DK1501485T3 - Tablet med höjt indhold af aktivt stof - Google Patents

Tablet med höjt indhold af aktivt stof

Info

Publication number
DK1501485T3
DK1501485T3 DK03722519T DK03722519T DK1501485T3 DK 1501485 T3 DK1501485 T3 DK 1501485T3 DK 03722519 T DK03722519 T DK 03722519T DK 03722519 T DK03722519 T DK 03722519T DK 1501485 T3 DK1501485 T3 DK 1501485T3
Authority
DK
Denmark
Prior art keywords
tablet
active substance
high content
content
substance
Prior art date
Application number
DK03722519T
Other languages
Danish (da)
English (en)
Inventor
Christian-Peter Luftensteiner
Jean-Claude Bianchi
Joerg Ogorka
Oskar Kalb
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9935351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1501485(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1501485T3 publication Critical patent/DK1501485T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK03722519T 2002-04-23 2003-04-22 Tablet med höjt indhold af aktivt stof DK1501485T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0209265A GB0209265D0 (en) 2002-04-23 2002-04-23 Organic compounds
PCT/EP2003/004151 WO2003090720A1 (en) 2002-04-23 2003-04-22 High drug load tablet

Publications (1)

Publication Number Publication Date
DK1501485T3 true DK1501485T3 (da) 2007-12-27

Family

ID=9935351

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03722519T DK1501485T3 (da) 2002-04-23 2003-04-22 Tablet med höjt indhold af aktivt stof

Country Status (32)

