EA200401146A1 - ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВ - Google Patents
ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4H-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВInfo
- Publication number
- EA200401146A1 EA200401146A1 EA200401146A EA200401146A EA200401146A1 EA 200401146 A1 EA200401146 A1 EA 200401146A1 EA 200401146 A EA200401146 A EA 200401146A EA 200401146 A EA200401146 A EA 200401146A EA 200401146 A1 EA200401146 A1 EA 200401146A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- group
- heteroaril
- pyridazino
- indol
- Prior art date
Links
- IUUZMSMGSOUFTO-UHFFFAOYSA-N 2-indol-1-ylacetamide Chemical compound C1=CC=C2N(CC(=O)N)C=CC2=C1 IUUZMSMGSOUFTO-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Данное изобретение относится к соединениям общей формулы (I), где X=H или галоген, R=H или (C-C)алкил, Rи Rнезависимо = H или группа (C-C)алкил, либо Rи Rобразуют вместе с атомом азота, несущим их, группу пирролидинил, пиперидинил, морфолино или 4-(C-C)алкилпиперазинил, и Het = гетероароматическая группа, представляющая собой группу пиридинил, хинолинил, изохинолинил, пиримидинил, пиразинил или пиридазинил, причем гетероароматическая группа возможно имеет в качестве заместителей один или несколько атомов галогена и/или одну или несколько групп (C-C)алкил, (C-C)алкокси в форме оснований, в виде солей присоединения кислоты, сольватов или гидратов; фармацевтическим композициям, содержащим упомянутые выше соединения, способам их получения и их промежуточным продуктам синтеза.Отчет о международном поиске был опубликован 2004.04.01.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0204158A FR2838124B1 (fr) | 2002-04-03 | 2002-04-03 | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| PCT/FR2003/001027 WO2003082874A2 (fr) | 2002-04-03 | 2003-04-02 | DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200401146A1 true EA200401146A1 (ru) | 2005-06-30 |
| EA007219B1 EA007219B1 (ru) | 2006-08-25 |
Family
ID=28052083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200401146A EA007219B1 (ru) | 2002-04-03 | 2003-04-02 | ПРОИЗВОДНЫЕ 3-ГЕТЕРОАРИЛ-3,5-ДИГИДРО-4-ОКСО-4Н-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВ |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US7235554B2 (ru) |
| EP (1) | EP1492792B1 (ru) |
| JP (2) | JP4575670B2 (ru) |
| KR (1) | KR100975999B1 (ru) |
| CN (2) | CN100406459C (ru) |
| AT (1) | ATE321763T1 (ru) |
| AU (1) | AU2003240930B2 (ru) |
| BR (1) | BR0309018A (ru) |
| CA (1) | CA2481460C (ru) |
| CY (1) | CY1104998T1 (ru) |
| DE (1) | DE60304327T2 (ru) |
| DK (1) | DK1492792T3 (ru) |
| EA (1) | EA007219B1 (ru) |
| ES (1) | ES2261940T3 (ru) |
| FR (1) | FR2838124B1 (ru) |
| HK (2) | HK1102371A1 (ru) |
| HR (1) | HRP20040911B1 (ru) |
| IL (2) | IL164257A0 (ru) |
| IS (1) | IS2483B (ru) |
| ME (2) | MEP23708A (ru) |
| MX (1) | MXPA04009635A (ru) |
| NO (1) | NO329426B1 (ru) |
| NZ (1) | NZ535741A (ru) |
| PL (1) | PL372617A1 (ru) |
| PT (1) | PT1492792E (ru) |
| RS (1) | RS51244B (ru) |
| UA (1) | UA77273C2 (ru) |
| WO (1) | WO2003082874A2 (ru) |
| ZA (1) | ZA200407945B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255065A1 (en) * | 2004-08-18 | 2008-10-16 | Genesense Technologies, Inc. | Small Interfering Rna Molecules Against Ribonucleotide Reductase and Uses Thereof |
| JP2009504752A (ja) * | 2005-08-19 | 2009-02-05 | シェーリング コーポレイション | 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト |
| JP2012516327A (ja) * | 2009-01-30 | 2012-07-19 | アストラゼネカ アクチボラグ | カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法 |
