DK150157C - Analogifremgangsmaade til fremstilling af furo-, thieno- eller pyrrolo (2,3-d)azepiner eller fysiologisk acceptable salte deraf med syrer eller baser - Google Patents

Analogifremgangsmaade til fremstilling af furo-, thieno- eller pyrrolo (2,3-d)azepiner eller fysiologisk acceptable salte deraf med syrer eller baser

Info

Publication number
DK150157C
DK150157C DK069382A DK69382A DK150157C DK 150157 C DK150157 C DK 150157C DK 069382 A DK069382 A DK 069382A DK 69382 A DK69382 A DK 69382A DK 150157 C DK150157 C DK 150157C
Authority
DK
Denmark
Prior art keywords
azepines
furo
thieno
pyrrolo
analogue
Prior art date
Application number
DK069382A
Other languages
Danish (da)
English (en)
Other versions
DK69382A (da
DK150157B (da
Inventor
Robert Sauter
Gerhart Griss
Wolfgang Grell
Rudolf Hurnaus
Bernhard Eisele
Walter Haarmann
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK69382A publication Critical patent/DK69382A/da
Publication of DK150157B publication Critical patent/DK150157B/da
Application granted granted Critical
Publication of DK150157C publication Critical patent/DK150157C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK069382A 1981-02-18 1982-02-17 Analogifremgangsmaade til fremstilling af furo-, thieno- eller pyrrolo (2,3-d)azepiner eller fysiologisk acceptable salte deraf med syrer eller baser DK150157C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3105858 1981-02-18
DE19813105858 DE3105858A1 (de) 1981-02-18 1981-02-18 "neue thieno-azepine, ihre herstellung und ihre verwendung als arzneimittel"

Publications (3)

Publication Number Publication Date
DK69382A DK69382A (da) 1982-08-19
DK150157B DK150157B (da) 1986-12-22
DK150157C true DK150157C (da) 1987-06-29

Family

ID=6125118

Family Applications (1)

Application Number Title Priority Date Filing Date
DK069382A DK150157C (da) 1981-02-18 1982-02-17 Analogifremgangsmaade til fremstilling af furo-, thieno- eller pyrrolo (2,3-d)azepiner eller fysiologisk acceptable salte deraf med syrer eller baser

Country Status (26)

Country Link
US (1) US4414225A (enFirst)
EP (1) EP0058341B1 (enFirst)
JP (1) JPS57150687A (enFirst)
AR (1) AR231983A1 (enFirst)
AT (1) ATE13298T1 (enFirst)
AU (1) AU547951B2 (enFirst)
CA (1) CA1171084A (enFirst)
CS (1) CS227039B2 (enFirst)
DD (1) DD202577A5 (enFirst)
DE (2) DE3105858A1 (enFirst)
DK (1) DK150157C (enFirst)
ES (4) ES509682A0 (enFirst)
FI (1) FI820509L (enFirst)
GB (1) GB2093030B (enFirst)
GR (1) GR76793B (enFirst)
HU (1) HU190984B (enFirst)
IE (1) IE52540B1 (enFirst)
IL (1) IL65051A (enFirst)
NO (1) NO157503C (enFirst)
NZ (1) NZ199759A (enFirst)
PH (1) PH17724A (enFirst)
PL (1) PL137354B1 (enFirst)
PT (1) PT74447B (enFirst)
SU (1) SU1091858A3 (enFirst)
YU (1) YU34982A (enFirst)
ZA (1) ZA821020B (enFirst)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3230696A1 (de) * 1982-08-18 1984-02-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8800891D0 (en) * 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
GB8909132D0 (en) * 1989-04-21 1989-06-07 Lilly Industries Ltd Pharmaceutical compounds
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
GB9025890D0 (en) * 1990-11-28 1991-01-09 Lilly Industries Ltd Pharmaceutical compounds
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
CA2104371A1 (en) * 1991-12-26 1993-06-27 Tohru Nakao Condensed thiophene compound and pharmaceutical use thereof
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5696112A (en) * 1995-01-17 1997-12-09 American Cyanamid Company Fused heterocyclic azepines as vasopressin antagonists
FR2733750B1 (fr) * 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
US5939417A (en) * 1998-10-19 1999-08-17 Cell Pathways Inc 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
NZ550891A (en) * 2004-06-30 2009-10-30 Athersys Inc Substituted azepine derivatives as serotonin receptor modulators
DE602005027861D1 (de) * 2004-09-03 2011-06-16 Athersys Inc Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren
MX2008009178A (es) * 2006-01-19 2008-12-05 Athersys Inc Tiofenil y pirrolil acepinas como ligandos del receptor de serotonina 5-ht2c y sus usos.
EA026397B1 (ru) 2012-12-21 2017-04-28 ЭйБиТи ХОЛДИНГ КОМПАНИ Бензазепины в качестве лигандов серотониновых 5-ht-рецепторов и их применение
WO2014159067A1 (en) 2013-03-13 2014-10-02 Abt Holding Company Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849441A (en) * 1971-10-01 1974-11-19 American Cyanamid Co Substituted heterocyclic derivatives of azepine
US3846446A (en) * 1971-10-01 1974-11-05 American Cyanamid Co Substituted heterocyclic derivatives of azepine
US3758501A (en) * 1971-10-01 1973-09-11 M Weiss Substituted heterocyclic derivatives of azepine

Also Published As

Publication number Publication date
AU8055282A (en) 1982-08-26
ES515728A0 (es) 1983-06-01
DK69382A (da) 1982-08-19
PT74447A (de) 1982-03-01
GB2093030B (en) 1985-01-16
GR76793B (enFirst) 1984-09-04
HU190984B (en) 1986-12-28
ES8304987A1 (es) 1983-03-16
ES8306754A1 (es) 1983-06-01
IL65051A0 (en) 1982-04-30
NO820493L (no) 1982-08-19
CA1171084A (en) 1984-07-17
ES515729A0 (es) 1983-06-01
US4414225A (en) 1983-11-08
ES8306753A1 (es) 1983-06-01
IE52540B1 (en) 1987-12-09
EP0058341A1 (de) 1982-08-25
PL235121A1 (enFirst) 1982-10-25
FI820509A7 (fi) 1982-08-19
AR231983A1 (es) 1985-04-30
DE3105858A1 (de) 1982-09-02
PT74447B (de) 1984-10-09
SU1091858A3 (ru) 1984-05-07
IL65051A (en) 1986-11-30
DD202577A5 (de) 1983-09-21
ES515730A0 (es) 1983-06-01
AU547951B2 (en) 1985-11-14
NZ199759A (en) 1985-09-13
NO157503B (no) 1987-12-21
PH17724A (en) 1984-11-21
DK150157B (da) 1986-12-22
FI820509L (fi) 1982-08-19
DE3263462D1 (en) 1985-06-20
ES509682A0 (es) 1983-03-16
PL137354B1 (en) 1986-05-31
EP0058341B1 (de) 1985-05-15
ES8306755A1 (es) 1983-06-01
YU34982A (en) 1985-04-30
JPS57150687A (en) 1982-09-17
ZA821020B (en) 1983-10-26
ATE13298T1 (de) 1985-06-15
HUT34754A (en) 1985-04-28
IE820338L (en) 1982-08-18
NO157503C (no) 1988-03-30
GB2093030A (en) 1982-08-25
CS227039B2 (en) 1984-04-16

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