Country Link
US (6) US20050267125A1 (es)
EP (1) EP1501485B1 (es)
JP (4) JP2005529126A (es)
KR (1) KR100728846B1 (es)
CN (2) CN101653424A (es)
AR (3) AR039335A1 (es)
AT (1) ATE374016T1 (es)
AU (1) AU2003229705C1 (es)
BR (1) BR0309528A (es)
CA (1) CA2483199C (es)
CY (1) CY1106996T1 (es)
DE (1) DE60316552T2 (es)
DK (1) DK1501485T3 (es)
ES (1) ES2290457T3 (es)
GB (1) GB0209265D0 (es)
GE (1) GEP20094627B (es)
HK (1) HK1073253A1 (es)
HR (1) HRP20040996B1 (es)
IL (1) IL164678A (es)
MX (1) MXPA04010496A (es)
MY (1) MY136406A (es)
NO (1) NO341027B1 (es)
NZ (1) NZ536046A (es)
PE (1) PE20031045A1 (es)
PL (1) PL199779B1 (es)
PT (1) PT1501485E (es)
RU (2) RU2363450C2 (es)
SI (1) SI1501485T1 (es)
TN (1) TNSN04213A1 (es)
TW (1) TWI350184B (es)
WO (1) WO2003090720A1 (es)
ZA (1) ZA200408441B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
EP1720853B2 (en) 2004-02-11 2023-06-28 Natco Pharma Limited Pharmaceutical compositions of the 2 crystalline form of imatinib mesylate for use in the treatment of chronic myelogenous leukemia
WO2006040779A2 (en) * 2004-10-11 2006-04-20 Natco Pharma Limited Controlled release gastric floating matrix formulation containing imatinib
UA93673C2 (ru) 2005-03-07 2011-03-10 Баер Шеринг Фарма Акциенгезельшафт Фармацевтическая композиция, которая содержит омега-карбоксиарилзамещенную дифенилмочевину, для лечения paka
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
DK1884242T3 (da) 2005-05-26 2013-05-06 Dainippon Sumitomo Pharma Co Farmaceutisk sammensætning omfattende lurasidon
EP1762230B2 (de) 2005-08-15 2016-04-20 Siegfried International AG Filmtablette oder Granulat enthaltend ein Pyridylpyrimidin
CA2662265A1 (en) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Imatinib compositions
NZ575113A (en) 2006-09-22 2012-03-30 Novartis Ag Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors
EP1920767A1 (en) * 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Melt-processed imatinib dosage form
BRPI0817946A2 (pt) 2007-09-25 2015-05-05 Teva Pharma Composições de imatinibe estável
PT3067043T (pt) 2007-11-06 2023-03-01 Novartis Ag Composições farmacêuticas baseadas em superestruturas de antagonista/bloqueador de receptores da angiotensina (arb) e inibidores da endopeptidase neutra (nep)
JP2011526292A (ja) 2008-06-27 2011-10-06 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 神経線維腫および関連する腫瘍を抑制および／または治療する物質および方法
EP2370078A1 (en) 2008-12-01 2011-10-05 Novartis AG Method of optimizing the treatment of philadelphia-positive leukemia with imatinib mesylate
PL389357A1 (pl) 2009-10-22 2011-04-26 Tomasz Koźluk Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania
PL390611A1 (pl) 2010-03-04 2011-09-12 Tomasz Koźluk Sposób otrzymywania polimorficznej formy alfa i nowa forma polimorficzna mesylanu imatinibu
EP2582362A1 (en) 2010-06-21 2013-04-24 Zaklady Farmaceutyczne "Polpharma" S.A. Pharmaceutical compositions comprising imatinib or pharmaceutically acceptable salt thereof and processes for the manufacture thereof
WO2011161689A1 (en) * 2010-06-21 2011-12-29 Suven Nishtaa Pharma Pvt Ltd Imatinib mesilate pharmaceutical tablet
EP2603288A1 (en) 2010-08-11 2013-06-19 Synthon BV Pharmaceutical granulate comprising imatinib mesylate
TR201010618A2 (tr) 2010-12-20 2012-07-23 Bi̇lgi̇ç Mahmut İmatinib içeren bir oral dozaj formu ve bu oral dozaj formunun üretimi
CN102552268A (zh) * 2010-12-23 2012-07-11 天津泰普药品科技发展有限公司 一种含有α晶型甲磺酸伊马替尼的药物制剂
PL394169A1 (pl) 2011-03-09 2012-09-10 Adamed Spółka Z Ograniczoną Odpowiedzialnością Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania
US9750700B2 (en) 2011-06-22 2017-09-05 Natco Pharma Limited Imatinib mesylate oral pharmaceutical composition and process for preparation thereof
CN102349874B (zh) * 2011-08-26 2013-04-17 石药集团中奇制药技术（石家庄）有限公司 一种甲磺酸伊马替尼组合物及其制备方法
CN102349875A (zh) * 2011-10-11 2012-02-15 浙江华海药业股份有限公司 甲磺酸伊马替尼片的制备方法
JP2014532647A (ja) 2011-10-28 2014-12-08 ノバルティス アーゲー 消化管間質腫瘍を治療する方法
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
EA026665B1 (ru) 2011-11-24 2017-05-31 Имунекс Фарма Илак Санайи Ве Тикарет А.С. Твердые формы препаратов иматиниба, ресуспензируемые непосредственно перед применением
KR101428149B1 (ko) * 2011-12-23 2014-08-08 씨제이헬스케어 주식회사 이매티닙메실산염 함유 과립, 이를 포함하는 경구용 속방성 정제 조성물 및 그것의 제조방법
EP2817030A1 (en) 2012-02-21 2014-12-31 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
GB201204810D0 (en) 2012-03-20 2012-05-02 Pharos Pharmaceutical Oriented Services Ltd Pharmaceutical compositions
JP5928159B2 (ja) * 2012-05-28 2016-06-01 ニプロ株式会社 医薬組成物
CN104427986A (zh) 2012-07-11 2015-03-18 诺华股份有限公司 治疗胃肠道基质瘤的方法
RU2517216C2 (ru) * 2012-08-22 2014-05-27 Закрытое Акционерное Общество "БИОКАД" (ЗАО "БИОКАД") Фармацевтическая композиция иматиниба или его фармацевтически приемлемой соли, способ ее получения и способ(ы) лечения
GB201304699D0 (en) 2013-03-15 2013-05-01 Remedica Ltd Pharmaceutical compositions
KR101520792B1 (ko) * 2013-04-10 2015-05-15 보령제약 주식회사 고부하 이매티닙 정제
EP2803353B1 (en) 2013-05-14 2018-05-23 Hetero Research Foundation Compositions of Imatinib
CN104749226A (zh) * 2013-12-25 2015-07-01 辰欣药业股份有限公司 一种用电位滴定法测定甲磺酸伊马替尼含量的方法
WO2017078647A1 (en) 2015-11-05 2017-05-11 Koçak Farma Ilaç Ve Kimya Sanayi Anonim Şirketi Pharmaceutical compositions of imatinib
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3257499A1 (en) 2016-06-17 2017-12-20 Vipharm S.A. Process for preparation of imatinib methanesulfonate capsules
WO2019016673A2 (en) 2017-07-20 2019-01-24 Kashiv Pharma Llc STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION OF IMATINIB
AU2020312840A1 (en) 2019-07-15 2022-01-20 Intas Pharmaceuticals Ltd. Pharmaceutical composition of imatinib

