DK1492792T3 - 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-acetamidderivater, deres fremstilling og deres terapeutiske anvendelse - Google Patents

3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-acetamidderivater, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number
DK1492792T3
DK1492792T3 DK03730299T DK03730299T DK1492792T3 DK 1492792 T3 DK1492792 T3 DK 1492792T3 DK 03730299 T DK03730299 T DK 03730299T DK 03730299 T DK03730299 T DK 03730299T DK 1492792 T3 DK1492792 T3 DK 1492792T3
Authority
DK
Denmark
Prior art keywords
sub
pyridazino
indole
dihydro
heteroaryl
Prior art date
Application number
DK03730299T
Other languages
English (en)
Inventor
Jacques X Froissant
Benoit Marabout
Frederic Puech
Frank Marguet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1492792T3 publication Critical patent/DK1492792T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DK03730299T 2002-04-03 2003-04-02 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-acetamidderivater, deres fremstilling og deres terapeutiske anvendelse DK1492792T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0204158A FR2838124B1 (fr) 2002-04-03 2002-04-03 Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DK1492792T3 true DK1492792T3 (da) 2006-08-14

Family

ID=28052083

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03730299T DK1492792T3 (da) 2002-04-03 2003-04-02 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indol-1-acetamidderivater, deres fremstilling og deres terapeutiske anvendelse

Country Status (29)

Country Link
US (4) US7235554B2 (da)
EP (1) EP1492792B1 (da)
JP (2) JP4575670B2 (da)
KR (1) KR100975999B1 (da)
CN (2) CN100406459C (da)
AT (1) ATE321763T1 (da)
AU (1) AU2003240930B2 (da)
BR (1) BR0309018A (da)
CA (1) CA2481460C (da)
CY (1) CY1104998T1 (da)
DE (1) DE60304327T2 (da)
DK (1) DK1492792T3 (da)
EA (1) EA007219B1 (da)
ES (1) ES2261940T3 (da)
FR (1) FR2838124B1 (da)
HK (2) HK1074632A1 (da)
HR (1) HRP20040911B1 (da)
IL (2) IL164257A0 (da)
IS (1) IS2483B (da)
ME (2) ME00081B (da)
MX (1) MXPA04009635A (da)
NO (1) NO329426B1 (da)
NZ (1) NZ535741A (da)
PL (1) PL372617A1 (da)
PT (1) PT1492792E (da)
RS (1) RS51244B (da)
UA (1) UA77273C2 (da)
WO (1) WO2003082874A2 (da)
ZA (1) ZA200407945B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017932A1 (en) * 2004-08-18 2006-02-23 Genesense Technologies Inc. Small interfering rna molecules against ribonucleotide reductase and uses thereof
CA2619419A1 (en) * 2005-08-19 2007-03-22 Schering Corporation Fused tricyclic mglur1 antagonists as therapeutic agents
JP2012516327A (ja) * 2009-01-30 2012-07-19 アストラゼネカ アクチボラグ カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法
CN105330665B (zh) * 2015-11-04 2017-10-03 衡阳师范学院 一种抑制激肽释放酶klk7的化合物、制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) * 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
KR100975999B1 (ko) 2010-08-17
CY1104998T1 (el) 2009-11-04
FR2838124A1 (fr) 2003-10-10
IL164257A0 (en) 2005-12-18
US20080255129A1 (en) 2008-10-16
CA2481460C (en) 2011-02-15
CN100406459C (zh) 2008-07-30
MEP23708A (en) 2010-06-10
NO329426B1 (no) 2010-10-18
UA77273C2 (en) 2006-11-15
US7323467B2 (en) 2008-01-29
HK1102371A1 (en) 2007-11-16
ME00081B (me) 2010-10-10
EA007219B1 (ru) 2006-08-25
ATE321763T1 (de) 2006-04-15
WO2003082874A3 (fr) 2004-04-01
JP5277208B2 (ja) 2013-08-28
CN100543016C (zh) 2009-09-23
CN1656099A (zh) 2005-08-17
NZ535741A (en) 2007-03-30
US20080076775A1 (en) 2008-03-27
RS51244B (sr) 2010-12-31
CA2481460A1 (en) 2003-10-09
US20050124615A1 (en) 2005-06-09
US7405306B2 (en) 2008-07-29
RS86904A (en) 2006-12-15
EA200401146A1 (ru) 2005-06-30
KR20040094904A (ko) 2004-11-10
EP1492792B1 (fr) 2006-03-29
IS2483B (is) 2008-12-15
NO20044153L (no) 2004-12-27
PL372617A1 (en) 2005-07-25
IS7478A (is) 2004-09-30
AU2003240930B2 (en) 2009-07-30
WO2003082874A2 (fr) 2003-10-09
HRP20040911B1 (en) 2012-11-30
JP4575670B2 (ja) 2010-11-04
ZA200407945B (en) 2005-11-30
AU2003240930A1 (en) 2003-10-13
EP1492792A2 (fr) 2005-01-05
IL164257A (en) 2009-11-18
DE60304327D1 (de) 2006-05-18
BR0309018A (pt) 2005-02-01
PT1492792E (pt) 2006-08-31
MXPA04009635A (es) 2005-07-13
CN1970538A (zh) 2007-05-30
ES2261940T3 (es) 2006-11-16
US7235554B2 (en) 2007-06-26
HK1074632A1 (en) 2005-11-18
JP2005527566A (ja) 2005-09-15
FR2838124B1 (fr) 2004-05-28
DE60304327T2 (de) 2006-12-28
HRP20040911A2 (en) 2004-12-31
JP2010248221A (ja) 2010-11-04
US20070219202A1 (en) 2007-09-20

