DK1480963T3 - Fremgangsmåde til fremstilling af 3-amidinophenylalanin-derivater - Google Patents

Fremgangsmåde til fremstilling af 3-amidinophenylalanin-derivater

Info

Publication number
DK1480963T3
DK1480963T3 DK03702270T DK03702270T DK1480963T3 DK 1480963 T3 DK1480963 T3 DK 1480963T3 DK 03702270 T DK03702270 T DK 03702270T DK 03702270 T DK03702270 T DK 03702270T DK 1480963 T3 DK1480963 T3 DK 1480963T3
Authority
DK
Denmark
Prior art keywords
derivatives
ethanol
intermediates
amidinophenylalanine
synthesis
Prior art date
Application number
DK03702270T
Other languages
English (en)
Inventor
Hugo Ziegler
Peter Wikstroem
Original Assignee
Wilex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilex Ag filed Critical Wilex Ag
Application granted granted Critical
Publication of DK1480963T3 publication Critical patent/DK1480963T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
DK03702270T 2002-02-28 2003-02-28 Fremgangsmåde til fremstilling af 3-amidinophenylalanin-derivater DK1480963T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00347/02A CH695999A5 (de) 2002-02-28 2002-02-28 Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
PCT/CH2003/000147 WO2003072559A1 (de) 2002-02-28 2003-02-28 Verfahren zur herstellung von 3-amidinophenylalanin-derivaten

Publications (1)

Publication Number Publication Date
DK1480963T3 true DK1480963T3 (da) 2007-09-10

Family

ID=27762105

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03702270T DK1480963T3 (da) 2002-02-28 2003-02-28 Fremgangsmåde til fremstilling af 3-amidinophenylalanin-derivater

Country Status (12)

Country Link
US (5) US7211670B2 (da)
EP (1) EP1480963B1 (da)
JP (2) JP5247970B2 (da)
CN (1) CN100369906C (da)
AT (1) ATE361285T1 (da)
AU (1) AU2003205498A1 (da)
CH (1) CH695999A5 (da)
DE (1) DE50307171D1 (da)
DK (1) DK1480963T3 (da)
ES (1) ES2282601T3 (da)
PT (1) PT1480963E (da)
WO (1) WO2003072559A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) * 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
DE10323898A1 (de) * 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
CA2583771C (en) * 2004-10-14 2013-08-27 Wilex Ag Method for cleaning 3-hydroxyamidinophenylalanine derivatives by the precipitation and recrystallization of salt and an aromatic sulfonic acid
DE102004057195A1 (de) * 2004-11-26 2006-06-01 Wilex Ag Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
JPWO2013147161A1 (ja) * 2012-03-29 2015-12-14 東レ株式会社 ニペコチン酸誘導体及びその医薬用途
MX2022011173A (es) 2020-03-10 2022-10-18 Redhill Biopharma Ltd Tratamiento de infeccion por coronavirus.
US11471448B2 (en) 2020-12-15 2022-10-18 Redhill Biopharma Ltd. Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia
CN114105910B (zh) * 2021-11-02 2024-04-12 北京悦康科创医药科技股份有限公司 一种羟基脒基苯丙氨酸衍生物、药物组合物与用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2375611A (en) * 1941-08-19 1945-05-08 May & Baker Ltd Production of amidines
US5518735A (en) * 1990-11-15 1996-05-21 Pentapharm Ag Meta-substituted phenylalanine derivatives
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
CH689611A5 (de) * 1995-03-01 1999-07-15 Pentapharm Ag Urokinase-Inhibitoren.
KR0173034B1 (ko) 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
TW513402B (en) 1997-05-30 2002-12-11 Daiichi Seiyaku Co Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives
ES2188003T3 (es) * 1998-09-18 2003-06-16 Pentapharm Ag Inhibidores de la uroquinasa.
DE10002510A1 (de) 2000-01-21 2001-07-26 Boehringer Ingelheim Pharma Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JP4778181B2 (ja) 2000-01-28 2011-09-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アセチル−アミジニオフェニルアラニル−シクロヘキシルグリシル−ピリジニオアラニンアミドの製造方法
CH695999A5 (de) * 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.

Also Published As

Publication number Publication date
US20050176962A1 (en) 2005-08-11
JP2010265288A (ja) 2010-11-25
ES2282601T3 (es) 2007-10-16
US8642761B2 (en) 2014-02-04
EP1480963B1 (de) 2007-05-02
US20070123706A1 (en) 2007-05-31
ATE361285T1 (de) 2007-05-15
USRE46424E1 (en) 2017-06-06
JP5247970B2 (ja) 2013-07-24
US20120065398A1 (en) 2012-03-15
CH695999A5 (de) 2006-11-15
US7884206B2 (en) 2011-02-08
DE50307171D1 (de) 2007-06-14
CN1639142A (zh) 2005-07-13
AU2003205498A1 (en) 2003-09-09
US20110087025A1 (en) 2011-04-14
PT1480963E (pt) 2007-05-31
EP1480963A1 (de) 2004-12-01
US8088921B2 (en) 2012-01-03
WO2003072559A1 (de) 2003-09-04
CN100369906C (zh) 2008-02-20
US7211670B2 (en) 2007-05-01
JP2005532270A (ja) 2005-10-27

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