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH176497A (de) 1934-09-14 1935-04-15 Schmid Ernst Alarmvorrichtung.
US3453368A (en) * 1966-01-13 1969-07-01 Hoffmann La Roche Smaller high potency compressed tablets of ascorbic acid
US3751277A (en) * 1971-03-24 1973-08-07 Dow Chemical Co Tablet coating process and composition
US4562024A (en) 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US4639458A (en) 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
US4666705A (en) * 1985-06-03 1987-05-19 E. R. Squibb & Sons, Inc. Controlled release formulation
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
EP0277092B1 (de) * 1987-01-14 1992-01-29 Ciba-Geigy Ag Therapeutisches System für schwerlösliche Wirkstoffe
JPS63267731A (ja) * 1987-04-23 1988-11-04 Asahi Chem Ind Co Ltd 錠剤組成物
JPH03501967A (ja) 1987-07-22 1991-05-09 ヨハン・ヴィッゴ・ファーベル エイズの処置に有用なフシジン酸
YU120988A (en) 1988-06-23 1990-06-30 Lek Tovarna Farmacevtskih Process for preparing new dispersion pills of cimetidine
US5368864A (en) 1988-11-25 1994-11-29 Henning Berlin Gmbh Chemie- Und Pharmawerk Formulation of oxypurinol and/or its alkali and alkaline earth salts
US4911921A (en) 1989-02-02 1990-03-27 Mallinckrodt, Inc. High ibuprofen content granulations
DE4031881C2 (de) 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby
US5635208A (en) 1993-07-20 1997-06-03 Mcneil-Ppc, Inc. Granulation process for producing an acetaminophen and diphenhydramine hydrochloride composition and composition produced by same
US5506248A (en) * 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
ES2179079T3 (es) 1993-10-12 2003-01-16 Mitsubishi Pharma Corp Comprimidos que contienen granulos entericos.
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
DE69530308T2 (de) * 1994-09-22 2003-10-16 Akzo Nobel Nv Verfahren zur herstellung von dosierungsformen durch feuchtgranulierung
ES2079327B1 (es) 1994-12-13 1996-08-01 Lilly Sa Formulaciones farmaceuticas de cefaclor.
US6106865A (en) 1995-01-09 2000-08-22 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
GB9501127D0 (en) 1995-01-20 1995-03-08 Wellcome Found Tablet
TW442301B (en) 1995-06-07 2001-06-23 Sanofi Synthelabo Pharmaceutical compositions containing irbesartan
US5994348A (en) 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
US5805889A (en) * 1995-10-20 1998-09-08 Sun Microsystems, Inc. System and method for integrating editing and versioning in data repositories
US6123964A (en) 1995-10-27 2000-09-26 Merck & Co., Inc. Wet granulation formulation of a growth hormone secretagogue
ES2231369T3 (es) 1996-02-29 2005-05-16 Fujisawa Pharmaceutical Co., Ltd. Granulo de disgregacion rapida de un edulcorante sintetico que contiene acido silicico y/o dioxido de silicio.
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
JP3212531B2 (ja) * 1997-03-21 2001-09-25 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース、低置換度ヒドロキシプロピルセルロース崩壊剤及びその製造方法
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
FI109088B (fi) 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
IL136142A0 (en) 1997-11-17 2001-05-20 Smithkline Beecham Corp High drug load immediate and modified release oral dosage formulations and processes for their manufacture
DE19758100B4 (de) * 1997-12-18 2006-05-04 Lichtwer Pharma Ag Verfahren zum Herstellen von Pflanzenextrakt enthaltenden pharmazeutischen Formulierungen
NZ507271A (en) 1998-03-06 2003-03-28 Eurand Internat S Fast disintegrating tablets
UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
CA2239931A1 (en) 1998-07-15 2000-01-15 Bernard Charles Sherman Pharmaceutical tablet comprising norfloxacin
SI1105105T1 (sl) * 1998-08-12 2006-08-31 Altana Pharma Ag Oralna dajalna oblika za piridin-2-ilmetilsulfinil-1J-benzimidazole
FR2785538B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
KR100650489B1 (ko) 1998-11-10 2006-11-28 바이엘 헬스케어 아게 목시플록사신 제약 제제
