DK1448562T3 - Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer - Google Patents

Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer

Info

Publication number
DK1448562T3
DK1448562T3 DK02782289T DK02782289T DK1448562T3 DK 1448562 T3 DK1448562 T3 DK 1448562T3 DK 02782289 T DK02782289 T DK 02782289T DK 02782289 T DK02782289 T DK 02782289T DK 1448562 T3 DK1448562 T3 DK 1448562T3
Authority
DK
Denmark
Prior art keywords
phosphodiesterase inhibitors
derivatives useful
substituted tetracyclic
pyrroloquinolone derivatives
tetracyclic pyrroloquinolone
Prior art date
Application number
DK02782289T
Other languages
Danish (da)
English (en)
Inventor
Weiqin Jiang
Zhihua Sui
Original Assignee
Ortho Mcneil Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharmaceutical Co filed Critical Ortho Mcneil Pharmaceutical Co
Application granted granted Critical
Publication of DK1448562T3 publication Critical patent/DK1448562T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
DK02782289T 2001-11-14 2002-11-12 Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer DK1448562T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33297701P 2001-11-14 2001-11-14
PCT/US2002/036117 WO2003042213A1 (en) 2001-11-14 2002-11-12 Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
DK1448562T3 true DK1448562T3 (da) 2007-09-24

Family

ID=23300709

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02782289T DK1448562T3 (da) 2001-11-14 2002-11-12 Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer

Country Status (15)

Country Link
US (1) US6686349B2 (pt)
EP (1) EP1448562B1 (pt)
JP (1) JP4484517B2 (pt)
CN (1) CN1280292C (pt)
AT (1) ATE368040T1 (pt)
CA (1) CA2467269C (pt)
CY (1) CY1107747T1 (pt)
DE (1) DE60221425T2 (pt)
DK (1) DK1448562T3 (pt)
ES (1) ES2289159T3 (pt)
HK (1) HK1069169A1 (pt)
MY (1) MY128241A (pt)
PT (1) PT1448562E (pt)
TW (1) TWI264437B (pt)
WO (1) WO2003042213A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19629299A1 (de) * 1996-07-20 1998-01-22 Agfa Gevaert Ag Verfahren und Vorrichtung zum Aufnehmen einer Bildinformation
DK1534707T5 (da) * 2002-06-19 2010-01-11 Janssen Pharmaceutica Nv Substituerede 2,4-dihydropyrrolo[3,4-b]quinolin-9-on-derivater egnede som phosphodiesteraseinhibitorer
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) * 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
EP1914235A1 (en) * 2006-10-10 2008-04-23 Universite de Lille 2 Droit et Santé Chiral tetra-hydro beta-carboline derivatives and applications thereof as antiparasitic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN110862391B (zh) * 2019-11-13 2020-09-25 株洲千金药业股份有限公司 一种他达拉非杂质g的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH625521A5 (pt) 1976-10-15 1981-09-30 Sandoz Ag
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
DE4436509A1 (de) 1994-10-13 1996-04-18 Hoechst Schering Agrevo Gmbh Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
UA72611C2 (uk) * 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази

Also Published As

Publication number Publication date
WO2003042213A1 (en) 2003-05-22
EP1448562B1 (en) 2007-07-25
PT1448562E (pt) 2007-08-31
CA2467269C (en) 2011-04-05
EP1448562A1 (en) 2004-08-25
CN1280292C (zh) 2006-10-18
JP2005511626A (ja) 2005-04-28
TWI264437B (en) 2006-10-21
ES2289159T3 (es) 2008-02-01
DE60221425T2 (de) 2008-06-26
JP4484517B2 (ja) 2010-06-16
ATE368040T1 (de) 2007-08-15
HK1069169A1 (en) 2005-05-13
CA2467269A1 (en) 2003-05-22
TW200408640A (en) 2004-06-01
CY1107747T1 (el) 2013-04-18
CN1615309A (zh) 2005-05-11
DE60221425D1 (de) 2007-09-06
MY128241A (en) 2007-01-31
US6686349B2 (en) 2004-02-03
US20030144268A1 (en) 2003-07-31

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