| CN105330665B (zh) * | 2015-11-04 | 2017-10-03 | 衡阳师范学院 | 一种抑制激肽释放酶klk7的化合物、制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
| FR2788696B1 (fr) * | 1999-01-26 | 2004-03-05 | Synthelabo | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
| FR2811990A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| FR2811897A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES |
| FR2833953B1 (fr) * | 2001-12-21 | 2004-12-03 | Sanofi Synthelabo | DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2002
- 2002-04-03 FR FR0204158A patent/FR2838124B1/fr not_active Expired - Fee Related
-
2003
- 2003-02-04 UA UA20041008012A patent/UA77273C2/uk unknown
- 2003-04-02 DK DK03730299T patent/DK1492792T3/da active
- 2003-04-02 PT PT03730299T patent/PT1492792E/pt unknown
- 2003-04-02 ES ES03730299T patent/ES2261940T3/es not_active Expired - Lifetime
- 2003-04-02 MX MXPA04009635A patent/MXPA04009635A/es active IP Right Grant
- 2003-04-02 AU AU2003240930A patent/AU2003240930B2/en not_active Ceased
- 2003-04-02 BR BR0309018-3A patent/BR0309018A/pt not_active IP Right Cessation
- 2003-04-02 CA CA2481460A patent/CA2481460C/en not_active Expired - Fee Related
- 2003-04-02 ME MEP-237/08A patent/MEP23708A/xx unknown
- 2003-04-02 US US10/509,695 patent/US7235554B2/en not_active Expired - Lifetime
- 2003-04-02 KR KR1020047015629A patent/KR100975999B1/ko not_active IP Right Cessation
- 2003-04-02 JP JP2003580339A patent/JP4575670B2/ja not_active Expired - Fee Related
- 2003-04-02 DE DE60304327T patent/DE60304327T2/de not_active Expired - Lifetime
- 2003-04-02 AT AT03730299T patent/ATE321763T1/de active
- 2003-04-02 ME MEP-2008-237A patent/ME00081B/me unknown
- 2003-04-02 EA EA200401146A patent/EA007219B1/ru not_active IP Right Cessation
- 2003-04-02 IL IL16425703A patent/IL164257A0/xx unknown
- 2003-04-02 CN CNB038122227A patent/CN100406459C/zh not_active Expired - Fee Related
- 2003-04-02 RS YUP-869/04A patent/RS51244B/sr unknown
- 2003-04-02 EP EP03730299A patent/EP1492792B1/fr not_active Expired - Lifetime
- 2003-04-02 CN CNB2006101003182A patent/CN100543016C/zh not_active Expired - Fee Related
- 2003-04-02 NZ NZ535741A patent/NZ535741A/en not_active IP Right Cessation
- 2003-04-02 PL PL03372617A patent/PL372617A1/xx unknown
- 2003-04-02 WO PCT/FR2003/001027 patent/WO2003082874A2/fr active Application Filing
-
2004
- 2004-09-23 IL IL164257A patent/IL164257A/en not_active IP Right Cessation
- 2004-09-30 IS IS7478A patent/IS2483B/is unknown
- 2004-09-30 NO NO20044153A patent/NO329426B1/no not_active IP Right Cessation
- 2004-10-01 ZA ZA2004/07945A patent/ZA200407945B/en unknown
- 2004-10-04 HR HRP20040911 patent/HRP20040911B1/xx not_active IP Right Cessation
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2005
- 2005-10-04 HK HK07108859.6A patent/HK1102371A1/xx not_active IP Right Cessation
- 2005-10-04 HK HK05108771A patent/HK1074632A1/xx not_active IP Right Cessation
-
2006
- 2006-06-29 CY CY20061100885T patent/CY1104998T1/el unknown
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2007
- 2007-05-16 US US11/749,342 patent/US7323467B2/en not_active Expired - Lifetime
- 2007-10-04 US US11/867,366 patent/US7405306B2/en not_active Expired - Fee Related
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2008
- 2008-06-20 US US12/143,059 patent/US20080255129A1/en not_active Abandoned
-
2010
- 2010-06-22 JP JP2010141683A patent/JP5277208B2/ja not_active Expired - Fee Related
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |