) * 1963-06-06
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
US3621027A (en) * 1968-03-18 1971-11-16 Endo Lab 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DK376078A (da) * 1977-08-26 1979-02-27 Wellcome Found Fremgangsmaade til fremstilling af amidazoler
US4140858A (en) * 1977-12-19 1979-02-20 Warner-Lambert Company 3-(1H-imidazol-1-ylmethyl)-2-(disubstitutedaminomethyl)indoles and a method for their production
DE2960547D1 (en) * 1978-02-24 1981-11-05 Pfizer Ltd 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them

Also Published As

Publication number Publication date
ES8104278A1 (es) 1981-04-01
MY8500285A (en) 1985-12-31
DD149525A5 (de) 1981-07-15
PL222470A1 (pl) 1980-12-01
FR2450832A1 (fr) 1980-10-03
IT8020399A0 (it) 1980-03-06
BE882113A (fr) 1980-09-08
SE440778B (sv) 1985-08-19
US4273782A (en) 1981-06-16
ZA801328B (en) 1981-03-25
NO152217C (no) 1985-08-21
IL59524A0 (en) 1980-06-30
DK42580A (da) 1980-09-08
KE3467A (en) 1984-11-09
PL128296B1 (en) 1984-01-31
FI66860B (fi) 1984-08-31
SU1277894A3 (ru) 1986-12-15
CH649546A5 (de) 1985-05-31
NO152217B (no) 1985-05-13
ATA125780A (de) 1983-12-15
IE49542B1 (en) 1985-10-30
HU184727B (en) 1984-10-29
KR830001928A (ko) 1983-05-19
FI800672A (fi) 1980-09-08
JPS55133380A (en) 1980-10-17
DK151884B (da) 1988-01-11
NZ193052A (en) 1984-07-06
CA1120479A (en) 1982-03-23
DE3008632A1 (de) 1980-10-16
AR227015A1 (es) 1982-09-15
KR850000760B1 (ko) 1985-05-25
AU5623180A (en) 1980-09-11
YU41911B (en) 1988-02-29
NL8001351A (nl) 1980-09-09
ES489220A0 (es) 1981-04-01
FI66860C (fi) 1984-12-10
HK89884A (en) 1984-11-23
IE800453L (en) 1980-09-07
YU61480A (en) 1983-12-31
AU516957B2 (en) 1981-07-02
PT70914A (en) 1980-04-01
GR67237B (pl) 1981-06-25
DE3008632C2 (pl) 1988-02-25
ES496889A0 (es) 1982-08-01
IL59524A (en) 1982-11-30
LU82224A1 (fr) 1980-06-06
SE8001736L (sv) 1980-09-08
IT1218420B (it) 1990-04-19
ES8205789A1 (es) 1982-08-01
NL182959C (nl) 1988-06-16
AT375366B (de) 1984-07-25
JPS6141513B2 (pl) 1986-09-16
SG67284G (en) 1985-03-15
CS253702B2 (en) 1987-12-17
PH15198A (en) 1982-09-17
NO800650L (no) 1980-09-08
FR2450832B1 (pl) 1983-04-22

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