Similar Documents

Publication Publication Date Title
HRP20020712B1 (hr) Farmaceutske strukture koje sadrže derivate azetidina, novi derivati azetidina i njihovo pripremanje
NO20065184L (no) 1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav
WO2003051366A3 (en) 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
TR200102490T2 (tr) Fenil ve piridinil türevleri
TW200607808A (en) Pyrido-pyrimidine derivatives, preparation thereof and application thereof
ATE319704T1 (de) Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
NO20022124L (no) Imidazopyridinderivater som fosfodiesterase VII-inhibitorer
HUP0302193A2 (hu) 1,4-Diazabiciklo[3.2.2]nonán-benzoxazol,-benzotiazol és -benzimidazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
HK1074632A1 (en) 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-acetamide derivatives, preparation and use thereof in medicaments
WO2005095399A3 (fr) Derives pyrrolo (2,3-b) pyridine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
DK393486D0 (da) Dihydropyridin-derivater og fremgangsmaade til fremstilling deraf
CY1106029T1 (el) Παραγωγα 3-ετepοαρυλιο-3,5-διυδρο-4-οξο-4η-πυριδαζινο[4,5-β]ινδολη-1-καρβοξαμιδο, η παρασκευη τους και η εφαρμογη τους στη θepαπευτικη
YU49902A (sh) Supstituisani derivati piperazina kao mtp inhibitori
RS59904A (en) Derivatives of 5-(pyridin-3-yl)-1-azabicyclo(3.2.1)octane, the preparation thereof and the application of same in therapeutics
NO20064073L (no) Derivater fra 2H- eller 3H-benzo[e]indazol-1-yl-karbamat, deres fremstilling og terapeutisk anvendelse derav
NO20041704L (no) Substituerte alkylaminopyridazinonderivater, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger som inneholder disse
MX2007003159A (es) Derivados piridinicos de indolin-2-ona, prepracion y uso terapeutico de los mismos.
NO20035026D0 (no) Dihydroimidazo [5,1-A]-<beta>-karbolinderivater, fremgangsmåte til deres fremstilling og anvendelse derav som legemiddel
CO5631444A2 (es) Derivados 3-heteroaril-3,5-dihidro-4-oxo-4h-piridazino [4,5- b] indol-1-ecetamida
ATE500241T1 (de) Phenyl- und pyridyl-piperidine mit tnf-wirkung
GR1001123B (el) Μεθοδος παρασκευης 1,4-διυδροπυριδινων.