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
IT1311907B1 (it) 1999-04-06 2002-03-20 Zambon Spa Compresse deglutibili ad alto contenuto di n-acetilcisteina.
UA72922C2 (uk) 1999-08-03 2005-05-16 Ліллі Айкос Ллк ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ З <font face="Symbol">b</font>-КАРБОЛІНОМ (ВАРІАНТИ) ТА СПОСІБ ЛІКУВАННЯ СЕКСУАЛЬНОЇ ДИСФУНКЦІЇ
US6294198B1 (en) * 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
US6264983B1 (en) 1999-09-16 2001-07-24 Rhodia, Inc. Directly compressible, ultra fine acetaminophen compositions and process for producing same
US6582721B1 (en) 1999-09-17 2003-06-24 Alcon, Inc. Stable carotene-xanthophyll beadlet compositions and methods of use
JP2001139462A (ja) 1999-11-10 2001-05-22 Dai Ichi Seiyaku Co Ltd 新規製剤
IL144763A0 (en) * 1999-12-08 2002-06-30 Pharmacia Corp Valdecoxib compositions
BR0016236A (pt) 1999-12-09 2002-12-24 Boots Co Plc Agentes terapêuticos
ITMI992711A1 (it) * 1999-12-27 2001-06-27 Novartis Ag Composti organici
DE10003757A1 (de) * 2000-01-28 2001-08-02 Knoll Ag Ibuprofen-Wirkstoffzubereitung
OA12381A (en) 2000-03-03 2004-09-06 Ranbaxy Lab Ltd Orally administered controlled delivery system foronce daily administration of ciprofloxacin.
AU2001243243B2 (en) 2000-03-22 2004-10-14 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
DE10015479A1 (de) 2000-03-29 2001-10-11 Basf Ag Feste orale Darreichungsformen mit retardierter Wirkstofffreisetzung und hoher mechanischer Stabilität
CA2405793A1 (en) 2000-04-12 2001-10-18 Novartis Ag Combination of organic compounds
SK18062002A3 (sk) 2000-06-22 2003-07-01 Novartis Ag Pevné orálne farmaceutické kompozície obsahujúce valsartan
JP4698000B2 (ja) 2000-06-27 2011-06-08 旭化成ケミカルズ株式会社 水易溶性薬物含有錠剤
EP1364660B1 (en) 2001-02-27 2010-12-22 Senju Pharmaceutical Co., Ltd. Drug-releasing system of biodegradable polymer type
US7888341B2 (en) * 2002-04-10 2011-02-15 The United States Of America As Represented By The Department Of Veterans Affairs Combination of glivec (STI571) with a cyclin-dependent kinase inhibitor, especially flavopiridol, in the treatment of cancer
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
HRP20040996B1 (en) 2010-11-30
IL164678A (en) 2014-02-27
AR039335A1 (es) 2005-02-16
TWI350184B (en) 2011-10-11
GEP20094627B (en) 2009-03-10
ZA200408441B (en) 2005-08-31
IL164678A0 (en) 2005-12-18
NO341027B1 (no) 2017-08-07
CA2483199A1 (en) 2003-11-06
JP2005529126A (ja) 2005-09-29
PE20031045A1 (es) 2004-02-10
EP1501485A1 (en) 2005-02-02
US20140135340A1 (en) 2014-05-15
PT1501485E (pt) 2007-12-18
AR072755A2 (es) 2010-09-22
PL371495A1 (en) 2005-06-27
JP2015143250A (ja) 2015-08-06
AR084101A2 (es) 2013-04-24
NO20045072L (no) 2005-01-20
PL199779B1 (pl) 2008-10-31
MY136406A (en) 2008-09-30
RU2004134323A (ru) 2005-08-10
US20050267125A1 (en) 2005-12-01
CA2483199C (en) 2010-08-17
AU2003229705A1 (en) 2003-11-10
JP5798269B2 (ja) 2015-10-21
RU2363450C2 (ru) 2009-08-10
JP2013079271A (ja) 2013-05-02
RU2405540C1 (ru) 2010-12-10
TNSN04213A1 (en) 2007-03-12
WO2003090720A1 (en) 2003-11-06
AU2003229705B2 (en) 2007-01-25
ES2290457T3 (es) 2008-02-16
MXPA04010496A (es) 2004-12-13
BR0309528A (pt) 2005-02-15
US20120177737A1 (en) 2012-07-12
DE60316552T2 (de) 2008-07-03
DE60316552D1 (de) 2007-11-08
GB0209265D0 (en) 2002-06-05
KR100728846B1 (ko) 2007-06-14
JP5752107B2 (ja) 2015-07-22
US9011911B2 (en) 2015-04-21
US20100203133A1 (en) 2010-08-12
SI1501485T1 (sl) 2008-08-31
US20160101105A1 (en) 2016-04-14
TW200404009A (en) 2004-03-16
CN1646103A (zh) 2005-07-27
HRP20040996A2 (en) 2005-06-30
EP1501485B1 (en) 2007-09-26
KR20040101550A (ko) 2004-12-02
CN101653424A (zh) 2010-02-24
CY1106996T1 (el) 2012-09-26
AU2003229705C1 (en) 2017-09-07
HK1073253A1 (en) 2005-09-30
ATE374016T1 (de) 2007-10-15
US20150209291A1 (en) 2015-07-30
JP2010031019A (ja) 2010-02-12
NZ536046A (en) 2007-08-31

Similar Documents

Publication Publication Date Title
DK1501485T3 (da) Tablet med höjt indhold af aktivt stof
CY2016042I2 (el) Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
ATE442131T1 (de) Stabilisierte supergesättigte feste lísungen von steroidalen arzneimitteln
DE60323235D1 (de) Pramipexol-tablette mit verzögerter wirkstoffabgabe
DK1362582T3 (da) Overtrukket fast doseringsform
CY2017048I2 (el) Νεες φαρμακευτικες χρησεις των παραγωγων σταυροσπορινης
MA28802B1 (fr) Utilisations therapeutiques d&#39;inhibiteurs de rtp801
DE60331153D1 (de) Reboxetin enthaltende tablette mit verzögerter wirkstoffabgabe
DK1558578T3 (da) Nye Alkynforbindelser med MCH-antagonistisk virkning og lægemiddel indeholdende disse forbindelser.
IS7894A (is) Skammtaform með ofnæmisvaka
AU2003223352A8 (en) Transparent consistent active replication of multithreaded application programs
NO20043696L (no) Gamma-sekretaseinhibitorer
DK1803718T3 (da) 4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter
DK3042674T3 (da) Anordning og fremgangsmåde til lyofilisering af et aktivt stof
DE60333294D1 (de) Kontrollierte verabreichung von arzneien
FR2838446B1 (fr) Melanges de stabilisants
NO20045679D0 (no) Nye fysiologisk aktive substanser
DE60336538D1 (de) Stabilisiervorrichtung
DK3138566T3 (da) Behandling af phenylketonuri med bh4
DK1425019T3 (da) Farmaceutisk sammensætning omfattende et androgen
DK1675852T3 (da) Heterocykliske 7-amino-alkylidenyl-quinoloner og -naphthyridoner
IS7833A (is) Efnasambönd með sameinaða heteróhringi
FI20077133A (fi) Essitalopraamin kiteinen emäs ja essitalopraamiemästä sisältäviä, suussa hajoavia tabletteja
DE60326568D1 (de) Pendellager
NO20044188L (no) Kontrollerte frigjoringsdoseformer